Enhanced apoptosis of peripheral CD5-negative B lymphocytes from chronically hepatitis C virus-infected patients: Reversal after antiviral treatment

Journal of Virology

Volumn 78, Issue 20, 2004, Pages 11379-11384

  Toubi, Elias ^a   Kessel, Aharon ^a   Peri, Regina ^a   Shmuel, Zehava ^a   Bamberger, Ellen ^a   Sabo, Edmond ^a   Zuckerman, Eli ^a  

^a BNAI ZION MEDICAL CENTER   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIVIRUS AGENT; CD5 ANTIGEN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPOCORTIN 5; PEGINTERFERON; RIBAVIRIN;

ADULT; APOPTOSIS; ARTICLE; B LYMPHOCYTE; CLINICAL ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; FEMALE; HEPATITIS C; HEPATITIS C VIRUS; HUMAN; HUMAN CELL; MALE; OPTICAL DENSITY; PATIENT; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSAL REACTION; SENSITIVITY ANALYSIS;

ADULT; ANTIGENS, CD5; ANTIVIRAL AGENTS; APOPTOSIS; AUTOIMMUNITY; B-LYMPHOCYTES; CELLS, CULTURED; FEMALE; FLOW CYTOMETRY; HEPACIVIRUS; HEPATITIS C, CHRONIC; HUMANS; MALE; MIDDLE AGED; NF-KAPPA B;

EID: 4644351628     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.78.20.11379-11384.2004     Document Type: Article

References (40)

