Immunoneutralization of the aminoprocalcitonin peptide of procalcitonin protects rats from lethal endotoxaemia: Neuroendocrine and systemic studies

Clinical Science

Volumn 119, Issue 12, 2010, Pages 519-534

  Tavares, Eva ^a   Miñano, Francisco J ^a,b  

^a HOSPITAL UNIVERSITARIO DE VALME   (Spain)

^b UNIVERSITY OF SEVILLE   (Spain)

Author keywords

Adrenocorticotropic hormone (ACTH); Aminoprocalcitonin peptide (N PCT); Cytokine; Mortality; Procalcitonin (ProCT); Septic shock

Indexed keywords

AMINOPROCALCITONIN (1-57); AMINOPROCALCITONIN (44-57); AMINOPROCALCITONIN (44-57) ANTIBODY; ANTIINFECTIVE AGENT; CORTICOTROPIN; INTERLEUKIN 10; INTERLEUKIN 1BETA; PEPTIDE; PROCALCITONIN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANOREXIA; ANTISEPSIS; ARTICLE; BLOOD LEVEL; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENDOTOXEMIA; GENE EXPRESSION; HUMAN; HYPOTHALAMUS; IMMUNONEUTRALIZATION; IMMUNOTHERAPY; MALE; MORBIDITY; MORTALITY; NONHUMAN; PRIORITY JOURNAL; RAT; SEPSIS; SURVIVAL; UPREGULATION;

ANIMALS; CALCITONIN; CYTOKINES; DISEASE MODELS, ANIMAL; EATING; ENDOTOXEMIA; GENE EXPRESSION; HYPOTHALAMUS; IMMUNOTHERAPY; INFLAMMATION MEDIATORS; LIPOPOLYSACCHARIDES; MALE; PEPTIDE FRAGMENTS; PROTEIN PRECURSORS; RATS; RATS, WISTAR; SURVIVAL ANALYSIS;

EID: 78649861063     PISSN: 01435221     EISSN: None     Source Type: Journal    
DOI: 10.1042/CS20100007     Document Type: Article

References (51)

