Identification of human ST2 protein in the sera of patients with autoimmune diseases

Biochemical and Biophysical Research Communications

Volumn 284, Issue 5, 2001, Pages 1104-1108

  Kuroiwa, Kenji ^a,b   Arai, Takao ^b   Okazaki, Hitoaki ^a   Minota, Seiji ^a   Tominaga, Shin ichi ^a  

^a JICHI MEDICAL UNIVERSITY   (Japan)

^b TOKYO UNIVERSITY OF SCIENCE   (Japan)

Author keywords

ELISA; Glycosylation; Immunoblotting; Immunoprecipitation; ST2 gene

Indexed keywords

MONOCLONAL ANTIBODY; PROTEIN; PROTEIN ST 2; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; AUTOIMMUNE DISEASE; CONTROLLED STUDY; GLYCOSYLATION; HUMAN; IMMUNOBLOTTING; IMMUNOPATHOGENESIS; IMMUNOPRECIPITATION; MONKEY; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BLOOD LEVEL; SYSTEMIC LUPUS ERYTHEMATOSUS;

EID: 0034816240     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1006/bbrc.2001.5090     Document Type: Article

References (29)

1. A putative protein of a growth-specific cDNA from BALB/c-3T3 cells is highly similar to the extracellular portion of mouse interleukin 1 receptor
2. Murine ST2 gene is a member of the primary response gene family induced by growth factors
3. Induction of a mitogen-responsive gene after expression of the Ha-ras oncogene in NIH3T3 fibroblasts
4. Alternative promoter usage of the Fos-responsive gene Fit-1 generates mRNA isoforms coding for either secreted or membrane-bound proteins related to the IL-1 receptor
5. Growth factor-induced delayed early response gene
6. Molecular cloning of the murine ST2 gene. Characterization and chromosomal mapping
7. Assignment of human ST2 gene to chromosome 2 at q11.2
8. Interleukin-1 receptor cluster: Gene organization of IL1R2, IL1R1, IL1RL2 (IL-1RrP2), IL1RL1(T1/ST2), and IL18R1 (IL-1Rrp) on human chromosome 2q
9. The cloning and nucleotide sequence of human ST2L cDNA
10. Presence of a novel primary response gene ST2L, encoding a product highly similar to the interleukin 1 receptor type I
11. Nucleotide sequence of a complementary DNA for human ST2
12. T1/ST2 signaling establishes it as a member of an expanding interleukin-1 receptor family
13. Identification and characterization of two members of a novel class of the interleukin-1 receptor (IL-1R) family
14. The expression of ST2 gene in helper T cells and the binding of ST2 protein to myeloma-derived RPMI8226 cells
15. Selective expression of a stable cell surface molecule on type 2 but not type 1 helper T cells
16. T1/ST2 is preferentially expressed on murine Th2 cells, independent of interleukin 4, interleukin 5, and interleukin 10, and important for Th2 effector function
17. Presence and expression of a novel variant form of ST2 gene product in human leukemic cell line UT-7/GM
18. + T cells from schistosome egg-induced granulomas: Analysis of Th cell cytokine coexpression ex vivo
19. Crucial role of the interleukin 1 receptor family member T1/ST2 in T helper cell type 2-mediated lung mucosal immune responses
20. The absence of interleukin 1 receptor-related T1/ST2 does not affect T helper cell type 2 development and its effector function
21. Myeloid dendritic cells induce Th2 responses to inhaled antigen, leading to eosinophilic airway inflammation
22. T1/ST2-deficient mice demonstrate the importance of T1/ST2 in developing primary T helper cell type 2 responses
23. T1-deficient and T1-Fc-transgenic mice develop a normal protective Th2-type immune response following infection with Nippostrongylus brasiliensis
24. + T cells: Induction of type 2 cytokine production by T1/ST2 cross-linking
25. Construction of ELISA system to quantify human ST2 protein in sera of patients
26. Studies on natural ST2 gene products in the human leukemic cell line UT-7 using monoclonal antihuman ST2 antibodies
27. pEF-BOS, a powerful mammalian expression vector
28. Cleavage of structural proteins during the assembly of the head of bacteriophage T4
29. Sugar separates humans from apes