Alterations in the Notch4 pathway in cerebral endothelial cells by the HIV aspartyl protease inhibitor, nelfinavir

BMC Neuroscience

Volumn 9, Issue , 2008, Pages

  Grigorian, Aline ^a   Hurford, Rosemary ^a,b   Chao, Ying ^a,b   Patrick, Christina ^b   Dianne, T Dianne ^a,c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA TOCOPHEROL; AMYLOID PRECURSOR PROTEIN; GAMMA SECRETASE; GELATINASE A; GLYCOGEN SYNTHASE KINASE 3BETA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDINAVIR; NELFINAVIR; NOTCH1 RECEPTOR; NOTCH4 RECEPTOR; PROTEINASE INHIBITOR; REACTIVE OXYGEN METABOLITE; RITONAVIR; SAQUINAVIR; VASCULOTROPIN; ASPARTIC PROTEINASE; C14ORF129 PROTEIN, HUMAN; NOTCH RECEPTOR; NOTCH4 PROTEIN, HUMAN; ONCOPROTEIN; REPRESSOR PROTEIN;

ANGIOGENESIS; ARTICLE; BLOOD BRAIN BARRIER; CELL FUNCTION; CELL NUCLEUS; CELL SURVIVAL; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DRUG MECHANISM; ENDOTHELIUM CELL; ENZYME PHOSPHORYLATION; ENZYME SUBSTRATE; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INHIBITION KINETICS; NUCLEOTIDE SEQUENCE; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PROCESSING; SIGNAL TRANSDUCTION; BRAIN ARTERY; BRAIN VEIN; CELL CULTURE; CYTOLOGY; DRUG ANTAGONISM; DRUG EFFECT; FRONTAL LOBE; METABOLISM; OXIDATIVE STRESS; PHOSPHORYLATION; VASCULARIZATION;

ASPARTIC ENDOPEPTIDASES; CELL SURVIVAL; CELLS, CULTURED; CEREBRAL ARTERIES; CEREBRAL VEINS; ENDOTHELIAL CELLS; FRONTAL LOBE; HIV PROTEASE INHIBITORS; HUMANS; INDINAVIR; NELFINAVIR; OXIDATIVE STRESS; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS; REACTIVE OXYGEN SPECIES; RECEPTOR, NOTCH1; RECEPTORS, NOTCH; REPRESSOR PROTEINS; RITONAVIR; SAQUINAVIR; VITAMIN E;

EID: 40949138759     PISSN: None     EISSN: 14712202     Source Type: Journal    
DOI: 10.1186/1471-2202-9-27     Document Type: Article

References (49)

