Activation of Cdk2/Cyclin E complexes is dependent on the origin of replication licensing factor Cdc6 in mammalian cells

Cell Cycle

Volumn 9, Issue 22, 2010, Pages 4533-4541

  Lunn, Cara L ^a   Chrivia, John C ^a   Baldassare, Joseph J ^a  

^a SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

cdc6; CDK2 activation; Chromatin association; ERK; Fibroblast; Origin of replication

Indexed keywords

CELL CYCLE PROTEIN 6; CYCLIN DEPENDENT KINASE 2; CYCLIN E;

ADULT; ANIMAL CELL; ARTICLE; CHROMATIN IMMUNOPRECIPITATION; HUMAN; HUMAN CELL; MAMMAL CELL; NONHUMAN; NUCLEAR LOCALIZATION SIGNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; RNA INTERFERENCE;

MAMMALIA;

EID: 78649813571     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.9.22.13789     Document Type: Article

References (43)

1. 1 phase of the human cell cycle. Science 1992; 257:1689-94.
2. Gu Y, Rosenblatt J, Morgan DO. Cell cycle regulation of CDK2 activity by phosphorylation of Thr160 and Tyr15. EMBO J 1992; 11:3995-4005.
3. Pagano M, Pepperkok R, Lukas J, Baldin V, Ansorge W, Bartek J, Draetta G. Regulation of the cell cycle by the cdk2 protein kinase in cultured human fibroblasts. J Cell Biol 1993; 121:101-11. (Pubitemid 23097366)
4. 1 phase progression: cycling on cue. Cell 1994; 79:551-5.
5. DeGregori J. The Rb network. J Cell Sci 2004; 117:3411-3.
6. Cobrinik D. Pocket proteins and cell cycle control. Oncogene 2005; 24:2796-809. (Pubitemid 40638091)
7. Dynlacht BD, Moberg K, Lees JA, Harlow E, Zhu L. Specific regulation of E2F family members by cyclin-dependent kinases 1997.
8. Chi Y, Welcker M, Hizli AA, Posakony JJ, Aebersold R, Clurman BE. Identification of CDK2 substrates in human cell lysates. Genome Biol 2008; 9:149.
9. Morgan DO. Principles of CDK regulation. Nature 1995; 374:131-4.
10. Honda R, Lowe ED, Dubinina E, Skamnaki V, Cook A, Brown NR, Johnson LN. The structure of cyclin E1/CDK2: implications for CDK2 activation and CDK2-independent roles. EMBO J 2005; 24:452-63. (Pubitemid 40343248)
11. Tassan JP, Schultz SJ, Bartek J, Nigg EA. Cell cycle analysis of the activity, subcellular localization and subunit composition of human CAK (CDK-activating kinase). J Cell Biol 1994; 127:467-78. (Pubitemid 24313734)
12. Poon RY, Hunter T. Dephosphorylation of Cdk2 Thr160 by the cyclin-dependent kinase-interacting phosphatase KAP in the absence of cyclin. Science 1995; 270:90-3.
13. Galaktionov K, Lee AK, Eckstein J, Draetta G, Meckler J, Loda M, Beach D. CDC25 phosphatases as potential human oncogenes. Science 1995; 269:1575-7.
14. Perry JA, Kornbluth S. Cdc25 and Wee1: Analogous opposites? Cell Div 2007; 2:12.
15. Holmes JK, Solomon MJ. The role of Thr160 phosphorylation of Cdk2 in substrate recognition. Eur J Biochem 2001; 268:4647-52.
16. Brown NR, Noble ME, Lawrie AM, Morris MC, Tunnah P, Divita G, et al. Effects of phosphorylation of threonine 160 on cyclin-dependent kinase 2 structure and activity. J Biol Chem 1999; 274:8746-56. (Pubitemid 29164672)
17. 1-phase progression. Genes Dev 1999; 13:1501-12.
18. Boxem M. Cyclin-dependent kinases in C. elegans. Cell Div 2006; 1:6.
19. Keenan SM, Bellone C, Baldassare JJ. Cyclin-dependent kinase 2 nucleocytoplasmic translocation is regulated by extracellular regulated kinase. J Biol Chem 2001; 276:22404-9. (Pubitemid 37410915)
20. Desai D, Wessling HC, Fisher RP, Morgan DO. Effects of phosphorylation by CAK on cyclin binding by CDC2 and CDK2. Mol Cell Biol 1995; 15:345-50. (Pubitemid 24379932)
