Curcumin inhibits invasion and metastasis in the human ovarian cancer cells SKOV3 by CXCL12-CXCR4 axis

African Journal of Biotechnology

Volumn 9, Issue 48, 2010, Pages 8230-8234

  Xiaoling, M U ^a   Jing, Zhao ^a   Fang, Xu ^a   Liangdan, Tang ^a  

^a CHONGQING MEDICAL UNIVERSITY   (China)

Author keywords

Curcumin; Invasion; Metastasis; Ovarian cancer

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; CHEMOKINE RECEPTOR CXCR4; CURCUMIN; MATRIGEL; STROMAL CELL DERIVED FACTOR 1;

ARTICLE; CANCER CELL CULTURE; CANCER GROWTH; CANCER INHIBITION; CANCER INVASION; CELL ASSAY; CELL COUNT; CELL MIGRATION; CELL STRAIN SKOV3; CONCENTRATION RESPONSE; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; METASTASIS INHIBITION; OVARY METASTASIS; PROTEIN EXPRESSION; WESTERN BLOTTING;

EID: 78649836793     PISSN: 16845315     EISSN: None     Source Type: Journal    
DOI: 10.5897/ajb10.1227     Document Type: Article

References (25)

1. Backwill F (2004). The significance of cancer cell expression of the chemokine receptor CXCR4. Semin Cancer Biol.14: 171-179.
2. Backwill F, Mantovani A (2001). Inflammation and cancer: back to virchow? Lancet. 357: 539-545.
3. Balasubramanian S, Eckert RL (2007). Keratinocyte proliferation, differentiation, and apoptosis-differential mechanisms of regulation by curcumin, EGCG and apigenin. Toxicol. Appl. Pharmacol. 224(3): 214-219.
4. Beg A, Baltimore D (1996). An essential role for NF-İB in preventing TNF-Ş induced cell death. Science, 274: 782-784.
5. Bhandarkar SS, Arbiser JL (2007). Curcumin as an inhibitor of angiogenesis. Adv. Exp. Med. Biol. 595: 185-195.
6. Brennan P, O'Neill LA (1998). Inhibition of nuclear factor kappaB by direct modification in whole cells-mechanism of action of nordihydroguaiaritic acid, curcumin and thiol modifiers. Biochem. Pharmacol. 55(7): 965-973.
7. Chambers AF, Groom AC, MacDonald IC (2002). Dissemination and growth of cancer cells in metastatic sites. Nat. Rev. Cancer, 2: 563-572.
8. Chen HW, Yu SL, Chen JJ, Li HN, Lin YC, Yao PL, Chou HY, Chien CT, Chen WJ, Lee YT, Yang PC (2004). Antiinvasive gene expression profile of curcumin in lung adenocarcinoma based on a high throughput microarray analysis. Mol. Pharmacol. 65(1): 99-110.
9. Choi BH, Kim CG, Lim Y, Shin SY, Lee YH (2008). Curcumin downregulates the multidrug-resistance mdr1b gene by inhibiting the PI3K/Akt/NF-kappaB pathway. Cancer Lett. 259(1): 111-118.
10. Fang X, Mu XL, Zhao J (2009). Effects of curcumin on invasion and metastasis in the human cervical cancer cells Caski. Chinese J. Cancer Res. 21(2): 159-162.
11. Guo LY, Cai XF, Lee JJ, Kang SS, Shin EM, Zhou HY, Jung JW, Kim YS (2008). Comparison of suppressive effects of demethoxycurcumin and bisdemethoxycurcumin on expressions of inflammatory mediators in vitro and in vivo. Arch. Pharm. Res. 31(4): 490-496.
12. Kaifi JT, Yekebas EF, Schurr P, Obonyo D, Wachowiak R, Busch P, Heinecke A, Pantel K, Izbicki JR (2005). Tumor-cell homing to lymph nodes and bone marrow and CXCR4 expression in esophageal cancer. J. Natl. Cancer Inst. 97(24): 1840-1847.
13. Kim J, Takeuchi H, Lam ST, Turner RR, Wang HJ, Kuo C, Foshag L, Bilchik AJ, Hoon DS (2005). Chemokine receptor CXCR4 expression in colorectal cancer patients increases the risk for recurrence and for poor survival. J. Clin. Oncol. 23(12): 2744-2753.
14. Kryczek I, Wei S, Keller E, Liu R, Zou W (2007). Stromal derived factor (SDF-1/CXCL12) and human tumor pathogenesis. Am. J. Physiol. Cell Physiol. 292: C987-C995.
15. Liotta LA (2001). An attractive force in metastasis. Nature, 410: 24-25.
16. Mabuchi S, Ohmichi M, Nishio Y, Hayasaka T, Kimura A, Ohta T, Kawagoe J, Takahashi K, Yada-Hashimoto N, Seino-Noda H, Sakata M, Motoyama T, Kurachi H, Testa JR, Tasaka K, Murata Y. (2004). Inhibition of inhibitor of nuclear factor-kappaB phosphorylation increases the efficacy of paclitaxel in in vitro and in vivo ovarian cancer models. Clin. Cancer Res. 10(22): 7645-54.
17. Menon LG, Kuttan R, Kuttan G (1999). Anti-metastatic activity of curcumin and catechin. Cancer Lett. 141: 159-165.
18. Muller A, Homey B, Soto H, Ge N, Catron D, Buchanan ME, McClanahan T, Murphy E, Yuan W, Wagner SN, Barrera JL, Mohar A, Verástegui E, Zlotnik A (2001). Involvement of chemokine receptors in breast cancer metastasis. Nature, 410(6824): 50-56.
19. Naora H, Montell DJ (2005). Ovarian cancer metastasis: integrating insights from disparate model organisms. Nat. Rev. Cancer, 5: 355-366.
20. Pantel K, Brakenhoff RH (2004). Dissecting the metastatic cascade. Nat. Rev. Cancer, 4: 448-456.
21. Russell HV, Hicks J, Okcu MF, Nuchtern JG (2004). CXCR4 expression in neuroblastoma primary tumors is associated with clinical presentation of bone and bone marrow metastases. J. Pediatr. Surg. 39: 1506-1511.
22. Shirozu M, Nakano T, Inazawa J, Tashiro K, Tada H, Shinohara T, Honjo T(1995). Structure and chromosomal localization of the human stromal cell-derived factor 1(SDF1) gene. Genomics, 28: 495-500.
23. Zhao J, Zhao Y (2004). Effects of curcumin on proliferation and apoptosis of human cervical carcinoma hela cells in vitro. Chinese J. Cancer Res. 16(3): 225-228.
24. Zhao J, Zhao Y, Zhang Y, Chen W (2007). Anti-tumor effect of curcumin on human cervical carcinoma Hela cells in vitro and in vivo. Chinese J. Cancer Res. 19(1): 32-36.
25. Zhao J, Zhao Y, Zheng W, Lu Y, Feng G, Yu S (2008). Neuroprotective effect of curcumin on transient focal cerebral ischemia in rats. Brain Res. 1229: 224-232.