IKAP/hELP1 downregulation in neuroblastoma cells causes enhanced cell adhesion mediated by contactin overexpression

Cell Adhesion and Migration

Volumn 4, Issue 4, 2010, Pages 541-550

  Cohen Kupiec, Rachel ^a   Weinstein, Shiri ^a   Kantor, Gal ^a   Peer, Dan ^a   Weil, Miguel ^a  

^a TEL AVIV UNIVERSITY   (Israel)

Author keywords

Contactin; Familial dysautonomia; IKAP hELP1; Laminin; Neuronal differentiation; Peripheral nervous system

Indexed keywords

CALCEIN; CONTACTIN; LAMININ; MESSENGER RNA; SHORT HAIRPIN RNA; CARRIER PROTEIN; IKBKAP PROTEIN, HUMAN; RETINOIC ACID; TENASCIN;

ADRENAL TUMOR; ARTICLE; CELL ADHESION; CELL AGGREGATION; CELL CULTURE; CELL MATURATION; CELL STRUCTURE; DOWN REGULATION; FLUORESCENCE ACTIVATED CELL SORTING; GENE; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; IKAP GENE; NERVE CELL DIFFERENTIATION; NEURAL CREST; NEUROBLASTOMA CELL; PERIPHERAL NERVOUS SYSTEM; PHENOTYPE; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; BIOSYNTHESIS; CELL DIFFERENTIATION; CELL SIZE; DRUG EFFECT; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; NERVE CELL; NEUROBLASTOMA; PATHOLOGY; RNA INTERFERENCE; SINGLE CELL ANALYSIS; TUMOR CELL LINE;

CARRIER PROTEINS; CELL ADHESION; CELL AGGREGATION; CELL DIFFERENTIATION; CELL LINE, TUMOR; CELL SIZE; CONTACTINS; DOWN-REGULATION; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LAMININ; NEUROBLASTOMA; NEURONS; RNA INTERFERENCE; SINGLE-CELL ANALYSIS; TENASCIN; TRETINOIN;

EID: 78649812844     PISSN: 19336918     EISSN: 19336926     Source Type: Journal    
DOI: 10.4161/cam.4.4.12923     Document Type: Article

References (38)

