Genetics of interleukin 1 receptor-like 1 in immune and inflammatory diseases

Current Genomics

Volumn 11, Issue 8, 2010, Pages 591-606

  Akhabir, Loubna ^a   Sandford, Andrew ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Asthma; Genetics; IL1RL1; Immunity; Inflammation; Respiratory; SNP

Indexed keywords

IMMUNOGLOBULIN E; INTERLEUKIN 1; INTERLEUKIN 1 RECEPTOR; INTERLEUKIN 33;

ALLERGIC RHINITIS; ARTICLE; ASTHMA; ATOPIC DERMATITIS; ATOPY; BRONCHUS HYPERREACTIVITY; CARDIOVASCULAR DISEASE; CELIAC DISEASE; CHRONIC OBSTRUCTIVE LUNG DISEASE; CROHN DISEASE; DIABETES MELLITUS; ENTERITIS; EOSINOPHIL COUNT; GENE; GENE CONTROL; GENE EXPRESSION; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; HEPATITIS C; HUMAN; HUMORAL IMMUNITY; IMMUNE RESPONSE; IMMUNOPATHOLOGY; INFLAMMATORY DISEASE; INSULIN DEPENDENT DIABETES MELLITUS; INTERLEUKIN 1 RECEPTOR LIKE 1 GENE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; NOSE POLYP; PNEUMOCONIOSIS; POLLEN ALLERGY; RHEUMATOID ARTHRITIS; RHINOSINUSITIS; RUBELLA VIRUS; SCHIZOPHRENIA; SCLEROSIS; SINGLE NUCLEOTIDE POLYMORPHISM; SYSTEMIC LUPUS ERYTHEMATOSUS; ULCERATIVE COLITIS;

ANIMALIA;

EID: 78650008419     PISSN: 13892029     EISSN: None     Source Type: Journal    
DOI: 10.2174/138920210793360907     Document Type: Article

References (89)

1. Mitcham, J. L.; Parnet, P.; Bonnert, T. P.; Garka, K. E.; Gerhart, M. J.; Slack, J. L.; Gayle, M. A.; Dower, S. K.; Sims, J. E. T1/ST2 signaling establishes it as a member of an expanding interleukin-1 receptor family. J. Biol. Chem., 1996, 271(10), 5777-5783.
2. Kumar, S.; Minnich, M. D.; Young, P. R. ST2/T1 protein functionally binds to two secreted proteins from Balb/c 3T3 and human umbilical vein endothelial cells but does not bind interleukin 1. J. Biol. Chem., 1995, 270(46), 27905-27913.
3. Schmitz, J.; Owyang, A.; Oldham, E.; Song, Y.; Murphy, E.; McClanahan, T. K.; Zurawski, G.; Moshrefi, M.; Qin, J.; Li, X.; Gorman, D. M.; Bazan, J. F.; Kastelein, R. A. IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines. Immunity, 2005, 23(5), 479-490.
4. Murphy, G. E. J.; Xu, D.; Liew, F. Y.; McInnes, I. B. Role of interleukin 33 in human immunopathology. Ann. Rheum. Dis., 2010, 69(Suppl 1), i43-i47.
5. Liew, F. Y.; Pitman, N. I.; McInnes, I. B. Disease-associated functions of IL-33: the new kid in the IL-1 family. Nat. Rev. Immunol., 2010, 10(2), 103-110.
6. Li, H.; Tago, K.; Io, K.; Kuroiwa, K.; Arai, T.; Iwahana, H.; Tominaga, S.-I.; Yanagisawa, K. The cloning and nucleotide sequence of human ST2L cDNA. Genomics, 2000, 67(3), 284-290.
7. Iwahana, H.; Yanagisawa, K.; Ito-Kosaka, A.; Kuroiwa, K.; Tago, K.; Komatsu, N.; Katashima, R.; Itakura, M.; Tominaga, S.-i. Different promoter usage and multiple transcription initiation sites of the interleukin-1 receptor-related human ST2 gene in UT-7 and TM12 cells. Eur. J. Biochem., 1999, 264(2), 397-406.
8. Bergers, G.; Reikerstorfer, A.; Braselmann, S.; Graninger, P.; Busslinger, M. Alternative promoter usage of the Fos-responsive gene Fit-1 generates mRNA isoforms coding for either secreted or membrane-bound proteins related to the IL-1 receptor. EMBO J., 1994, 13(5), 1176-1188.
9. Tago, K.; Noda, T.; Hayakawa, M.; Iwahana, H.; Yanagisawa, K.; Yashiro, T.; Tominaga, S.-i. Tissue distribution and subcellular localization of a variant form of the human ST2 gene product, ST2V. Biochem. Biophys. Res. Commun., 2001, 285(5), 1377-1383.
