Urotensin II receptor antagonist attenuates monocrotaline-induced cardiac hypertrophy in rats

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 299, Issue 6, 2010, Pages

  Gao, Shan ^a   Oh, Young Bin ^a   Shah, Amin ^a   Park, Woo Hyun ^a   Chung, Myoung Ja ^a   Lee, Young Ho ^b   Kim, Suhn Hee ^a  

^a Chonbuk National University Medical School   (South Korea)

^b Yonsei University College of Medicine   (South Korea)

Author keywords

Atrial natriuetic peptide; Hypoxia; Pulmonary hypertension

Indexed keywords

ATRIAL NATRIURETIC FACTOR; G PROTEIN COUPLED RECEPTOR; INOSITOL 1,3,4 TRISPHOSPHATE; MONOCROTALINE; PHOSPHOLIPASE C; PROTEIN KINASE C; URANTIDE; UROTENSIN RECEPTOR ANTAGONIST;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARDIOVASCULAR EFFECT; CONTROLLED STUDY; DRUG BLOOD LEVEL; HEART ATRIUM CONTRACTILITY; HEART PERFUSION; HEART VENTRICLE HYPERTROPHY; HUMAN; HYPOXIA; LUNG ARTERY PRESSURE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PULMONARY ARTERY; RAT; VASOCONSTRICTION;

ANIMALS; ATRIAL FUNCTION; ATRIAL NATRIURETIC FACTOR; CARDIOTONIC AGENTS; CELL HYPOXIA; DISEASE MODELS, ANIMAL; HUMANS; HYPERTROPHY, RIGHT VENTRICULAR; INFUSIONS, INTRAVENOUS; INFUSIONS, SUBCUTANEOUS; MALE; MONOCROTALINE; MYOCARDIAL CONTRACTION; MYOCARDIUM; PEPTIDE FRAGMENTS; PULMONARY ARTERY; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, G-PROTEIN-COUPLED; SIGNAL TRANSDUCTION; TIME FACTORS; UROTENSINS; VASOCONSTRICTION; VENTRICULAR FUNCTION, RIGHT;

EID: 78649744382     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00438.2010     Document Type: Article

References (44)