1. Slaugenhaupt SA, Gusella JF. Familial dysautonomia. Curr Opin Genet Dev 2002; 12:307-11.
2. Axelrod FB. Familial dysautonomia. Muscle Nerve 2004; 29:352-63.
3. Anderson SL, Coli R, Daly IW, Kichula EA, Rork MJ, Volpi SA, et al. Familial dysautonomia is caused by mutations of the IKAP gene. Am J Hum Genet 2001; 68:753-8.
4. Slaugenhaupt SA, Blumenfeld A, Gill SP, Leyne M, Mull J, Cuajungco MP, et al. Tissue-specific expression of a splicing mutation in the IKBKAP gene causes familial dysautonomia. Am J Hum Genet 2001; 68:598-605.
5. Neer EJ, Schmidt CJ, Nambudripad R, Smith TF. The ancient regulatory-protein family of WD-repeat proteins. Nature 1994; 371:297-300.
6. Blatch GL, Lassle M. The tetratricopeptide repeat: a structural motif mediating protein-protein interactions. Bioessays 1999; 21:932-9.
7. Krogan NJ, Kim M, Ahn SH, Zhong G, Kobor MS, Cagney G, et al. RNA polymerase II elongation factors of Saccharomyces cerevisiae: a targeted proteomics approach. Mol Cell Biol 2002; 22: 6979-92.
8. Hawkes NA, Otero G, Winkler GS, Marshall N, Dahmus ME, Krappmann D, et al. Purification and characterization of the human elongator complex. J Biol Chem 2002; 277:3047-52.
9. Winkler GS, Kristjuhan A, Erdjument-Bromage H, Tempst P, Svejstrup JQ. Elongator is a histone H3 and H4 acetyltransferase important for normal histone acetylation levels in vivo. Proc Natl Acad Sci USA 2002; 99:3517-22.
10. Rahl PB, Chen CZ, Collins RN. Elp1p, the yeast homolog of the FD disease syndrome protein, negatively regulates exocytosis independently of transcriptional elongation. Mol Cell 2005; 17:841-53.
11. Huang B, Johansson MJ, Bystrom AS. An early step in wobble uridine tRNA modification requires the Elongator complex. RNA 2005; 11:424-36.
12. Close P, Hawkes N, Cornez I, Creppe C, Lambert CA, Rogister B, et al. Transcription impairment and cell migration defects in elongator-depleted cells: implication for familial dysautonomia. Mol Cell 2006; 22: 521-31.
13. Okada Y, Yamagata K, Hong K, Wakayama T, Zhang Y. A role for the elongator complex in zygotic paternal genome demethylation. Nature 463:554-8.
14. Johansen LD, Naumanen T, Knudsen A, Westerlund N, Gromova I, Junttila M, et al. IKAP localizes to membrane ruffles with filamin A and regulates actin cytoskeleton organization and cell migration. J Cell Sci 2008; 121:854-64.
15. Creppe C, Malinouskaya L, Volvert ML, Gillard M, Close P, Malaise O, et al. Elongator controls the migration and differentiation of cortical neurons through acetylation of alpha-tubulin. Cell 2009; 136:551-64.
16. Chen YT, Hims MM, Shetty RS, Mull J, Liu L, Leyne M, et al. Loss of mouse Ikbkap, a subunit of elongator, leads to transcriptional deficits and embryonic lethality that can be rescued by human IKBKAP. Mol Cell Biol 2009; 29:736-44.
17. Thiele CJ. Neuroblastoma. In: Masters J, ed. Human Cell Culture 1998; 1:21-53.
18. Biedler JL, Helson L, Spengler BA. Morphology and growth, tumorigenicity and cytogenetics of human neuroblastoma cells in continuous culture. Cancer Res 1973; 33:2643-52.
19. Biedler JL, Roffler-Tarlov S, Schachner M, Freedman LS. Multiple neurotransmitter synthesis by human neuroblastoma cell lines and clones. Cancer Res 1978; 38:3751-7.
20. Encinas M, Iglesias M, Liu Y, Wang H, Muhaisen A, Cena V, et al. Sequential treatment of SH-SY5Y cells with retinoic acid and brain-derived neurotrophic factor gives rise to fully differentiated, neurotrophic factor-dependent, human neuron-like cells. J Neurochem 2000; 75:991-1003.
21. Jamsa A, Hasslund K, Cowburn RF, Backstrom A, Vasange M. The retinoic acid and brain-derived neurotrophic factor differentiated SH-SY5Y cell line as a model for Alzheimer's disease-like tau phosphorylation. Biochem Biophys Res Commun 2004; 319:993-1000.
22. Carbonetto S, Cochard P. In vitro studies on the control of nerve fiber growth by the extracellular matrix of the nervous system. J Physiol (Paris) 1987; 82:258-70.
23. Carbonetto S, Evans D, Cochard P. Nerve fiber growth in culture on tissue substrata from central and peripheral nervous systems. J Neurosci 1987; 7:610-20.
24. Chen ZL, Strickland S. Laminin gamma1 is critical for Schwann cell differentiation, axon myelination and regeneration in the peripheral nerve. J Cell Biol 2003; 163:889-99.
25. Pietri T, Eder O, Breau MA, Topilko P, Blanche M, Brakebusch C, et al. Conditional beta1-integrin gene deletion in neural crest cells causes severe developmental alterations of the peripheral nervous system. Development 2004; 131:3871-83.
26. Denda S, Reichardt LF. Studies on integrins in the nervous system. Methods Enzymol 2007; 426:203-21.
27. Vaughan L, Weber P, D'Alessandri L, Zisch AH, Winterhalter KH. Tenascin-contactin/F11 interactions: a clue for a developmental role? Perspect Dev Neurobiol 1994; 2:43-52.
28. Zacharias U, Rauch U. Competition and cooperation between tenascin-R, lecticans and contactin 1 regulate neurite growth and morphology. J Cell Sci 2006; 119:3456-66.
29. Brellier F, Tucker RP, Chiquet-Ehrismann R. Tenascins and their implications in diseases and tissue mechanics. Scand J Med Sci Sports 2009; 19:511-9.
30. Mechtersheimer G, Staudter M, Moller P. Expression of the natural killer (NK) cell-associated antigen CD56(Leu-19), which is identical to the 140 kDa isoform of N-CAM, in neural and skeletal muscle cells and tumors derived therefrom. Ann NY Acad Sci 1992; 650:311-6.
31. Salzer JL, Brophy PJ, Peles E. Molecular domains of myelinated axons in the peripheral nervous system. Glia 2008; 56:1532-40.
32. Falk J, Bonnon C, Girault JA, Faivre-Sarrailh C. F3/contactin, a neuronal cell adhesion molecule implicated in axogenesis and myelination. Biol Cell 2002; 94: 327-34.
33. Mirsky R, Jessen KR. The neurobiology of Schwann cells. Brain Pathol 1999; 9:293-311.
34. Webster HD. Myelin injury and repair. Adv Neurol 1993; 59:67-73.
35. Solinger JA, Paolinelli R, Kloss H, Scorza FB, Marchesi S, Sauder U, et al. The Caenorhabditis elegans Elongator complex regulates neuronal alpha-tubulin acetylation. PLoS Genet 6:1000820.
36. Fogelson MH, Rorke LB, Kaye R. Spinal cord changes in familial dysautonomia. Arch Neurol 1967; 17: 103-8.
37. Cheishvili D, Maayan C, Smith Y, Ast G, Razin A. IKAP/hELP1 deficiency in the cerebrum of familial dysautonomia patients results in downregulation of genes involved in oligodendrocyte differentiation and in myelination. Hum Mol Genet 2007; 16:2097-104.
38. Solmesky LJ, Abekasis M, Bulvik S, Weil M. Bone morphogenetic protein signaling is involved in human mesenchymal stem cell survival in serum-free medium. Stem Cells Dev 2009; 18:1283-92.