Differentiation of mouse embryonic stem cells into endoderm without embryoid body formation

PLoS ONE

Volumn 5, Issue 11, 2010, Pages

  Kim, Peter T W ^a   Hoffman, Brad G ^a   Plesner, Annette ^a   Helgason, Cheryl D ^a   Bruce Verchere, C ^a   Chung, Stephen W ^a   Warnock, Garth L ^a   Mui, Alice L F ^a   Ong, Christopher J ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLASE; BASIC FIBROBLAST GROWTH FACTOR; BUCLADESINE; C PEPTIDE; CARBOXYPEPTIDASE H; CYTOKERATIN; GLUCAGON; HEPATOCYTE NUCLEAR FACTOR 3BETA; INSULIN; NEUROGENIN 3; OCTAMER TRANSCRIPTION FACTOR 4; RETINOIC ACID; TRANSCRIPTION FACTOR NKX6.1; TRANSCRIPTION FACTOR PAX6; TRANSCRIPTION FACTOR PDX 1; TRANSCRIPTION FACTOR SOX1; TRANSCRIPTION FACTOR SOX17; TRANSCRIPTION FACTOR SOX7; CYCLIC CMP; DIBUTYRYL CYCLIC 3',5' CYTIDINE MONOPHOSPHATE; DIBUTYRYL CYCLIC-3',5'-CYTIDINE MONOPHOSPHATE; DRUG DERIVATIVE; FIBROBLAST GROWTH FACTOR 2; FOXA2 PROTEIN, MOUSE; HIGH MOBILITY GROUP B PROTEIN; POU5F1 PROTEIN, MOUSE; SOX17 PROTEIN, MOUSE; SOX7 PROTEIN, MOUSE; TRANSCRIPTION FACTOR SOX;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; EMBRYO; EMBRYO DEVELOPMENT; EMBRYO PATTERN FORMATION; EMBRYONIC STEM CELL; EMBRYONIC STRUCTURES; ENDODERM; MESODERM; MOUSE; NEUROECTODERM; NONHUMAN; PANCREAS CELL; PLURIPOTENT STEM CELL; PROTEIN EXPRESSION; ANIMAL; C57BL MOUSE; CELL CULTURE; CULTURE TECHNIQUE; CYTOLOGY; DRUG EFFECT; EMBRYOID BODY; FEMALE; GENE EXPRESSION; GENETICS; IMMUNOHISTOCHEMISTRY; MALE; METABOLISM; METHODOLOGY; PANCREAS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TIME;

MURINAE;

ANIMALS; CELL CULTURE TECHNIQUES; CELL DIFFERENTIATION; CELLS, CULTURED; CYCLIC CMP; EMBRYOID BODIES; EMBRYONIC STEM CELLS; ENDODERM; FEMALE; FIBROBLAST GROWTH FACTOR 2; GENE EXPRESSION; HEPATOCYTE NUCLEAR FACTOR 3-BETA; HMGB PROTEINS; IMMUNOHISTOCHEMISTRY; INSULIN; MALE; MICE; MICE, INBRED C57BL; OCTAMER TRANSCRIPTION FACTOR-3; PANCREAS; PLURIPOTENT STEM CELLS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SOXF TRANSCRIPTION FACTORS; TIME FACTORS; TRETINOIN;

EID: 78649783119     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0014146     Document Type: Article

References (43)

