메뉴 건너뛰기




Volumn 22, Issue 11, 2010, Pages 851-861

Role of the NF-κB transcription factor c-Rel in the generation of CD8+T-cell responses to Toxoplasma gondii

Author keywords

Adaptive immune response; Cytokines; Immunization; Inflammation; Memory; Parasite infection

Indexed keywords

ANTIGEN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; OVALBUMIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR REL;

EID: 78649796996     PISSN: 09538178     EISSN: 14602377     Source Type: Journal    
DOI: 10.1093/intimm/dxq439     Document Type: Article
Times cited : (12)

References (68)
  • 1
    • 0031897632 scopus 로고    scopus 로고
    • NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses
    • Ghosh, S., May, M. J. and Kopp, E. B. 1998. NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses. Annu. Rev. Immunol. 16:225.
    • (1998) Annu. Rev. Immunol. , vol.16 , pp. 225
    • Ghosh, S.1    May, M.J.2    Kopp, E.B.3
  • 2
    • 0028174061 scopus 로고
    • Function and activation of NFkappa B in the immune system
    • Baeuerle, P. A. and Henkel, T. 1994. Function and activation of NFkappa B in the immune system. Annu. Rev. Immunol. 12:141.
    • (1994) Annu. Rev. Immunol. , vol.12 , pp. 141
    • Baeuerle, P.A.1    Henkel, T.2
  • 3
    • 67650724069 scopus 로고    scopus 로고
    • Regulation and function of NF-kappaB transcription factors in the immune system
    • Vallabhapurapu, S. and Karin, M. 2009. Regulation and function of NF-kappaB transcription factors in the immune system. Annu. Rev. Immunol. 27:693.
    • (2009) Annu. Rev. Immunol. , vol.27 , pp. 693
    • Vallabhapurapu, S.1    Karin, M.2
  • 4
    • 0024359776 scopus 로고
    • Expression of the c-rel and c-myc proto-oncogenes in avian tissues
    • Moore, B. E. and Bose, H. R. Jr. 1989. Expression of the c-rel and c-myc proto-oncogenes in avian tissues. Oncogene 4:845.
    • (1989) Oncogene , vol.4 , pp. 845
    • Moore, B.E.1    Bose H.R., Jr.2
  • 5
    • 0025179104 scopus 로고
    • The murine c-rel protooncogene encodes two mRNAs the expression of which is modulated by lymphoid stimuli
    • Grumont, R. J. and Gerondakis, S. 1990. The murine c-rel protooncogene encodes two mRNAs the expression of which is modulated by lymphoid stimuli. Oncogene Res. 5:245.
    • (1990) Oncogene Res , vol.5 , pp. 245
    • Grumont, R.J.1    Gerondakis, S.2
  • 6
    • 0023137250 scopus 로고
    • Detection of c-rel-related transcripts in mouse hematopoietic tissues, fractionated lymphocyte populations, and cell lines
    • Brownell, E., Mathieson, B., Young, H. A., Keller, J., Ihle, J. N. and Rice, N. R. 1987. Detection of c-rel-related transcripts in mouse hematopoietic tissues, fractionated lymphocyte populations, and cell lines. Mol. Cell. Biol. 7:1304.
    • (1987) Mol. Cell. Biol. , vol.7 , pp. 1304
    • Brownell, E.1    Mathieson, B.2    Young, H.A.3    Keller, J.4    Ihle, J.N.5    Rice, N.R.6
  • 7
    • 0026472154 scopus 로고
    • Role of rel family genes in normal and malignant lymphoid cell growth
    • Gilmore, T. D. 1992. Role of rel family genes in normal and malignant lymphoid cell growth. Cancer Surv. 15:69.
    • (1992) Cancer Surv. , vol.15 , pp. 69
    • Gilmore, T.D.1
  • 8
    • 0025045773 scopus 로고
    • Identification of protein complexes containing the c-rel proto-oncogene product in avian hematopoietic cells
    • Davis, J. N., Bargmann, W. and Bose, H. R. Jr. 1990. Identification of protein complexes containing the c-rel proto-oncogene product in avian hematopoietic cells. Oncogene 5:1109.
    • (1990) Oncogene , vol.5 , pp. 1109
    • Davis, J.N.1    Bargmann, W.2    Bose H.R., Jr.3
  • 9
    • 34249799899 scopus 로고    scopus 로고
    • Genome-wide analysis of gene expression in T cells to identify targets of the NF-kappa B transcription factor c-Rel
    • Bunting, K., Rao, S., Hardy, K. et al. 2007. Genome-wide analysis of gene expression in T cells to identify targets of the NF-kappa B transcription factor c-Rel. J. Immunol. 178:7097.
