Inactivation of active thrombin-activable fibrinolysis inhibitor takes place by a process that involves conformational instability rather than proteolytic cleavage

Journal of Biological Chemistry

Volumn 275, Issue 17, 2000, Pages 12410-12415

  Marx, Pauline F ^a,b   Hackeng, Tilman M ^c   Dawson, Philip E ^c   Griffin, John H ^c   Meijers, Joost C M ^a,b   Bouma, Bonno N ^a,b  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b UTRECHT UNIVERSITY   (Netherlands)

^c SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIFIBRINOLYTIC AGENT; THROMBIN; THROMBOMODULIN;

ARTICLE; CONFORMATIONAL TRANSITION; FIBRINOLYSIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN STABILITY; SITE DIRECTED MUTAGENESIS; TEMPERATURE DEPENDENCE;

CARBOXYPEPTIDASE U; CARBOXYPEPTIDASES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CLONING, MOLECULAR; ENZYME ACTIVATION; FIBRIN; FIBRINOLYSIS; HUMANS; LYSINE; MUTATION; RECOMBINANT PROTEINS; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; THROMBIN; THROMBOMODULIN; TIME FACTORS;

EID: 0034725047     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.275.17.12410     Document Type: Article

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