Nicorandil normalizes prolonged repolarisation in the first transgenic rabbit model with Long-QT syndrome 1 both in vitro and in vivo

European Journal of Pharmacology

Volumn 650, Issue 1, 2011, Pages 309-316

  Biermann, Jürgen ^a   Wu, Kezhong ^a   Odening, Katja E ^a,b   Asbach, Stefan ^a   Koren, Gideon ^b   Peng, Xuwen ^c   Zehender, Manfred ^a   Bode, Christoph ^a   Brunner, Michael ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

^b BROWN UNIVERSITY   (United States)

^c PENN STATE COLLEGE OF MEDICINE   (United States)

Author keywords

Dispersion of repolarisation; Electrophysiological studies; Long QT Syndrome; Nicorandil; Polymorphic ventricular tachycardia; Transgenic rabbit model

Indexed keywords

ISOPRENALINE; NICORANDIL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COMBINATION CHEMOTHERAPY; CONTROLLED STUDY; DRUG DOSE TITRATION; DRUG EFFECT; FEMALE; HEART MUSCLE POTENTIAL; HEART MUSCLE REFRACTORY PERIOD; HEART RATE; HEART REPOLARIZATION; IN VITRO STUDY; IN VIVO STUDY; ISOLATED HEART; LONG QT SYNDROME; MALE; MONOTHERAPY; NONHUMAN; PRIORITY JOURNAL; QT DISPERSION; RABBIT; TRANSGENIC ANIMAL;

ACTION POTENTIALS; ANIMALS; ANIMALS, GENETICALLY MODIFIED; DISEASE MODELS, ANIMAL; FEMALE; HEART; HUMANS; MALE; NICORANDIL; PERFUSION; RABBITS; ROMANO-WARD SYNDROME; TIME FACTORS;

EID: 78649723140     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2010.10.016     Document Type: Article

References (48)