1. Banks WA Ercal N Price TO The blood-brain barrier in neuroAIDS Current HIV Research 2006, 4(3):259-266 10.2174/157016206777709447 16842079
2. Dallasta LM Pisarov LA Esplen JE Werley JV Moses AV Nelson JA Achim CL Blood-brain barrier tight junction disruption in human immunodeficiency virus-1 encephalitis The American Journal of Pathology 1999, 155(6):1915-1927 1866950 10595922
3. Toborek M Lee YW Flora G Pu H Andras IE Wylegala E Hennig B Nath A Mechanisms of the blood-brain barrier disruption in HIV-1 infection Cellular and Molecular Neurobiology 2005, 25(1):181-199 10.1007/ s10571-004-1383-x
4. Wang X Chai H Yao Q Chen C Molecular mechanisms of HIV protease inhibitor-induced endothelial dysfunction Journal of Acquired Immune Deficiency Syndromes 2007, 44(5):493-499 10.1097/QAI.0b013e3180322542 17245228
5. Mondal D Pradhan L Ali M Agrawal KC HAART drugs induce oxidative stress in human endothelial cells and increase endothelial recruitment of mononuclear cells: Exacerbation by inflammatory cytokines and amelioration by antioxidants Cardiovascular Toxicology 2004, 4(3):287-302 10.1385/CT:4:3:287 15470276
6. Sgadari C Barillari G Toschi E Carlei D Bacigalupo I Baccarini S Palladino C Leone P Bugarini R Malavasi L HIV protease inhibitors are potent anti-angiogenic molecules and promote regression of Kaposi sarcoma Nature medicine 2002, 8(3):225-232 10.1038/nm0302-225 11875492
7. Curry CL Reed LL Golde TE Miele L Nickoloff BJ Foreman KE Gamma secretase inhibitor blocks Notch activation and induces apoptosis in Kaposi's sarcoma tumor cells Oncogene 2005, 24(42):6333-6344 15940249
8. Ikezoe T Saito T Bandobashi K Yang Y Koeffler HP Taguchi H HIV-1 protease inhibitor induces growth arrest and apoptosis of human multiple myeloma cells via inactivation of signal transducer and activator of transcription 3 and extracellular signal-regulated kinase 1/2 Molecular Cancer Therapeutics 2004, 3(4):473-479 15078991
9. Yang Y Ikezoe T Takeuchi T Adachi Y Ohtsuki Y Takeuchi S Koeffler HP Taguchi H HIV-1 protease inhibitor induces growth arrest and apoptosis of human prostate cancer LNCaP cells in vitro and in vivo in conjunction with blockade of androgen receptor STAT3 and AKT signaling Cancer Science 2005, 96(7):425-433 10.1111/j.1349-7006.2005.00063.x 16053514
10. Taylor KL Henderson AM Hughes CC Notch activation during endothelial cell network formation in vitro targets the basic HLH transcription factor HESR-1 and downregulates VEGFR-2/KDR expression Microvascular Research 2002, 64(3):372-383 10.1006/mvre.2002.2443 12453432
11. Liu ZJ Shirakawa T Li Y Soma A Oka M Dotto GP Fairman RM Velazquez OC Herlyn M Regulation of Notch1 and Dll4 by vascular endothelial growth factor in arterial endothelial cells: Implications for modulating arteriogenesis and angiogenesis Molecular and Cellular Biology 2003, 23(1):14-25 10.1128/MCB.23.1.14-25.2003
12. Baron M An overview of the Notch signalling pathway Seminars in Cell & Developmental Biology 2003, 14(2):113-119 10.1016/ S1084-9521(02)00179-9 12651094
13. Shirayoshi Y Yuasa Y Suzuki T Sugaya K Kawase E Ikemura T Nakatsuji N Proto-oncogene of int-3, a mouse Notch homologue, is expressed in endothelial cells during early embryogenesis Genes Cells 1997, 2(3):213-224 10.1046/j.1365-2443.1997.d01-310.x 9189758
14. Leong KG Hu X Li L Noseda M Larrivee B Hull C Hood L Wong F Karsan A Activated Notch4 inhibits angiogenesis: Role of beta 1-integrin activation Molecular and Cellular Biology 2002, 22(8):2830-2841 10.1128/ MCB.22.8.2830-2841.2002
15. Matsumoto T Turesson I Book M Gerwins P Claesson-Welsh L p38 MAP kinase negatively regulates endothelial cell survival, proliferation, and differentiation in FGF-2-stimulated angiogenesis The Journal of Cell Biology 2002, 156(1):149-160 10.1083/jcb.200103096 11781339