1. Agnello, V., R. T. Chung, and L. M. Kaplan. 1992. A role for hepatitis C virus infection in type II cryoglobulinemia. N. Engl. J. Med. 327:1490-1495.
2. Alter, H. J., and L. B. Seeff. 2000. Recovery, persistence, and sequelae in hepatitis C virus infection: a perspective on long term outcome. Semin. Liver Dis. 20:17-35.
3. Beg, A. A., and D. Baltimore. 1996. An essential role for NF-kappaB in preventing TNF-alpha-induced cell death. Science 274:782-784.
4. Cerny, A., and F. V. Chisari. 1999. Pathogenesis of chronic hepatitis C: immunological features of hepatic injury and viral persistence. Hepatology 30:595-601.
5. Crotta, S., A. Stilla, A. Wack, A. D'Andrea, S. Nuti, U. D'Oro, M. Mosca, F. Filliponi, R. M. Brunetto, F. Bonino, S. Abrignani, and N. B. Valiante. 2002. Inhibition of natural killer cells through engagement of CD81 by the major hepatitis C virus envelope protein. J. Exp. Med. 195:35-41.
6. Curry, M. P., L. Golden-Mason, N. Nolan, N. A. Parfrey, J. E. Hegarty, and C. O'Farrelly. 2000. Expansion of peripheral blood CD5+ B cells is associated with mild disease in chronic hepatitis C virus infection. J. Hepatol. 32:121-125.
7. Dauphinee, M., Z. Tovar, and N. Talal. 1988. B cells expressing CD5 are increased in Sjögren's syndrome. Arthrit. Rheum. 31:642-647.
8. Franzin, F., D. G. Efremov, G. Pozzato, P. Tulissi, F. Batista, and O. R. Burrone. 1995. Clonal B cell expansion in peripheral blood of HCV-infected patients. Br. J. Hematol. 90:548-552.
9. Giannini, C., P. Caini, F. Giannelli, F. Fontana, D. Kremsdorf, C. Brechot, and A. L. Zigrego. 2002. Hepatitis C virus core protein expression in human B cell lines does not significantly modify main proliferative and apoptosis pathways. J. Gen. Virol. 83:1665-1671.
10. + B cells. Science 236:81-83.
11. Hassan, J., C. Feighery, B. Bresniham, and A. Whelan. 1990. Increased CD5+ B cells in patients with infectious mononucleosis. Br. J. Haematol. 74:375-376.
12. Hoofnagle, J. H., and T. S. Tralka. 1997. The National Institutes of Health Consensus Development Conference on Management of Hepatitis C Virus. Introduction. Hepatology 26(Suppl. 1):1S-2S.
13. Kitay-Cohen, Y., A. Amiel, N. Hilzenrat, D. Buskila, Y. Ashur, M. Fejgin, F. Gaber, R. Safadi, R. Tur-Kaspa, and M. Lishmer. 2000. Bcl-2 rearrangement in patients with chronic hepatitis C associated with essential mixed cryoglobulinemia type II. Blood 96:2910-2912.
14. Knodell, R. G., K. G. Ishak, W. C. Black, T. S. Chen, R. Craig, N. Kaplowitz, T. W. Kieman, and J. Wollman. 1981. Formulation and application of a numerical scoring system for assessing histological activity in asymptomatic chronic active hepatitis. Hepatology 1:431-435.
15. Lai, M. M. C., and C. F. Ware. 1999. Hepatitis C virus core protein: possible roles in viral pathogenesis. Curr. Top. Microbiol. Immunol. 242:117-134.
16. Levy, S., S. C. Todd, and H. T. Maecker. 1998. CD81, a molecule involved in signal transduction and cell adhesion in the immune system. Annu. Rev. Immunol. 16:89-106.
17. Lowry, O. H., N. J. Rosebrough, A. L. Farr, and R. Randell. 1951. Protein measurement with the folin reagent. J. Biol. Chem. 193:265-275.
18. Mariette, X. 2001. Lymphomas complicating Sjogren's syndrome and hepatitis C virus infection may share a common pathogenesis: chronic stimulation of rheumatoid factor B cells. Clin. Rheum. Dis. 60:1007-1010.
19. Mayumi, M., S. Sumimoto, S. Kanazashi, D. Hata, K. Yamaoka, Y. Higaki, T. Ishigami, K. M. Kim, T. Heike, and K. Katamura. 1996. Negative signaling in B cells by surface immunoglobulins. J. Allergy Clin. Immunol. 98:S238-S247.
20. Misiani, R., P. Bellavita, D. Fenili, G. Borelli, D. Marchesi, M. Massazza, G. Vendramin, B. Comotti, E. Tanzi, and G. Scudeller. 1992. Hepatitis C infection in patients with essential mixed cryoglobulinemia. Ann. Int. Med. 117:573-577.
21. Monteverde, A., M. Ballare, and S. Pileri. 1997. Hepatic lymphoid aggregates in chronic hepatitis C and mixed cryoglobulinemia. Springer Semin. Immunopathol. 19:99-110.