1. Wells JM, Melton DA (1999) Vertebrate endoderm development. Annu Rev Cell Dev Biol 15: 393-410.
2. Tam PP, Behringer RR (1997) Mouse gastrulation: the formation of a mammalian body plan. Mech Dev 68: 3-25.
3. Lumelsky NBO, Laeng P, et al. (2001) Differentiation of embryonic stem cells to insulin secreting structures similar to pancreatic islets. Science 292: 1389-1394.
4. Hori Y, Rulifson IC, Tsai BC, Heit JJ, Cahoy JD, et al. (2002) Growth inhibitors promote differentiation of insulin-producing tissue from embryonic stem cells. Proc Natl Acad Sci U S A 99: 16105-16110.
5. Hansson M, Tonning A, Frandsen U, Petri A, Rajagopal J, et al. (2004) Artifactual insulin release from differentiated embryonic stem cells. Diabetes 53: 2603-2609.
6. Rajagopal J, Anderson WJ, Kume S, Martinez OI, Melton DA (2003) Insulin staining of ES cell progeny from insulin uptake. Science 299: 363.
7. D'Amour KA, Bang AG, Eliazer S, Kelly OG, Agulnick AD, et al. (2006) Production of pancreatic hormone-expressing endocrine cells from human embryonic stem cells. Nat Biotechnol 24: 1392-1401.
8. Kroon E, Martinson LA, Kadoya K, Bang AG, Kelly OG, et al. (2008) Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in vivo. Nat Biotechnol.
9. Zhang D, Jiang W, Liu M, Sui X, Yin X, et al. (2009) Highly efficient differentiation of human ES cells and iPS cells into mature pancreatic insulinproducing cells. Cell Res 19: 429-438.
10. Beddington RS, Robertson EJ (1989) An assessment of the developmental potential of embryonic stem cells in the midgestation mouse embryo. Development 105: 733-737.
11. Rossant J (2004) Lineage development and polar asymmetries in the periimplantation mouse blastocyst. Semin Cell Dev Biol 15: 573-581.
12. Tam PP, Kanai-Azuma M, Kanai Y (2003) Early endoderm development in vertebrates: lineage differentiation and morphogenetic function. Curr Opin Genet Dev 13: 393-400.
13. D'Amour KA, Agulnick AD, Eliazer S, Kelly OG, Kroon E, et al. (2005) Efficient differentiation of human embryonic stem cells to definitive endoderm. Nat Biotechnol 23: 1534-1541.
14. Kanai-Azuma M, Kanai Y, Gad JM, Tajima Y, Taya C, et al. (2002) Depletion of definitive gut endoderm in Sox17-null mutant mice. Development 129: 2367-2379.
15. Hart AH, Hartley L, Sourris K, Stadler ES, Li R, et al. (2002) Mixl1 is required for axial mesendoderm morphogenesis and patterning in the murine embryo. Development 129: 3597-3608.
16. Darlington GJ (1999) Molecular mechanisms of liver development and differentiation. Curr Opin Cell Biol 11: 678-682.
17. Ang SL, Wierda A, Wong D, Stevens KA, Cascio S, et al. (1993) The formation and maintenance of the definitive endoderm lineage in the mouse: involvement of HNF3/forkhead proteins. Development 119: 1301-1315.
18. Monaghan AP, Kaestner KH, Grau E, Schutz G (1993) Postimplantation expression patterns indicate a role for the mouse forkhead/HNF-3 alpha, beta and gamma genes in determination of the definitive endoderm, chordamesoderm and neuroectoderm. Development 119: 567-578.
19. Sasaki H, Hogan BL (1993) Differential expression of multiple fork head related genes during gastrulation and axial pattern formation in the mouse embryo. Development 118: 47-59.
20. Hill CS (2001) TGF-beta signalling pathways in early Xenopus development. Curr Opin Genet Dev 11: 533-540.
21. Kumar M, Jordan N, Melton D, Grapin-Botton A (2003) Signals from lateral plate mesoderm instruct endoderm toward a pancreatic fate. Dev Biol 259: 109-122.
22. Strickland S, Mahdavi V (1978) The induction of differentiation in teratocarcinoma stem cells by retinoic acid. Cell 15: 393-403.
