Dipyridamole inhibits human peritoneal mesothelial cell proliferation in vitro and attenuates rat peritoneal fibrosis in vivo

Kidney International

Volumn 59, Issue 6, 2001, Pages 2316-2324

  Hung, Kuan Yu ^a   Shyu, Ren Shi ^a   Fang, Cheng Chung ^a   Tsai, Chien Chen ^a   Lee, Po Huang ^a   Tsai, Tun Jun ^a   Hsieh, Bor Shen ^a  

^a NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

Animal model; cAMP; CAPD; Collagen; Extracellular matrix; Mesothelial cell; Mitogenesis; Uremia

Indexed keywords

COLLAGEN TYPE 1; CYCLIC AMP; DEXTRAN; DIPYRIDAMOLE; MESSENGER RNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL PROLIFERATION; COLLAGEN SYNTHESIS; CONTINUOUS AMBULATORY PERITONEAL DIALYSIS; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; FIBROSIS; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MALE; MESOTHELIUM CELL; NONHUMAN; PERITONEUM; PERITONEUM ADHESION; PRIORITY JOURNAL; RAT;

EID: 0035019827     PISSN: 00852538     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1523-1755.2001.00749.x     Document Type: Article

References (23)

1. Jacobs C: Current trends in dialysis therapy. Kidney Int 51(Suppl 62):S93-S95, 1997
2. Dobbie JW: Pathogenesis of peritoneal fibrosing syndrome (sclerosing peritonitis) in peritoneal dialysis. Perit Dial Int 12:14-27, 1992
3. Fitzgerald GA: Dipyridamole, N Engl J Med 316:1247-1257, 1987
4. Iimura O, Kusano E, Amemiya M, et al: Dipyridamole enhances interleukin-1β-stimulated nitric oxide production by cultured rat vascular smooth muscle cells. Eur J Pharmacol 296:319-326, 1996
5. Hillis GS, Duthie LA, Macleod AM: Dipyridamole inhibits human mesangial cell proliferation. Nephron 78:172-178, 1998
6. Tsai TJ, Lin RH, Chang CC, et al: Vasodilator agents modulate rat glomerular mesangial cell growth and collagen synthesis. Nephron 70:91-100, 1995
7. Tzamaloukas AH: Peritonitis in peritoneal dialysis patients: An overview. Adv Renal Replacement Ther 3:232-236, 1996
8. Calame W, Afram C, Blijleven N, et al: Establishing an experimental infection model for peritoneal dialysis: Effect of inoculum and volume. Perit Dial Int 13(Suppl 2);S79-S80, 1993
9. Wieczorowska K, Khanna R, Moore HL, et al: Rat model of peritoneal fibrosis: Preliminary observations, Adv Perit Dial 11:48-51, 1995
10. Tsai TJ, Yen CJ, Fang CC, et al: Effect of intraperitoneally administered agents on human peritoneal mesothelial cell growth. Nephron 71:23-28, 1995
11. Fang CC, Yen CJ, Chen YM, et al: Hydralazine inhibits human peritoneal mesothelial cell proliferation and collagen synthesis, Nephrol Dial Transplant 11:2276-2281, 1996
12. Smith PK, Krohn RI, Hermanson GT, et al: Measurement of protein using bicinchoninic acid. Anal Biochem 150:76-85, 1985
13. Renvall S, Lehto M, Penttinen R: Development of peritoneal fibrosis occurs under the mesothelial cell layer, J Surg Resear 43:407-412, 1987
14. Ford CW, Hamel JC, Stapert D, Yancey RJ: Establishment of an experimental model of a Staphylococcus aureus abscess in mice by use of dextran and gelatin microcarriers. J Med Microbiol 28:259-266, 1988
15. Mullarniemi H, Frilander M, Turunen M, Saxen L: The effect of glove powders and their constituents on adhesion and granuloma formation in the abdominal cavity of the rabbit. Acta Chir Scand 131:312-317, 1966
16. Frazier-Jessen MR, Kovacs E: Abdominal wall thickness as a means of assessing peritoneal fibrosis in mice. J Immunol Method 162:115-121, 1993
17. Nakamoto M: Pathogenesis of peritoneal fibrosis and peritoneal small vessel changes. Pent Dial Int 16(Suppl 1);S39-S41, 1996
18. Fang CC, Yen CJ. Chen YM, et al: Pentoxifylline inhibits human peritoneal mesothelial cell growth and collagen synthesis: Effects on TGF-β. Kidney Int 57:2626-2633, 2000
19. Fracasso A, Baggio B, Ossi E, et al: Glycosaminoglycans prevent the functional and morphological peritoneal derangement in an experimental model of PF. Am J Kidney Dis 33:105-110, 1999
20. Rottembourg J, Issad B, Langlois P: Sclerosing encapsulating peritonitis during CAPD. Evaluation of the potential risk factors, in Frontiers in Peritoneal Dialysis, edited by Maher JF, Winchester JF, New York, Field, Rich and Assoc., Inc., 1986, pp 643-649
21. DiZerega GS: Biochemical events in peritoneal tissue repair. Eur J Surg 163(Suppl 577):10-16, 1997
22. Holtz G: Prevention and management of peritoneal adhesions. Fertil Steril 41:497-507, 1984
23. Sitter T, Spannagl M, Schiffl H, et al: Imbalance between intraperitoneal coagulation and fibrinolysis during peritonitis of CAPD patients: The role of mesothelial cells. Nephrol Dial Transplant 10:677-683, 1995