    • (2007) J. Immunol. , vol.178 , pp. 7097
    • Bunting, K.1    Rao, S.2    Hardy, K.3
  • 10
    • 0029150389 scopus 로고
    • Mice lacking the c-rel proto-oncogene exhibit defects in lymphocyte proliferation, humoral immunity, and interleukin-2 expression
    • Kontgen, F., Grumont, R. J., Strasser, A. et al. 1995. Mice lacking the c-rel proto-oncogene exhibit defects in lymphocyte proliferation, humoral immunity, and interleukin-2 expression. Genes Dev. 9:1965.
    • (1995) Genes Dev. , vol.9 , pp. 1965
    • Kontgen, F.1    Grumont, R.J.2    Strasser, A.3
  • 11
    • 0036738421 scopus 로고    scopus 로고
    • Critical roles of c-Rel in autoimmune inflammation and helper T cell differentiation
    • Hilliard, B. A., Mason, N., Xu, L. et al. 2002. Critical roles of c-Rel in autoimmune inflammation and helper T cell differentiation. J. Clin. Invest. 110:843.
    • (2002) J. Clin. Invest. , vol.110 , pp. 843
    • Hilliard, B.A.1    Mason, N.2    Xu, L.3
  • 12
    • 0142241399 scopus 로고    scopus 로고
    • Transcriptional regulation of type I diabetes by NF-kappa B
    • Lamhamedi-Cherradi, S. E., Zheng, S., Hilliard, B. A. et al. 2003. Transcriptional regulation of type I diabetes by NF-kappa B. J. Immunol. 171:4886.
    • (2003) J. Immunol. , vol.171 , pp. 4886
    • Lamhamedi-Cherradi, S.E.1    Zheng, S.2    Hilliard, B.A.3
  • 13
    • 50949094396 scopus 로고    scopus 로고
    • c-Rel is essential for the development of innate and T cell-induced colitis
    • Wang, Y., Rickman, B. H., Poutahidis, T. et al. 2008. c-Rel is essential for the development of innate and T cell-induced colitis. J. Immunol. 180:8118.
    • (2008) J. Immunol. , vol.180 , pp. 8118
    • Wang, Y.1    Rickman, B.H.2    Poutahidis, T.3
  • 14
    • 0032881384 scopus 로고    scopus 로고
    • Mice lacking the transcription factor subunit Rel can clear an influenza infection and have functional anti-viral cytotoxic T cells but do not develop an optimal antibody response
    • Harling-McNabb, L., Deliyannis, G., Jackson, D. C., Gerondakis, S., Grigoriadis, G. and Brown, L. E. 1999. Mice lacking the transcription factor subunit Rel can clear an influenza infection and have functional anti-viral cytotoxic T cells but do not develop an optimal antibody response. Int. Immunol. 11:1431.
    • (1999) Int. Immunol. , vol.11 , pp. 1431
    • Harling-McNabb, L.1    Deliyannis, G.2    Jackson, D.C.3    Gerondakis, S.4    Grigoriadis, G.5    Brown, L.E.6
  • 15
    • 0036533516 scopus 로고    scopus 로고
    • The cross-priming APC requires a Rel-dependent signal to induce CTL
    • Mintern, J. D., Belz, G., Gerondakis, S., Carbone, F. R. and Heath, W. R. 2002. The cross-priming APC requires a Rel-dependent signal to induce CTL. J. Immunol. 168:3283.
    • (2002) J. Immunol. , vol.168 , pp. 3283
    • Mintern, J.D.1    Belz, G.2    Gerondakis, S.3    Carbone, F.R.4    Heath, W.R.5
  • 16
    • 0037108366 scopus 로고    scopus 로고
    • Differential requirement for NF-kappa B family members in control of helminth infection and intestinal inflammation
    • Artis, D., Shapira, S., Mason, N. et al. 2002. Differential requirement for NF-kappa B family members in control of helminth infection and intestinal inflammation. J. Immunol. 169:4481.
    • (2002) J. Immunol. , vol.169 , pp. 4481
    • Artis, D.1    Shapira, S.2    Mason, N.3
  • 17
    • 0037087436 scopus 로고    scopus 로고
    • Cutting edge: identification of c-Rel-dependent and-independent pathways of IL-12 production during infectious and inflammatory stimuli
    • Mason, N., Aliberti, J., Caamano, J. C., Liou, H. C. and Hunter, C. A. 2002. Cutting edge: identification of c-Rel-dependent and-independent pathways of IL-12 production during infectious and inflammatory stimuli. J. Immunol. 168:2590.