1. Ames RS, Sarau HM, Chambers JK, Willette RN, Aiyar NV, Romanic AM, Louden CS, Foley JJ, Sauermelch CF, Coatney RW, Ao Z, Disa J, Holmes SD, Stadel JM, Martin JD, Liu WS, Glover GI, Wilson S, McNulty DE, Ellis CE, Elshourbagy NA, Shabon U, Trill JJ, Hay DW, Ohlstein EH, Bergsma DJ, Douglas SA. Human urotensin-II is a potent vasoconstrictor and agonist for the orphan receptor GPR14. Nature 401: 282-286, 1999. (Pubitemid 129515542)
2. Baliga RS, Zhao L, Madhani M, Lopez-Torondel B, Visintin C, Selwood D, Wilkins MR, MacAllister RJ, Hobbs AJ. Synergy between natriuretic peptides and phosphodiesterase 5 inhibitors ameliorates pulmonary arterial hypertension. Am J Respir Crit Care Med 178: 861-869, 2008.
3. Bousette N, Giaid A. Urotensin-II and cardiovascular diseases. Curr Hypertens Rep 8: 479-483, 2006.
4. Bousette N, Hu F, Ohlstein EH, Dhanak D, Douglas SA, Giaid A. Urotensin-II blockade with SB-611812 attenuates cardiac dysfunction in a rat model of coronary artery ligation. J Mol Cell Cardiol 41: 285-295, 2006. (Pubitemid 44080219)
5. Chen YF. Atrial natriuretic peptide in hypoxia. Peptides 26: 1068-1077, 2005.
6. Cho KW, Kim SH, Hwang YH, Seul KH. Extracellular fluid translocation in perfused rabbit atria: implication in control of atrial natriuretic peptide secretion. J Physiol 468: 591-607, 1993.
7. Cho KW, Kim SH, Koh GY, Seul KH, Huh KS, Chu D, Rapp NS, Moon HB, Kim KK, Kook YJ. Plasma concentration of atrial natriuretic peptide in different phases of Korean hemorrhagic fever. Nephron 51: 215-219, 1989. (Pubitemid 19037695)
8. Cho KW, Lee SJ, Wen JF, Kim SH, Seul KH, Lee HS. Mechanical control of extracellular space in rabbit atria: an intimate modulator of the translocation of extracellular fluid and released atrial natriuretic peptide. Exp Physiol 87: 185-194, 2002.
9. Cho KW, Seul KH, Kim SH, Seul KM, Koh GY. Atrial pressure, distension, and pacing frequency in ANP secretion in isolated perfused rabbit atria. Am J Physiol Regul Integr Comp Physiol 260: R39-R46, 1991.
10. Cho KW, Seul KH, Ryu H, Kim SH, Koh GY. Characteristics of distension-induced release of immunoreactive atrial natriuretic peptide in isolated perfused rabbit atria. Regul Pept 22: 333-345, 1988.
11. Christou H, Morita T, Hsieh CM, Koike H, Arkonac B, Perrella MA, Kourembanas S. Prevention of hypoxia-induced pulmonary hypertension by enhancement of endogenous heme oxygenase-1 in the rat. Circ Res 86: 1224-1229, 2000. (Pubitemid 30436662)
12. Conlon JM, Yano K, Waugh D, Hazon N. Distribution and molecular forms of urotensin II and its role in cardiovascular regulation in vertebrates. J Exp Zool 275: 226-238, 1996. (Pubitemid 26311114)
13. Coulouarn Y, Lihrmann I, Jegou S, Anouar Y, Tostivint H, Beauvillain JC, Conlon JM, Bern HA, Vaudry H. Cloning of the cDNA encoding the urotensin II precursor in frog and human reveals intense expression of the urotensin II gene in motoneurons of the spinal cord. Proc Natl Acad Sci USA 95: 15803-15808, 1998. (Pubitemid 29018781)
14. Deuchar GA, Morecroft I, Dempsie Y, Herold N, Nilsen M, Hicks MN, MacLean MR. The in vivo effects of human urotensin II in the rabbit and rat pulmonary circulation: effects of experimental pulmonary hypertension. Eur J Pharmacol 537: 135-142, 2006.
15. Dietz JR. Mechanisms of atrial natriuretic peptide secretion from the atrium. Cardiovasc Res 68: 8-17, 2005. (Pubitemid 41268613)
16. Djordjevic T, BelAiba RS, Bonello S, Pfeilschifter J, Hess J, Görlach A. Human urotensin II is a novel activator of NADPH oxidase in human pulmonary artery smooth muscle cells. Arterioscler Thromb Vasc Biol 25: 519-525, 2005. (Pubitemid 40315672)
17. Douglas SA, Dhanak D, Johns DG. From 'gills to pills': urotensin-II as a regulator of mammalian cardiorenal function. Trends Pharmacol Sci 25: 76-85, 2004. (Pubitemid 38183393)
18. Fan C, Su Q, Li Y, Liang L, Angelini DJ, Guggino WB, Johns RA. Hypoxia-induced mitogenic factor/FIZZ1 induces intracellular calcium release through the PLC-IP3 pathway. Am J Physiol Lung Cell Mol Physiol 297: L263-L270, 2009.
19. Fontes-Sousa AP, Bras-Silva C, Pires AL, Monteiro-Sousa D, Leite- Moreira AF. Urotensin II acutely increases myocardial length and distensibility: potential implications for diastolic function and ventricular remodeling. Naunyn Schmiedebergs Arch Pharmacol 376: 107-115, 2007.
20. Gao S, Shah A, Oh YB, Park WH, Kim SH. Urotensin II stimulates high frequency-induced ANP secretion via PLC-PI 3K-PKC pathway. Peptides 31: 164-169, 2010.
