Oligomerization of Cavβ subunits is an essential correlate of Ca2+ channel activity

FASEB Journal

Volumn 24, Issue 12, 2010, Pages 5013-5023

  Lao, Qi Zong ^a   Kobrinsky, Evgeny ^a   Liu, Zhuo ^a   Soldatov, Nikolai M ^a  

^a NATIONAL INSTITUTE ON AGING   (United States)

Author keywords

Calcium channel regulation; Calcium signaling; High order protein complexes; Protein protein interaction

Indexed keywords

CALCIUM CHANNEL; CALCIUM CHANNEL L TYPE; CALCIUM CHANNEL L TYPE 1.2; CALCIUMVBETA SUBUNIT; MEMBRANE ASSOCIATED GUANYLATE CYCLASE KINASE; UNCLASSIFIED DRUG; VOLTAGE GATED CALCIUM CHANNEL; CALCIUM; PROTEIN SUBUNIT;

ARTICLE; CALCIUM CURRENT; CELL MEMBRANE; CELL STRAIN COS7; CHEMICAL STRUCTURE; CONFOCAL LASER MICROSCOPY; CYTOSOL; FLUORESCENCE RESONANCE ENERGY TRANSFER; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IMMUNOPRECIPITATION; MEMBRANE DEPOLARIZATION; MUSCLE CONTRACTION; NUCLEOTIDE SEQUENCE; OLIGOMERIZATION; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN MOTIF; SMOOTH MUSCLE FIBER; VASCULAR SMOOTH MUSCLE; WESTERN BLOTTING; CELL CULTURE; CONFOCAL MICROSCOPY; ELECTROPHYSIOLOGY; GENETICS; METABOLISM; PHYSIOLOGY; PROTEIN MULTIMERIZATION;

BLOTTING, WESTERN; CALCIUM; CALCIUM CHANNELS, L-TYPE; CELLS, CULTURED; ELECTROPHYSIOLOGY; FLUORESCENCE RESONANCE ENERGY TRANSFER; HUMANS; IMMUNOPRECIPITATION; MICROSCOPY, CONFOCAL; PROTEIN MULTIMERIZATION; PROTEIN SUBUNITS;

EID: 78649731860     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.10-165381     Document Type: Article

References (41)

