Increased coupled gating of L-type Ca2+ channels during hypertension and timothy syndrome

Circulation Research

Volumn 106, Issue 4, 2010, Pages 748-756

  Navedo, Manuel F ^a   Cheng, Edward P ^a   Yuan, Can ^a   Votaw, Scott ^a   Molkentin, Jeffery D ^c   Scott, John D ^a,b   Santana, Luis F ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^c CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

Author keywords

Arrhythmias; Calmodulin; Cav1.2 channels; PKC

Indexed keywords

CALCIUM CHANNEL L TYPE; CALCIUM CHANNEL L TYPE CAV1.2; MUTANT PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTERY MUSCLE; ARTICLE; AUTISM; CARBOXY TERMINAL SEQUENCE; CHANNEL GATING; CONTROLLED STUDY; ELECTROPHYSIOLOGY; FLUORESCENCE RESONANCE ENERGY TRANSFER; HEART ARRHYTHMIA; HYPERTENSION; MALFORMATION SYNDROME; MOLECULAR INTERACTION; MOUSE; NERVE CELL EXCITABILITY; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; QT PROLONGATION; RAT; REGULATORY MECHANISM; TIMOTHY SYNDROME;

A KINASE ANCHOR PROTEINS; ANIMALS; CALCIUM CHANNELS, L-TYPE; CALCIUM SIGNALING; CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASES; CALMODULIN; CELLS, CULTURED; ENZYME ACTIVATION; ENZYME ACTIVATORS; FLUORESCENCE RESONANCE ENERGY TRANSFER; HUMANS; HYPERTENSION; ION CHANNEL GATING; LONG QT SYNDROME; MEMBRANE POTENTIALS; MICE; MICE, KNOCKOUT; MICROSCOPY, CONFOCAL; MUSCLE, SMOOTH, VASCULAR; MUTATION; MYOCYTES, CARDIAC; MYOCYTES, SMOOTH MUSCLE; PATCH-CLAMP TECHNIQUES; PROTEIN KINASE C-ALPHA; PROTEIN KINASE INHIBITORS; PROTEIN STRUCTURE, TERTIARY; PROTEIN TRANSPORT; RABBITS; RATS; RATS, SPRAGUE-DAWLEY; RECOMBINANT FUSION PROTEINS; TIME FACTORS; TRANSFECTION;

EID: 77949347334     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.109.213363     Document Type: Article

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