1. Y. Aizawa, H. Uchiyama, M. Yamaura, T. Nakayama, and M. Arita Effects of the ATP-sensitive K channel opener nicorandil on the QT interval and the effective refractory period in patients with congenital long QT syndrome. Investigator Group for K-Channel Openers and Arrhythmias J. Electrocardiol. 31 1998 117 123
2. T. Akagi, K. Sarazawa, Y. Inai, M. Kitagawa, N. Takahashi, I. Hamanaka, T. Yamazaki, M. Takebe, N. Hama, Y. Hiraoka, K. Ueda, K. Nakazawa, and N. Matsumoto Continuous administration of nicorandil decreases QT dispersion during the chronic phase of acute myocardial infarction Int. Heart J. 47 2006 351 361
3. L.C. Baker, B. London, B.R. Choi, G. Koren, and G. Salama Enhanced dispersion of repolarization and refractoriness in transgenic mouse hearts promotes reentrant ventricular tachycardia Circ. Res. 86 2000 396 407
4. M. Brunner, W. Guo, G.F. Mitchell, P.D. Buckett, J.M. Nerbonne, and G. Koren Characterization of mice with a combined suppression of I(to) and I(K, slow) Am. J. Physiol. Heart Circ. Physiol. 281 2001 H1201 H1209
5. M. Brunner, X. Peng, G.X. Liu, X.Q. Ren, O. Ziv, B.R. Choi, R. Mathur, M. Hajjiri, K.E. Odening, E. Steinberg, E.J. Folco, E. Pringa, J. Centracchio, R.R. Macharzina, T. Donahay, L. Schofield, N. Rana, M. Kirk, G.F. Mitchell, A. Poppas, M. Zehender, and G. Koren Mechanisms of cardiac arrhythmias and sudden death in transgenic rabbits with long QT syndrome J. Clin. Invest. 118 2008 2246 2259
6. I.K. Chang, M.K. Shyu, C.N. Lee, M.L. Kau, Y.H. Ko, S.N. Chow, and F.J. Hsieh Prenatal diagnosis and treatment of fetal long QT syndrome: a case report Prenat. Diagn. 22 2002 1209 1212
7. T. Chibana, F. Nagamine, R. Sunagawa, K. Oshiro, Y. Nakada, M. Shimabukuro, T. Shinzato, K. Murakami, G. Mimura, and M. Sakanashi Comparison of the acute hemodynamic and coronary vasodilating effects between nicorandil and glyceryl trinitrate Arzneimittelforschung 41 1991 591 594
8. B.R. Choi, W. Nho, T. Liu, and G. Salama Life span of ventricular fibrillation frequencies Circ. Res. 91 2002 339 345
9. L. Crotti, G. Celano, F. Dagradi, and P.J. Schwartz Congenital long QT syndrome Orphanet J. Rare Dis. 3 2008 18
10. F.E. Cruz Filho, I.G. Maia, M.L. Fagundes, R.C. Barbosa, P.A. Alves, R.M. Sa, S.H. Boghossian, and J.C. Ribeiro Electrical behavior of T-wave polarity alternans in patients with congenital long QT syndrome J. Am. Coll. Cardiol. 36 2000 167 173
11. L.A. DiCarlo Jr., F. Morady, A.B. Schwartz, E.N. Shen, J.M. Baerman, R.B. Krol, M.M. Scheinman, and R.J. Sung Clinical significance of ventricular fibrillation-flutter induced by ventricular programmed stimulation Am. Heart J. 109 1985 959 963
12. C. Donger, I. Denjoy, M. Berthet, N. Neyroud, C. Cruaud, M. Bennaceur, G. Chivoret, K. Schwartz, P. Coumel, and P. Guicheney KVLQT1 C-terminal missense mutation causes a forme fruste long-QT syndrome Circulation 96 1997 2778 2781
13. I.R. Efimov, B. Ermentrout, D.T. Huang, and G. Salama Activation and repolarization patterns are governed by different structural characteristics of ventricular myocardium: experimental study with voltage-sensitive dyes and numerical simulations J. Cardiovasc. Electrophysiol. 7 1996 512 530
14. L. Fabritz, P. Kirchhof, M.R. Franz, L. Eckardt, G. Monnig, P. Milberg, G. Breithardt, and W. Haverkamp Prolonged action potential durations, increased dispersion of repolarization, and polymorphic ventricular tachycardia in a mouse model of proarrhythmia Basic Res. Cardiol. 98 2003 25 32
15. T.P. Flagg, B. Patton, R. Masia, C. Mansfield, A.N. Lopatin, K.A. Yamada, and C.G. Nichols Arrhythmia susceptibility and premature death in transgenic mice overexpressing both SUR1 and Kir6.2[DeltaN30, K185Q] in the heart Am. J. Physiol. Heart Circ. Physiol. 293 2007 H836 H845
16. D.W. Frazier, P.D. Wolf, J.M. Wharton, A.S. Tang, W.M. Smith, and R.E. Ideker Stimulus-induced critical point. Mechanism for electrical initiation of reentry in normal canine myocardium J. Clin. Invest. 83 1989 1039 1052
17. Y. Fujimoto, H. Morita, K.K. Fukushima, and T. Ohe Nicorandil abolished repolarisation alternans in a patient with idiopathic long QT syndrome Heart 82 1999 e8
18. H. Fujita, T. Ogura, M. Tamagawa, H. Uemura, T. Sato, A. Ishida, M. Imamaki, F. Kimura, M. Miyazaki, and H. Nakaya A key role for the subunit SUR2B in the preferential activation of vascular KATP channels by isoflurane Br. J. Pharmacol. 149 2006 573 580
19. I. Goldenberg, W. Zareba, and A.J. Moss Long QT Syndrome Curr. Probl. Cardiol. 33 2008 629 694
20. M. Hirose, N. Tsujino, T. Nakada, S. Yano, H. Imamura, and M. Yamada Mechanisms of preventive effect of nicorandil on ischaemia-induced ventricular tachyarrhythmia in isolated arterially perfused canine left ventricular wedges Basic Clin. Pharmacol. Toxicol. 102 2008 504 514
21. S.F. Idriss, and P.D. Wolf Transmural action potential repolarization heterogeneity develops postnatally in the rabbit J. Cardiovasc. Electrophysiol. 15 2004 795 801
22. J. Imagawa, G.F. Baxter, and D.M. Yellon Myocardial protection afforded by nicorandil and ischaemic preconditioning in a rabbit infarct model in vivo J. Cardiovasc. Pharmacol. 31 1998 74 79
23. E.S. Kaufman, S.G. Priori, C. Napolitano, P.J. Schwartz, S. Iyengar, R.C. Elston, A.H. Schnell, E.Z. Gorodeski, G. Rammohan, N.O. Bahhur, D. Connuck, L. Verrilli, D.S. Rosenbaum, and A.M. Brown Electrocardiographic prediction of abnormal genotype in congenital long QT syndrome: experience in 101 related family members J. Cardiovasc. Electrophysiol. 12 2001 455 461