    • (2002) J. Immunol. , vol.168 , pp. 2590
    • Mason, N.1    Aliberti, J.2    Caamano, J.C.3    Liou, H.C.4    Hunter, C.A.5
  • 18
    • 0037443540 scopus 로고    scopus 로고
    • Inhibition of NF-kappa B activity in T and NK cells results in defective effector cell expansion and production of IFN-gamma required for resistance to Toxoplasma gondii
    • Tato, C. M., Villarino, A., Caamano, J. H., Boothby, M. and Hunter, C. A. 2003. Inhibition of NF-kappa B activity in T and NK cells results in defective effector cell expansion and production of IFN-gamma required for resistance to Toxoplasma gondii. J. Immunol. 170:3139.
    • (2003) J. Immunol. , vol.170 , pp. 3139
    • Tato, C.M.1    Villarino, A.2    Caamano, J.H.3    Boothby, M.4    Hunter, C.A.5
  • 19
    • 1542619262 scopus 로고    scopus 로고
    • T cell-intrinsic expression of c-Rel regulates Th1 cell responses essential for resistance to Toxoplasma gondii
    • Mason, N. J., Liou, H. C. and Hunter, C. A. 2004. T cell-intrinsic expression of c-Rel regulates Th1 cell responses essential for resistance to Toxoplasma gondii. J. Immunol. 172:3704.
    • (2004) J. Immunol. , vol.172 , pp. 3704
    • Mason, N.J.1    Liou, H.C.2    Hunter, C.A.3
  • 20
    • 0032864097 scopus 로고    scopus 로고
    • The NF-kappa B family member RelB is required for innate and adaptive immunity to Toxoplasma gondii
    • Caamano, J., Alexander, J., Craig, L., Bravo, R. and Hunter, C. A. 1999. The NF-kappa B family member RelB is required for innate and adaptive immunity to Toxoplasma gondii. J. Immunol. 163:4453.
    • (1999) J. Immunol. , vol.163 , pp. 4453
    • Caamano, J.1    Alexander, J.2    Craig, L.3    Bravo, R.4    Hunter, C.A.5
  • 21
    • 0034669923 scopus 로고    scopus 로고
    • Identification of a role for NF-kappa B2 in the regulation of apoptosis and in maintenance of T cell-mediated immunity to Toxoplasma gondii
    • Caamano, J., Tato, C., Cai, G. et al. 2000. Identification of a role for NF-kappa B2 in the regulation of apoptosis and in maintenance of T cell-mediated immunity to Toxoplasma gondii. J. Immunol. 165:5720.
    • (2000) J. Immunol. , vol.165 , pp. 5720
    • Caamano, J.1    Tato, C.2    Cai, G.3
  • 22
    • 0023895411 scopus 로고
    • Interferon-gamma: the major mediator of resistance against Toxoplasma gondii
    • Suzuki, Y., Orellana, M. A., Schreiber, R. D. and Remington, J. S. 1988. Interferon-gamma: the major mediator of resistance against Toxoplasma gondii. Science 240:516.
    • (1988) Science , vol.240 , pp. 516
    • Suzuki, Y.1    Orellana, M.A.2    Schreiber, R.D.3    Remington, J.S.4
  • 23
    • 0027264849 scopus 로고
    • Interleukin 12 is required for the T-lymphocyte-independent induction of interferon gamma by an intracellular parasite and induces resistance in T-cell-deficient hosts
    • Gazzinelli, R. T., Hieny, S., Wynn, T. A., Wolf, S. and Sher, A. 1993. Interleukin 12 is required for the T-lymphocyte-independent induction of interferon gamma by an intracellular parasite and induces resistance in T-cell-deficient hosts. Proc. Natl Acad. Sci. USA 90:6115.
    • (1993) Proc. Natl Acad. Sci. USA , vol.90 , pp. 6115
    • Gazzinelli, R.T.1    Hieny, S.2    Wynn, T.A.3    Wolf, S.4    Sher, A.5
  • 24
    • 0026021838 scopus 로고
    • Synergistic role of CD4+ and CD8+ T lymphocytes in IFNgamma production and protective immunity induced by an attenuated Toxoplasma gondii vaccine
    • Gazzinelli, R. T., Hakim, F. T., Hieny, S., Shearer, G. M. and Sher, A. 1991. Synergistic role of CD4+ and CD8+ T lymphocytes in IFNgamma production and protective immunity induced by an attenuated Toxoplasma gondii vaccine. J. Immunol. 146:286.
