High maternal vitamin E intake by diet or supplements is associated with congenital heart defects in the offspring

BJOG: An International Journal of Obstetrics and Gynaecology

Volumn 116, Issue 3, 2009, Pages 416-423

  Smedts, H P M ^a   De Vries, J H ^b   Rakhshandehroo, M ^a,b   Wildhagen, M F ^a   Verkleij Hagoort, A C ^a   Steegers, E A ^a   Steegers Theunissen, R P M ^a,c  

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b WAGENINGEN UNIVERSITY   (Netherlands)

^c SOPHIA CHILDREN S HOSPITAL   (Netherlands)

Author keywords

Antioxidants; Heart anomalies; Nutrients; Risk factors

Indexed keywords

ALPHA TOCOPHEROL; RETINOL;

ADULT; ARTICLE; CARDIOVASCULAR RISK; CONGENITAL HEART MALFORMATION; CONTROLLED STUDY; DIET SUPPLEMENTATION; FEMALE; FOOD FREQUENCY QUESTIONNAIRE; HUMAN; MAJOR CLINICAL STUDY; MATERNAL NUTRITION; OUTCOME ASSESSMENT; PRIORITY JOURNAL; VITAMIN INTAKE; VITAMIN SUPPLEMENTATION;

ADULT; ANTIOXIDANTS; CASE-CONTROL STUDIES; DIETARY SUPPLEMENTS; FEMALE; HEART DEFECTS, CONGENITAL; HUMANS; MATERNAL NUTRITIONAL PHYSIOLOGICAL PHENOMENA; PRECONCEPTION CARE; PREGNANCY; RISK FACTORS; VITAMIN E; YOUNG ADULT;

EID: 58549085805     PISSN: 14700328     EISSN: 14710528     Source Type: Journal    
DOI: 10.1111/j.1471-0528.2008.01957.x     Document Type: Article

References (39)

