The third conformation of p38α MAP kinase observed in phosphorylated p38α and in solution

Structure

Volumn 18, Issue 12, 2010, Pages 1571-1578

  Akella, Radha ^a   Min, Xiaoshan ^a,b   Wu, Qiong ^a   Gardner, Kevin H ^a   Goldsmith, Elizabeth J ^a  

^a UNIVERSITY OF TEXAS AT DALLAS   (United States)

^b AMGEN INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN P 38 ALPHA; UNCLASSIFIED DRUG;

ARTICLE; CARBOXY TERMINAL SEQUENCE; CRYSTALLIZATION; CRYSTALLOGRAPHY; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN PHOSPHORYLATION; PROTEIN STRUCTURE;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; MICE; MITOGEN-ACTIVATED PROTEIN KINASE 14; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; MODELS, BIOLOGICAL; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN INTERACTION DOMAINS AND MOTIFS; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; SOLUTIONS;

EID: 78649775811     PISSN: 09692126     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.str.2010.09.015     Document Type: Article

References (54)

1. M. Avitzour, R. Diskin, B. Raboy, N. Askari, D. Engelberg, and O. Livnah Intrinsically active variants of all human p38 isoforms FEBS J. 274 2007 963 975
2. A.J. Bardwell, L.J. Flatauer, K. Matsukuma, J. Thorner, and L. Bardwell A conserved docking site in MEKs mediates high-affinity binding to MAP kinases and cooperates with a scaffold protein to enhance signal transmission J. Biol. Chem. 276 2001 10374 10386
3. A.J. Bardwell, E. Frankson, and L. Bardwell Selectivity of docking sites in MAPK kinases J. Biol. Chem. 284 2009 13165 13173
4. L. Bardwell, and K. Shah Analysis of mitogen-activated protein kinase activation and interactions with regulators and substrates Methods 40 2006 213 223
5. L. Bardwell, and J. Thorner A conserved motif at the amino termini of MEKs might mediate high-affinity interaction with the cognate MAPKs Trends Biochem. Sci. 21 1996 373 374
6. D. Barsyte-Lovejoy, A. Galanis, and A.D. Sharrocks Specificity determinants in MAPK signaling to transcription factors J. Biol. Chem. 277 2002 9896 9903
7. S. Bellon, M.J. Fitzgibbon, T. Fox, H.M. Hsiao, and K.P. Wilson The structure of phosphorylated p38γ is monomeric and reveals a conserved activation-loop conformation Structure 7 1999 1057 1065
8. A.S. Borders, L. de Almeida, L.J. Van Eldik, and D.M. Watterson The p38α mitogen-activated protein kinase as a central nervous system drug discovery target BMC Neurosci. 9 Suppl 2 2008 S12
9. V. Breukels, and G.W. Vuister Binding of calcium is sensed structurally and dynamically throughout the second calcium-binding domain of the sodium/calcium exchanger Proteins 78 2010 1813 1824
10. B.J. Canagarajah, A. Khokhlatchev, M.H. Cobb, and E.J. Goldsmith Activation mechanism of the MAP kinase ERK2 by dual phosphorylation Cell 90 1997 859 869
11. CCP4 (Collaborative Computational Project, Number 4) The CCP4 suite: programs for protein crystallography Acta Crystallogr. D Biol. Crystallogr. 50 1994 760 763
12. C.I. Chang, B.E. Xu, R. Akella, M.H. Cobb, and E.J. Goldsmith Crystal structures of MAP kinase p38 complexed to the docking sites on its nuclear substrate MEF2A and activator MKK3b Mol. Cell 9 2002 1241 1249
13. W.L. DeLano The PyMOL Molecular Graphics System 2002 Delano Scientific San Carlos, CA
14. Q. Deng, R. Liao, B.L. Wu, and P. Sun High intensity ras signaling induces premature senescence by activating p38 pathway in primary human fibroblasts J. Biol. Chem. 279 2004 1050 1059
15. R.J. Dickinson, and S.M. Keyse Diverse physiological functions for dual-specificity MAP kinase phosphatases J. Cell Sci. 119 2006 4607 4615