10. Gracie, J. A.; Robertson, S. E.; McInnes, I. B. Interleukin-18. J. Leukoc. Biol., 2003, 73(2), 213-224.
11. McInnes, I.; Liew, F.; Gracie, J. A. Interleukin-18: a therapeutic target in rheumatoid arthritis? Arthritis Res. Ther., 2005, 7(1), 38 -41.
12. Nakanishi, K.; Yoshimoto, T.; Tsutsui, H.; Okamura, H. Interleukin-18 is a unique cytokine that stimulates both Th1 and Th2 responses depending on its cytokine milieu. Cytokine Growth Factor Rev., 2001, 12(1), 53-72.
13. Kang, M.-J.; Homer, R. J.; Gallo, A.; Lee, C. G.; Crothers, K. A.; Cho, S. J.; Rochester, C.; Cain, H.; Chupp, G.; Yoon, H. J.; Elias, J. A. IL-18 is induced and IL-18 receptor {alpha} plays a critical role in the pathogenesis of cigarette smoke-induced pulmonary emphysema and inflammation. J. Immunol., 2007, 178(3), 1948-1959.
14. Watanabe, M.; Kaneko, H.; Shikano, H.; Aoki, M.; Sakaguchi, H.; Matsui, E.; Inoue, R.; Kato, Z.; Kasahara, K.; Fukutomi, O.; Kondo, T.; Kondo, N. Predominant expression of 950delCAG of IL-18Rα chain cDNA is associated with reduced IFN-γ production and high serum IgE levels in atopic Japanese children. J. Allergy Clin. Immunol., 2002, 109(4), 669-675.
15. Wittmann, M.; Purwar, R.; Hartmann, C.; Gutzmer, R.; Werfel, T. Human keratinocytes respond to interleukin-18: implication for the course of chronic inflammatory skin diseases. J. Investig. Dermatol., 2005, 124(6), 1225-1233.
16. Kawakami, K.; Qureshi, M. H.; Zhang, T.; Okamura, H.; Kurimoto, M.; Saito, A. IL-18 protects mice against pulmonary and disseminated infection with Cryptococcus neoformans by inducing IFN-gamma production. J. Immunol., 1997, 159(11), 5528-5534.
17. Dayer, J.-M. Interleukin-18, rheumatoid arthritis, and tissue destruction. J. Clin. Invest., 1999, 104(10), 1337-1339.
18. Zhu, G.; Whyte, M.; Vestbo, J.; Carlsen, K.; Carlsen, K.; Lenney, W.; Silverman, M.; Helms, P.; Pillai, S. Interleukin 18 receptor 1 gene polymorphisms are associated with asthma. Eur. J. Hum. Genet., 2008, 16(9), 1083-90.
19. Reijmerink, N. E.; Postma, D. S.; Bruinenberg, M.; Nolte, I. M.; Meyers, D. A.; Bleecker, E. R.; Koppelman, G. H. Association of IL1RL1, IL18R1, and IL18RAP gene cluster polymorphisms with asthma and atopy. J. Allergy Clin. Immunol., 2008, 122(3), 651-654.e8.
20. Yanagisawa, K.; Naito, Y.; Kuroiwa, K.; Arai, T.; Furukawa, Y.; Tomizuka, H.; Miura, Y.; Kasahara, T.; Tetsuka, T.; Tominaga, S.-i. The expression of ST2 gene in helper T cells and the binding of ST2 protein to myeloma-derived RPMI8226 cells. J. Biochem., 1997, 121(1), 95-103.
21. Suzukawa, M.; Iikura, M.; Koketsu, R.; Nagase, H.; Tamura, C.; Komiya, A.; Nakae, S.; Matsushima, K.; Ohta, K.; Yamamoto, K.; Yamaguchi, M. An IL-1 cytokine member, IL-33, induces human basophil activation via Its ST2 receptor. J. Immunol., 2008, 181(9), 5981-5989.
22. Suzukawa, M.; Koketsu, R.; Iikura, M.; Nakae, S.; Matsumoto, K.; Nagase, H.; Saito, H.; Matsushima, K.; Ohta, K.; Yamamoto, K.; Yamaguchi, M. Interleukin-33 enhances adhesion, CD11b expression and survival in human eosinophils. Lab. Invest., 2008, 88(11), 1245-1253.
23. Pushparaj, P. N.; Tay, H. K.; H'ng, S. C.; Pitman, N.; Xu, D.; McKenzie, A.; Liew, F. Y.; Melendez, A. J. The cytokine interleukin-33 mediates anaphylactic shock. Proc. Natl. Acad. Sci. USA, 2009, 106(24), 9773-9778.
