Increased soluble leptin receptor levels in morbidly obese patients with insulin resistance and nonalcoholic fatty liver disease

Obesity

Volumn 18, Issue 12, 2010, Pages 2268-2273

  Medici, Valentina ^a   Ali, Mohamed R ^a   Seo, Suk ^a   Aoki, Christopher A ^a   Rossaro, Lorenzo ^a   Kim, Kyoungmi ^b   Fuller, Will D ^a   Vidovszky, Tamas J ^a   Smith, William ^a   Jiang, Joy X ^a   Maganti, Kalyani ^a   Havel, Peter J ^c   Kamboj, Amit ^a   Ramsamooj, Rajendra ^a   Török, Natalie J ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LEPTIN; LEPTIN RECEPTOR;

ADULT; ARTICLE; BARIATRIC SURGERY; BLOOD; BODY MASS; DIABETES MELLITUS; DISEASE COURSE; FATTY LIVER; FEMALE; HUMAN; INSULIN RESISTANCE; LIVER; MALE; MIDDLE AGED; MORBID OBESITY; PATHOLOGY; PHYSIOLOGY; REGRESSION ANALYSIS;

ADULT; BARIATRIC SURGERY; BODY MASS INDEX; DIABETES MELLITUS; DISEASE PROGRESSION; FATTY LIVER; FEMALE; HUMANS; INSULIN RESISTANCE; LEPTIN; LIVER; MALE; MIDDLE AGED; OBESITY, MORBID; RECEPTORS, LEPTIN; REGRESSION ANALYSIS;

ANIMALIA;

EID: 78649938445     PISSN: 19307381     EISSN: 1930739X     Source Type: Journal    
DOI: 10.1038/oby.2010.95     Document Type: Article

References (38)