22. Monteverde, A., M. T. Rivano, G. C. Allegra, A. I. Monteverde, P. Zigrossi, P. Baglioni, M. Gobbi, B. Falini, G. Bordin, and S. Pileri. 1988. Essential mixed cryoglobulinemia, type II: a manifestation of a low-grade malignant lymphoma? Acta Hematol. 79:20-25.
23. O'Garra, A., R. Chang, N. Go, R. Hasyings, G. Haughton, and M. Howard. 1992. Ly-1 B (B-1) cells are main source of B cell-derived interleukin 10. Eur. J. Immunol. 22:711-717.
24. Pers, J. O., C. Jamin, F. Prendine-Hug, P. Lydyard, and P. Youinou. 1999. The role of CD5-expressing B cells in health and disease. Int. J. Mol. Med. 3:239-245.
25. Piazolla, G., C. Tortorella, O. Schiraldi, and S. Antonaci. 2000. Relationship between interferon-gamma, IL-10, and IL-12 production in chronic hepatitis C and in vitro effects of interferon-alpha. J. Clin. Immunol. 20:541.
26. Pietrogrande, M., M. Corona, S. Milani, A. Rosti, M. Ramella, and G. Tordato. 1995. Relationship between rheumatoid factor and the immune response against hepatitis C virus in essential mixed cryoglobulinemia. Clin. Exp. Rheumatol. 13(Suppl. 13):S109-S113.
27. Pileri, P., Y. Uematsu, S. Campagnoli, G. Galli, F. Falugi, R. Petracca, A. J. Weiner, M. Houghton, D. Rosa, G. Grandi, and S. Abrignani. 1998. Binding of hepatitis C virus to CD81. Science 282:938-941.
28. Sarih, M., N. Bouchrit, and A. Beslimane. 2000. Different cytokine profiles of peripheral blood mononuclear cells from patients with persistent and self-limited hepatitis C virus infection. Immunol. Lett. 74:117-120.
29. Sasso, E. H. 2000. The rheumatoid factor response in the etiology of mixed cryoglobulinemia associated with hepatitis C virus infection. Ann. Med. Interne (Paris) 15:30-40.
30. Silvestri, F., A. Sperotto, and R. Fanin. 2000. Hepatitis C and lymphoma. Curr. Oncol. Rep. 2:172-175.
31. Sung, V. M., S. Shimodaria, A. L. Doughty, G. R. Picchio, H. Can, T. S. Yen, K. L. Lindsay, A. M. Levine, and M. M. Lai. 2003. Establishment of B-cell lymphoma cell lines persistently infected with hepatitis C virus in vivo and in vitro: the apoptotic effects of virus infection. J. Virol. 77:2134-2146.
32. Toubi, E., A. Kessel, L. Goldstein, G. Slobodin, E. Sabo, Z. Shmuel, and E. Zuckerman. 2001. Enhanced peripheral T-cell apoptosis in chronic hepatitis C virus infection: association with liver disease severity. J. Hepatol. 35:774-780.
33. Towbin, H., T. Staehelin, and J. Gordon. 1979. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc. Natl. Acad. Sci. USA 76:4350-4354.
34. Tseng, C. K., and G. R. Klimpel. 2002. Binding of hepatitis C virus envelope protein E2 to CD8 inhibits NK cell function. J. Exp. Med. 195:43-49.
35. Tsuji, R. F., G. P. Geba, Y. Wang, K. Kawamoto, L. A. Malis, and P. W. Askenase. 1997. Required early complement activation in contact sensitivity with generation of local C5-dependent chemotactic activity and late T cell interferon gamma: a possible initiating role of B cells. J. Exp. Med. 186:1015-1026.
36. Wurster, A. L., D. J. Withers, T. Ucida, M. F. White, and M. J. Grusby. 2002. Stat6 and IRS-2 cooperate in interleukin 4 (IL-4)-induced proliferation and differentiation but are dispensable for IL-4-dependent rescue from apoptosis. Mol. Cell. Biol. 22:117-126.
37. Zignego, A. L., F. Giannelli, M. E. Marrocchi, A. Mazzocca, C. Ferri, C. Giannini, M. Monti, P. Caini, G. L. Villa, G. Laffi, and P. Gentilini. 2000. T(14:18) translocation in chronic hepatitis C virus infection. Hepatology 31:474-479.
38. Zuckerman, E., A. Kessel, G. Slobodin, E. Sabo, D. Yeshurun, and E. Toubi. 2003. Antiviral treatment down-regulates peripheral B-cell CD81 expression and CD5 expansion in chronic hepatitis C virus infection. J. Virol. 77:10432-10436.
39. Zuckerman, E., G. Slobodin, A. Kessel, E. Sabo, D. Yeshurun, K. Halas, and E. Toubi. 2002. Peripheral B-cell CD5 expansion and CD81 overexpression and their association with disease severity and autoimmune markers in chronic hepatitis C virus infection. Clin. Exp. Immunol. 128:353-358.
40. Zuckerman, E., T. Zuckerman, D. Sahar, S. Steichman, D. Attias, E. Sabbo, D. Yeshurun, and J. Rowe. 2001. Bcl-2 and immunoglobulin gene rearrangement in patients with HCV infection. Br. J. Haematol. 112:364-369.