Regulation of phosphorylation of tau by protein kinases in rat brain

Neurochemical Research

Volumn 31, Issue 12, 2006, Pages 1473-1480

  Sengupta, Amitabha ^a   Grundke Iqbal, Inge ^a   Iqbal, Khalid ^a  

^a NEW YORK STATE INSTITUTE FOR BASIC RESEARCH IN DEVELOPMENTAL DISABILITIES   (United States)

Author keywords

Alzheimer disease; Neurofibrillary degeneration; Tau; Tau hyperphosphorylation

Indexed keywords

BRADYKININ; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIN DEPENDENT KINASE 5; GLYCOGEN SYNTHASE KINASE 3; ISOPRENALINE; MICROTUBULE ASSOCIATED PROTEIN; PROTEIN KINASE; PROTEIN KINASE (CALCIUM,CALMODULIN) II; SERINE; TAU PROTEIN; TUBULIN; WORTMANNIN;

ALZHEIMER DISEASE; ANIMAL TISSUE; ARTICLE; BRAIN SLICE; CEREBROSPINAL FLUID; CONTROLLED STUDY; ENZYME ACTIVITY; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; RAT; REGULATORY MECHANISM;

ALZHEIMER DISEASE; ANDROSTADIENES; ANIMALS; BLOTTING, WESTERN; BRADYKININ; BRAIN CHEMISTRY; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CYCLIN-DEPENDENT KINASE 5; ENZYME ACTIVATORS; ENZYME INHIBITORS; GLYCOGEN SYNTHASE KINASE 3; HUMANS; ISOPROTERENOL; MALE; MICROTUBULES; PHOSPHORYLATION; PROTEIN KINASES; RATS; TAU PROTEINS;

EID: 33845425431     PISSN: 03643190     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11064-006-9205-9     Document Type: Article

References (38)