16. Espinosa L Ingles-Esteve J Aguilera C Bigas A Phosphorylation by glycogen synthase kinase-3 beta down-regulates Notch activity, a link for Notch and Wnt pathways The Journal of Biological Chemistry 2003, 278(34):32227-32235 10.1074/jbc.M304001200 12794074
17. Foltz DR Nye JS Hyperphosphorylation and association with RBP of the intracellular domain of Notch1 Biochemical and Biophysical Research Communications 2001, 286(3): 84-492 10.1006/bbrc.2001.5421
18. Foltz DR Santiago MC Berechid BE Nye JS Glycogen synthase kinase-3beta modulates notch signaling and stability Curr Biol 2002, 12(12):1006-1011 10.1016/S0960-9822(02)00888-6 12123574
19. Barry M Gibbons S Back D Mulcahy F Protease inhibitors in patients with HIV disease. Clinically important pharmacokinetic considerations Clinical pharmacokinetics 1997, 32(3):194-209 9084959
20. Li HL Roch JM Sundsmo M Otero D Sisodia S Thomas R Saitoh T Defective neurite extension is caused by a mutation in amyloid beta/A4 (A beta) protein precursor found in familial Alzheimer's disease Journal of neurobiology 1997, 32(5):469-480 10.1002/ (SICI)1097-4695(199705)32:5<469::AID-NEU3>3.0.CO;2-3 9110259
21. Shawber CJ Kitajewski J Notch function in the vasculature: Insights from zebrafish, mouse and man Bioessays 2004, 26(3):225-234 10.1002/ bies.20004 14988924
22. McKenzie G Ward G Stallwood Y Briend E Papadia S Lennard A Turner M Champion B Hardingham GE Cellular Notch responsiveness is defined by phosphoinositide 3-kinase-dependent signals BMC cell biology 2006, 7:10 1403772 16507111 10.1186/1471-2121-7-10
23. Ruel L Bourouis M Heitzler P Pantesco V Simpson P Drosophila shaggy kinase and rat glycogen synthase kinase-3 have conserved activities and act downstream of Notch Nature 1993, 362(6420):557-560 10.1038/362557a0 8385271
24. De Barros S Zakaroff-Girard A Lafontan M Galitzky J Bourlier V Inhibition of human preadipocyte proteasomal activity by HIV protease inhibitors or specific inhibitor lactacystin leads to a defect in adipogenesis, which involves matrix metalloproteinase-9 The Journal of pharmacology and experimental therapeutics 2007, 320(1):291-299 10.1124/ jpet.106.111849
25. Tovo PA Highly active antiretroviral therapy inhibits cytokine production in HIV-uninfected subjects AIDS 2000, 14(6):743-744 10.1097/ 00002030-200004140-00014 10807198
26. Gruber A Wheat JC Kuhen KL Looney DJ Wong-Staal F Differential effects of HIV-1 protease inhibitors on dendritic cell immunophenotype and function The Journal of Biological Chemistry 2001, 276(51):47840-47843 11602580
27. Barillari G Sgadari C Toschi E Monini P Ensoli B HIV protease inhibitors as new treatment options for Kaposi's sarcoma Drug Resist Updat 2003, 6(4):173-181 10.1016/S1368-7646(03)00060-8 12962683
28. Kim SH Yin YI Li YM Sisodia SS Evidence that assembly of an active gamma-secretase complex occurs in the early compartments of the secretory pathway The Journal of Biological Chemistry 2004, 279(47):48615-48619 10.1074/jbc.C400396200 15456788
29. Pouyssegur J Mechta-Grigoriou F Redox regulation of the hypoxia-inducible factor Biological Chemistry 2006, 387(10-11):1337-1346 10.1515/BC.2006.167 17081104
30. Pore N Gupta AK Cerniglia GJ Jiang Z Bernhard EJ Evans SM Koch CJ Hahn SM Maity A Nelfinavir down-regulates hypoxia-inducible factor 1alpha and VEGF expression and increases tumor oxygenation: Implications for radiotherapy Cancer Research 2006, 66(18):9252-9259 10.1158/ 0008-5472.CAN-06-1239 16982770
31. Pore N Gupta AK Cerniglia GJ Maity A HIV protease inhibitors decrease VEGF/HIF-1alpha expression and angiogenesis in glioblastoma cells Neoplasia 2006, 8(11):889-895 1716015 17132220 10.1593/neo.06535
32. Gupta AK Cerniglia GJ Mick R McKenna WG Muschel RJ HIV protease inhibitors block Akt signaling and radiosensitize tumor cells both in vitro and in vivo Cancer Research 2005, 65(18): 256-8265 10.1158/ 0008-5472.CAN-05-1220 16166302