23. Blumentrath J, Neye H, Verspohl EJ (2001) Effects of retinoids and thiazolidinediones on proliferation, insulin release, insulin mRNA, GLUT 2 transporter protein and mRNA of INS-1 cells. Cell Biochem Funct 19: 159-169.
24. Stafford D, Prince VE (2002) Retinoic acid signaling is required for a critical early step in zebrafish pancreatic development. Curr Biol 12: 1215-1220.
25. Buehr M, Smith A (2003) Genesis of embryonic stem cells. Philos Trans R Soc Lond B Biol Sci 358: 1397-1402; discussion 1402.
26. Sander M, Neubuser A, Kalamaras J, Ee HC, Martin GR, et al. (1997) Genetic analysis reveals that PAX6 is required for normal transcription of pancreatic hormone genes and islet development. Genes Dev 11: 1662-1673.
27. St-Onge L, Sosa-Pineda B, Chowdhury K, Mansouri A, Gruss P (1997) Pax6 is required for differentiation of glucagon-producing alpha-cells in mouse pancreas. Nature 387: 406-409.
28. Pfaffl MW (2001) A new mathematical model for relative quantification in realtime RT-PCR. Nucleic Acids Res 29: e45.
29. Yan M, Dai T, Deak JC, Kyriakis JM, Zon LI, et al. (1994) Activation of stressactivated protein kinase by MEKK1 phosphorylation of its activator SEK1. Nature 372: 798-800.
30. Futaki S, Hayashi Y, Emoto T, Weber CN, Sekiguchi K (2004) Sox7 plays crucial roles in parietal endoderm differentiation in F9 embryonal carcinoma cells through regulating Gata-4 and Gata-6 expression. Mol Cell Biol 24: 10492-10503.
31. Gudas LJ (1994) Retinoids and vertebrate development. J Biol Chem 269: 15399-15402.
32. Harris TM, Childs G (2002) Global gene expression patterns during differentiation of F9 embryonal carcinoma cells into parietal endoderm. Funct Integr Genomics 2: 105-119.
33. Thompson JR, Gudas LJ (2002) Retinoic acid induces parietal endoderm but not primitive endoderm and visceral endoderm differentiation in F9 teratocarcinoma stem cells with a targeted deletion of the Rex-1 (Zfp-42) gene. Mol Cell Endocrinol 195: 119-133.
34. Deltour L, Leduque P, Blume N, Madsen O, Dubois P, et al. (1993) Differential expression of the two nonallelic proinsulin genes in the developing mouse embryo. Proc Natl Acad Sci U S A 90: 527-531.
35. Devaskar SU, Singh BS, Carnaghi LR, Rajakumar PA, Giddings SJ (1993) Insulin II gene expression in rat central nervous system. Regul Pept 48: 55-63.
36. Molotkov A, Molotkova N, Duester G (2005) Retinoic acid generated by Raldh2 in mesoderm is required for mouse dorsal endodermal pancreas development. Dev Dyn 232: 950-957.
37. Micallef SJ, Janes ME, Knezevic K, Davis RP, Elefanty AG, et al. (2005) Retinoic acid induces Pdx1-positive endoderm in differentiating mouse embryonic stem cells. Diabetes 54: 301-305.
38. Deutsch G, Jung J, Zheng M, Lora J, Zaret KS (2001) A bipotential precursor population for pancreas and liver within the embryonic endoderm. Development 128: 871-881.
39. Kato S, Sekine K (1999) FGF-FGFR signaling in vertebrate organogenesis. Cell Mol Biol (Noisy-le-grand) 45: 631-638.
40. Szebenyi G, Fallon JF (1999) Fibroblast growth factors as multifunctional signaling factors. Int Rev Cytol 185: 45-106.
41. Miralles F, Czernichow P, Ozaki K, Itoh N, Scharfmann R (1999) Signaling through fibroblast growth factor receptor 2b plays a key role in the development of the exocrine pancreas. Proc Natl Acad Sci U S A 96: 6267-6272.
42. Hart AW, Baeza N, Apelqvist A, Edlund H (2000) Attenuation of FGF signaling in mouse beta-cells leads to diabetes. Nature 408: 864-868.
43. Jung J, Zheng M, Goldfarb M, Zaret KS (1999) Initiation of mammalian liver development from endoderm by fibroblast growth factors. Science 284: 1998-2003.