16. R. Diskin, M. Lebendiker, D. Engelberg, and O. Livnah Structures of p38alpha active mutants reveal conformational changes in L16 loop that induce autophosphorylation and activation J. Mol. Biol. 365 2007 66 76
17. P. Emsley, and K. Cowtan Coot: model-building tools for molecular graphics Acta Crystallogr. D Biol. Crystallogr. 60 2004 2126 2132
18. H. Enslen, D.M. Brancho, and R.J. Davis Molecular determinants that mediate selective activation of p38 MAP kinase isoforms EMBO J. 19 2000 1301 1311
19. B.T. Farmer 2nd, K.L. Constantine, V. Goldfarb, M.S. Friedrichs, M. Wittekind, J. Yanchunas Jr., J.G. Robertson, and L. Mueller Localizing the NADP+ binding site on the MurB enzyme by NMR Nat. Struct. Biol. 3 1996 995 997
20. R.J. Gum, and P.R. Young Identification of two distinct regions of p38 MAPK required for substrate binding and phosphorylation Biochem. Biophys. Res. Commun. 266 1999 284 289
21. Y.S. Heo, S.K. Kim, C.I. Seo, Y.K. Kim, B.J. Sung, H.S. Lee, J.I. Lee, S.Y. Park, J.H. Kim, and K.Y. Hwang Structural basis for the selective inhibition of JNK1 by the scaffolding protein JIP1 and SP600125 EMBO J. 23 2004 2185 2195
22. J.J. Hopfield Relation between structure, co-operativity and spectra in a model of hemoglobin action J. Mol. Biol. 77 1973 207 222
23. C.Y. Huang, and J.E. Ferrell Jr. Ultrasensitivity in the mitogen-activated protein kinase cascade Proc. Natl. Acad. Sci. USA 93 1996 10078 10083
24. D. Jacobs, D. Glossip, H. Xing, A.J. Muslin, and K. Kornfeld Multiple docking sites on substrate proteins form a modular system that mediates recognition by ERK MAP kinase Genes Dev. 13 1999 163 175
25. B.A. Johnson Using NMRView to visualize and analyze the NMR spectra of macromolecules Methods Mol. Biol. 278 2004 313 352
26. G.L. Johnson, and R. Lapadat Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases Science 298 2002 1911 1912
27. T. Kallunki, T. Deng, M. Hibi, and M. Karin c-Jun can recruit JNK to phosphorylate dimerization partners via specific docking interactions Cell 87 1996 929 939
28. T. Lee, A.N. Hoofnagle, Y. Kabuyama, J. Stroud, X. Min, E.J. Goldsmith, L. Chen, K.A. Resing, and N.G. Ahn Docking motif interactions in MAP kinases revealed by hydrogen exchange mass spectrometry Mol. Cell 14 2004 43 55
29. S. Liu, J.P. Sun, B. Zhou, and Z.Y. Zhang Structural basis of docking interactions between ERK2 and MAP kinase phosphatase 3 Proc. Natl. Acad. Sci. USA 103 2006 5326 5331
30. R.F. Loeser, E.A. Erickson, and D.L. Long Mitogen-activated protein kinases as therapeutic targets in osteoarthritis Curr. Opin. Rheumatol. 20 2008 581 586
31. S.J. Mansour, K.A. Resing, J.M. Candi, A.S. Hermann, J.W. Gloor, K.R. Herskind, M. Wartmann, R.J. Davis, and N.G. Ahn Mitogen-activated protein (MAP) kinase phosphorylation of MAP kinase kinase: determination of phosphorylation sites by mass spectrometry and site-directed mutagenesis J. Biochem. 116 1994 304 314
32. L.R. Masterson, A. Mascioni, N.J. Traaseth, S.S. Taylor, and G. Veglia Allosteric cooperativity in protein kinase A Proc. Natl. Acad. Sci. USA 105 2008 506 511
33. Z. Otwinowski, and W. Minor Processing of X-ray diffraction data collected in oscillation mode Methods Enzymol. 276 1997 307 326
34. A. Remenyi, M.C. Good, R.P. Bhattacharyya, and W.A. Lim The role of docking interactions in mediating signaling input, output, and discrimination in the yeast MAPK network Mol. Cell 20 2005 951 962
35. J.M. Salvador, P.R. Mittelstadt, T. Guszczynski, T.D. Copeland, H. Yamaguchi, E. Appella, A.J. Fornace Jr., and J.D. Ashwell Alternative p38 activation pathway mediated by T cell receptor-proximal tyrosine kinases Nat. Immunol. 6 2005 390 395