    • (1991) J. Immunol. , vol.146 , pp. 286
    • Gazzinelli, R.T.1    Hakim, F.T.2    Hieny, S.3    Shearer, G.M.4    Sher, A.5
  • 25
    • 4844230473 scopus 로고    scopus 로고
    • New lessons from old pathogens: what parasitic infections have taught us about the role of nuclear factor-kappaB in the regulation of immunity
    • Mason, N. J., Artis, D. and Hunter, C. A. 2004. New lessons from old pathogens: what parasitic infections have taught us about the role of nuclear factor-kappaB in the regulation of immunity. Immunol. Rev. 201:48.
    • (2004) Immunol. Rev. , vol.201 , pp. 48
    • Mason, N.J.1    Artis, D.2    Hunter, C.A.3
  • 26
    • 69049085640 scopus 로고    scopus 로고
    • Kinetics and phenotype of vaccine-induced CD8+ T cell responses to Toxoplasma gondii
    • Jordan, K. A., Wilson, E. H., Tait, E. D. et al. 2009. Kinetics and phenotype of vaccine-induced CD8+ T cell responses to Toxoplasma gondii. Infect. Immun. 77:3894.
    • (2009) Infect. Immun. , vol.77 , pp. 3894
    • Jordan, K.A.1    Wilson, E.H.2    Tait, E.D.3
  • 27
    • 35748974538 scopus 로고    scopus 로고
    • Presentation of Toxoplasma gondii antigens via the endogenous Mhc class I pathway in non-professional and professional antigen presenting cells
    • Dzierszinski, F., Pepper, M., Stumhofer, J. S. et al. 2007. Presentation of Toxoplasma gondii antigens via the endogenous Mhc class I pathway in non-professional and professional antigen presenting cells. Infect Immun. 75:5200.
    • (2007) Infect Immun , vol.75 , pp. 5200
    • Dzierszinski, F.1    Pepper, M.2    Stumhofer, J.S.3
  • 28
    • 0031771224 scopus 로고    scopus 로고
    • c-Rel is essential for B lymphocyte survival and cell cycle progression
    • Tumang, J. R., Owyang, A., Andjelic, S. et al. 1998. c-Rel is essential for B lymphocyte survival and cell cycle progression. Eur. J. Immunol. 28:4299.
    • (1998) Eur. J. Immunol. , vol.28 , pp. 4299
    • Tumang, J.R.1    Owyang, A.2    Andjelic, S.3
  • 29
    • 33751501463 scopus 로고    scopus 로고
    • Random migration precedes stable target cell interactions of tumor-infiltrating T cells
    • Mrass, P., Takano, H., Ng, L. G. et al. 2006. Random migration precedes stable target cell interactions of tumor-infiltrating T cells. J. Exp. Med. 203:2749.
    • (2006) J. Exp. Med. , vol.203 , pp. 2749
    • Mrass, P.1    Takano, H.2    Ng, L.G.3
  • 32
    • 28744431910 scopus 로고    scopus 로고
    • Loss of CD8 and TCR binding to Class I MHC ligands following T cell activation
    • Kao, C., Daniels, M. A. and Jameson, S. C. 2005. Loss of CD8 and TCR binding to Class I MHC ligands following T cell activation. Int. Immunol. 17:1607.
    • (2005) Int. Immunol. , vol.17 , pp. 1607
    • Kao, C.1    Daniels, M.A.2    Jameson, S.C.3
  • 33
    • 22544440843 scopus 로고    scopus 로고
    • Transient loss of MHC class I tetramer binding after CD8+ T cell activation reflects altered T cell effector function
    • Drake, D. R. 3rd, Ream, R. M., Lawrence, C. W. and Braciale, T. J. 2005. Transient loss of MHC class I tetramer binding after CD8+ T cell activation reflects altered T cell effector function. J. Immunol. 175:1507.
    • (2005) J. Immunol. , vol.175 , pp. 1507
    • Drake D.R. 3rd1    Ream, R.M.2    Lawrence, C.W.3    Braciale, T.J.4
  • 34
    • 0035666616 scopus 로고    scopus 로고
    • Expression of inhibitory "killer cell lectin-like receptor G1" identifies unique subpopulations of effector and memory CD8 T cells
    • Beyersdorf, N. B., Ding, X., Karp, K. and Hanke, T. 2001. Expression of inhibitory "killer cell lectin-like receptor G1" identifies unique subpopulations of effector and memory CD8 T cells. Eur. J. Immunol. 31:3443.
