Endothelial cell adhesion to the extracellular matrix induces c-Src-dependent VEGFR-3 phosphorylation without the activation of the receptor intrinsic kinase activity

Circulation Research

Volumn 106, Issue 12, 2010, Pages 1839-1848

  Galvagni, Federico ^a   Pennacchini, Susanna ^a   Salameh, Ahmad ^a   Rocchigiani, Marina ^a   Neri, Francesco ^a   Orlandini, Maurizio ^a   Petraglia, Felice ^b   Gotta, Stefano ^a   Sardone, Gian Luca ^a   Matteucci, Giacomo ^c   Terstappen, Georg C ^a   Oliviero, Salvatore ^a  

^a UNIVERSITY OF SIENA   (Italy)

^b Dipartimento di Pediatria   (Italy)

^c NOVARTIS VACCINES AND DIAGNOSTICS   (Italy)

Author keywords

angiogenesis; biochemistry; cell adhesion; endothelial cells; signaling

Indexed keywords

ADAPTOR PROTEIN; C SRC PROTEIN; COLLAGEN TYPE 1; CRK LIKE PROTEIN; EPIDERMAL GROWTH FACTOR; INTEGRIN; MUTANT PROTEIN; PHOSPHOTRANSFERASE; PHOSPHOTRANSFERASE INHIBITOR; PROTEIN SHC; PROTEIN TYROSINE KINASE; RECOMBINANT PROTEIN; TYROSINE; UNCLASSIFIED DRUG; VASCULOTROPIN RECEPTOR 3;

ARTICLE; BINDING SITE; CATALYSIS; CELL ADHESION; CONTROLLED STUDY; EMBRYO; ENDOTHELIUM CELL; ENZYME ACTIVATION; ENZYME ACTIVITY; EXTRACELLULAR MATRIX; FIBROBLAST; GENE SILENCING; HUMAN; HUMAN CELL; MASS SPECTROMETRY; MOLECULAR MECHANICS; NEWBORN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN TARGETING; RECEPTOR INTRINSIC ACTIVITY;

ANIMALS; CELL ADHESION; CELL LINE; CELLS, CULTURED; COLLAGEN TYPE I; ENDOTHELIUM, VASCULAR; EXTRACELLULAR MATRIX; HUMANS; MAP KINASE KINASE 4; MICE; MICE, KNOCKOUT; MODELS, ANIMAL; PHOSPHORYLATION; PROTEIN-TYROSINE KINASES; PROTO-ONCOGENE PROTEINS C-CRK; PROTO-ONCOGENE PROTEINS C-FYN; PROTO-ONCOGENE PROTEINS C-YES; SHC SIGNALING ADAPTOR PROTEINS; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-3;

EID: 77954214925     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.109.206326     Document Type: Article

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