Effects of protons and HZE particles on glutamate transport in astrocytes, neurons and mixed cultures

Radiation Research

Volumn 174, Issue 6 A, 2010, Pages 669-678

  Sanchez, Martha C ^a   Nelson, Gregory A ^a   Green, Lora M ^a,b  

^a LOMA LINDA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Jerry L Pettis Memorial VA Medical Center   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUTAMATE TRANSPORTER; GLUTAMIC ACID; PROTON;

ARTICLE; ASTROCYTE; BRAIN NERVE CELL; CELL ISOLATION; CELL TRANSPORT; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; NERVE CELL CULTURE; NEUROCHEMISTRY; NUCLEON; PARTICLE RADIATION; PRIORITY JOURNAL; PROTEIN FUNCTION; RADIATION DOSE; RADIATION EXPOSURE; RADIATION RESPONSE; RADIOACTIVITY;

ASTROCYTES; BIOLOGICAL TRANSPORT; CARBON; CELLS, CULTURED; COSMIC RADIATION; EXCITATORY AMINO ACID TRANSPORTER 1; EXCITATORY AMINO ACID TRANSPORTER 2; GLUTAMIC ACID; HUMANS; LINEAR ENERGY TRANSFER; NEURONS; PARAQUAT; PROTONS; REACTIVE OXYGEN SPECIES;

EID: 78649992842     PISSN: 00337587     EISSN: None     Source Type: Journal    
DOI: 10.1667/RR2106.1     Document Type: Article

References (48)