21. Gong H, Wang YX, Zhu YZ, Wang WW, Wang MJ, Yao T, Zhu YC. Cellular distribution of GPR14 and the positive inotropic role of urotensin II in the myocardium in adult rat. J Appl Physiol 97: 2228-2235, 2004. (Pubitemid 39552464)
22. Han JH, Cao C, Kim SZ, Cho KW, Kim SH. Decreases in ANP secretion by lysophosphatidylcholine through protein kinase C. Hypertension 41: 1380-1385, 2003. (Pubitemid 36706093)
23. Jin H, Yang RH, Chen YF, Jackson RM, Oparil S. Atrial natriuretic peptide attenuates the development of pulmonary hypertension in rats adapted to chronic hypoxia. J Clin Invest 85: 115-120, 1990.
24. Johns DG, Ao Z, Naselsky D, Herold CL, Maniscalco K, Sarov-Blat L, Steplewski K, Aiyar N, Douglas SA. Urotensin-II-mediated cardiomyocyte hypertrophy: effect of receptor antagonism and role of inflammatory mediators. Naunyn Schmiedebergs Arch Pharmacol 370: 238-250, 2004.
25. Kay JM, Harris P, Heath D. Pulmonary hypertension produced in rats by ingestion of Crotalaria spectabilis seeds. Thorax 22: 176-179, 1967.
26. Kim SH, Han JH, Lim SH, Lee SJ, Kim SZ, Cho KW. Attenuation of inhibitory effect of CNP on the secretion of ANP from hypertrophied atria. Am J Physiol Regul Integr Comp Physiol 281: R1456-R1463, 2001.
27. Liu Q, Pong SS, Zeng Z, Zhang Q, Howard AD, Williams DL Jr, Davidoff M, Wang R, Austin CP, McDonald TP, Bai C, George SR, Evans JF, Caskey CT. Identification of urotensin II as the endogenous ligand for the orphan G-protein-coupled receptor GPR14. Biochem Biophys Res Commun 266: 174-178, 1999.
28. McGrath MF, de Bold ML, de Bold AJ. The endocrine function of the heart. Trends Endocrinol Metab 16: 469-477, 2005.
29. Nothacker HP, Wang Z, McNeill AM, Saito Y, Merten S, O'Dowd B, Duckles SP, Civelli O. Identification of the natural ligand of an orphan G-protein-coupled receptor involved in the regulation of vasoconstriction. Nat Cell Biol 1: 383-385, 1999.
30. Onan D, Pipolo L, Yang E, Hannan RD, Thomas WG. Urotensin II promotes hypertrophy of cardiac myocytes via mitogen-activated protein kinases. Mol Endocrinol 18: 2344-2354, 2004.
31. Pakala R. Role of urotensin II in atherosclerotic cardiovascular diseases. Cardiovasc Revasc Med 9: 166-178, 2008.
32. Prosser HC, Forster ME, Richards AM, Pemberton CJ. Urotensin II and urotensin II-related peptide (URP) in cardiac ischemia-reperfusion injury. Peptides 29: 770-777, 2008.
33. Ross B, McKendy K, Giaid A. Role of urotensin II in health and disease. Am J Physiol Regul Integr Comp Physiol 298: R1156-R1172, 2010.
34. Russell FD, Molenaar P. Investigation of signaling pathways that mediate the inotropic effect of urotensin-II in human heart. Cardiovasc Res 63: 673-681, 2004.
35. Saetrum Opgaard O, Nothacker H, Ehlert FJ, Krause DN. Human urotensin II mediates vasoconstriction via an increase in inositol phosphates. Eur J Pharmacol 406: 265-271, 2000.
36. Sauzeau V, Le Mellionnec E, Bertoglio J, Scalbert E, Pacaud P, Loirand G. Human urotensin II-induced contraction and arterial smooth muscle cell proliferation are mediated by RhoA and Rho-kinase. Circ Res 88: 1102-1104, 2001.
37. + exchanger. Am J Physiol Heart Circ Physiol 298: H1365-H1374, 2010.
38. Skvorak JP, Sutton ET, Rao PS, Dietz JR. Mechanism of anoxia-induced atrial natriuretic peptide release in the isolated rat atria. Am J Physiol Regul Integr Comp Physiol 271: R237-R243, 1996.
39. Tolle M, van der Giet M. Cardiorenovascular effects of urotensin II and the relevance of the UT receptor. Peptides 29: 743-763, 2008.
40. Watanabe T, Pakala R, Katagiri T, Benedict CR. Synergistic effect of urotensin II with serotonin on vascular smooth muscle cell proliferation. J Hypertens 19: 2191-2196, 2001. (Pubitemid 33135241)
41. Zhang Y, Li J, Cao J, Chen J, Yang J, Zhang Z, Du J, Tang C. Effect of chronic hypoxia on contents of urotensin II and its functional receptors in rat myocardium. Heart Vessels 16: 64-68, 2002.
42. Zhang YG, Li YG, Liu BG, Wei RH, Wang DM, Tan XR, Bu DF, Pang YZ, Tang CS. Urotensin II accelerates cardiac fibrosis and hypertrophy of rats induced by isoproterenol. Acta Pharmacol Sin 28: 36-43, 2007.
43. Zhou P, Wu SY, Yu CF, Wang H, Tang CS, Lin L, Yuan WJ. Effects of urotensin II on isolated rat hearts under normal perfusion and ischemia reperfusion. [In Chinese.] Sheng Li Xue Bao 55: 442-448, 2003.
44. Zhu YC, Zhu YZ, Moore PK. The role of urotensin II in cardiovascular and renal physiology and diseases. Br J Pharmacol 148: 884-901, 2006.