36. M. Saxena, and T. Mustelin Extracellular signals and scores of phosphatases: all roads lead to MAP kinase Semin. Immunol. 12 2000 387 396
37. J.F. Schindler, J.B. Monahan, and W.G. Smith p38 pathway kinases as anti-inflammatory drug targets J. Dent. Res. 86 2007 800 811
38. A.D. Sharrocks, S.H. Yang, and A. Galanis Docking domains and substrate-specificity determination for MAP kinases Trends Biochem. Sci. 25 2000 448 453
39. J.A. Smith, C.E. Poteet-Smith, D.A. Lannigan, T.A. Freed, A.J. Zoltoski, and T.W. Sturgill Creation of a stress-activated p90 ribosomal S6 kinase. The carboxyl-terminal tail of the MAPK-activated protein kinases dictates the signal transduction pathway in which they function J. Biol. Chem. 275 2000 31588 31593
40. T.A. Steitz The structural basis of the transition from initiation to elongation phases of transcription, as well as translocation and strand separation, by T7 RNA polymerase Curr. Opin. Struct. Biol. 14 2004 4 9
41. D. Stock, C. Gibbons, I. Arechaga, A.G. Leslie, and J.E. Walker The rotary mechanism of ATP synthase Curr. Opin. Struct. Biol. 10 2000 672 679
42. G.M. Suel, S.W. Lockless, M.A. Wall, and R. Ranganathan Evolutionarily conserved networks of residues mediate allosteric communication in proteins Nat. Struct. Biol. 10 2003 59 69
43. T. Tanoue, M. Adachi, T. Moriguchi, and E. Nishida A conserved docking motif in MAP kinases common to substrates, activators and regulators Nat. Cell Biol. 2 2000 110 116
44. T. Tanoue, R. Maeda, M. Adachi, and E. Nishida Identification of a docking groove on ERK and p38 MAP kinases that regulates the specificity of docking interactions EMBO J. 20 2001 466 479
45. M. Vogtherr, K. Saxena, S. Hoelder, S. Grimme, M. Betz, U. Schieborr, B. Pescatore, M. Robin, L. Delarbre, and T. Langer NMR characterization of kinase p38 dynamics in free and ligand-bound forms Angew. Chem. Int. Ed. Engl. 45 2006 993 997
46. Z. Wang, B.J. Canagarajah, J.C. Boehm, S. Kassisa, M.H. Cobb, P.R. Young, S. Abdel-Meguid, J.L. Adams, and E.J. Goldsmith Structural basis of inhibitor selectivity in MAP kinases Structure 6 1998 1117 1128
47. Z. Wang, P.C. Harkins, R.J. Ulevitch, J. Han, M.H. Cobb, and E.J. Goldsmith The structure of mitogen-activated protein kinase p38 at 2.1-A resolution Proc. Natl. Acad. Sci. USA 94 1997 2327 2332
48. J.L. Wilsbacher, and M.H. Cobb Bacterial expression of activated mitogen-activated protein kinases Methods Enzymol. 332 2001 387 400
49. Y. Xia, Z. Wu, B. Su, B. Murray, and M. Karin JNKK1 organizes a MAP kinase module through specific and sequential interactions with upstream and downstream components mediated by its amino-terminal extension Genes Dev. 12 1998 3369 3381
50. B. Xu, J.L. Wilsbacher, T. Collisson, and M.H. Cobb The N-terminal ERK-binding site of MEK1 is required for efficient feedback phosphorylation by ERK2 in vitro and ERK activation in vivo J. Biol. Chem. 274 1999 34029 34035
51. T. Zarubin, and J. Han Activation and signaling of the p38 MAP kinase pathway Cell Res. 15 2005 11 18
52. H. Zhou, M. Zheng, J. Chen, C. Xie, A.R. Kolatkar, T. Zarubin, Z. Ye, R. Akella, S. Lin, and E.J. Goldsmith Determinants that control the specific interactions between TAB1 and p38α Mol. Cell. Biol. 26 2006 3824 3834
53. T. Zhou, L. Sun, J. Humphreys, and E.J. Goldsmith Docking interactions induce exposure of activation loop in the MAP kinase ERK2 Structure 14 2006 1011 1019
54. A. Zuniga, J. Torres, J. Ubeda, and R. Pulido Interaction of mitogen-activated protein kinases with the kinase interaction motif of the tyrosine phosphatase PTP-SL provides substrate specificity and retains ERK2 in the cytoplasm J. Biol. Chem. 274 1999 21900 21907