1. J. Raber, R. Rola, A. LeFevour, D. Morhardt, J. Curley, S. Mizumatsu, S. R. VandenBerg and J. R. Fike, Radiation-induced cognitive impairments are associated with changes in indicators of hippocampal neurogenesis. Radiat. Res. 162, 39-47 (2004). (Pubitemid 39044717)
2. B. Shukitt-Hale, G. Casadesus, I. Cantuti-Castelvetri, B. M. Rabin and J. A. Joseph, Cognitive deficits induced by 56Fe radiation exposure. Adv. Space Res. 31, 119-126 (2003).
3. J. A. Joseph, B. Shukitt-Hale, J. McEwen and B. M. Rabin, CNS-induced deficits of heavy particle irradiation in space: the aging connection. Adv. Space Res. 25, 2057-2064 (2000).
4. R. Rola, S. Otsuka, A. Obenaus, G. A. Nelson, C. L. Limoli, S. R. VandenBerg and J. R. Fike, Indicators of hippocampal neurogenesis are altered by 56Fe-particle irradiation in a dosedependent manner. Radiat. Res. 162, 442-446 (2004).
5. P. J. Tofilon and J. R. Fike, The radioresponse of the central nervous system: A dynamic process. Radiat. Res. 153, 357-370 (2000).
6. J. D. Chapman and M. J. Allalunis-Turner, Cellular and molecular targets in normal tissue radiation injury. In Radiation Injury to the Nervous System (P. Gutin, S. Leibel and G. Sheline, Eds.), pp. 6-7. Raven Press, New York, 1991.
7. F. Noel and P. J. Tofilon, Astrocytes protect against X-rayinduced neuronal toxicity in vitro. Neuroreport 20, 1133-1137 (1998).
8. E. A. Blakely and P. Y. Chang, A review of ground-based heavy ion radiobiology relevant to space radiation risk assessment: Cataracts and CNS effects. Adv. Space Res. 40, 1307-1319 (2007).
9. K. Nojima, K. Ando, H. Fujiwara and S. Ando, Effects of carbon ions on primary cultures of mouse brain cells. Adv. Space Res. 25, 2051-2056 (2000).
10. R. Rola, V. Sarkissian, A. Obenaus, G. A. Nelson, S. Otsuka, C. L. Limoli and J. R. Fike, High-LET radiation induces inflammation and persistent changes in markers of hippocampal neurogenesis. Radiat. Res. 164, 556-560 (2005).
11. S. Mizumatsu, M. L. Monje, D. R. Morhardt, R. Rola, T. D. Palmer and J. R. Fike, Extreme sensitivity of adult neurogenesis to low doses of X-irradiation. Cancer Res. 63, 4021-4027 (2003).
12. R. Rola, K. Fishman, J. Baure, S. Rosi, K. R. Lamborn, A. Obenaus, G. A. Nelson and J. R. Fike, Hippocampal neurogenesis and neuroinflammation after cranial irradiation with 56Fe particles. Radiat. Res. 169, 626-632 (2008).
13. M. L. Monje, S. Mizumatsu, J. R. Fike and T. D. Palmer, Irradiation induces neural precursor-cell dysfunction. Nat. Med. 8, 955-962 (2002).
14. 56Feparticle radiation reduces neuronal output and attenuates lipopolysaccharide-induced inhibition of long-term potentiation in the mouse hippocampus. Radiat. Res. 169, 523-530 (2008).
15. J. R. Fike, S. Rosi and C. L. Limoli, Neural precursor cells and central nervous system radiation sensitivity. Semin. Radiat. Oncol. 19, 122-132 (2009).
16. N. C. Danbolt, Glutamate uptake. Prog. Neurobiol. 65, 1-105 (2001).
17. M. C. Sanchez, A. Benitez, L. Ortloff and L. M. Green, Alterations in glutamate uptake in NT2-derived neurons and astrocytes after exposure to gamma radiation. Radiat. Res. 171, 41-52 (2009).
18. S. J. Pleasure, C. Page and V. M. Lee, Pure, postmitotic, polarized human neurons derived from NTera 2 cells provide a system for expressing exogenous proteins in terminally differentiated neurons. J. Neurosci. 12, 1802-1815 (1992).
19. J. K. Sandhu, M. Sikorska and P. R. Walker, Characterization of astrocytes derived from human NTera-2/D1 embryonal carcinoma cells. J. Neurosci. Res. 68, 604-614 (2002).
20. A. Volterra, D. Trotti, C. Tromba, S. Floridi and G. Racagni, Glutamate uptake inhibition by oxygen free radicals in rat cortical astrocytes. J. Neurosci. 14, 2924-2932 (1994).
21. J. K. Sandhu, S. Pandey, M. Ribecco-Lutkiewicz, R. Monette, H. Borowy-Borowski, P. R. Walker and M. Sikorska, Molecular mechanisms of glutamate neurotoxicity in mixed cultures of NT2-derived neurons and astrocytes: protective effects of coenzyme Q10. J. Neurosci. Res. 72, 691-703 (2003).
22. P. W. Andrews, Retinoic acid induces neuronal differentiation of a cloned human embryonal carcinoma cell line in vitro. Dev. Biol. 103, 285-293 (1984).
23. V. M. Lee and P. W. Andrews, Differentiation of NTERA-2 clonal human embryonal carcinoma cells into neurons involves the induction of all three neurofilament proteins. J Neurosci. 6, 514-521 (1986).
24. M. Bani-Yaghoub, J. F. Bechberger, T. M. Underhill and C. C. Naus, The effects of gap junction blockage on neuronal differentiation of human NTera2/clone D1 cells. Exp. Neurol. 156, 16-32 (1999). (Pubitemid 29152980)
