Estimating the affinity of protein-ligand complex from changes to the charge-state distribution of a protein in electrospray ionization mass spectrometry

Biochemical and Biophysical Research Communications

Volumn 403, Issue 2, 2010, Pages 190-193

  Blackburn, Elizabeth A ^a   Maclean, John K F ^b   Sherborne, Bradley S ^b   Walkinshaw, Malcolm D ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Electrospray ionization mass spectrometry; FKBP12; Immunophilin; Ligand affinity

Indexed keywords

RAPAMYCIN;

ARTICLE; BINDING AFFINITY; CORRELATION ANALYSIS; ELECTROSPRAY MASS SPECTROMETRY; LIGAND BINDING; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN PROTEIN INTERACTION;

DNA, RECOMBINANT; HUMANS; LIGANDS; PROTEIN BINDING; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TACROLIMUS BINDING PROTEIN 1A;

EID: 78649904208     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2010.11.003     Document Type: Article

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