24. Brint, E. K.; Xu, D.; Liu, H.; Dunne, A.; McKenzie, A. N. J.; O'Neill, L. A. J.; Liew, F. Y. ST2 is an inhibitor of interleukin 1 receptor and Toll-like receptor 4 signaling and maintains endotoxin tolerance. Nat. Immunol., 2004, 5(4), 373-379.
25. Kurowska-Stolarska, M.; Stolarski, B.; Kewin, P.; Murphy, G.; Corrigan, C. J.; Ying, S.; Pitman, N.; Mirchandani, A.; Rana, B.; Van Rooijen, N.; Shepherd, M.; McSharry, C.; McInnes, I. B.; Xu, D.; Liew, F. Y. IL-33 amplifies the polarization of alternatively activated macrophages that contribute to airway inflammation. J. Immunol., 2009, 183(10), 6469-6477.
26. Weinberg, E. O.; Shimpo, M.; De Keulenaer, G. W.; MacGillivray, C.; Tominaga, S.-i.; Solomon, S. D.; Rouleau, J.-L.; Lee, R. T. Expression and regulation of ST2, an interleukin-1 receptor family member, in cardiomyocytes and myocardial infarction. Circulation, 2002, 106(23), 2961-2966.
27. Mildner, M.; Storka, A.; Lichtenauer, M.; Mlitz, V.; Ghannadan, M.; Hoetzenecker, K.; Nickl, S.; Dome, B.; Tschachler, E.; Ankersmit, H. J. Primary sources and immunological prerequisites for sST2 secretion in humans. Cardiovasc. Res., 2010, Epub ahead of print.
28. Coyle, A. J.; Lloyd, C.; Tian, J.; Nguyen, T.; Erikkson, C.; Wang, L.; Ottoson, P.; Persson, P.; Delaney, T.; Lehar, S.; Lin, S.; Poisson, L.; Meisel, C.; Kamradt, T.; Bjerke, T.; Levinson, D.; Gutierrez-Ramos, J. C. Crucial role of the interleukin 1 receptor family member T1/St2 in T helper cell type 2-mediated lung mucosal immune responses. J. Exp. Med., 1999, 190(7), 895-902.
29. Neill, D. R.; Wong, S. H.; Bellosi, A.; Flynn, R. J.; Daly, M.; Langford, T. K. A.; Bucks, C.; Kane, C. M.; Fallon, P. G.; Pannell, R.; Jolin, H. E.; McKenzie, A. N. J. Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity. Nature, 2010, 464(7293), 1367-1370.
30. Hayakawa, H.; Hayakawa, M.; Kume, A.; Tominaga, S.-i. Soluble ST2 blocks interleukin-33 signaling in allergic airway inflammation. J. Biol. Chem., 2007, 282(36), 26369-26380.
31. Fagundes, C. T.; Amaral, F. A.; Souza, A. L. S.; Vieira, A. T.; Xu, D.; Liew, F. Y.; Souza, D. G.; Teixeira, M. M. ST2, an IL-1R family member, attenuates inflammation and lethality after intestinal ischemia and reperfusion. J. Leukoc. Biol., 2007, 81(2), 492-499.
32. Spahn, J. D. Asthma biomarkers in sputum. Immunol. Allergy Clin. North Am., 2007, 27(4), 607-622.
33. Lambrecht, B. N.; De Veerman, M.; Coyle, A. J.; Gutierrez-Ramos, J.-C.; Thielemans, K.; Pauwels, R. A. Myeloid dendritic cells induce Th2 responses to inhaled antigen, leading to eosinophilic airway inflammation. J. Clin. Invest., 2000, 106(4), 551-559.
34. Lohning, M.; Stroehmann, A.; Coyle, A. J.; Grogan, J. L.; Lin, S.; Gutierrez-Ramos, J.-C.; Levinson, D.; Radbruch, A.; Kamradt, T. T1/ST2 is preferentially expressed on murine Th2 cells, independent of interleukin 4, interleukin 5, and interleukin 10, and important for Th2 effector function. Proc. Natl. Acad. Sci. USA, 1998, 95(12), 6930-6935.
35. Oshikawa, K.; Yanagisawa, K.; Tominaga, S.; Sugiyama, Y. Expression and function of the ST2 gene in a murine model of allergic airway inflammation. Clin. Exp. Allergy, 2002, 32(10), 1520-1526.
36. Ali, M.; Zhang, G.; Thomas, W. R.; McLean, C. J.; Bizzintino, J. A.; Laing, I. A.; Martin, A. C.; Goldblatt, J.; Souëf, P. N. L.; Hayden, C. M. Investigations into the role of ST2 in acute asthma in children. Tissue Antigens, 2009, 73(3), 206-212.