1. Raetz, C. R. H. and and Whitfield, C. (2002) Lipopolysaccharide endotoxins. Annu. Rev. Biochem. 71, 635-700
2. Tracey, K. J., Beutler, B., Lowry, S. F., Merryweather, J., Wolpe, S., Milsark, I. W., Hariri, R. J., Fahey, T. J., Zentella, A. and Albert, J. D. (1986) Shock and tissue injury induced by recombinant human cachectin. Science 234, 470-473
3. Netea, M. G., van der Meer, J. W., van Deuren, M. and and Kullberg, B. J. (2003) Proinflammatory cytokines and sepsis syndrome: not enough, or too much of a good thing? Trends Immunol. 24, 254-258
4. Buras, J. A., Holzmann, B. and Sitkovsky, M. (2005) Animal models of sepsis: setting the stage. Nat. Rev. Drug Discovery 4, 854-865
5. Micek, S. T., Shah, R. A. and Kollef, M. H. (2003) Management of severe sepsis: integration of multiple pharmacologic interventions. Pharmacotherapy 23, 1486-1496
6. Bochud, P. Y. and Calandra, T. (2003) Pathogenesis of sepsis: new concepts and implications for future treatment. Br. Med. J. 326, 262-266
7. Becker, K. L., Nylén, E. S., White, J. C., Müller, B. and Snider, R. H. (2004) Procalcitonin and the calcitonin gene family of peptides in inflammation, infection, and sepsis: a journey from calcitonin back to its precursors. J. Clin. Endocrinol. Metab. 89, 1512-1525
8. Burns, D. M., Birnbaum, R. S. and Roos, B. A. (1989) A neuroendocrine peptide derived from the amino-terminal half of rat procalcitonin. Mol. Endocrinol. 3, 140-147
9. Le Moullec, J., Jullienne, A., Chenais, J., Lasmoles, F., Guliana, J., Milhaud, G. and Moukhtar, M. (1984) The complete sequence of human preprocalcitonin. FEBS Lett. 167, 93-97
10. Steenbergh, P. H., Hoppener, J. W., Zandberg, J., Visser, A., Lips, C. J. and Jansz, H. S. (1986) Structure and expression of the human calcitonin/CGRP genes. FEBS Lett. 209, 97-103
11. Russwurm, S., Wiederhold, M., Oberhoffer, M., Stonans, I., Zipfel, P. F. and Reinhart, K. (1999) Molecular aspects and natural source of procalcitonin. Clin. Chem. Lab. Med. 37, 787-797
12. Snider, R. H., Nylen, E. S. and Becker, K. L. (1997) Procalcitonin and its component peptides in systemic inflammation: immunochemical characterization. J. Invest. Med. 45, 552-560
13. Born, W., Beglinger, C. and Fischer, J. A. (1991) Diagnostic relevance of the amino-terminal cleavage peptide of procalcitonin (PAS-57), calcitonin and calcitonin gene-related peptide in medullary thyroid carcinoma patients. Regul. Pept. 32, 311-319
14. Müller, B., White, J. C., Nylén, E., Snider, R. S., Becker, K. L. and Habener, J. F. (2001) Ubiquitous expression of the calcitonin-I gene in multiple tissues in response to sepsis. J. Clin. Endocrinol. Metab. 86, 396-404
15. Assicot, M., Gendrel, D., Carsin, H., Raymond, J., Guilbaud, J. and Bohuon, C. (1993) High serum procalcitonin concentrations in patients with sepsis and infection. Lancet 341, 515-518
16. Whang, K. T., Steinwald, P. M., White, J. C., Nylen, E. S., Snider, R. H., Simon, G. L., Goldberg, R. L. and Becker, K. L. (1998) Serum calcitonin precursors in sepsis and systemic inflammation. J. Clin. Endocrinol. Metab. 83, 3296-3301
17. Becker, K. L., Snider, R. and Nylen, E. S. (2009) Procalcitonin in sepsis and systemic inflammation: a harmful biomarker and a therapeutic target. Br. J. Pharmacol. 159, 253-264
18. Müller, B. and and Becker, K. L. (2001) Procalcitonin: how a hormone became a marker and mediator of sepsis. Swiss Med. Wkly 131, 595-602
19. Dandona, P., Nix, D., Wilson, M. F., Aljada, A., Love, L., Assicot, M. and Bohuon, C. (1994) Procalcitonin increase after endotoxin injection in normal subjects. J. Clin. Endocrinol. Metab. 79, 1605-1608
20. Monneret, G., Arpin, M., Venet, F., Maghni, K., Debard, A. L., Pachot, A., Lepape, A. and Bienvenu, J. (2003) Calcitonin gene related peptide and N-procalcitonin modulate CD11b upregulation in lipopolysaccharide activated monocytes and neutrophils. Intens. Care Med. 29, 923-928
21. Martinez, J. M., Wagner, K. E., Snider, R. H., Nylén, E. S., Müller, B., Sarani, B., Becker, K. L. and White, J. C. (2001) Late immunoneutralization of procalcitonin arrests the progression of lethal porcine sepsis. Surg. Infect. 2, 193-203
22. Wagner, K. E., Martinez, J. M., Vath, S. D., Snider, R. H., Nylén, E. S., Becker, K. L., Müller, B. and White, J. C. (2002) Early immunoneutralization of calcitonin in precursors markedly attenuates the adverse physiology response to sepsis in pigs. Crit. Care Med. 30, 2313-2321
23. Tavares, E., Maldonado, R. and Miñano, F. J. (2007) N-procalcitonin: central effects on feeding and energy homeostasis in rats. Endocrinology 148, 1891-1901
24. Tavares, E. and Miñano, F. J. (2008) Procalcitonin N-terminal peptide causes catabolic effects via the hypothalamus and prostaglandin- dependent pathways. Neuroendocrinology 88, 316-326
