UV-induced interaction between p38 MAPK and p53 serves as a molecular switch in determining cell fate

FEBS Letters

Volumn 584, Issue 23, 2010, Pages 4711-4716

  Gong, Xiaowei ^a   Liu, Aihua ^a   Ming, Xiaoyan ^a   Deng, Peng ^a   Jiang, Yong ^a  

^a SOUTHERN MEDICAL UNIVERSITY   (China)

Author keywords

Cell apoptosis; Cell survival; DNA damage; P38 mitogen activated protein kinase; P53

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN P53;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL FATE; CELL PROTECTION; CELL SURVIVAL; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA DAMAGE; EMBRYO; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; ULTRAVIOLET RADIATION;

ANIMALS; APOPTOSIS; CELL LINE; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, RADIATION; GENE KNOCKOUT TECHNIQUES; HUMANS; MICE; NIH 3T3 CELLS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PROTEIN BINDING; SERINE; TUMOR SUPPRESSOR PROTEIN P53; ULTRAVIOLET RAYS;

EID: 78649686256     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.febslet.2010.10.057     Document Type: Article

References (27)

1. Aylon Y., Oren M. Living with p53, dying of p53. Cell 2007, 130:597-600.
2. Brown L., Benchimol S. The involvement of MAPK signaling pathways in determining the cellular response to p53 activation: cell cycle arrest or apoptosis. J. Biol. Chem. 2006, 281:3832-3840.
3. Li Q., et al. Axin determines cell fate by controlling the p53 activation threshold after DNA damage. Nat. Cell Biol. 2009, 11:1128-1134.
4. Jiang Y., Chen C., Li Z., Guo W., Gegner J.A., Lin S., Han J. Characterization of the structure and function of a new mitogen-activated protein kinase (p38beta). J. Biol. Chem. 1996, 271:17920-17926.
5. Johnson G.L., Lapadat R. Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases. Science 2002, 298:1911-1912.
6. She Q.B., Chen N., Dong Z. ERKs and p38 kinase phosphorylate p53 protein at serine 15 in response to UV radiation. J. Biol. Chem. 2000, 275:20444-20449.
7. Bulavin D.V., Fornace A.J. P38 MAP kinase's emerging role as a tumor suppressor. Adv. Cancer Res. 2004, 92:95-118.
8. Bulavin D.V., Saito S., Hollander M.C., Sakaguchi K., Anderson C.W., Appella E., Fornace A.J. Phosphorylation of human p53 by p38 kinase coordinates N-terminal phosphorylation and apoptosis in response to UV radiation. EMBO J. 1999, 18:6845-6854.
9. Porras A., Zuluaga S., Black E., Valladares A., Alvarez A.M., Ambrosino C., Benito M., Nebreda A.R. P38 alpha mitogen-activated protein kinase sensitizes cells to apoptosis induced by different stimuli. Mol. Biol. Cell 2004, 15:922-933.
10. Chouinard N., Valerie K., Rouabhia M., Huot J. UVB-mediated activation of p38 mitogen-activated protein kinase enhances resistance of normal human keratinocytes to apoptosis by stabilizing cytoplasmic p53. Biochem. J. 2002, 365:133-145.
11. Park J.M., Greten F.R., Li Z.W., Karin M. Macrophage apoptosis by anthrax lethal factor through p38 MAP kinase inhibition. Science 2002, 297:2048-2051.
12. Latonen L., Taya Y., Laiho M. UV-radiation induces dose-dependent regulation of p53 response and modulates p53-HDM2 interaction in human fibroblasts. Oncogene 2001, 20:6784-6793.
13. Shaulian E., Schreiber M., Piu F., Beeche M., Wagner E.F., Karin M. The mammalian UV response: c-Jun induction is required for exit from p53-imposed growth arrest. Cell 2000, 103:897-907.
14. Knezevic D., Zhang W., Rochette P.J., Brash D.E. Bcl-2 is the target of a UV-inducible apoptosis switch and a node for UV signaling. Proc. Natl. Acad. Sci. USA 2007, 104:11286-11291.
15. Gong X., Ming X., Deng P., Jiang Y. Mechanisms regulating the nuclear translocation of p38 MAP kinase. J. Cell. Biochem. 2010, 110:1420-1429.
16. Takekawa M., Adachi M., Nakahata A., Nakayama I., Itoh F., Tsukuda H., Taya Y., Imai K. P53-inducible wip1 phosphatase mediates a negative feedback regulation of p38 MAPK-p53 signaling in response to UV radiation. EMBO J. 2000, 19:6517-6526.
17. Wu G.S. The functional interactions between the p53 and MAPK signaling pathways. Cancer Biol. Ther. 2004, 3:156-161.
18. Das S., Raj L., Zhao B., Kimura Y., Bernstein A., Aaronson S.A., Lee S.W. Hzf Determines cell survival upon genotoxic stress by modulating p53 transactivation. Cell 2007, 130:624-637.
19. Cuadrado A., Lafarga V., Cheung P.C., Dolado I., Llanos S., Cohen P., Nebreda A.R. A new p38 MAP kinase-regulated transcriptional coactivator that stimulates p53-dependent apoptosis. EMBO J. 2007, 26:2115-2126.
20. Li G., Ho V.C. P53-dependent DNA repair and apoptosis respond differently to high- and low-dose ultraviolet radiation. Br. J. Dermatol. 1998, 139:3-10.
21. Mathonnet G., Leger C., Desnoyers J., Drouin R., Therrien J.P., Drobetsky E.A. UV wavelength-dependent regulation of transcription-coupled nucleotide excision repair in p53-deficient human cells. Proc. Natl. Acad. Sci. USA 2003, 100:7219-7224.
22. Reinhardt H.C., Aslanian A.S., Lees J.A., Yaffe M.B. P53-deficient cells rely on ATM- and ATR-mediated checkpoint signaling through the p38MAPK/MK2 pathway for survival after DNA damage. Cancer Cell 2007, 11:175-189.
23. Tomicic M.T., Christmann M., Kaina B. Apoptosis in UV-C light irradiated p53 wild-type, apaf-1 and p53 knockout mouse embryonic fibroblasts: interplay of receptor and mitochondrial pathway. Apoptosis 2005, 10:1295-1304.
24. Hofmann T.G., Möller A., Sirma H., Zentgraf H., Taya Y., Dröge W., Will H., Schmitz M.L. Regulation of p53 activity by its interaction with homeodomain-interacting protein kinase-2. Nat. Cell Biol. 2002, 4:1-10.
25. Weber H.O., Ludwig R.L., Morrison D., Kotlyarov A., Gaestel M., Vousden K.H. HDM2 phosphorylation by MAPKAP kinase 2. Oncogene 2005, 24:1965-1972.
26. Bean L.J., Stark G.R. Phosphorylation of serines 15 and 37 is necessary for efficient accumulation of p53 following irradiation with UV. Oncogene 2001, 20:1076-1084.
27. Lemaire M., Ducommun B., Nebreda A.R. UV-induced downregulation of the CDC25B protein in human cells. FEBS Lett. 2010, 584:1199-1204.