37. Oshikawa, K.; Kuroiwa, K.; Tago, K.; Iwahana, H.; Yanagisawa, K. E. N.; Ohno, S.; Tominaga, S.-I.; Sugiyama, Y. Elevated Soluble ST2 Protein Levels in Sera of Patients with Asthma with an Acute Exacerbation. Am. J. Respir. Crit. Care Med., 2001, 164(2), 277-281.
38. Kearley, J.; Buckland, K. F.; Mathie, S. A.; Lloyd, C. M. Resolution of allergic inflammation and airway hyperreactivity is dependent upon disruption of the T1/ST2-IL-33 pathway. Am. J. Respir. Crit. Care Med., 2009, 179(9), 772-781.
39. Ober, C.; Cox, N. J.; Abney, M.; Di Rienzo, A.; Lander, E. S.; Changyaleket, B.; Gidley, H.; Kurtz, B.; Lee, J.; Nance, M.; Pettersson, A.; Prescott, J.; Richardson, A.; Schlenker, E.; Summerhill, E.; Willadsen, S.; Parry, R. Genome-wide search for asthma susceptibility loci in a founder population. The collaborative study on the genetics of asthma. Hum. Mol. Genet., 1998, 7(9), 1393-1398.
40. Postma, D. S.; Meyers, D. A.; Jongepier, H.; Howard, T. D.; Koppelman, G. H.; Bleecker, E. R. Genomewide screen for pulmonary function in 200 families ascertained for asthma. Am. J. Respir. Crit. Care Med., 2005, 172(4), 446-452.
41. Wjst, M.; Fischer, G.; Immervoll, T.; Jung, M.; Saar, K.; Rueschendorf, F.; Reis, A.; Ulbrecht, M.; Gomolka, M.; Weiss, E. H.; Jaeger, L.; Nickel, R.; Richter, K.; Kjellman, N. I. M.; Griese, M.; von Berg, A.; Gappa, M.; Riedel, F.; Boehle, M.; van Koningsbruggen, S.; Schoberth, P.; Szczepanski, R.; Dorsch, W.; Silbermann, M.; Loesgen, S.; Scholz, M.; Bickeböller, H.; Wichmann, H.-E. On behalf of the german asthma genetics, G., A genomewide search for linkage to asthma. Genomics, 1999, 58(1), 1-8.
42. Sweet, M. J.; Leung, B. P.; Kang, D.; Sogaard, M.; Schulz, K.; Trajkovic, V.; Campbell, C. C.; Xu, D.; Liew, F. Y. A novel pathway regulating lipopolysaccharide-induced shock by ST2/T1 via inhibition of toll-like receptor 4 expression. J. Immunol., 2001, 166(11), 6633-6639.
43. Reijmerink, N. E.; Bottema, R. W. B.; Kerkhof, M.; Gerritsen, J.; Stelma, F. F.; Thijs, C.; Schayck, C. P. v.; Smit, H. A.; Brunekreef, B.; Koppelman, G. H.; Postma, D. S. TLR-related pathway analysis: novel gene-gene interactions in the development of asthma and atopy. Allergy, 2009, 65(2), 199-207.
44. Daley, D.; Lemire, M.; Akhabir, L.; Chan-Yeung, M.; He, J.; McDonald, T.; Sandford, A.; Stefanowicz, D.; Tripp, B.; Zamar, D.; Bosse, Y.; Ferretti, V.; Montpetit, A.; Tessier, M.-C.; Becker, A.; Kozyrskyj, A.; Beilby, J.; McCaskie, P.; Musk, B.; Warrington, N.; James, A.; Laprise, C.; Palmer, L.; Paré, P.; Hudson, T. Analyses of associations with asthma in four asthma population samples from Canada and Australia. Hum. Genet., 2009, 125(4), 445-459.
45. Wang, T.-T.; Tavera-Mendoza, L. E.; Laperriere, D.; Libby, E.; Burton MaCleod, N.; Nagai, Y.; Bourdeau, V.; Konstorum, A.; Lallemant, B.; Zhang, R.; Mader, S.; White, J. H. Large-scale in silico and microarray-based identification of direct 1,25-dihydroxyvitamin D3 target genes. Mol. Endocrinol., 2005, 19(11), 2685-2695.
46. Bossé, Y.; Lemire, M.; Poon, A.; Daley, D.; He, J.-Q.; Sandford, A.; White, J.; James, A.; Musk, A.; Palmer, L.; Raby, B.; Weiss, S.; Kozyrskyj, A.; Becker, A.; Hudson, T.; Laprise, C. Asthma and genes encoding components of the vitamin D pathway. Respir. Res., 2009, 10(1), 98.
