Human herpesvirus-8 infection leads to expansion of the preimmune/natural effector B cell compartment

PLoS ONE

Volumn 5, Issue 11, 2010, Pages

  Della Bella, Silvia ^a   Taddeo, Adriano ^a   Colombo, Elena ^a   Brambilla, Lucia ^b   Bellinvia, Monica ^b   Pregliasco, Fabrizio ^a   Cappelletti, Monica ^a   Calabrò, Maria Luisa ^c   Villa, Maria Luisa ^a  

^a UNIVERSITY OF MILAN   (Italy)

^b FONDAZIONE IRCCS CA GRANDA OSPEDALE MAGGIORE POLICLINICO   (Italy)

^c VENETO INSTITUTE OF ONCOLOGY IOV IRCCS   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; B7 ANTIGEN; CD19 ANTIGEN; CD20 ANTIGEN; CD27 ANTIGEN; CD38 ANTIGEN; CD5 ANTIGEN; CD86 ANTIGEN; HLA DR ANTIGEN; IMMUNOGLOBULIN D; IMMUNOGLOBULIN M; INTERLEUKIN 6; INTERLEUKIN 7; KI 67 ANTIGEN; VIRUS ANTIBODY;

ADULT; AGED; ANTIBODY TITER; ANTIGEN EXPRESSION; APOPTOSIS; ARTICLE; B LYMPHOCYTE; B LYMPHOCYTE ACTIVATION; CELL EXPANSION; CLINICAL ARTICLE; CONTROLLED STUDY; EFFECTOR CELL; FEMALE; FLOW CYTOMETRY; HERPES VIRUS INFECTION; HUMAN; HUMAN CELL; HUMAN HERPESVIRUS 8; HUMAN HERPESVIRUS 8 INFECTION; HYPERGAMMAGLOBULINEMIA; KAPOSI SARCOMA; LYMPHOCYTE PROLIFERATION; MALE; PERIPHERAL LYMPHOCYTE; PHENOTYPE; PROTEIN BLOOD LEVEL; T LYMPHOCYTE; VIRUS LOAD; BLOOD; HOST PATHOGEN INTERACTION; IMMUNOLOGY; IMMUNOPHENOTYPING; METABOLISM; MIDDLE AGED; PHYSIOLOGY; VIROLOGY;

HUMAN HERPESVIRUS 8;

AGED; AGED, 80 AND OVER; APOPTOSIS; B-LYMPHOCYTE SUBSETS; B-LYMPHOCYTES; FEMALE; FLOW CYTOMETRY; HERPESVIRIDAE INFECTIONS; HERPESVIRUS 8, HUMAN; HOST-PATHOGEN INTERACTIONS; HUMANS; IMMUNOPHENOTYPING; MALE; MIDDLE AGED; SARCOMA, KAPOSI; VIRAL LOAD;

EID: 78649736418     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0015029     Document Type: Article

References (57)