    • (2001) Eur. J. Immunol. , vol.31 , pp. 3443
    • Beyersdorf, N.B.1    Ding, X.2    Karp, K.3    Hanke, T.4
  • 35
    • 0037944109 scopus 로고    scopus 로고
    • Differential regulation of killer cell lectin-like receptor G1 expression on T cells
    • Robbins, S. H., Terrizzi, S. C., Sydora, B. C., Mikayama, T. and Brossay, L. 2003. Differential regulation of killer cell lectin-like receptor G1 expression on T cells. J. Immunol. 170:5876.
    • (2003) J. Immunol. , vol.170 , pp. 5876
    • Robbins, S.H.1    Terrizzi, S.C.2    Sydora, B.C.3    Mikayama, T.4    Brossay, L.5
  • 36
    • 34548027000 scopus 로고    scopus 로고
    • Inflammation directs memory precursor and short-lived effector CD8(+) T cell fates via the graded expression of T-bet transcription factor
    • Joshi, N. S., Cui, W., Chandele, A. et al. 2007. Inflammation directs memory precursor and short-lived effector CD8(+) T cell fates via the graded expression of T-bet transcription factor. Immunity 27:281.
    • (2007) Immunity , vol.27 , pp. 281
    • Joshi, N.S.1    Cui, W.2    Chandele, A.3
  • 37
    • 0347382593 scopus 로고    scopus 로고
    • Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells
    • Kaech, S. M., Tan, J. T., Wherry, E. J., Konieczny, B. T., Surh, C. D. and Ahmed, R. 2003. Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells. Nat. Immunol. 4:1191.
    • (2003) Nat. Immunol. , vol.4 , pp. 1191
    • Kaech, S.M.1    Tan, J.T.2    Wherry, E.J.3    Konieczny, B.T.4    Surh, C.D.5    Ahmed, R.6
  • 38
    • 44449145582 scopus 로고    scopus 로고
    • IL-12 signaling drives CD8+ T cell IFN-gamma production and differentiation of KLRG1+ effector subpopulations during Toxoplasma gondii infection
    • Wilson, D. C., Matthews, S. and Yap, G. S. 2008. IL-12 signaling drives CD8+ T cell IFN-gamma production and differentiation of KLRG1+ effector subpopulations during Toxoplasma gondii infection. J. Immunol. 180:5935.
    • (2008) J. Immunol. , vol.180 , pp. 5935
    • Wilson, D.C.1    Matthews, S.2    Yap, G.S.3
  • 39
    • 34548027168 scopus 로고    scopus 로고
    • Generation of CD8 T cell memory is regulated by IL-12
    • Pearce, E. L. and Shen, H. 2007. Generation of CD8 T cell memory is regulated by IL-12. J. Immunol. 179:2074.
    • (2007) J. Immunol. , vol.179 , pp. 2074
    • Pearce, E.L.1    Shen, H.2
  • 40
    • 0033621956 scopus 로고    scopus 로고
    • The Rel/NFkappaB family directly activates expression of the apoptosis inhibitor Bcl-x(L)
    • Chen, C., Edelstein, L. C. and Gelinas, C. 2000. The Rel/NFkappaB family directly activates expression of the apoptosis inhibitor Bcl-x(L). Mol. Cell Biol. 20:2687.
    • (2000) Mol. Cell Biol. , vol.20 , pp. 2687
    • Chen, C.1    Edelstein, L.C.2    Gelinas, C.3
  • 41
    • 50549083200 scopus 로고    scopus 로고
    • CD4+ T cell help improves CD8+ T cell memory by retained CD27 expression
    • Matter, M. S., Claus, C. and Ochsenbein, A. F. 2008. CD4+ T cell help improves CD8+ T cell memory by retained CD27 expression. Eur. J. Immunol. 38:1847.
    • (2008) Eur. J. Immunol. , vol.38 , pp. 1847
    • Matter, M.S.1    Claus, C.2    Ochsenbein, A.F.3
  • 42
    • 0036550559 scopus 로고    scopus 로고
    • Effector and memory T-cell differentiation: implications for vaccine development
    • Kaech, S. M., Wherry, E. J. and Ahmed, R. 2002. Effector and memory T-cell differentiation: implications for vaccine development. Nat. Rev. Immunol. 2:251.
    • (2002) Nat. Rev. Immunol. , vol.2 , pp. 251
    • Kaech, S.M.1    Wherry, E.J.2    Ahmed, R.3
  • 43
    • 0033023431 scopus 로고    scopus 로고
    • c-Rel is crucial for lymphocyte proliferation but dispensable for T cell effector function
    • Liou, H. C., Jin, Z., Tumang, J., Andjelic, S., Smith, K. A. and Liou, M. L. 1999. c-Rel is crucial for lymphocyte proliferation but dispensable for T cell effector function. Int. Immunol. 11:361.
