The crystal structure of thrombin-activable fibrinolysis inhibitor (TAFI) provides the structural basis for its intrinsic activity and the short half-life of TAFIa

Journal of Biological Chemistry

Volumn 283, Issue 43, 2008, Pages 29416-29423

  Anand, Kanchan ^c,d   Pallares, Irantzu ^a   Valnickova, Zuzana ^b   Christensen, Trine ^b   Vendrell, Josep ^a   Wendt, K Ulrich ^c   Schreuder, Herman A ^c   Enghild, Jan J ^b   Avilés, Francesc X ^a  

^a UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

^b AARHUS UNIVERSITY   (Denmark)

^c SANOFI AVENTIS DEUTSCHLAND GMBH   (Germany)

^d EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; BINDING ENERGY; BINDING SITES; ENZYME ACTIVITY; POLYSACCHARIDES;

ACTIVE SITES; ANIMAL STUDIES; BASE-LINES; BLOOD CLOTS; ENZYMATIC ACTIVITIES; IN VITRO; INTRINSIC ACTIVITIES; LYSINE RESIDUES; MUTAGENESIS STUDIES; STRUCTURAL BASES; STRUCTURAL EXPLANATIONS; SULFATE IONS;

CRYSTAL STRUCTURE;

AMINO ACID; HEPARIN; HISTONE; SULFATE; THROMBIN ACTIVATABLE FIBRINOLYSIS INHIBITOR;

AMINO ACID SEQUENCE; ARTICLE; BINDING AFFINITY; BINDING SITE; CATALYSIS; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; FIBRINOLYSIS; GLYCOSYLATION; LIGAND BINDING; PRIORITY JOURNAL; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY; SITE DIRECTED MUTAGENESIS; X RAY CRYSTALLOGRAPHY;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CARBOXYPEPTIDASE U; CATTLE; CRYSTALLOGRAPHY, X-RAY; HUMANS; IONS; MODELS, BIOLOGICAL; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PROTEIN CONFORMATION; SEQUENCE HOMOLOGY, AMINO ACID;

ANIMALIA;

EID: 57649223597     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M804003200     Document Type: Article

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