Dipyridamole inhibits lipopolysaccharide-induced cyclooxygenase-2 and monocyte chemoattractant protein-1 via heme oxygenase-1-mediated reactive oxygen species reduction in rat mesangial cells

European Journal of Pharmacology

Volumn 650, Issue 1, 2011, Pages 445-450

  Chen, Yen Cheng ^a   Chen, Cheng Hsien ^a,b   Ko, Wen Sheng ^a   Cheng, Chung Yi ^a,b   Sue, Yuh Mou ^a,b   Chen, Tso Hsiao ^a,b  

^a TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^b TAIPEI MEDICAL UNIVERSITY   (Taiwan)

Author keywords

Cyclooxygenase 2 (COX 2); Dipyridamole; Heme oxygenase 1 (HO 1); Lipopolysaccharide; Monocyte chemoattractant protein 1 (MCP 1)

Indexed keywords

ACETYLCYSTEINE; CYCLIC AMP; CYCLIC GMP; CYCLOOXYGENASE 2; DIPYRIDAMOLE; HEME OXYGENASE 1; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; MONOCYTE CHEMOTACTIC PROTEIN 1; PROTOPORPHYRIN TIN; REACTIVE OXYGEN METABOLITE;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; ENZYME INDUCTION; ENZYME INHIBITION; INFLAMMATION; MESANGIUM CELL; NONHUMAN; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION;

ANIMALS; ANTI-INFLAMMATORY AGENTS; CHEMOKINE CCL2; CYCLOOXYGENASE 2; DIPYRIDAMOLE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HEME OXYGENASE-1; LIPOPOLYSACCHARIDES; MESANGIAL CELLS; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; RATS; REACTIVE OXYGEN SPECIES;

EID: 78649729565     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2010.09.058     Document Type: Article

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