The mechanism of antimalarial action of [Au(CQ)(PPh3)]PF 6: Structural effects and increased drug lipophilicity enhance heme aggregation inhibition at lipid/water interfaces

Journal of Inorganic Biochemistry

Volumn 105, Issue 2, 2011, Pages 276-282

  Navarro, Maribel ^a   Castro, William ^a   Martínez, Alberto ^b   Sánchez Delgado, Roberto A ^b  

^a INSTITUTO VENEZOLANO DE INVESTIGACIONES CIENTÍFICAS   (Venezuela)

^b CITY UNIVERSITY OF NEW YORK   (United States)

Author keywords

Hematin; Chloroquine; DNA; Gold; Malaria; Partition coefficient; Plasmodium falciparum; Resistance

Indexed keywords

ANTIMALARIAL AGENT; CHLOROQUINE; DNA; GOLD CHLOROQUINE (TRIPHENYLPHOSPHINE)HEXAFLUOROPHOSPHATE; GOLD DERIVATIVE; HEMATIN; HEMATIN BETA; HEME; HEMOZOIN; LIPID; OCTANOL; UNCLASSIFIED DRUG; WATER;

ANTIMALARIAL ACTIVITY; ARTICLE; CIRCULAR DICHROISM; CONTROLLED STUDY; DRUG DNA INTERACTION; DRUG MECHANISM; DRUG PROTEIN BINDING; FLUOROMETRY; HEME AGGREGATION INHIBITION; INFRARED SPECTROSCOPY; INTERCALATION COMPLEX; LIPOPHILICITY; MALARIA FALCIPARUM; MELTING POINT; NONHUMAN; PARTITION COEFFICIENT; PH; PLASMODIUM BERGHEI; PLASMODIUM BERGHEI INFECTION; PLASMODIUM FALCIPARUM; PROTEIN FUNCTION; SPECTROPHOTOMETRY; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTIMALARIALS; CHLOROQUINE; DNA; HEMEPROTEINS; HEMIN; HUMANS; INHIBITORY CONCENTRATION 50; INTERCALATING AGENTS; ORGANOGOLD COMPOUNDS; PLASMODIUM FALCIPARUM;

PLASMODIUM FALCIPARUM;

EID: 78649780791     PISSN: 01620134     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jinorgbio.2010.11.005     Document Type: Article

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