25. P. Guida and M. E. Vazquez, Cytotoxic and cell cycle effects in human neuronal progenitor cells exposed to 1 GeV/n Fe ions. Adv. Space Res. 39, 1004-1010 (2007).
26. C. L. Limoli, E. Giedzinski, J. Baure, R. Rola and J. R. Fike, Redox changes induced in hippocampal precursor cells by heavy ion irradiation. Radiat. Environ. Biophys. 46, 167-172 (2007).
27. Y. Chen and R. A. Swanson, The glutamate transporters EAAT2 and EAAT3 mediate cysteine uptake in cortical neuron cultures. J. Neurochem. 84, 1332-1339 (2003).
28. K. Aoyama, S. W. Suh, A. M. Hamby, J. Liu, W. Y. Chan, Y. Chen and R. A. Swanson, Neuronal glutathione deficiency and age-dependent neurodegeneration in the EAAC1 deficient mouse. Nat. Neurosci. 9, 119-126 (2006).
29. J. Levenson, E. Weeber, J. C. Selcher, L. S. Kategaya, J. D. Sweatt and A. Eskin, Long-term potentiation and contextual fear conditioning increase neuronal glutamate uptake. Nat. Neurosci. 5, 155-161 (2002).
30. R. Molteni, Z. Ying and F. Gomez-Pinilla, Differential effects of acute and chronic exercise on plasticity-related genes in the rat hippocampus revealed by microarray. Eur. J. Neurosci. 16, 1107-1116 (2002).
31. E. Giedzinski, R. Rola, J. R. Fike and C. L. Limoli, Efficient production of reactive oxygen species in neural precursor cells after exposure to 250 MeV protons. Radiat. Res. 164, 540-544 (2005).
32. N. Hamada, Recent insights into the biological action of heavyion radiation. J. Radiat. Res. (Tokyo) 50, 1-9 (2009).
33. D. Trotti, D. Rossi, O. Gjesdal, L. M. Levy, G. Racagni, N. C. Danbolt and A. Volterra, Peroxynitrite inhibits glutamate transporter subtypes. J. Biol. Chem. 271, 5976-5979 (1996).
34. K. E. Davis, D. J. Straff, E. A. Weinstein, P. G. Bannerman, D. M. Correale, J. D. Rothstein and M. B. Robinson, Multiple signaling pathways regulate cell surface expression and activity of the excitatory amino acid carrier 1 subtype of Glu transporter in C6 glioma. J. Neurosci. 18, 2475-2485 (1998).
35. G. Gegelashvili, Y. Dehnes, N. C. Danbolt and A. Schousboe, The high-affinity glutamate transporters GLT1, GLAST, and EAAT4 are regulated via different signalling mechanisms. Neurochem. Int. 37, 163-170 (2000).
36. N. J. Maragakis and J. D. Rothstein, Glutamate transporters in neurologic disease. Arch. Neurol. 58, 365-370 (2001).
37. P. Kugler and A. Schmitt, Complementary neuronal and glial expression of two high-affinity glutamate transporter GLT1/ EAAT2 forms in rat cerebral cortex. Histochem. Cell Biol. 119, 425-435 (2003).
38. J. C. Szerb and B. Issekutz, Increase in the stimulation-induced overflow of glutamate by fluoroacetate, a selective inhibitor of the glial tricarboxylic cycle. Brain Res. 410, 116-120 (1987).
39. D. O. Keyser and T. C. Pellmar, Synaptic transmission in the hippocampus: critical role for glial cells. Glia 10, 237-243 (1994).
40. K. Nakajima, S. Yamamoto, S. Kohsaka and T. Kurihara, Neuronal stimulation leading to upregulation of glutamate transporter-1 (GLT-1) in rat microglia in vitro. Neurosci. Lett. 436, 331-334 (2008).
41. E. A. Newman and K. R. Zahs, Modulation of neuronal activity by glial cells in the retina. J. Neurosci. 18, 4022-4028 (1998).
42. A. Araque, V. Parpura, R. P. Sanzgiri and P. G. Haydon, Glutamate-dependent astrocyte modulation of synaptic transmission between cultured hippocampal neurons. Eur. J. Neurosci. 10, 2129-2142 (1998).
43. G. Bonvento, N. Sibson and L. Pellerin, Does glutamate image your thoughts? Trends Neurosci. 25, 359-364 (2002).
44. P. J. Magistretti and L. Pellerin, Astrocytes couple synaptic activity to glucose utilization in the brain. News Physiol. Sci. 14, 177-182 (1999).
45. Z. Cohen, I. Bouchelet, A. Olivier, J. G. Villemure, R. Ball, D. B. Stanimirovic and E. Hamel, Multiple microvascular and astroglial 5-hydroxytryptamine receptor subtypes in human brain: Molecular and pharmacologic characterization. J. Cereb. Blood Flow Metab. 19, 908-917 (1999).
46. R. Abounader, A. Elhusseiny, Z. Cohen, A. Olivier, D. Stanimirovic, R. Quirion and E. Hamel, Expression of neuropeptide Y receptors mRNA and protein in human brain vessels and cerebromicrovascular cells in culture. J. Cereb. Blood Flow Metab. 19, 155-163 (1999).
47. A. Elhusseiny, Z. Cohen, A. Olivier, D. B. Stanimirovic and E. Hamel, Functional acetylcholine muscarinic receptor subtypes in human brain microcirculation: identification and cellular localization. J. Cereb. Blood Flow Metab. 19, 794-802 (1999).
48. K. Braet, L. Cabooter, K. Paemeleire and L. Leybaert, Calcium signal communication in the central nervous system. Biol. Cell 96, 79-91 (2004). (Pubitemid 38240401)