Chronic exposure to nicotine and saquinavir decreases endothelial Notch-4 expression and disrupts blood-brain barrier integrity

Journal of Neurochemistry

Volumn 115, Issue 2, 2010, Pages 515-525

  Manda, Vamshi K ^a   Mittapalli, Rajendar K ^a   Geldenhuys, Werner J ^a,b   Lockman, Paul R ^a  

^a TEXAS TECH UNIVERSITY HEALTH SCIENCES CENTER   (United States)

^b NORTHEAST OHIO MEDICAL UNIVERSITY   (United States)

Author keywords

Endothelial cell toxicity; Nicotine; Notch 4; Osmotic pumps; Protease inhibitors; Ritonaivir; ROS; Saquinqavir

Indexed keywords

CIGARETTE SMOKE; NICOTINE; NOTCH4 RECEPTOR; PROTEIN ZO1; REACTIVE OXYGEN METABOLITE; RITONAVIR; SAQUINAVIR;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; CONTROLLED STUDY; DOWN REGULATION; ENDOTHELIAL DYSFUNCTION; ENDOTHELIUM CELL; HIV ASSOCIATED DEMENTIA; LONG TERM EXPOSURE; MALE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SMOKING;

ANALYSIS OF VARIANCE; ANIMALS; BLOOD-BRAIN BARRIER; BRAIN; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DELIVERY SYSTEMS; DRUG INTERACTIONS; ENDOTHELIAL CELLS; HIV PROTEASE INHIBITORS; MALE; MEMBRANE PROTEINS; NICOTINE; OXIDATIVE STRESS; PHOSPHOPROTEINS; PROTO-ONCOGENE PROTEINS; RATS; RATS, INBRED F344; REACTIVE OXYGEN SPECIES; RECEPTORS, NOTCH; SAQUINAVIR; SMOKING; VITAMIN E;

EID: 78649985708     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2010.06948.x     Document Type: Article

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