1. Antman K, Chang Y (2000) Kaposi's Sarcoma. N Engl J Med 342: 1027-1038.
2. Barozzi P, Potenza L, Riva G, Vallerini D, Quadrelli C, et al. (2007) B cells and Herpesviruses: A model of lymphoproliferation. Autoimmun Rev 7: 132-136.
3. Hengge UR, Ruzicka T, Tyring SK, Stuschke M, Roggendorf M, et al. (2002) Update on Kaposi's sarcoma and other HHV8 associated diseases: part 2, pathogenesis, Castleman's disease, and pleural effusion lymphoma. Lancet Infect Dis 2: 344-352.
4. Ganem D (2010) KSHV and the pathogenesis of Kaposi sarcoma: listening to human biology and medicine. J Clin Invest 120: 939-949.
5. Schulz TF (1998) Kaposi's sarcoma-associated herpesvirus (human herpesvirus- 8). J Gen Virol 79: 1573-1591.
6. Rappocciolo G, Jenkins FJ, Hensler HR, Piazza P, Jais M, et al. (2006) DCSIGN is a receptor for human herpesvirus-8 on dendritic cells and macrophages. J Immunol 176: 1741-1749.
7. Dagna L, Broccolo F, Paties CT, Ferrarini M, Sarmati L, et al. (2005) A relapsing inflammatory syndrome and active human herpesvirus 8 infection. N Engl J Med 353: 156-162.
8. Della Bella S, Taddeo A, Calabrò ML, Brambilla L, Bellinvia M, et al. (2008) Peripheral blood endothelial progenitors as potential reservoirs of Kaposi's Sarcoma Herpesvirus. PLoS ONE 3: e1520.
9. Rappocciolo G, Hensler HR, Jais M, Reinhart TA, Pegu A, et al. (2008) Human herpesvirus 8 infects and replicates in primary cultures of activated B lymphocytes through DC-SIGN. J Virol 82: 4793-4806.
10. Monini P, Colombini S, Stürzl M, Goletti D, Cafaro A, et al. (1999) Reactivation and Persistence of Human Herpesvirus-8 Infection in B Cells and Monocytes by Th-1 Cytokines Increased in Kaposi's Sarcoma. Blood 93: 4044-4058.
11. Gregory SM, West JA, Dillon PJ, Hilscher C, Dittmer DP, et al. (2009) Toll-like receptor signaling controls reactivation of KSHV from latency. Proc Natl Acad Sci USA 106: 11725-11730.
12. Boulanger E, Hermine O, Fermand JP, Radford-Weiss I, Brousse N, et al. (2004) Human herpesvirus 8 (HHV-8)-associated peritoneal primary effusion lymphoma (PEL) in two HIV-negative elderly patients. Am J Hematol 76: 88-91.
13. Calabrò ML, Sheldon J, Favero A, Simpson GR, Fiore JR, et al. (1998) Seroprevalence of Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8 in several regions of Italy. J Hum Virol 1: 207-213.
14. Thomsen AR, Johansen J, Marker O, Christensen JP (1996) Exhaustion of CTL memory and recrudescence of viremia in lymphocytic choriomeningitis virusinfected MHC class IL-deficient mice and B cell-deficient mice. J Immunol 157: 3074-3080.
15. LeBien TW, Tedder TF (2008) B lymphocytes: how they develop and function. Blood 112: 1570-1580.
16. van Zelm MC, Szczepanski T, van der Burg M, van Dongen JJ (2007) Replication history of B lymphocytes reveals homeostatic proliferation and extensive antigen-induced B cell expansion. J Exp Med 204: 645-655.
17. Crowley JE, Treml LS, Stadanlick JE, Carpenter E, Cancro MP (2005) Homeostatic niche specification among naïve and activated B cells: a growing role for the BLyS family of receptors and ligands. Semin Immunol 17: 193-199.
18. Mackay F, Schneider P (2009) Cracking the BAFF code. Nat Rev Immunol 9: 491-502.
19. Cagigi A, Nilsson A, Pensieroso S, Chiodi F (2010) Dysfunctional B-cell responses during HIV-1 infection: implication for influenza vaccination and highly active antiretroviral therapy. Lancet Infect Dis 10: 499-503.
20. Pensieroso S, Cagigi A, Palma P, Nilsson A, Capponi C, et al. (2009) Timing of HAART defines the integrity of memory B cells and the longevity of humoral responses in HIV-1 vertically-infected children. Proc Natl Acad Sci USA 106: 7939-7944.