1. v1.2 calcium channels. PLoS ONE 4, e5587
2. Lipscombe, D., Madison, D. V., Poenie, M., Reuter, H., Tsien, R. Y., and Tsien, R. W. (1988) Spatial distribution of calcium channels and cytosolic calcium transients in growth cones and cell bodies of sympathetic neurons. Proc. Natl. Acad. Sci. U. S. A. 85, 2398-2402
3. 2+ channels. Proc. Natl. Acad. Sci. U. S. A. 102, 11112-11117
4. 2+ channels at the base of major dendrites in hippocampal pyramidal neurons. Nature 347, 281-284
5. 2+ channels. Annu. Rev. Cell Dev. Biol. 16, 521-555
6. Dolphin, A. C. (2003) β Subunits of voltage-gated calcium channels. J. Bioenergetics Biomembranes 35, 599-620
7. McGee, A. W., Nunziato, D. A., Maltez, J. M., Prehoda, K. E., Pitt, G. S., and Bredt, D. S. (2004) Calcium channel function regulated by the SH3-GK module in β subunits. Neuron 42, 89-99
8. Opatowsky, Y., Chen, C.-C., Campbell, K. P., and Hirsch, J. A. (2004) Structural analysis of the voltage-dependent calcium channel β subunit functional core and its complex with the α1 interaction domain. Neuron 42, 387-399
9. Van Petegem, F., Clark, K. A., Chatelain, F. C., and Minor, D. L., Jr. (2004) Structure of a complex between a voltage-gated calcium channel β-subunit and an α-subunit domain. Nature 429, 671-675
10. 1-β subunit interaction of voltage-gated Ca2 channels. Nature 429, 675-680
11. 1-subunit. Nature 368, 67-70
12. vβ subunits. Proc. Natl. Acad. Sci. U. S. A. 105, 8154-8159
13. 2+ channel complex purified from brain. Science 261, 486-489
14. 2+ channel β subunits revealed by their expression in adult rat heart cells. J. Physiol. 541, 435-452
15. vβ subunits, and lack of functional reserve, in protein kinase A modulation of cardiac Cav1.2 channels. Circ. Res. 102, e54-64
16. 2+ channel modulation by recombinant auxiliary β subunits expressed in young adult heart cells. Circ. Res. 86, 175-184
17. Canti, C., Davies, A., Berrow, N. S., Butcher, A. J., Page, K. M., and Dolphin, A. C. (2001) Evidence for two concentration-dependent processes for β-subunit effects on α1B calcium channels. Biophys. J. 81, 1439-1451
18. Tareilus, E., Roux, M., Qin, N., Olcese, R., Zhou, J., Stefani, E., and Birnbaumer, L. (1997) A Xenopus oocyte β subunit: evidence for a role in the assembly/expression of voltage-gated calcium channels that is separate from its role as a regulatory subunit. Proc. Natl. Acad. Sci. U. S. A. 94, 1703-1708
19. v2.2) calcium channel currents through a hyperpolarizing shift of "ultra-slow" and "closed-state" inactivation. J. Gen. Physiol. 123, 401-416
20. 2+ overload causes mitochondrial-dependent apoptosis in ventricular myocytes. Circ. Res. 97, 1009-1017
21. Hullin, R., Asmus, F., Ludwig, A., Hersel, J., and Boekstegers, P. (1999) Subunit expression of the cardiac L-type calcium channel is differentially regulated in diastolic heart failure of the cardiac allograft. Circulation 100, 155-163
22. 2+ channels leads to single-channel activity characteristic of heart failure. PLoS ONE 2, e292
23. 1b-subunit by size-exclusion chromatography and its role on channel function. J. Biol. Chem. 279, 21689-21694
24. Y67C FRET reference standards. Biophys. J. 91, L99-101
25. v1.2 calcium channel. J. Biol. Chem. 283, 15577-15588
26. Wittig, I., Braun, H.-P., and Schägger, H. (2006) Blue native PAGE. Nat. Protocols 1, 418-428
27. Hullin, R., Singer-Lahat, D., Freichel, M., Biel, M., Dascal, N., Hofmann, F., and Flockerzi, V. (1992) Calcium channel β subunit heterogeneity: functional expression of cloned cDNA from heart, aorta and brain. EMBO J. 11, 885-890
28. v3.1: comparison with the cardiac L-type voltage-gated calcium channel monomer architecture. J. Biol. Chem. 284, 22310-22321
29. Akiyama, Y., and Ito, K. (1993) Folding and assembly of bacterial alkaline phosphatase in vitro and in vivo. J. Biol. Chem. 268, 8146-8150
30. Yeh, M. F., and Trela, J. M. (1976) Purification and characterization of a repressible alkaline phosphatase from Thermus aquaticus. J. Biol. Chem. 251, 3134-3139
31. Powers, P. A., Liu, S., Hogan, K., and Gregg, R. G. (1992) Skeletal muscle and brain isoforms of a β-subunit of human voltage-dependent calcium channels are encoded by a single gene. J. Biol. Chem. 267, 22967-22972
32. 2-subunits. FASEB J. 21, 1527-1538
33. Foell, J. D., Balijepalli, R. C., Delisle, B. P., Yunker, A. M. R., Robia, S. L., Walker, J. W., McEnery, M. W., January, C. T., and Kamp, T. J. (2004) Molecular heterogeneity of calcium channel β-subunits in canine and human heart: evidence for differential subcellular localization. Physiol. Genomics 17, 183-200
34. Swamy, M., Siegers, G. M., Minguet, S., Wollscheid, B., and Schamel, W. W. A. (2006) Blue native polyacrylamide gel electrophoresis (BN-PAGE) for the identification and analysis of multiprotein complexes. Sci. STKE 2006, p14
35. 2+ channel opening. FASEB J. 19, 1573-1575
36. 2+ channel β subunit as a basis for understanding its functional properties. FEBS Lett. 445, 366-370
37. 2+ channels during hypertension and Timothy syndrome. Circ. Res. 106, 748-756
38. Levy, D., Ehret, G. B., Rice, K., Verwoert, G. C., Launer, L. J., Dehghan, A., Glazer, N. L., Morrison, A. C., Johnson, A. D., Aspelund, T., Aulchenko, Y., Lumley, T., Kottgen, A., Vasan, R. S., Rivadeneira, F., Eiriksdottir, G., Guo, X., Arking, D. E., Mitchell, G. F., Mattace-Raso, F. U. S., Smith, A. V., Taylor, K., Scharpf, R. B., Hwang, S.-J., Sijbrands, E. J. G., Bis, J., Harris, T. B., Ganesh, S. K., O'Donnell, C. J., Hofman, A., Rotter, J. I., Coresh, J., Benjamin, E. J., Uitterlinden, A. G., Heiss, G., Fox, C. S., Witteman, J. C. M., Boerwinkle, E., Wang, T. J., Gudnason, V., Larson, M. G., Chakravarti, A., Psaty, B. M., and van Duijn, C. M. (2009) Genome-wide association study of blood pressure and hypertension. Nat. Genet. 41, 677-687
39. McGee, A. W., Dakoji, S. R., Olsen, O., Bredt, D. S., Lim, W. A., and Prehoda, K. E. (2001) Structure of the SH3-guanylate kinase module from PSD-95 suggests a mechanism for regulated assembly of MAGUK scaffolding proteins. Mol. Cell 8, 1291-1301
40. Gonzalez-Gutierrez, G., Miranda-Laferte, E., Nothmann, D., Schmidt, S., Neely, A., and Hidalgo, P. (2008) The guanylate kinase domain of the β-subunit of voltage-gated calcium channels suffices to modulate gating. Proc. Natl. Acad. Sci. U. S. A. 105, 14198-14203
41. v2 calcium channels. Implications for episodic ataxia type 2. J. Biol. Chem. 285, 835-844