21. Lents NH, Keenan SM, Bellone C, Baldassare JJ. Stimulation of the Raf/MEK/ERK cascade is necessary and sufficient for activation and Thr-160 phosphorylation of a nuclear-targeted CDK2. J Biol Chem 2002; 277:47469-75. (Pubitemid 36159264)
22. Furstenthal L, Kaiser BK, Swanson C, Jackson PK. Cyclin E uses Cdc6 as a chromatin-associated receptor required for DNA replication. J Cell Biol 2001; 152:1267-78. (Pubitemid 34280183)
23. Aladjem MI. Replication in context: dynamic regulation of DNA replication patterns in metazoans. Nat Rev Genet 2007; 8:588-600.
24. Mendez J, Stillman B. Chromatin association of human origin recognition complex, cdc6 and minichromosome maintenance proteins during the cell cycle: assembly of prereplication complexes in late mitosis. Mol Cell Biol 2000; 20:8602-12.
25. Arias EE, Walter JC. Strength in numbers: preventing rereplication via multiple mechanisms in eukaryotic cells. Genes Dev 2007; 21:497-518.
26. Borlado LR, Mendez J. CDC6: from DNA replication to cell cycle checkpoints and oncogenesis. Carcinogenesis 2008; 29:237-43.
27. Machida YJ, Teer JK, Dutta A. Acute reduction of an origin recognition complex (ORC) subunit in human cells reveals a requirement of ORC for Cdk2 activation. J Biol Chem 2005; 280:27624-30.
28. 1 progression in untransformed human cells. Cell Cycle 2009; 8:125-36.
29. Nevis KR, Cordeiro-Stone M, Cook JG. Origin licensing and p53 status regulate Cdk2 activity during G(1). Cell Cycle 2009; 8:1952-63.
30. Rivard N, Boucher MJ, Asselin C, L'Allemain G. MAP kinase cascade is required for p27 downregulation and S phase entry in fibroblasts and epithelial cells. Am J Physiol 1999; 277:652-64.
31. Kortylewski M, Heinrich PC, Kauffmann ME, Bohm M, MacKiewicz A, Behrmann I. Mitogen-activated protein kinases control p27/Kip1 expression and growth of human melanoma cells. Biochem J 2001; 357:297-303.
32. Morgan DO. The Cell Cycle: Principles of Control. Sunderland, MA: New Science Press Ltd 2007.
33. Roberts JM, Sherr CJ. Bared essentials of CDK2 and cyclin E. Nat Genet 2003; 35:9-10.
34. Cook JG, Park CH, Burke TW, Leone G, DeGregori J, Engel A, Nevins JR. Analysis of Cdc6 function in the assembly of mammalian prereplication complexes. Proc Natl Acad Sci USA 2002; 99:1347-52.
35. Mailand N, Diffley JF. CDKs promote DNA replication origin licensing in human cells by protecting Cdc6 from APC/C-dependent proteolysis. Cell 2005; 122:915-26.
36. 2/M checkpoint control. PLoS Genet 6:1000863.
37. Cook JG. Replication licensing and the DNA damage checkpoint. Front Biosci 2009; 14:5013-30.
38. Delmolino LM, Saha P, Dutta A. Multiple mechanisms regulate subcellular localization of human CDC6. J Biol Chem 2001; 276:26947-54.
39. Pelizon C, Madine MA, Romanowski P, Laskey RA. Unphosphorylatable mutants of Cdc6 disrupt its nuclear export but still support DNA replication once per cell cycle. Genes Dev 2000; 14:2526-33.
40. Hateboer G, Wobst A, Petersen BO, Le Cam L, Vigo E, Sardet C, Helin K. Cell cycle-regulated expression of mammalian CDC6 is dependent on E2F. Mol Cell Biol 1998; 18:6679-97.
41. Coller HA. What's taking so long? S-phase entry from quiescence versus proliferation. Nat Rev Mol Cell Biol 2007; 8:667-70.
42. 1 events and regulation of cell proliferation. Science 1989; 246:603-8.
43. 1 progression by its effect on cyclin D1 expression and cyclin-dependent kinase 4 activity. J Biol Chem 2000; 275:18046-53.