1. Grundke-Iqbal I, Iqbal K, Quinlan M et al (1986) Microtubule-associated protein tau. A component of Alzheimer paired helical filaments. J Biol Chem 261:6084-6089
2. Grundke-Iqbal I, Iqbal K, Tung YC et al (1986) Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology. Proc Natl Acad Sci USA 83:4913-4917
3. Iqbal K, Grundke-Iqbal I, Smith AJ et al (1989) Identification and localization of a tau peptide to paired helical filaments of Alzheimer disease. Proc Natl Acad Sci USA 86:5646-5650
4. Lee VM, Balin BJ, Otvos L Jr. et al (1991) A68: a major subunit of paired helical filaments and derivatized forms of normal Tau. Science 251:675-678
5. Iqbal K, Grundke-Iqbal I, Zaidi T et al (1986) Defective brain microtubule assembly in Alzheimer's disease. Lancet 2:421-426
6. Kopke E, Tung YC, Shaikh S et al (1993) Microtubule-associated protein tau. Abnormal phosphorylation of a non-paired helical filament pool in Alzheimer disease. J Biol Chem 268:24374-24384
7. Iqbal K, Zaidi T, Bancher C et al (1994) Alzheimer paired helical filaments. Restoration of the biological activity by dephosphorylation. FEBS Lett 349:104-108
8. Alonso A, Zaidi T, Grundke-Iqbal I et al (1994) Role of abnormally phosphorylated tau in the breakdown of microtubules in Alzheimer disease. Proc Natl Acad Sci USA 91:5562-5566
9. Alonso A, Grundke-Iqbal I, Barra HS et al (1997) Abnormal phosphorylation of tau and the mechanism of Alzheimer neurofibrillary degeneration: sequestration of microtubule-associated proteins 1 and 2 and the disassembly of microtubules by the abnormal tau. Proc Natl Acad Sci USA 94:298-303
10. Alonso A, Li B, Grundke-Iqbal I et al (2006) Polymerization of hyperphosphorylated tau into filaments eliminates its inhibitory activity. Proc Natl Acad Sci USA 23:8864-8869
11. Alonso A, Grundke-Iqbal I, Iqbal K (1996) Alzheimer's disease hyperphosphorylated tau sequesters normal tau into tangles of filaments and disassembles microtubules. Nat Med 2:783-787
12. Wang JZ, Gong CX, Zaidi T et al (1995) Dephosphorylation of Alzheimer paired helical filaments by protein phosphatase-2A and -2B. J Biol Chem 270:4854-4860
13. Wang JZ, Grundke-Iqbal I, Iqbal K (1996) Restoration of biological activity of Alzheimer abnormally phosphorylated tau by dephosphorylation with protein phosphatase-2A, -2B and -1. Brain Res Mol Brain Res 38:200-208
14. Morishima-Kawashima M, Hasegawa M, Takio K et al (1995) Proline-directed and non-proline-directed phosphorylation of PHF-tau. J Biol Chem 270:823-829
15. Hanger DP, Betts JC, Loviny TL et al (1998) New phosphorylation sites identified in hyperphosphorylated tau (paired helical filament-tau) from Alzheimer's disease brain using nanoelectrospray mass spectrometry. J Neurochem 71:2465-2476
16. Liu SJ, Zhang JY, Li HL et al (2004) Tau becomes a more favorable substrate for GSK-3 when it is prephosphorylated by PKA in rat brain. J Biol Chem 279:50078-50088
17. Sun L, Wang X, Liu S et al (2005) Bilateral injection of isoproterenol into hippocampus induces Alzheimer-like hyperphosphorylation of tau and spatial memory deficit in rat. FEBS Lett 579:251-258
18. Singh TJ, Zaidi T, Grundke-Iqbal I et al (1995) Modulation of GSK-3-catalyzed phosphorylation of microtubule-associated protein tau by non-proline-dependent protein kinases. FEBS Lett 358:4-8
19. Singh TJ, Grundke-Iqbal I, Iqbal K (1996) Differential phosphorylation of human tau isoforms containing three repeats by several protein kinases. Arch Biochem Biophys 328:43-50
20. Singh TJ, Grundke-Iqbal I, Wu WQ et al (1997) Protein kinase C and calcium/calmodulin-dependent protein kinase II phosphorylate three-repeat and four-repeat tau isoforms at different rates. Mol Cell Biochem 168:141-148
21. Sengupta A, Wu Q, Grundke-Iqbal I et al (1997) Potentiation of GSK-3-catalyzed Alzheimer-like phosphorylation of human tau by cdk5. Mol Cell Biochem 167:99-105
22. Sengupta A, Kabat J, Novak M et al (1998) Phosphorylation of tau at both Thr 231 and Ser 262 is required for maximal inhibition of its binding to microtubules. Arch Biochem Biophys 357:299-309
23. Lucas JJ, Hernandez F, Gomez-Ramos P et al (2001) Decreased nuclear beta-catenin, tau hyperphosphorylation and neurodegeneration in GSK-3beta conditional transgenic mice. Embo J 20:27-39
24. Cruz JC, Tseng HC, Goldman JA et al (2003) Aberrant Cdk5 activation by p25 triggers pathological events leading to neurodegeneration and neurofibrillary tangles. Neuron 40:471-483
25. Engel T, Hernandez F, Avila J et al (2006) Full reversal of Alzheimer's disease-like phenotype in a mouse model with conditional overexpression of glycogen synthase kinase-3. J Neurosci 26:5083-5090
26. 2+/calmodulin-dependent protein kinase II by stimulation with bradykinin in neuroblastoma x glioma hybrid NG108-15 cells. Brain Res Mol Brain Res 597:220-226
27. Troispoux C, Reiter E, Combarnous Y et al (1998) Beta2 adrenergic receptors mediate cAMP, tissue-type plasminogen activator and transferrin production in rat Sertoli cells. Mol Cell Endocrinol 142:75-86
28. Welsh GI, Foulstone EJ, Young SW et al (1994) Wortmannin inhibits the effects of insulin and serum on the activities of glycogen synthase kinase-3 and mitogen-activated protein kinase. Biochem J 303(Pt 1):15-20
29. Alger B, Dhanjal S, Dingledine R et al (1984), Editor^Editors. 1984, Plenum Press, New York, pp 381-437
30. Lipton P, Aitken PG, Dudek FE et al (1995) Making the best of brain slices: comparing preparative methods. J Neurosci Meth 59:151-156
31. Liu WK, Dickson DW, Yen SH (1993) Heterogeneity of tau proteins in Alzheimer's disease. Evidence for increased expression of an isoform and preferential distribution of a phosphorylated isoform in neurites. Am J Pathol 142:387-394
32. Hasegawa M, Watanabe A, Takio K et al (1993) Characterization of two distinct monoclonal antibodies to paired helical filaments: further evidence for fetal-type phosphorylation of the tau in paired helical filaments. J Neurochem 60:2068-2077
33. Greenberg SG, Davies P (1990) A preparation of Alzheimer paired helical filaments that displays distinct tau proteins by polyacrylamide gel electrophoresis. Proc Natl Acad Sci USA 87:5827-5831
34. Tanaka T, Zhong J, Iqbal K et al (1998) The regulation of phosphorylation of tau in SY5Y neuroblastoma cells: the role of protein phosphatases. FEBS Lett 426:248-254
35. Roskoski R Jr (1983) Assays of protein kinase. Meth Enzymol 99:3-6
36. Laemmli UK (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227:680-685
37. Kremer L, Dominguez JE, Avila J (1988) Detection of tubulin-binding proteins by an overlay assay. Anal Biochem 175:91-95
38. Lindwall G, Cole RD (1984) Phosphorylation affects the ability of tau protein to promote microtubule assembly. J Biol Chem 259:5301-5305