Functional acetylcholine muscarinic receptor subtypes in human brain microcirculation: Identification and cellular localization

Journal of Cerebral Blood Flow and Metabolism

Volumn 19, Issue 7, 1999, Pages 794-802

  Elhusseiny, Ahmed ^a   Cohen, Zvi ^a   Olivier, André ^a   Stanimirović, Danica B ^b   Hamel, Edith ^a  

^a MCGILL UNIVERSITY   (Canada)

^b NATIONAL RESEARCH COUNCIL CANADA   (Canada)

Author keywords

Astrocyte; Basal forebrain; Cerebral blood flow; Cerebral blood vessels; Endothelium; Smooth muscle

Indexed keywords

ACETYLCHOLINE; ADENYLATE CYCLASE; AMINO ACID; CARBACHOL; FORSKOLIN; INOSITOL TRISPHOSPHATE; MUSCARINIC M1 RECEPTOR; MUSCARINIC M2 RECEPTOR; MUSCARINIC M3 RECEPTOR; MUSCARINIC M4 RECEPTOR; MUSCARINIC M5 RECEPTOR; MUSCARINIC RECEPTOR; N [2 [2 (DIPROPYLAMINOMETHYL) 1 PIPERIDYL]ETHYL] 5,11 DIHYDRO 6 OXO 6H PYRIDO[2,3 B][1,4]BENZODIAZEPINE 11 CARBOXAMIDE; PHOSPHOLIPASE C; PIRENZEPINE;

ALZHEIMER DISEASE; AMINO ACID SEQUENCE; ARTICLE; BLOOD BRAIN BARRIER; BRAIN BLOOD FLOW; BRAIN CIRCULATION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DEGENERATIVE DISEASE; ENDOTHELIUM CELL; ENZYME INHIBITION; FEMALE; HUMAN; HUMAN TISSUE; MACROGLIA; MALE; MICROCIRCULATION; PERMEABILITY; PRIORITY JOURNAL; RECEPTOR DENSITY; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER;

EID: 0033495297     PISSN: 0271678X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004647-199907000-00010     Document Type: Article

References (9)

1. Abounader R, Elhusseiny A, Cohen Z, Olivier A, Stanimirović D, Quirion R, Hamel E (1999) Expression of neuropeptide Y receptors mRNA and protein in human brain vessels and cerebromicrovascular cells in culture. J Cereb Blood Flow Metab 19:155-163
2. Alkayed NJ, Birks EK, Narayanan J, Petri KA, Kohler-Cabot AE, Harder DR (1997) Role of P-450 arachidonic acid epoxygenase in the response of cerebral blood flow to glutamate in rats. Stroke 28:1066-1072
3. André C, Santos D, Koulakoff A (1994) Muscarinic receptor profiles of mouse brain astrocytes in culture vary with their tissue of origin but differ from those of neurons. Ear J Neurosci 6:1702-1709
4. Badaut J, Moro V, Seylaz J, Lasbennes F (1997) Distribution of muscarinic receptors on the endothelium of cortical vessels in the rat brain. Brain Res 778:25-33
5. Berridge MJ, Downes CP, Hanley MR (1982) Lithium amplifies agonist-dependent phosphatidylinositol responses in brain and salivary glands. Biochem J 206:587-595
6. Bonner TI, Buckley NJ, Brann MR (1987) Identification of a family of muscarinic acetylcholine receptor genes. Science 237:527-532
7. 5 muscarinic acetylcholine genes. Neuron 1:403-410
8. Chomczynski P, Sacchi N (1987) Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162:156-159
9. Cohen RI, Almazan G (1994) Rat oligodendrocytes express muscarinic receptors coupled to phosphoinositide hydrolysis and adenylyl cyclase. Eur J Neurosci 6:1213-1224