21. Ni J, Hembrador E, Di Bisceglie AM, Jacobson IM, Talal AH, et al. (2003) Accumulation of B lymphocytes with a naïve, resting phenotype in a subset of hepatitis C patients. J Immunol 170: 3429-3439.
22. Jacobi AM, Reiter K, Mackay M, Aranow C, Hiepe F, et al. (2008) Activated memory B cell subsets correlate with disease activity in systemic lupus erythematosus: delineation by expression of CD27, IgD, and CD95. Arthritis Rheum 58: 1762-1773.
23. Lee J, Kuchen S, Fischer R, Chang S, Lipsky PE (2009) Identification and characterization of a human CD5+ pre-naïve B cell population. J Immunol 182: 4116-4126.
24. Colonna-Romano G, Bulati M, Aquino A, Pellicanò M, Vitello S, et al. (2009) A double-negative (IgD-CD27-) B cell population is increased in the peripheral blood of elderly people. Mech Ageing Dev 130: 681-690.
25. Lanzavecchia A, Sallusto F (2009) Human B cell memory. Curr Opin Immunol 21: 298-304.
26. Weill JC, Weller S, Reynaud CA (2009) Human marginal zone B cells. Annu Rev Immunol 27: 267-285.
27. Weller S, Braun MC, Tan BK, Rosenwald A, Cordier C, et al. (2004) Human blood IgM "memory'' B cells are circulating splenic marginal zone B cells harboring a prediversified immunoglobulin repertoire. Blood 104: 3647-3654.
28. Frasca D, Landin AM, Lechner SC, Ryan JG, Schwartz R, et al. (2008) Aging down-regulates the transcription factor E2A, activatin-induced cytidine deaminase, and Ig class switch in human B cells. J Immunol 180: 5283-5290.
29. Ginaldi L, De Martinis M, D'Ostilio A, Marini L, Loreto F, et al. (2001) Changes in the expression of surface receptors on lymphocyte subsets in the elderly: quantitative flow cytometric analysis. Am J Hematol 67: 63-72.
30. Chong Y, Ikematsu H, Yamaji K, Nishimura M, Nabeshima S, et al. (2005) CD27(+) (memory) B cell decrease and apoptosis-resistant CD27(-) (naive) B cell increase in aged humans: implications for age-related peripheral B cell developmental disturbances. Int Immunol 17: 383-390.
31. Wirths S, Lanzavecchia A (2005) ABCB1 transporter discriminates human resting naive B cells from cycling transitional and memory B cells. Eur J Immunol 35: 3433-3441.
32. Anolik J, Looney RJ, Bottaro A, Sanz I, Young F (2003) Down-regulation of CD20 on B cells upon CD40 activation. Eur J Immunol 33: 2398-2409.
33. Valentine MA, Cotner T, Gaur L, Torres R, Clark EA (1987) Expression of the human B-cell surface protein CD20: alteration by phorbol 12-myristate 13- acetate. Proc Natl Acad Sci USA 84: 8085-8089.
34. Ghia P, Prato G, Scielzo C, Stella S, Geuna M, et al. (2004) Monoclonal CD5+ and CD5- B lymphocyte expansions are frequent in the peripheral blood of the elderly. Blood 103: 2337-2342.
35. Dagklis A, Fazi C, Sala C, Cantarelli V, Scielzo C, et al. (2009) The immunoglobulin gene repertoire of low-count chronic lymphocytic leukemia (CLL)-like monoclonal B lymphocytosis is different from CLL: diagnostic implications for clinical monitoring. Blood 114: 26-32.
36. Pillai S, Cariappa A (2009) The follicular versus marginal zone B lymphocyte cell fate decision. Nat Rev Immunol 9: 767-777.
37. Hirano T, Yasukawa K, Harada H, Taga T, Watanabe Y, et al. (1986) Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin. Nature 324: 73-76.
38. Xu G, Zhang Y, Zhang L, Ren G, Shi Y (2007) The role of IL-6 in inhibition of lymphocyte apoptosis by mesenchymal stem cells. Biochem Biophys Res Commun 361: 745-750.
39. Chandriani S, Ganem D (2010) Array-based transcript profiling and limitingdilution reverse transcription-PCR analysis identify additional latent genes in Kaposi's sarcoma-associated herpesvirus. J Virol 84: 5565-5573.