    • (1999) Int. Immunol. , vol.11 , pp. 361
    • Liou, H.C.1    Jin, Z.2    Tumang, J.3    Andjelic, S.4    Smith, K.A.5    Liou, M.L.6
  • 44
    • 33847345465 scopus 로고    scopus 로고
    • CD4+ and CD8+ T cell survival is regulated differentially by protein kinase Ctheta, c-Rel, and protein kinase B
    • Saibil, S. D., Jones, R. G., Deenick, E. K. et al. 2007. CD4+ and CD8+ T cell survival is regulated differentially by protein kinase Ctheta, c-Rel, and protein kinase B. J. Immunol. 178:2932.
    • (2007) J. Immunol. , vol.178 , pp. 2932
    • Saibil, S.D.1    Jones, R.G.2    Deenick, E.K.3
  • 46
    • 0037783958 scopus 로고    scopus 로고
    • Selective loss of c-Rel compromises dendritic cell activation of T lymphocytes
    • Boffa, D. J., Feng, B., Sharma, V. et al. 2003. Selective loss of c-Rel compromises dendritic cell activation of T lymphocytes. Cell. Immunol. 222:105.
    • (2003) Cell. Immunol. , vol.222 , pp. 105
    • Boffa, D.J.1    Feng, B.2    Sharma, V.3
  • 47
    • 34249818475 scopus 로고    scopus 로고
    • Distinct roles of different NF-kappa B subunits in regulating inflammatory and T cell stimulatory gene expression in dendritic cells
    • Wang, J., Wang, X., Hussain, S. et al. 2007. Distinct roles of different NF-kappa B subunits in regulating inflammatory and T cell stimulatory gene expression in dendritic cells. J. Immunol. 178:6777.
    • (2007) J. Immunol. , vol.178 , pp. 6777
    • Wang, J.1    Wang, X.2    Hussain, S.3
  • 48
    • 33645212840 scopus 로고    scopus 로고
    • Opposing roles of NF-kappaB family members in the regulation of NK cell proliferation and production of IFN-gamma
    • Tato, C. M., Mason, N., Artis, D. et al. 2006. Opposing roles of NF-kappaB family members in the regulation of NK cell proliferation and production of IFN-gamma. Int. Immunol. 18:505.
    • (2006) Int. Immunol. , vol.18 , pp. 505
    • Tato, C.M.1    Mason, N.2    Artis, D.3
  • 49
    • 73949090725 scopus 로고    scopus 로고
    • c-Rel is required for the development of thymic Foxp3+ CD4 regulatory T cells
    • Isomura, I., Palmer, S., Grumont, R. J. et al. 2009. c-Rel is required for the development of thymic Foxp3+ CD4 regulatory T cells. J. Exp. Med. 206:3001.
    • (2009) J. Exp. Med. , vol.206 , pp. 3001
    • Isomura, I.1    Palmer, S.2    Grumont, R.J.3
  • 50
    • 0033917674 scopus 로고    scopus 로고
    • Distinct roles for the NF-kappaB1 (p50) and c-Rel transcription factors in inflammatory arthritis
    • Campbell, I. K., Gerondakis, S., O'Donnell, K. and Wicks, I. P. 2000. Distinct roles for the NF-kappaB1 (p50) and c-Rel transcription factors in inflammatory arthritis. J. Clin. Invest. 105:1799.
    • (2000) J. Clin. Invest. , vol.105 , pp. 1799
    • Campbell, I.K.1    Gerondakis, S.2    O'Donnell, K.3    Wicks, I.P.4
  • 51
    • 0034161721 scopus 로고    scopus 로고
    • Decreased resistance of B cell-deficient mice to infection with Toxoplasma gondii despite unimpaired expression of IFN-gamma, TNF-alpha, and inducible nitric oxide synthase
    • Kang, H., Remington, J. S. and Suzuki, Y. 2000. Decreased resistance of B cell-deficient mice to infection with Toxoplasma gondii despite unimpaired expression of IFN-gamma, TNF-alpha, and inducible nitric oxide synthase. J. Immunol. 164:2629.
    • (2000) J. Immunol. , vol.164 , pp. 2629
    • Kang, H.1    Remington, J.S.2    Suzuki, Y.3
  • 52
    • 0033955713 scopus 로고    scopus 로고
    • B cells are essential for vaccination-induced resistance to virulent Toxoplasma gondii
    • Sayles, P. C., Gibson, G. W. and Johnson, L. L. 2000. B cells are essential for vaccination-induced resistance to virulent Toxoplasma gondii. Infect Immun. 68:1026.