47. Gudbjartsson, D. F.; Bjornsdottir, U. S.; Halapi, E.; Helgadottir, A.; Sulem, P.; Jonsdottir, G. M.; Thorleifsson, G.; Helgadottir, H.; Steinthorsdottir, V.; Stefansson, H.; Williams, C.; Hui, J.; Beilby, J.; Warrington, N. M.; James, A.; Palmer, L. J.; Koppelman, G. H.; Heinzmann, A.; Krueger, M.; Boezen, H. M.; Wheatley, A.; Altmuller, J.; Shin, H. D.; Uh, S.-T.; Cheong, H. S.; Jonsdottir, B.; Gislason, D.; Park, C.-S.; Rasmussen, L. M.; Porsbjerg, C.; Hansen, J. W.; Backer, V.; Werge, T.; Janson, C.; Jonsson, U.-B.; Ng, M. C. Y.; Chan, J.; So, W. Y.; Ma, R.; Shah, S. H.; Granger, C. B.; Quyyumi, A. A.; Levey, A. I.; Vaccarino, V.; Reilly, M. P.; Rader, D. J.; Williams, M. J. A.; van Rij, A. M.; Jones, G. T.; Trabetti, E.; Malerba, G.; Pignatti, P. F.; Boner, A.; Pescollderungg, L.; Girelli, D.; Olivieri, O.; Martinelli, N.; Ludviksson, B. R.; Ludviksdottir, D.; Eyjolfsson, G. I.; Arnar, D.; Thorgeirsson, G.; Deichmann, K.; Thompson, P. J.; Wjst, M.; Hall, I. P.; Postma, D. S.; Gislason, T.; Gulcher, J.; Kong, A.; Jonsdottir, I.; Thorsteinsdottir, U.; Stefansson, K. Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction. Nat. Genet., 2009, 41(3), 342-347.
48. Buysschaert, I. D.; Grulois, V.; Eloy, P.; Jorissen, M.; Rombaux, P.; Bertrand, B.; Collet, S.; Bobic, S.; Vlaminck, S.; Hellings, P. W.; Lambrechts, D. Genetic evidence for a role of IL33 in nasal polyposis. Allergy, 2009, 65(5), 616-622.
49. Wu, H.; Romieu, I.; Shi, M.; Hancock, D. B.; Li, H.; Sienra-Monge, J.-J.; Chiu, G. Y.; Xu, H.; del Rio-Navarro, B. E.; London, S. J. Evaluation of candidate genes in a genome-wide association study of childhood asthma in Mexicans. J. Allergy Clin. Immunol., 2009, 125(2), 321-327.e13.
50. Kato, A.; Schleimer, R. P. Beyond inflammation: airway epithelial cells are at the interface of innate and adaptive immunity. Curr. Opin. Immunol., 2007, 19(6), 711-720.
51. Mangan, Niamh E.; Dasvarma, A.; McKenzie, Andrew N.; Padraic, G. F. T1/ST2 expression on Th2 cells negatively regulates allergic pulmonary inflammation. Eur. J. Immunol., 2007, 37(5), 1302-1312.
52. Hacker, S.; Lambers, C.; Pollreisz, A.; Hoetzenecker, K.; Lichtenauer, M.; Mangold, A.; Niederpold, T.; Hacker, A.; Lang, G.; Dworschak, M.; Vukovich, T.; Gerner, C.; Klepetko, W.; Ankersmit, H. Increased soluble serum markers caspase-cleaved cytokeratin-18, histones, and ST2 indicate apoptotic turnover and chronic immune response in COPD. J. Clin. Lab. Anal., 2009, 23(6), 372-379.
53. Shimizu, M.; Matsuda, A.; Yanagisawa, K.; Hirota, T.; Akahoshi, M.; Inomata, N.; Ebe, K.; Tanaka, K.; Sugiura, H.; Nakashima, K.; Tamari, M.; Takahashi, N.; Obara, K.; Enomoto, T.; Okayama, Y.; Gao, P.-S.; Huang, S.-K.; Tominaga, S.-I.; Ikezawa, Z.; Shirakawa, T. Functional SNPs in the distal promoter of the ST2 gene are associated with atopic dermatitis. Hum. Mol. Genet., 2005, 14(19), 2919-2927.
54. Sakashita, M.; Yoshimoto, T.; Hirota, T.; Harada, M.; Okubo, K.; Osawa, Y.; Fujieda, S.; Nakamura, Y.; Yasuda, K.; Nakanishi, K.; Tamari, M. Association of serum interleukin-33 level and the interleukin-33 genetic variant with Japanese cedar pollinosis. Clin. Exp. Allergy, 2008, 38(12), 1875-1881.
55. Castano, R.; Bossé, Y.; Endam, L. M.; Desrosiers, M. Evidence of association of interleukin-1 receptor-like 1 gene polymorphisms with chronic rhinosinusitis. Am. J. Rhinol. Allergy, 2009, 23, 377-384.