1. Browning JD, Szczepaniak LS, Dobbins R et al. Prevalence of hepatic steatosis in an urban population in the United States: impact of ethnicity. Hepatology 2004;40:1387-1395.
2. Bellentani S, Saccoccio G, Masutti F et al. Prevalence of and risk factors for hepatic steatosis in Northern Italy. Ann Intern Med 2000;132:112-117.
3. Angulo P. Nonalcoholic fatty liver disease. N Engl J Med 2002;346: 1221-1231.
4. Marchesini G, Bugianesi E, Forlani G et al. Nonalcoholic fatty liver, steatohepatitis, and the metabolic syndrome. Hepatology 2003;37: 917-923.
5. Fassio E, Alvarez E, Domínguez N, Landeira G, Longo C. Natural history of nonalcoholic steatohepatitis: a longitudinal study of repeat liver biopsies. Hepatology 2004;40:820-826.
6. Havel PJ. Update on adipocyte hormones: regulation of energy balance and carbohydrate/lipid metabolism. Diabetes 2004;53(Suppl 1): S143-S151.
7. Janeckova R. The role of leptin in human physiology and pathophysiology. Physiol Res 2001;50:443-459.
8. Martin SS, Qasim A, Reilly M P. Leptin resistance: a possible interface of inflammation and metabolism in obesity-related cardiovascular disease. J Am Coll Cardiol 2008;52:1201-1210.
9. Potter JJ, Womack L, Mezey E, Anania FA. Transdifferentiation of rat hepatic stellate cells results in leptin expression. Biochem Biophys Res Commun 1998;244:178-182.
10. Ikejima K, Takei Y, Honda H et al. Leptin receptor-mediated signaling regulates hepatic fibrogenesis and remodeling of extracellular matrix in the rat. Gastroenterology 2002;122:1399-1410.
11. Otte C, Otte JM, Strodthoff D et al. Expression of leptin and leptin receptor during the development of liver fibrosis and cirrhosis. Exp Clin Endocrinol Diabetes 2004;112:10-17.
12. Chitturi S, Farrell G, Frost L et al. Serum leptin in NASH correlates with hepatic steatosis but not fibrosis: a manifestation of lipotoxicity? Hepatology 2002;36:403-409.
13. Angulo P, Alba LM, Petrovic LM et al. Leptin, insulin resistance, and liver fibrosis in human nonalcoholic fatty liver disease. J Hepatol 2004;41: 943-949.
14. Chalasani N, Crabb DW, Cummings OW et al. Does leptin play a role in the pathogenesis of human nonalcoholic steatohepatitis? Am J Gastroenterol 2003;98:2771-2776.
15. Lammert A, Kiess W, Bottner A, Glasow A, Kratzsch J. Soluble leptin receptor represents the main leptin binding activity in human blood. Biochem Biophys Res Commun 2001;283:982-988.
16. Huang L, Wang Z, Li C. Modulation of circulating leptin levels by its soluble receptor. J Biol Chem 2001;276:6343-6349.
17. Cohen P, Yang G, Yu X et al. Induction of leptin receptor expression in the liver by leptin and food deprivation. J Biol Chem 2005;280:10034-10039.
18. National Heart Lung and Blood Institute. The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure (JNC 7). .
19. National Heart Lung and Blood Institute. Third Report of the Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). .
20. Brunt EM, Janney CG, Di Bisceglie AM, Neuschwander-Tetri BA, Bacon BR. Nonalcoholic steatohepatitis: a proposal for grading and staging the histological lesions. Am J Gastroenterol 1999;94:2467-2474.
21. Uygun A, Kadayifci A, Yesilova Z et al. Serum leptin levels in patients with nonalcoholic steatohepatitis. Am J Gastroenterol 2000;95:3584-3589.
22. Nobili V, Manco M, Ciampalini P et al. Leptin, free leptin index, insulin resistance and liver fibrosis in children with non-alcoholic fatty liver disease. Eur J Endocrinol 2006;155:735-743.
23. Fracanzani AL, Valenti L, Bugianesi E et al. Risk of severe liver disease in nonalcoholic fatty liver disease with normal aminotransferase levels: a role for insulin resistance and diabetes. Hepatology 2008;48:792-798.
24. Mofrad P, Contos MJ, Haque M et al. Clinical and histologic spectrum of nonalcoholic fatty liver disease associated with normal ALT values. Hepatology 2003;37:1286-1292.
25. Ramadori G, Moriconi F, Malik I, Dudas J. Physiology and pathophysiology of liver inflammation, damage and repair. J Physiol Pharmacol 2008;59(Suppl 1):107-117.
26. Muhanna N, Horani A, Doron S, Safadi R. Lymphocyte-hepatic stellate cell proximity suggests a direct interaction. Clin Exp Immunol 2007;148: 338-347.
27. Muhanna N, Doron S, Wald O et al. Activation of hepatic stellate cells after phagocytosis of lymphocytes: A novel pathway of fibrogenesis. Hepatology 2008;48:963-977.
28. Sinha MK, Opentanova I, Ohannesian JP et al. Evidence of free and bound leptin in human circulation. Studies in lean and obese subjects and during short-term fasting. J Clin Invest 1996;98: 1277-1282.
29. Chan JL, Blüher S, Yiannakouris N et al. Regulation of circulating soluble leptin receptor levels by gender, adiposity, sex steroids, and leptin: observational and interventional studies in humans. Diabetes 2002;51:2105-2112.
30. Ge H, Huang L, Pourbahrami T, Li C. Generation of soluble leptin receptor by ectodomain shedding of membrane-spanning receptors in vitro and in vivo. J Biol Chem 2002;277: 45898-45903.
31. Maamra M, Bidlingmaier M, Postel-Vinay MC et al. Generation of human soluble leptin receptor by proteolytic cleavage of membrane-anchored receptors. Endocrinology 2001;142:4389-4393.
32. Kesteloot F, Desmoulière A, Leclercq I et al. ADAM metallopeptidase with thrombospondin type 1 motif 2 inactivation reduces the extent and stability of carbon tetrachloride-induced hepatic fibrosis in mice. Hepatology 2007;46:1620-1631.
33. Niiya M, Uemura M, Zheng XW et al. Increased ADAMTS-13 proteolytic activity in rat hepatic stellate cells upon activation in vitro and in vivo. J Thromb Haemost 2006;4:1063-1070.
34. Ockenga J, Tietge UJ, Böker KH et al. Distinct roles of free leptin, bound leptin and soluble leptin receptor during the metabolic-inflammatory response in patients with liver cirrhosis. Aliment Pharmacol Ther 2007;25:1301-1309.
35. Montez JM, Soukas A, Asilmaz E et al. Acute leptin deficiency, leptin resistance, and the physiologic response to leptin withdrawal. Proc Natl Acad Sci USA 2005;102:2537-2542.
36. Cohen SE, Kokkotou E, Biddinger SB et al. High circulating leptin receptors with normal leptin sensitivity in liver-specific insulin receptor knock-out (LIRKO) mice. J Biol Chem 2007;282:23672-23678.
37. Argentou M, Tiniakos DG, Karanikolas M et al. Adipokine serum levels are related to liver histology in severely obese patients undergoing bariatric surgery. Obes Surg 2009;19:1313-1323.
38. Zelber-Sagi S, Nitzan-Kaluski D, Halpern Z, Oren R. Prevalence of primary non-alcoholic fatty liver disease in a population-based study and its association with biochemical and anthropometric measures. Liver Int 2006;26:856-863.