24. M.J. Killeen, I.N. Sabir, A.A. Grace, and C.L. Huang Dispersions of repolarization and ventricular arrhythmogenesis: lessons from animal models Prog. Biophys. Mol. Biol. 98 2008 219 229
25. A.D. Krahn, J.S. Healey, V. Chauhan, D.H. Birnie, C.S. Simpson, J. Champagne, M. Gardner, S. Sanatani, D.V. Exner, G.J. Klein, R. Yee, A.C. Skanes, L.J. Gula, and M.H. Gollob Systematic assessment of patients with unexplained cardiac arrest: Cardiac Arrest Survivors With Preserved Ejection Fraction Registry (CASPER) Circulation 120 2009 278 285
26. H.R. Lu, P. Remeysen, K. Somers, A. Saels, and F. De Clerck Female gender is a risk factor for drug-induced long QT and cardiac arrhythmias in an in vivo rabbit model J. Cardiovasc. Electrophysiol. 12 2001 538 545
27. P. Milberg, R. Tegelkamp, N. Osada, R. Schimpf, C. Wolpert, G. Breithardt, M. Borggrefe, and L. Eckardt Reduction of dispersion of repolarization and prolongation of postrepolarization refractoriness explain the antiarrhythmic effects of quinidine in a model of short QT syndrome J. Cardiovasc. Electrophysiol. 18 2007 658 664
28. A.J. Moss, W. Zareba, W.J. Hall, P.J. Schwartz, R.S. Crampton, J. Benhorin, G.M. Vincent, E.H. Locati, S.G. Priori, C. Napolitano, A. Medina, L. Zhang, J.L. Robinson, K. Timothy, J.A. Towbin, and M.L. Andrews Effectiveness and limitations of beta-blocker therapy in congenital long-QT syndrome Circulation 101 2000 616 623
29. M. Motoyasu, H. Nishikawa, Y. Shimizu, T. Aoki, N. Ono, M. Unno, Y. Kakuta, T. Yazu, A. Kasai, and T. Yamakado A case of congenital long QT syndrome associated with T wave alternans Kokyu To Junkan 40 1992 195 198
30. B.D. Nearing, and R.L. Verrier Modified moving average analysis of T-wave alternans to predict ventricular fibrillation with high accuracy J. Appl. Physiol. 92 2002 541 549
31. J.M. Nerbonne, and W. Guo Heterogeneous expression of voltage-gated potassium channels in the heart: roles in normal excitation and arrhythmias J. Cardiovasc. Electrophysiol. 13 2002 406 409
32. K.E. Odening, O. Hyder, L. Chaves, L. Schofield, M. Brunner, M. Kirk, M. Zehender, X. Peng, and G. Koren Pharmacogenomics of anesthetic drugs in transgenic LQT1 and LQT2 rabbits reveal genotype-specific differential effects on cardiac repolarization Am. J. Physiol. Heart Circ. Physiol. 295 2008 H2264 H2272
33. S.G. Priori, R. Bloise, and L. Crotti The long QT syndrome Europace 3 2001 16 27
34. G. Salama, R. Lombardi, and J. Elson Maps of optical action potentials and NADH fluorescence in intact working hearts Am. J. Physiol. 252 1987 H384 H394
35. P.J. Schwartz, M. Periti, and A. Malliani The long Q-T syndrome Am. Heart J. 89 1975 378 390
36. P.J. Schwartz, A.J. Moss, G.M. Vincent, and R.S. Crampton Diagnostic criteria for the long QT syndrome. An update Circulation 88 1993 782 784
37. W. Shimizu, and C. Antzelevitch Cellular basis for the ECG features of the LQT1 form of the long-QT syndrome: effects of beta-adrenergic agonists and antagonists and sodium channel blockers on transmural dispersion of repolarization and torsade de pointes Circulation 98 1998 2314 2322
38. W. Shimizu, and C. Antzelevitch Effects of a K(+) channel opener to reduce transmural dispersion of repolarization and prevent torsade de pointes in LQT1, LQT2, and LQT3 models of the long-QT syndrome Circulation 102 2000 706 712
39. W. Shimizu, S. Kamakura, Y. Arakaki, T. Kamiya, and K. Shimomura T wave alternans in idiopathic long-QT syndrome: insight from body surface mapping Pacing Clin. Electrophysiol. 19 1996 1130 1133
40. W. Shimizu, T. Kurita, K. Matsuo, K. Suyama, N. Aihara, S. Kamakura, J.A. Towbin, and K. Shimomura Improvement of repolarization abnormalities by a K + channel opener in the LQT1 form of congenital long-QT syndrome Circulation 97 1998 1581 1588
41. J.M. Smith, E.A. Clancy, C.R. Valeri, J.N. Ruskin, and R.J. Cohen Electrical alternans and cardiac electrical instability Circulation 77 1988 110 121
42. N. Taira Similarity and dissimilarity in the mode and mechanism of action between nicorandil and classical nitrates: an overview J. Cardiovasc. Pharmacol. 10 Suppl 8 1987 S1 S9
43. C.A. Taira, J.A. Opezzo, M.A. Mayer, and C. Hocht Cardiovascular drugs inducing QT prolongation: facts and evidence Curr. Drug Saf. 5 1 2010 65 72
44. N. Treese, R. Erbel, and J. Meyer Acute hemodynamic effects of nicorandil in coronary artery disease J. Cardiovasc. Pharmacol. 20 Suppl 3 1992 S52 S56
45. H. Ueda, T. Hayashi, K. Tsumura, K. Yoshimaru, Y. Nakayama, and J. Yoshikawa Intravenous nicorandil can reduce QT dispersion and prevent bradyarrhythmia during percutaneous transluminal coronary angioplasty of the right coronary artery J. Cardiovasc. Pharmacol. Ther. 9 2004 179 184 (Pubitemid 39331064)
46. H. Ueda, Y. Nakayama, K. Tsumura, K. Yoshimaru, T. Hayashi, and J. Yoshikawa Intravenous nicorandil can reduce the occurrence of ventricular fibrillation and QT dispersion in patients with successful coronary angioplasty in acute myocardial infarction Can. J. Cardiol. 20 2004 625 629
47. G.M. Vincent The long-QT syndrome - bedside to bench to bedside N Engl J. Med. 348 2003 1837 1838
48. W. Zareba, and I. Cygankiewicz Long QT syndrome and short QT syndrome Prog. Cardiovasc. Dis. 51 2008 264 278