56. Kuroiwa, K.; Arai, T.; Okazaki, H.; Minota, S.; Tominaga, S.-i. Identification of Human ST2 Protein in the Sera of Patients with Autoimmune Diseases. Biochem. Biophys. Res. Commun., 2001, 284(5), 1104-1108.
57. Mok, M. Y.; Huang, F. P.; Ip, W. K.; Lo, Y.; Wong, F. Y.; Chan, E. Y. T.; Lam, K. F.; Xu, D. Serum levels of IL-33 and soluble ST2 and their association with disease activity in systemic lupus erythematosus. Rheumatology, 2010, 49(3), 520-527.
58. Han, J. W.; Zheng, H. F.; Cui, Y.; Sun, L. D.; Ye, D. Q.; Hu, Z.; Xu, J. H.; Cai, Z. M.; Huang, W.; Zhao, G. P.; Xie, H. F.; Fang, H.; Lu, Q. J.; Xu, J. H.; Li, X. P.; Pan, Y. F.; Deng, D. Q.; Zeng, F. Q.; Ye, Z. Z.; Zhang, X. Y.; Wang, Q. W.; Hao, F.; Ma, L.; Zuo, X. B.; Zhou, F. S.; Du, W. H.; Cheng, Y. L.; Yang, J. Q.; Shen, S. K.; Li, J.; Sheng, Y. J.; Zuo, X. X.; Zhu, W. F.; Gao, F.; Zhang, P. L.; Guo, Q.; Li, B.; Gao, M.; Xiao, F. L.; Quan, C.; Zhang, C.; Zhang, Z.; Zhu, K. J.; Li, Y.; Hu, D. Y.; Lu, W. S.; Huang, J. L.; Liu, S. X.; Li, H.; Ren, Y. Q.; Wang, Z. X.; Yang, C. J.; Wang, P. G.; Zhou, W. M.; Lv, Y. M.; Zhang, A. P.; Zhang, S. Q.; Lin, D.; Li, Y.; Low, H. Q.; Shen, M.; Zhai, Z. F.; Wang, Y.; Zhang, F. Y.; Yang, S.; Liu, J. J.; Zhang, X. J. Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus. Nat. Genet., 2009, 41(11), 1234-7.
59. Graham, R. R.; Hom, G.; Ortmann, W.; Behrens, T. W. Review of recent genome-wide association scans in lupus. J. Intern. Med., 2009, 265(6), 680-8.
60. Leung, B. P.; Xu, D.; Culshaw, S.; McInnes, I. B.; Liew, F. Y. A Novel therapy of murine collagen-induced arthritis with soluble T1/ST2. J. Immunol., 2004, 173(1), 145-150.
61. Palmer, G.; Talabot-Ayer, D.; Lamacchia, C.; Toy, D.; Seemayer, C. A.; Viatte, S.; Finckh, A.; Smith, D. E.; Gabay, C. Inhibition of interleukin-33 signaling attenuates the severity of experimental arthritis. Arthritis Rheum., 2009, 60(3), 738-749.
62. Matsuyama, Y.; Okazaki, H.; Tamemoto, H.; Kimura, H.; Kamata, Y.; Nagatani, K.; Nagashima, T.; Hayakawa, M.; Iwamoto, M.; Yoshio, T.; Tominaga, S.; Minota, S. Increased levels of interleukin 33 in sera and synovial fluid from patients with active rheumatoid arthritis. J. Rheumatol., 2010, 37(1), 18-25.
63. Xu, D.; Jiang, H.-R.; Li, Y.; Pushparaj, P. N.; Kurowska-Stolarska, M.; Leung, B. P.; Mu, R.; Tay, H. K.; McKenzie, A. N. J.; McInnes, I. B.; Melendez, A. J.; Liew, F. Y. IL-33 exacerbates autoantibody-induced arthritis. J. Immunol., 2010, 184(5), 2620-2626.
64. Orozco, G.; Barton, A. Update on the genetic risk factors for rheumatoid arthritis. Expert. Rev. Clin. Immunol., 2010, 6(1), 61-75.
65. Beltrán, C. J.; Núñez, L. E.; Díaz-Jiménez, D.; Farfan, N.; Candia, E.; Heine, C.; López, F.; González, M. J.; Quera, R.; Hermoso, M. A. Characterization of the novel ST2/IL-33 system in patients with inflammatory bowel disease. Inflamm. Bowel Dis., 2009, Epub ahead of print.
66. Pastorelli, L.; Garg, R. R.; Hoang, S. B.; Spina, L.; Mattioli, B.; Scarpa, M.; Fiocchi, C.; Vecchi, M.; Pizarro, T. T. Epithelialderived IL-33 and its receptor ST2 are dysregulated in ulcerative colitis and in experimental Th1/Th2 driven enteritis. Proc. Natl. Acad. Sci. USA, 2010, 107(17), 8017-8022.
