Catechol O-methyltransferase gene variant and birth weight predict early-onset antisocial behavior in children with attention-deficit/hyperactivity disorder

Archives of General Psychiatry

Volumn 62, Issue 11, 2005, Pages 1275-1278

  Thapar, Anita ^a   Langley, Kate ^a   Fowler, Tom ^a   Rice, Frances ^a   Turic, Darko ^a   Whittinger, Naureen ^a   Aggleton, John ^b   Van Den Bree, Marianne ^a   Owen, Michael ^a   O'Donovan, Michael ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

^b CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CATECHOL METHYLTRANSFERASE;

ADOLESCENT; ANTISOCIAL BEHAVIOR; ARTICLE; ATTENTION DEFICIT DISORDER; BIRTH WEIGHT; CHILD; CHILDHOOD; DIAGNOSTIC AND STATISTICAL MANUAL OF MENTAL DISORDERS; FAMILY; FEMALE; GENETIC VARIABILITY; GENOTYPE ENVIRONMENT INTERACTION; HIGH RISK POPULATION; HUMAN; HUMAN CELL; HYPERKINESIA; INTELLIGENCE QUOTIENT; INTERVIEW; MAJOR CLINICAL STUDY; MALE; ONSET AGE; PEDIATRIC HOSPITAL; STANDARDIZATION; SYMPTOM; UNITED KINGDOM;

ADOLESCENT; AGE FACTORS; AGE OF ONSET; ANTISOCIAL PERSONALITY DISORDER; ATTENTION DEFICIT DISORDER WITH HYPERACTIVITY; BIRTH WEIGHT; CATECHOL O-METHYLTRANSFERASE; CHILD; CHILD, PRESCHOOL; FEMALE; GENOTYPE; HUMANS; INFANT, NEWBORN; MALE; PREFRONTAL CORTEX; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; PSYCHIATRIC STATUS RATING SCALES; REGRESSION ANALYSIS; RISK FACTORS; VALINE; VARIATION (GENETICS);

EID: 27744534613     PISSN: 0003990X     EISSN: 15383636     Source Type: Journal    
DOI: 10.1001/archpsyc.62.11.1275     Document Type: Article

References (33)

