Flexibility of the thrombin-activatable fibrinolysis inhibitor pro-domain enables productive binding of protein substrates

Journal of Biological Chemistry

Volumn 285, Issue 49, 2010, Pages 38243-38250

  Valnickova, Zuzana ^a   Sanglas, Laura ^b   Arolas, Joan L ^c   Petersen, Steen V ^d   Schar, Christine ^a   Otzen, Daniel ^a   Aviles, Francesc X ^b   Gomis Rüth, F Xavier ^c   Enghild, Jan J ^a  

^a AARHUS UNIVERSITY   (Denmark)

^b UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

^c INSTITUT DE BIOLOGIA MOLECULAR DE BARCELONA   (Spain)

^d AARHUS UNIVERSITY   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; BULK SOLVENTS; CARBOXYPEPTIDASE; COMPLEX FORMATIONS; IN-VIVO; INHIBITOR COMPLEX; PEPTIDE SUBSTRATES; PROTEIN SUBSTRATE; PROTEOLYTIC ACTIVITIES; STRUCTURAL BASIS; TERMINAL RESIDUES;

PEPTIDES; SUBSTRATES;

CRYSTAL STRUCTURE;

CARBOXYPEPTIDASE INHIBITOR; ENZYME INHIBITOR; THROMBIN ACTIVATABLE FIBRINOLYSIS INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME BINDING; ENZYME SUBSTRATE; GEL PERMEATION CHROMATOGRAPHY; ISOTHERMAL TITRATION CALORIMETRY; LEECH; MASS SPECTROMETRY; NONHUMAN; POTATO; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN STRUCTURE; SURFACE PLASMON RESONANCE; TICK;

ANIMALS; CARBOXYPEPTIDASE U; CATTLE; CRYSTALLOGRAPHY, X-RAY; HUMANS; PROTEASE INHIBITORS; PROTEIN BINDING; PROTEIN STRUCTURE, QUATERNARY; PROTEIN STRUCTURE, TERTIARY; STRUCTURE-ACTIVITY RELATIONSHIP;

BOVINAE; HIRUDINIDA; IXODIDA; SOLANUM TUBEROSUM;

EID: 78649685979     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.150342     Document Type: Article

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