    • (2000) Infect Immun , vol.68 , pp. 1026
    • Sayles, P.C.1    Gibson, G.W.2    Johnson, L.L.3
  • 53
    • 45449113618 scopus 로고    scopus 로고
    • B cells amplify IFN-gamma production by T cells via a TNF-alpha-mediated mechanism
    • Menard, L. C., Minns, L. A., Darche, S. et al. 2007. B cells amplify IFN-gamma production by T cells via a TNF-alpha-mediated mechanism. J. Immunol. 179:4857.
    • (2007) J. Immunol. , vol.179 , pp. 4857
    • Menard, L.C.1    Minns, L.A.2    Darche, S.3
  • 54
    • 61449225548 scopus 로고    scopus 로고
    • Requirement of B cells for generating CD4+ T cell memory
    • Whitmire, J. K., Asano, M. S., Kaech, S. M. et al. 2009. Requirement of B cells for generating CD4+ T cell memory. J. Immunol. 182:1868.
    • (2009) J. Immunol. , vol.182 , pp. 1868
    • Whitmire, J.K.1    Asano, M.S.2    Kaech, S.M.3
  • 55
    • 77952291364 scopus 로고    scopus 로고
    • NF-kappaB1 contributes to T cell-mediated control of Toxoplasma gondii in the CNS
    • Harris, T. H., Wilson, E. H. and Tait, E. D. 2010. NF-kappaB1 contributes to T cell-mediated control of Toxoplasma gondii in the CNS. J. Neuroimmunol. 222:19.
    • (2010) J. Neuroimmunol. , vol.222 , pp. 19
    • Harris, T.H.1    Wilson, E.H.2    Tait, E.D.3
  • 56
    • 0035886848 scopus 로고    scopus 로고
    • c-Rel regulates interleukin 12 p70 expression in CD8(+) dendritic cells by specifically inducing p35 gene transcription
    • Grumont, R., Hochrein, H., O'Keeffe, M. et al. 2001. c-Rel regulates interleukin 12 p70 expression in CD8(+) dendritic cells by specifically inducing p35 gene transcription. J. Exp. Med. 194:1021.
    • (2001) J. Exp. Med. , vol.194 , pp. 1021
    • Grumont, R.1    Hochrein, H.2    O'Keeffe, M.3
  • 57
    • 27744607686 scopus 로고    scopus 로고
    • Distinct roles for the NF-kappaB1 and c-Rel transcription factors in the differentiation and survival of plasmacytoid and conventional dendritic cells activated by TLR-9 signals
    • O'Keeffe, M., Grumont, R. J., Hochrein, H. et al. 2005. Distinct roles for the NF-kappaB1 and c-Rel transcription factors in the differentiation and survival of plasmacytoid and conventional dendritic cells activated by TLR-9 signals. Blood 106:3457.
    • (2005) Blood , vol.106 , pp. 3457
    • O'Keeffe, M.1    Grumont, R.J.2    Hochrein, H.3
  • 58
    • 44449151187 scopus 로고    scopus 로고
    • Plasmacytoid dendritic cells are activated by Toxoplasma gondii to present antigen and produce cytokines
    • Pepper, M., Dzierszinski, F., Wilson, E. et al. 2008. Plasmacytoid dendritic cells are activated by Toxoplasma gondii to present antigen and produce cytokines. J. Immunol. 180:6229.
    • (2008) J. Immunol. , vol.180 , pp. 6229
    • Pepper, M.1    Dzierszinski, F.2    Wilson, E.3
  • 59
    • 64849085607 scopus 로고    scopus 로고
    • Programming for CD8 T cell memory development requires IL-12 or type I IFN
    • Xiao, Z., Casey, K. A., Jameson, S. C., Curtsinger, J. M. and Mescher, M. F. 2009. Programming for CD8 T cell memory development requires IL-12 or type I IFN. J. Immunol. 182:2786.
    • (2009) J. Immunol. , vol.182 , pp. 2786
    • Xiao, Z.1    Casey, K.A.2    Jameson, S.C.3    Curtsinger, J.M.4    Mescher, M.F.5
  • 60
    • 0037114146 scopus 로고    scopus 로고
    • The roles of IL-12 in providing a third signal for clonal expansion of naive CD8 T cells
    • Valenzuela, J., Schmidt, C. and Mescher, M. 2002. The roles of IL-12 in providing a third signal for clonal expansion of naive CD8 T cells. J. Immunol. 169:6842.