40. An J, Lichtenstein AK, Brent G, Rettig MB (2002) The Kaposi sarcomaassociated herpesvirus (KSHV) induces cellular interleukin 6 expression: role of the KSHV latency-associated nuclear antigen and the AP1 response element. Blood 99: 649-654.
41. Carroll PA, Brazeau E, Lagunoff M (2004) Kaposi's sarcoma associated herpesvirus infection of blood endothelial cells induces lymphatic differentiation. Virol 328: 7-18.
42. Della Bella S, Nicola S, Brambilla L, Riva A, Ferrucci S, et al. (2006) Quantitative and functional defects of dendritic cells in classic Kaposi's sarcoma. Clin Immunol 119: 317-329.
43. Moir S, Fauci AS (2009) B cells in HIV infection and disease. Nature Rev Immunol 9: 235-245.
44. Rosa D, Saletti G, De Gregorio E, Zorat F, Comar C, et al. (2005) Activation of naïve B lymphocytes via CD81, a pathogenetic mechanism for hepatitis C virusassociated B lymphocyte disorders. Proc Natl Acad Sci USA 102: 18544-18549.
45. Racanelli V, Frassanito MA, Leone P, Galiano M, De Re V, et al. (2006) Antibody production and in vitro behavior of CD27-defined B-cell subsets: persistent hepatitis C virus infection changes the rules. J Virol 80: 3923-3934.
46. Sato S, Fujimoto M, Hasegawa M, Takehara K (2004) Altered blood B lymphocyte homeostasis in systemic sclerosis: expanded naive B cells and diminished but activated memory B cells. Arthritis Rheum 50: 1918-1927.
47. Horikawa K, Takatsu K (2006) Interleukin-5 regulates genes involved in B-cell terminal maturation. Immunology 118: 497-508.
48. Avery DT, Deenick EK, Ma CS, Suryani S, Simpson N, et al. (2010) B cellintrinsic signaling through IL-21 receptor and STAT3 is required for establishing long-lived antibody responses in humans. J Exp Med 207: 155-171.
49. Palestro G, Turrini F, Pagano M, Chiusa L (1999) Castleman's disease. Adv Clin Pathol 3: 11-22.
50. Charles ED, Green RM, Marukian S, Talal AH, Lake-Bakaar GV, et al. (2008) Clonal expansion of immunoglobulin M+CD27+ B cells in HCV-associated mixed cryoglobulinemia. Blood 111: 1344-1356.
51. Chaganti S, Ma CS, Bell AI, Croom-Carter D, Hislop AD, et al. (2008) Epstein- Barr virus persistence in the absence of conventional memory B cells: IgM+IgD+CD27+ B cells harbor the virus in X-linked lymphoproliferative disease patients. Blood 112: 672-679.
52. Chaganti S, Heath EM, Bergler W, Kuo M, Buettner M, et al. (2009) Epstein- Barr virus colonization of tonsillar and peripheral blood B-cell subsets in primary infection and persistence. Blood 113: 6372-6381.
53. Brambilla L, Boneschi V, Taglioni M, Ferrucci S (2003) Staging of classic Kaposi's sarcoma: a useful tool for therapeutic choices. Eur J Dermatol 13: 83-86.
54. Taddeo A, Presicce P, Brambilla L, Bellinvia M, Villa ML, et al. (2008) Circulating endothelial progenitor cells are increased in patients with classic Kaposi's sarcoma. J Invest Dermatol 128: 2125-2128.
55. Della Bella S, Giannelli S, Taddeo A, Presicce P, Villa ML (2008) Application of six-color flow cytometry for the assessment of dendritic cell responses in whole blood assays. J Immunol Methods 339: 153-164.
56. Toubi E, Kessel A, Peri R, Shmuel Z, Bamberger E, et al. (2004) Enhanced apoptosis of peripheral CD5-negative B lymphocytes from chronically hepatitis C virus-infected patients: reversal after antiviral treatment. J Virol 78: 11379-11384.
57. Gasperini P, Barbierato M, Martinelli C, Rigotti P, Marchini F, et al. (2005) Use of a BJAB-derived cell line for isolation of human herpesvirus 8. J Clin Microbiol 43: 2866-2875.