67. Zhernakova, A.; Festen, E.; Franke, L.; Trynka, G.; Van Diemen, C.; Monsuur, A.; Bevova, M.; Nijmeijer, R.; Van 't Slot, R.; Heijmans, R.; Boezen, H.; Van Heel, D.; Van Bodegraven, A.; Stokkers, P.; Wijmenga, C.; Crusius, J.; RK, W. Genetic analysis of innate immunity in Crohn's disease and ulcerative colitis identifies two susceptibility loci harboring CARD9 and IL18RAP. Am. J. Hum. Genet., 2008, 82(5), 1202-10.
68. Van Heel, D. A.; Franke, L.; Hunt, K. A.; Gwilliam, R., Alexandra; Inouye, M.; Wapenaar, M. C.; Barnardo, M. C. N. M.; Bethel, G.; Holmes, G. K. T.; Feighery, C.; Jewell, D.; Kelleher, D.; Kumar, P.; Travis, S.; Walters, J. R. F.; Sanders, D. S.; Howdle, P.; Swift, J.; Playford, R. J.; McLaren, W. M.; Mearin, M. L.; Mulder, C. J.; McManus, R.; McGinnis, R.; Cardon, L. R.; Deloukas, P.; Wijmenga, C. A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21. Nat. Genet., 2007, 39(7), 827-829.
69. Imielinski, M.; Baldassano, R. N.; Griffiths, A.; Russell, R. K.; Annese, V.; Dubinsky, M.; Kugathasan, S.; Bradfield, J. P.; Walters, T. D.; Sleiman, P.; Kim, C. E.; Muise, A.; Wang, K.; Glessner, J. T.; Saeed, S.; Zhang, H.; Frackelton, E. C.; Hou, C.; Flory, J. H.; Otieno, G.; Chiavacci, R. M.; Grundmeier, R.; Castro, M.; Latiano, A.; Dallapiccola, B.; Stempak, J.; Abrams, D. J.; Taylor, K.; McGovern, D.; Heyman, M. B.; Ferry, G. D.; Kirschner, B.; Lee, J.; Essers, J.; Grand, R.; Stephens, M.; Levine, A.; Piccoli, D.; Van Limbergen, J.; Cucchiara, S.; Monos, D. S.; Guthery, S. L.; Denson, L.; Wilson, D. C.; Grant, S. F. A.; Daly, M.; Silverberg, M. S.; Satsangi, J.; Hakonarson, H. Common variants at five new loci associated with early-onset inflammatory bowel disease. Nat. Genet., 2009, 41(12), 1335-1340.
70. Mensah-Brown, E.; Shahin, A.; Parekh K, H. A., Shamisi MA, Hsu DK; Lukic, M. Functional capacity of macrophages determines the induction of type 1 diabetes. Ann. N. Y. Acad. Sci., 2006, 1084, 49-57.
71. Elbein, S. C.; Das, S. K.; Hallman, D. M.; Hanis, C. L.; Hasstedt, S. J. Genome-wide linkage and admixture mapping of type 2 diabetes in African American families from the American Diabetes Association GENNID (Genetics of NIDDM) Study Cohort. Diabetes, 2009, 58(1), 268-74.
72. Seki, K.; Sanada, S.; Kudinova, A. Y.; Steinhauser, M. L.; Handa, V.; Gannon; Joseph; Lee, R. T. Interleukin-33 prevents apoptosis and improves survival after experimental myocardial infarction through ST2 signaling. Circ. Heart Fail, 2009, 2(6), 684-691.
73. Weinberg, E. O.; Shimpo, M.; Hurwitz, S.; Tominaga, S.-I.; Rouleau, J.-L.; Lee, R. T. Identification of serum soluble ST2 receptor as a novel heart failure biomarker. Circulation, 2003, 107(5), 721-726.
74. Bartunek, J.; Delrue, L.; Van Durme, F.; Muller, O.; Casselman, F.; De Wiest, B.; Croes, R.; Verstreken, S.; Goethals, M.; de Raedt, H.; Sarma, J.; Joseph, L.; Vanderheyden, M.; Weinberg, E. O. Nonmyocardial production of ST2 protein in human hypertrophy and failure is related to diastolic load. J. Am. Coll. Cardiol., 2008, 52(25), 2166-2174.
75. Shah, R. V.; Chen-Tournoux, A. A.; Picard, M. H.; van Kimmenade, R. R. J.; Januzzi, J. L. Serum levels of the interleukin-1 receptor family member ST2, cardiac structure and function, and long-term mortality in patients with acute dyspnea. Circulation, 2009, 2(4), 311-319.
76. Dieplinger, B.; Gegenhuber, A.; Kaar, G.; Poelz, W.; Haltmayer, M.; Mueller, T. Prognostic value of established and novel biomarkers in patients with shortness of breath attending an emergency department. Clin. Biochem., 2010, 43(9), 714-719.