    • (2002) J. Immunol. , vol.169 , pp. 6842
    • Valenzuela, J.1    Schmidt, C.2    Mescher, M.3
  • 61
    • 18344362061 scopus 로고    scopus 로고
    • Type I IFNs provide a third signal to CD8 T cells to stimulate clonal expansion and differentiation
    • Curtsinger, J. M., Valenzuela, J. O., Agarwal, P., Lins, D. and Mescher, M. F. 2005. Type I IFNs provide a third signal to CD8 T cells to stimulate clonal expansion and differentiation. J. Immunol. 174:4465.
    • (2005) J. Immunol. , vol.174 , pp. 4465
    • Curtsinger, J.M.1    Valenzuela, J.O.2    Agarwal, P.3    Lins, D.4    Mescher, M.F.5
  • 62
    • 33751584436 scopus 로고    scopus 로고
    • Cutting Edge: IL-12 inversely regulates T-bet and eomesodermin expression during pathogen-induced CD8+ T cell differentiation
    • Takemoto, N., Intlekofer, A. M., Northrup, J. T., Wherry, E. J. and Reiner, S. L. 2006. Cutting Edge: IL-12 inversely regulates T-bet and eomesodermin expression during pathogen-induced CD8+ T cell differentiation. J. Immunol. 177:7515.
    • (2006) J. Immunol. , vol.177 , pp. 7515
    • Takemoto, N.1    Intlekofer, A.M.2    Northrup, J.T.3    Wherry, E.J.4    Reiner, S.L.5
  • 63
    • 69249133830 scopus 로고    scopus 로고
    • Effector T-cell differentiation during viral and bacterial infections: role of direct IL-12 signals for cell fate decision of CD8(+) T cells
    • Keppler, S. J., Theil, K., Vucikuja, S. and Aichele, P. 2009. Effector T-cell differentiation during viral and bacterial infections: role of direct IL-12 signals for cell fate decision of CD8(+) T cells. Eur. J. Immunol. 39:1774.
    • (2009) Eur. J. Immunol. , vol.39 , pp. 1774
    • Keppler, S.J.1    Theil, K.2    Vucikuja, S.3    Aichele, P.4
  • 64
    • 2442684151 scopus 로고    scopus 로고
    • Memory CD8 T-cell differentiation during viral infection
    • Wherry, E. J. and Ahmed, R. 2004. Memory CD8 T-cell differentiation during viral infection. J. Virol. 78:5535.
    • (2004) J. Virol. , vol.78 , pp. 5535
    • Wherry, E.J.1    Ahmed, R.2
  • 65
    • 43249116465 scopus 로고    scopus 로고
    • Druginduced cure drives conversion to a stable and protective CD8+ T central memory response in chronic Chagas disease
    • Bustamante, J. M., Bixby, L. M. and Tarleton, R. L. 2008. Druginduced cure drives conversion to a stable and protective CD8+ T central memory response in chronic Chagas disease. Nat. Med. 14:542.
    • (2008) Nat. Med. , vol.14 , pp. 542
    • Bustamante, J.M.1    Bixby, L.M.2    Tarleton, R.L.3
  • 66
    • 53149087102 scopus 로고    scopus 로고
    • Stable CD8+ T cell memory during persistent Trypanosoma cruzi infection
    • Bixby, L. M. and Tarleton, R. L. 2008. Stable CD8+ T cell memory during persistent Trypanosoma cruzi infection. J. Immunol. 181:2644.
    • (2008) J. Immunol. , vol.181 , pp. 2644
    • Bixby, L.M.1    Tarleton, R.L.2
  • 67
    • 30044440799 scopus 로고    scopus 로고
    • Effector and memory CD8+ T cell fate coupled by T-bet and eomesodermin
    • Intlekofer, A. M., Takemoto, N., Wherry, E. J. et al. 2005. Effector and memory CD8+ T cell fate coupled by T-bet and eomesodermin. Nat. Immunol. 6:1236.
    • (2005) Nat. Immunol. , vol.6 , pp. 1236
    • Intlekofer, A.M.1    Takemoto, N.2    Wherry, E.J.3
  • 68
    • 64549141966 scopus 로고    scopus 로고
    • RNAi-mediated c-Rel silencing leads to apoptosis of B cell tumor cells and suppresses antigenic immune response in vivo
    • Tian, W. and Liou, H. C. 2009. RNAi-mediated c-Rel silencing leads to apoptosis of B cell tumor cells and suppresses antigenic immune response in vivo. PLoS One 4:e5028.
    • (2009) PLoS One , vol.4
    • Tian, W.1    Liou, H.C.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.