33. Mottet D Dumont V Deccache Y Demazy C Ninane N Raes M Michiels C Regulation of hypoxia-inducible factor-1alpha protein level during hypoxic conditions by the phosphatidylinositol 3-kinase/Akt/glycogen synthase kinase 3beta pathway in HepG2 cells The Journal of Biological Chemistry 2003, 278(33):31277-31285 10.1074/jbc.M300763200 12764143
34. Kopan R Notch: A membrane-bound transcription factor Journal of Cell Science 2002, 115(Pt 6):1095-1097 11884509
35. Vekrellis K Ye Z Qiu WQ Walsh D Hartley D Chesneau V Rosner MR Selkoe DJ Neurons regulate extracellular levels of amyloid beta-protein via proteolysis by insulin-degrading enzyme J Neurosci 2000, 20(5):1657-1665 10684867
36. Schutt M Zhou J Meier M Klein HH Long-term effects of HIV-1 protease inhibitors on insulin secretion and insulin signaling in INS-1 beta cells The Journal of Endocrinology 2004, 183(3):445-454 10.1677/ joe.1.05620 15590971
37. Bachmeier CJ Spitzenberger TJ Elmquist WF Miller DW Quantitative assessment of HIV-1 protease inhibitor interactions with drug efflux transporters in the blood-brain barrier Pharmaceutical Research 2005, 22(8):1259-1268 10.1007/s11095-005-5271-y 16078135
38. Perloff MD von Moltke LL Fahey JM Greenblatt DJ Induction of P-glycoprotein expression and activity by ritonavir in bovine brain microvessel endothelial cells The Journal of Pharmacy and Pharmacology 2007, 59(7):947-953 10.1211/jpp.59.7.0006
39. Storch CH Theile D Lindenmaier H Haefeli WE Weiss J Comparison of the inhibitory activity of anti-HIV drugs on P-glycoprotein Biochemical Pharmacology 2007, 73(10):1573-1581 10.1016/j.bcp.2007.01.027 17328866
40. Johnstone RW Ruefli AA Smyth MJ Multiple physiological functions for multidrug transporter P-glycoprotein? Trends in Biochemical Sciences 2000, 25(1):1-6 10.1016/S0968-0004(99)01493-0 10637601
41. Molla A Vasavanonda S Kumar G Sham HL Johnson M Grabowski B Denissen JF Kohlbrenner W Plattner JJ Leonard JM Human serum attenuates the activity of protease inhibitors toward wild-type and mutant human immunodeficiency virus Virology 1998, 250(2):255-262 10.1006/ viro.1998.9383 9792836
42. Kramer H Neuralized: Regulating notch by putting away delta Developmental Cell 2001, 1(6):725-726 10.1016/S1534-5807(01)00095-8 11740931
43. Carroll KD Bu W Palmeri D Spadavecchia S Lynch SJ Marras SA Tyagi S Lukac DM Kaposi's Sarcoma-associated herpesvirus lytic switch protein stimulates DNA binding of RBP-Jk/CSL to activate the Notch pathway Journal of Virology 2006, 80(19):9697-9709 1617261 16973574 10.1128/ JVI.00746-06
44. Shankar SS Dube MP Clinical aspects of endothelial dysfunction associated with human immunodeficiency virus infection and antiretroviral agents Cardiovascular toxicology 2004, 4(3):261-269 10.1385/CT:4:3:261 15470273
45. Navarra T Del Turco S Papa A Battaglia D Lazzerini G Basta G Lack of effect of alpha-tocopherol on in vitro angiogenesis Microvascular Research 2006, 72(1-2):12-19 10.1016/j.mvr.2006.04.003 16750838
46. Capaldini L Protease inhibitors' metabolic side effects: Cholesterol, triglycerides, blood sugar, and "Crix belly." Interview with Lisa Capaldini, M.D. Interview by John S. James AIDS treatment news 1997, 277:1-4
47. Vagnucci AH Jr Li WW Alzheimer's disease and angiogenesis Lancet 2003, 361(9357):605-608 10.1016/S0140-6736(03)12521-4 12598159
48. Kogure K Kato H Altered gene expression in cerebral ischemia Stroke; A Journal of Cerebral Circulation 1993, 24(12):2121-2127 8248999
49. Jogi A Ora I Nilsson H Lindeheim A Makino Y Poellinger L Axelson H Pahlman S Hypoxia alters gene expression in human neuroblastoma cells toward an immature and neural crest-like phenotype Proceedings of the National Academy of Sciences of the United States of America 2002, 99(10):7021-7026 124521 12011461 10.1073/pnas.102660199