25. Romanovsky, A. A., Ivanov, A. I. and Shimansky, Y. P. (2002) Selected contribution: ambient temperature for experiments in rats: a new method for determining the zone of thermal neutrality. J. Appl. Physiol. 92, 2667-2679
26. Johnson, J. D., O'Connor, K. A., Hansen, M. K., Watkins, L. R. and Maier, S. F. (2003) Effects of prior stress on LPS-induced cytokine and sickness responses. Am. J. Physiol. Regul. Integr. Comp. Physiol. 284, R422-R432
27. Brennan, M. P., Sinusas, A. J., Horvath, T. L. and Collins, J. G. (2009) Harding MJ. Correlation between body weight changes and postoperative pain in rats treated with meloxicam or buprenorphine. Lab. Anim. 38, 87-93
28. Tavares, E., Maldonado, R., Ojeda, M. L. and and Miñano, F. J. (2005) Circulating inflammatory mediators during start of fever in differential diagnosis of Gram-negative and Gram-positive infections in leukopenic rats. Clin. Diagn. Lab. Immunol. 12, 1085-1093
29. Ada\ms, S. D., Radhakrishnan, R. S., Helmer, K. S. and Mercer, D. W. (2008) Effects of anesthesia on lipopolysaccharide-induced changes in serum cytokines. J. Trauma 65, 170-174
30. Liles, J. H. and Flecknell, P. A. (1992) The use of non-steroidal anti-inflammatory drugs for the relief of pain in laboratory rodents and rabbits. Lab. Anim. 26, 241-255
31. Piersma, F. E., Daemen, M. A., Bogaard, A. E. and Buurman, W. A. (1999) Interference of pain control employing opioids in in vivo immunological experiments. Lab. Anim. 33, 328-333
32. Rossi Paccani, S., Boncristiano, M. and Baldari, C. T. (2003) Molecular mechanisms underlying suppression of lymphocyte responses by nonsteroidal antiinflammatory drugs. Cell. Mol. Life Sci. 60, 1071-1083
33. Nylen, E., Whang, K. T., Steinwald, P. M., Snider, R. H., White, J. C. and Becker, K. L. (1998) Mortality is increased by procalcitonin and decreased by an antiserum reactive to procalcitonin in experimental sepsis. Crit. Care Med. 26, 1001-1006
34. Givalois, L., Dornand, J., Mekaouche, M., Solier, M. D., Bristow, A. F., Ixart, G., Siaud, P., Assenmacher, I. and Barbanel, G. (1994) Temporal cascade of plasma level surges in ACTH, corticosterone, and cytokines in endotoxin-challenged rats. Am. J. Physiol. 267, R164-R170
35. Jacobson, L. (2005) Hypothalamic-pituitary-adrenocortical axis regulation. Endocrinol. Metab. Clin. North Am. 34, 271-292
36. Webster, J. I., Tonelli, L. and Sternberg, E. M. (2002) Neuroendocrine regulation of immunity. Annu. Rev. Immunol. 20, 125-163
37. Howard, M., Muchamuel, T., Andrade, S. and Menon, S. (1993) Interleukin 10 protects mice from lethal endotoxemia. J. Exp. Med. 77, 1205-1208
38. Eskandari, M. K., Bolgos, G., Miller, C., Nguyen, D. T., DeForge, L. E. and Remick, D. G. (1992) Anti-tumor necrosis factor antibody therapy fails to prevent lethality after cecal ligation and puncture or endotoxemia. J. Immunol. 148, 2724-2730
39. Cohen, J. (2002) The immunopathogenesis of sepsis. Nature 420, 885-891
40. Parrillo, J. E. (1993) Pathogenetic mechanisms of septic shock. N. Engl. J. Med. 328, 1471-1485
41. Annane, D., Bellisant, E. and Cavaillon, J. (2005) Septic shock. Lancet 365, 63-78
42. Meisner, M. (2002) Pathobiochemistry and clinical use of procalcitonin. Clin. Chim. Acta 323, 17-29
43. Becker, K. L., Snider, R. H. and Nylen, E. S. (2008) Procalcitonin assay in systemic inflammation, infection, and sepsis: clinical utility and limitations. Crit. Care Med. 36, 941-952
44. Braithwaite, S. S. (1998) Procalcitonin: marker or mediator? Crit. Care. Med. 26, 977-978
45. Becker, K. L., Nylén, E. S., Snider, R. H., Müller, B. and White, J. C. (2003) Immunoneutralization of procalcitonin as therapy of sepsis. J. Endotoxin Res. 9, 367-374
46. Sharshar, T., Hopkinson, N. S., Orlikowski, D. and Annane, D. (2005) The brain in sepsis: culprit and victim. Crit. Care Med. 9, 37-44
47. Ertel, W., Morrison, M. H., Wang, P., Ba, Z. F., Ayala, A. and Chaudry, I. H. (1991) The complex pattern of cytokines in sepsis. Association between prostaglandins, cachectin, and interleukins. Ann. Surg. 21, 141-148
48. Sexton, P. M., Christopoulos, G., Christopoulos, A., Nylen, E. S., Snider, R. H. and Becker, K. L. (2008) Procalcitonin has bioactivity at calcitonin receptor family complexes: potential mediator implications in sepsis. Crit. Care Med. 36, 1637-1640
49. Becskei, C., Riediger, T., Zünd, D., Wooley, P. and Lutz, T. A. (2004) Immunohistochemical mapping of calcitonin receptors in the adult rat brain. Brain Res. 1030, 221-233
50. Vassalli, P. (1992) The pathophysiology of tumor necrosis factors. Annu. Rev. Immunol. 10, 411-452
51. Oberholzer, A., Oberholzer, C. and Moldawer, L. L. (2002) Interleukin-10: a complex role in the pathogenesis of sepsis syndromes and its potential as an antiinflammatory drug. Crit. Care Med. 30, S58-S63