1. Hoffman JI, Kaplan S. The incidence of congenital heart disease. J Am Coll Cardiol 2002 39 : 1890 900.
2. Botto LD, Correa A. Decreasing the burden of congenital heart anomalies: an epidemiologic evaluation of risk factors and survival. Prog Pediatr Cardiol 2003 18 : 111 21.
3. Steegers-Theunissen RP, Steegers EA. Nutrient-gene interactions in early pregnancy: a vascular hypothesis. Eur J Obstet Gynecol Reprod Biol 2003 106 : 115 17.
4. Shaw GM, O'Malley CD, Wasserman CR, Tolarova MM, Lammer EJ. Maternal periconceptional use of multivitamins and reduced risk for conotruncal heart defects and limb deficiencies among offspring. Am J Med Genet 1995 59 : 536 45.
5. Kapusta L, Haagmans ML, Steegers EA, Cuypers MH, Blom HJ, Eskes TK. Congenital heart defects and maternal derangement of homocysteine metabolism. J Pediatr 1999 135 : 773 4.
6. Verkleij-Hagoort AC, Verlinde M, Ursem NT et al. Maternal hyperhomocysteinemia is a risk factor for congenital heart disease. BJOG 2006 113 : 1412 18.
7. Hobbs CA, Cleves MA, Melnyk S, Zhao W, James SJ. Congenital heart defects and abnormal maternal biomarkers of methionine and homocysteine metabolism. Am J Clin Nutr 2005 81 : 147 53.
8. Brauer PR, Tierney BJ. Consequences of elevated homocysteine during embryonic development and possible modes of action. Curr Pharm Des 2004 10 : 2719 32.
9. Hobbs CA, Cleves MA, Zhao W, Melnyk S, James SJ. Congenital heart defects and maternal biomarkers of oxidative stress. Am J Clin Nutr 2005 82 : 598 604.
10. Limpach A, Dalton M, Miles R, Gadson P. Homocysteine inhibits retinoic acid synthesis: a mechanism for homocysteine-induced congenital defects. Exp Cell Res 2000 260 : 166 74.
11. Debier C, Larondelle Y. Vitamins A and E: metabolism, roles and transfer to offspring. Br J Nutr 2005 93 : 153 74.
12. Gimeno A, Zaragoza R, Vivo-Sese I, Vina JR, Miralles VJ. Retinol, at concentrations greater than the physiological limit, induces oxidative stress and apoptosis in human dermal fibroblasts. Exp Dermatol 2004 13 : 45 54.
13. Botto LD, Loffredo C, Scanlon KS et al. Vitamin A and cardiac outflow tract defects. Epidemiology 2001 12 : 491 6.
14. Botto LD, Mulinare J, Erickson JD. Do multivitamin of folic acid supplements reduce the risk for congenital heart defects? Evidence and gaps. Am J Med Genet A 2003 121 : 95 101.
15. Feunekes GI, Van Staveren WA, De Vries JH, Burema J, Hautvast JG. Relative and biomarker-based validity of a food-frequency questionnaire estimating intake of fats and cholesterol. Am J Clin Nutr 1993 58 : 489 96.
16. Netherlands Nutrition Centre. Dutch National Food Consumption Survey 1992. In Dutch. (Zo eet Nederland 1992). The Hague, the Netherlands : Netherlands Nutrition Centre, 1993.
17. Netherlands Nutrition Centre. Dutch National Food Consumption Survey 1998. In Dutch. (Zo eet Nederland 1998). The Hague, the Netherlands : Netherlands Nutrition Centre, 1998.
18. NEVO. Dutch Food Composition Database 2001. The Hague, the Netherlands : Netherlands Nutrition Centre, 2001.
19. Verkleij-Hagoort AC, De Vries JH, Stegers MP, Lindemans J, Ursem NT, Steegers-Theunissen RP. Validation of the assessment of folate and vitamin B12 intake in women of reproductive age: the method of triads. Eur J Clin Nutr 2007 61 : 610 15.
20. Statistics Netherlands. Classification of Educational Level. Voorburg/Heerlen, the Netherlands 1998 www.cbs.nl/NR/rdonlyres/641A2C7C-55E4- 4368-9575-7B9053EA207B/0/2007PubSOI0708.pdf Accessed 16 June 2007.
21. Lao O, van Duijn K, Kersbergen P, De Knijff P, Kayser M. Proportioning whole-genome single-nucleotide-polymorphism diversity for the identification of geographic population structure and genetic ancestry. Am J Hum Genet 2006 78 : 680 90.
22. Willett WC, Howe GR, Kushi LH. Adjustment for total energy intake in epidemiologic studies. Am J Clin Nutr 1997 65 : 1220S 31S.
23. Health Council. Nutritional Norms: Vitamin A and Provitamin A, Vitamin E. The Hague, the Netherlands : Health Council of the Netherlands, 1989.
24. Food and Nutrition Board. Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium and Carotenoids. Washington, DC : The National Academies Press, 2000.
25. Willet W. Nature of variation in diet. In : Willet W, editor. Nutritional Epidemiology. New York, NY : Oxford University Press 1998. pp. 33 50.
26. Devine CM, Bove CF, Olson CM. Continuity and change in women's weight orientations and lifestyle practices through pregnancy and the postpartum period: the influence of life course trajectories and transitional events. Soc Sci Med 2000 50 : 567 82.
27. Cikot RJ, Steegers-Theunissen RP, Thomas CM, De Boo TM, Merkus HM, Steegers EA. Longitudinal vitamin and homocysteine levels in normal pregnancy. Br J Nutr 2001 85 : 49 58.
28. Verkleij-Hagoort AC, De Vries JH, Ursem NT, De Jonge R, Hop WC, Steegers-Theunissen RP. Dietary intake of B-vitamins in mothers born a child with a congenital heart defect. Eur J Nutr 2006 45 : 478 86.
29. Goldberg GR, Black AE, Jebb SA, Cole TJ, Murgatroyd PR, Coward WA, et al. Critical evaluation of energy intake data using fundamental principles of energy physiology: 1. Deprivation of cut-off limits to identify under-reporting. Eur J Clin Nutr 1991 45 : 569 81.
30. Jauniaux E, Poston L, Burton GJ. Placental-related diseases of pregnancy: involvement of oxidative stress and implications in human evolution. Hum Reprod Update 2006 12 : 747 55.
31. Burton GJ, Hempstock J, Jauniaux E. Oxygen, early embryonic metabolism and free radical-mediated embryopathies. Reprod Biomed Online 2003 6 : 84 96.
32. Poston L, Briley AL, Seed PT, Kelly FJ, Shennan AH. Vitamin C and vitamin E in pregnant women at risk for pre-eclampsia (VIP trial): randomised placebo-controlled trial. Lancet 2006 367 : 1145 54.
33. Bowry VW, Ingold KU, Stocker R. Vitamin E in human low-density lipoprotein. When and how this antioxidant becomes a pro-oxidant. Biochem J 1992 288 : 341 4.
34. Pearson P, Lewis SA, Britton J, Young IS, Fogarty A. The pro-oxidant activity of high-dose vitamin E supplements in vivo. BioDrugs 2006 20 : 271 3.
35. Schneider C. Chemistry and biology of vitamin E. Mol Nutr Food Res 2005 49 : 7 30.
36. Van Haaften RI, Haenen GR, Van Bladeren PJ, Bogaards JJ, Evelo CT, Bast A. Inhibition of various glutathione S-transferase isoenzymes by RRR-alpha-tocopherol. Toxicol In Vitro 2003 17 : 245 51.
37. Vujkovic M, Ocke MC, Van der Spek PJ, Yazdanpanah N, Steegers EA, Steegers-Theunissen RP. Maternal Western dietary patterns and the risk of developing a cleft lip with or without a cleft palate. Obstet Gynecol 2007 110 : 378 84.
38. Sivan E, Reece EA, Wu YK, Homko CJ, Polansky M, Borenstein M. Dietary vitamin E prophylaxis and diabetic embryopathy: morphologic and biochemical analysis. Am J Obstet Gynecol 1996 175 : 793 9.
39. Reece EA, Wu YK. Prevention of diabetic embryopathy in offspring of diabetic rats with use of a cocktail of deficient substrates and an antioxidant. Am J Obstet Gynecol 1997 176 : 790 7.