77. Boisot, S.; Beede, J.; Isakson, S.; Chiu, A.; Clopton, P.; Januzzi, J.; Maisel, A. S.; Fitzgerald, R. L. Serial Sampling of ST2 Predicts 90-Day Mortality Following Destabilized Heart Failure. J. Card. Fail., 2008, 14(9), 732-738.
78. Shimpo, M.; Morrow, D. A.; Weinberg, E. O.; Sabatine, M. S.; Murphy, S. A.; Antman, E. M.; Lee, R. T. Serum Levels of the Interleukin-1 Receptor Family Member ST2 Predict Mortality and Clinical Outcome in Acute Myocardial Infarction. Circulation, 2004, 109(18), 2186-2190.
79. Pascual-Figal, D. A.; Ordoñez-Llanos, J.; Tornel, P. L.; Vázquez, R.; Puig, T.; Valdés, M.; Cinca, J.; de Luna, A. B.; Bayes-Genis, A. Soluble ST2 for predicting sudden cardiac death in patients with chronic heart failure and left ventricular systolic dysfunction. J. Am. Coll. Cardiol., 2009, 54(23), 2174-2179.
80. Moore, S. A.; Januzzi Jr, J. L. Found in Translation: Soluble ST2 and Heart Disease. J. Am. Coll. Cardiol., 2010, 55(3), 251-253.
81. Weir, R. A. P.; Miller, A. M.; Murphy, G. E. J.; Clements, S.; Steedman, T.; Connell, J. M. C.; McInnes, I. B.; Dargie, H. J.; McMurray, J. J. V. Serum Soluble ST2: A Potential Novel Mediator in Left Ventricular and Infarct Remodeling After Acute Myocardial Infarction. J. Am. Coll. Cadiol., 2010, 55(3), 243-250.
82. Hoogerwerf, J.; Tanck, M.; Van Zoelen, M.; Wittebole, X.; Laterre, P.; Van der Poll, T. Soluble ST2 plasma concentrations predict mortality in severe sepsis. Intensive Care Med., 2010, 36(4), 630-7.
83. Baker, C.; Chaudry, I.; Gaines, H.; Baue, A. Evaluation of factors affecting mortality rate after sepsis in a murine cecal ligation and puncture model. Surgery, 1983, 94(2), 331-5.
84. Jones, L. A.; Roberts, F.; Nickdel, M. B.; Frank, B.; McKenzie, A. N. J.; Henriquez, F. L.; Alexander, J.; Roberts, C. W. IL-33 receptor (T1/ST2) signalling is necessary to prevent the development of encephalitis in mice infected with Toxoplasma gondii. Eur. J. Immunol., 2010, 40(2), 426-436.
85. Dhiman, N.; Ovsyannikova, I. G.; Vierkant, R. A.; Pankratz, V. S.; Jacobson, R. M.; Poland, G. A. Associations between cytokine/cytokine receptor single nucleotide polymorphisms and humoral immunity to measles, mumps and rubella in a Somali population. Tissue Antigens, 2008, 72(3), 211-20.
86. Imada, Y.; Fujimoto, M.; Hirata, K.; Hirota, T.; Suzuki, Y.; Saito, H.; Matsumoto, K.; Akazawa, A.; Katsunuma, T.; Yoshihara, S.; Ebisawa, M.; Shibasaki, M.; Arinami, T.; Tamari, M.; Noguchi, E. Large scale genotyping study for asthma in the Japanese population. BMC Res. Notes, 2009, 2(1), 54.
87. Humphreys, N. E.; Xu, D.; Hepworth, M. R.; Liew, F. Y.; Grencis, R. K. IL-33, a Potent Inducer of Adaptive Immunity to Intestinal Nematodes. J. Immunol., 2008, 180(4), 2443-2449.
88. Saito, T.; Ji, G.; Shinzawa, H.; Okumoto, K.; Hattori, E.; Adachi, T.; Takeda, T.; Sugahara, K.; Ito, J.-I.; Watanabe, H.; Saito, K.; Togashi, H.; Ishii, K.; Matsuura, T.; Inageda, K.; Muramatsu, M.; Kawata, S. Genetic variations in humans associated with differences in the course of hepatitis C. Biochem. Biophys. Res. Commun., 2004, 317(2), 335-341.
89. Marvie, P.; Lisbonne, M.; L'Helgoualc'h, A.; Rauch, M.; Turlin, B.; Preisser, L.; Bourd-Boittin, K.; Théret, N.; Gascan, H.; Piquet-Pellorce, C.; Samson, M. Interleukin-33 overexpression is associated with liver fibrosis in mice and humans. J. Cell. Mol. Med., 2010, 14(68), 1726-39.