1. Raine A. The role of prefrontal deficits, low autonomic arousal, and early health factors in the development of antisocial and aggressive behavior in children. J Child Psychol Psychiatry. 2002;43:417-434.
2. Anderson SW, Bechara A, Damasio H, Tranel D, Damasio AR. Impairment of social and moral behavior related to early damage in human prefrontal cortex. Nat Neurosci. 1999;2:1032-1037.
3. Anderson SW, Damasio H, Tranel D, Damasio AR. Long-term sequelae of prefrontal cortex damage acquired in early childhood. Dev Neuropsychol. 2000;18:281-896.
4. Winterer G, Goldman D. Genetics of human prefrontal function. Brain Res Brain Res Rev. 2003;43:134-163.
5. Gogos JA, Morgan M, Luine V, Santha M, Ogawa S, Pfaff D, Karayiorgou M. Catechol-O-methyltransferase-deficient mice exhibit sexually dimorphic changes in catecholamine levels and behavior. Proc Natl Acad Sci U S A. 1998;95:9991-9996.
6. Huotari M, Gogos JA, Karayiorgou M, Koponen O, Forsberg M, Raasmaja A, Hyttinen J, Mannisto PT. Brain catecholamine metabolism in catechol-O- methyltransferase (COMT)-deficient mice. Eur J Neurosci. 2002;15:246-256.
7. Lewis DA, Melchitzky DS, Sesack SR, Whitehead RE, Auh S, Sampson A. Dopamine transporter immunoreactivity in monkey cerebral cortex: regional, laminar, and ultrastructural localization. J Comp Neurol. 2001;432:119-136.
8. Moffitt TE. "Life-course-persistent" and "adolescence- limited" antisocial behavior: a developmental taxonomy. Psychol Rev. 1993;100:674-701.
9. Thapar A, Harrington R, McGuffin P. Examining the comorbidity of ADHDrelated behaviors and conduct problems using a twin study design. Br J Psychiatry. 2001;179:224-229.
10. Brennan PA, Grekin ER, Mednick SA. Prenatal and perinatal influences on conduct disorder and serious delinquency. In: Lahey BB, Moffitt TE, Caspi A, eds. Causes of Conduct Disorder and Juvenile Delinquency. New York, NY: The Guilford Press; 2003:319-341.
11. Rhee SH, Waldman ID. Genetic and environmental influences on antisocial behavior: a meta-analysis of twin and adoption studies. Psychological Bulletin. 2002;128:490-529.
12. Tibbetts S, Piquero A. The influence of gender, low birth weight and disadvantaged environment on predicting early onset of offending: a test of Moffitt's interactional hypothesis. Criminology. 1999;37:843-878.
13. Botting N, Powls A, Cooke RW, Marlow N. Attention deficit hyperactivity disorders and other psychiatric outcomes in very low birthweight children at 12 years. J Child Psychol Psychiatry. 1997;38:931-941.
14. Brooks AA, Johnson MR, Steer PJ, Pawson ME, Abdalla HI. Birth weight: nature or nurture? Early Hum Dev. 1995;42:29-35.
15. Rutter M, Silberg J. Gene-environment interplay in relation to emotional and behavioral disturbance. Annu Rev Psychol. 2002;53:463-490.
16. Angold A, Prendergast M, Cox A, Harrington R, Simonoff E, Rutter M. The Child and Adolescent Psychiatric Assessment. Psychol Med. 1995;25:739-753.
17. Wechsler D. Wechsler Intelligence Scale for Children. 3rd ed. London, England: Psychological Corp; 1992.
18. Walton KA, Murray LJ, Gallagher AM, Cran GW, Savage MJ, Boreham C. Parental recall of birthweight: a good proxy for recorder birthweight? Eur J Epidemiol. 2000;16:793-796.
19. Hsu TM, Chen X, Duan S, Miller RD, Kwok PY. Universal SNP genotyping assay with fluorescence polarization detection. Biotechniques. 2001;31:560, 562, 564-568.
20. Rutter M, Giller H, Hagell A. Antisocial Behavior by Young People. New York, NY: Cambridge University Press; 1998.
21. Taylor E, Chadwick O, Heptinstall E, Danckaerts M. Hyperactivity and conduct problems as risk factors for adolescent development. J Am Acad Child Adolesc Psychiatry. 1996;35:1213-1226.
22. Dolan RJ. On the neurology of morals. Nat Neurosci. 1999;2:927-929.
23. Egan MF, Goldberg TE, Kolachana BS, Callicott JH, Mazzanti CM, Straub RE, Goldman D, Weinberger DR. Effect of COMT Val108/158 Met genotype on frontal lobe function and risk for schizophrenia. Proc Natl Acad Sci U S A. 2001;98:6917-6922.
24. Malhotra AK, Kestler LJ, Mazzanti C, Bates JA, Goldberg T, Goldman D. A functional polymorphism in the COMT gene and performance on a test of prefrontal cognition. Am J Psychiatry. 2002;159:652-654.
25. Weinberger DR, Egan MF, Bertolino A, Callicott JH, Mattay VS, Lipska BK, Berman KF, Goldberg TE. Prefrontal neurons and the genetics of schizophrenia. Biol Psychiatry. 2001;50:825-844.
26. Mattay VS, Goldberg TE, Fera F, Hariri AR, Tessitore A, Egan MF, Kolachana B, Callicott JH, Weinberger DR. Catechol O-methyltransferase Val158-Met genotype and individual variation in the brain response to amphetamine. Proc Natl Acad Sci U S A. 2003;100:6186-6191.
27. Diamond A, Briand L, Fossella J, Gehlbach L. Genetic and neurochemical modulation of prefrontal cognitive functions in children. Am J Psychiatry. 2004;161:125-132.
28. Fossella J, Sommer T, Fan J, Wu Y, Swanson JM, Pfaff DW, Posner MI. Assessing the molecular genetics of attention networks. BMC Neurosci. 2002;3:14.
29. Tsai SJ, Yu YW, Chen TJ, Chen JY, Liou YJ, Chen MC, Hong CJ. Association study of a functional catechol-O-methyltransferase-gene polymorphism and cognitive function in healthy females. Neurosci Lett. 2003;338:123-126.
30. Goldberg TE, Egan MF, Gscheidle T, Coppola R, Weickert T, Kolachana BS, Goldman D, Weinberger DR. Executive subprocesses in working memory: relationship to catechol-O-methyltransferase val158met genotype and schizophrenia. Arch Gen Psychiatry. 2003;60:889-896.
31. Bilder RM, Volavka J, Czobor P, Malhotra AK, Kennedy JL, Ni X, Goldman RS, Hoptman MJ, Sheitman B, Lindenmayer JP, Citrome L, McEvoy JP, Kunz M, Chakos M, Cooper TB, Lieberman JA. Neurocognitive correlates of the COMT Val(158)Met polymorphism in chronic schizophrenia. Biol Psychiatry. 2002;52:701-707.
32. Mills S, Langley K, Van den Bree M, Street E, Turic D, Owen MJ, O'Donovan MC, Thapar A. No evidence of association between catechol-O-methyltransferase (COMT) Val158Met genotype and performance on neuropsychological tasks in children with ADHD: a case-control study. BMC Psychiatry. 2004;4:15.
33. Caspi A, McClay J, Moffitt TE, Mill J, Martin J, Craig IW, Taylor A, Poulton R. Role of genotype in the cycle of violence in maltreated children. Science. 2002;297:851-854.