Synthetic inositol phosphoglycans related to GPI lack insulin-mimetic activity

ACS Chemical Biology

Volumn 5, Issue 11, 2010, Pages 1075-1086

  Hecht, Marie Lyn ^a,b,c,d   Tsai, Yu Hsuan ^a,b   Liu, Xinyu ^c   Wolfrum, Christian ^c,d   Seeberger, Peter H ^a,b,c  

^a MAX PLANCK INSTITUTE OF COLLOIDS AND INTERFACES   (Germany)

^b FREIE UNIVERSITÄT BERLIN   (Germany)

^c ETH ZURICH   (Switzerland)

^d Competence Center for Systems Physiology and Metabolic Diseases Zurich ^*  (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; GLYCAN DERIVATIVE; GLYCOSYLPHOSPHATIDYLINOSITOL; INOSITOL; INOSITOL DERIVATIVE; INOSITOL PHOSPHOGLYCAN DERIVATIVE; INSULIN; PROTEIN KINASE B; UNCLASSIFIED DRUG;

ADIPOCYTE; ADIPOSE TISSUE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; DRUG ACTIVITY; DRUG EFFECT; DRUG IDENTIFICATION; DRUG MECHANISM; DRUG SYNTHESIS; ENZYME PHOSPHORYLATION; EX VIVO STUDY; GLUCOSE HOMEOSTASIS; GLUCOSE TRANSPORT; IN VITRO STUDY; IN VIVO STUDY; INSULIN LIKE ACTIVITY; INSULIN TOLERANCE TEST; LIPOGENESIS; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; WILD TYPE;

3T3 CELLS; ADIPOCYTES; ANIMALS; BIOMIMETIC MATERIALS; CARBOHYDRATE SEQUENCE; DRUG TOLERANCE; GLUCOSE; GLYCOSYLPHOSPHATIDYLINOSITOLS; HYPOGLYCEMIC AGENTS; INOSITOL PHOSPHATES; INSULIN; MICE; MOLECULAR SEQUENCE DATA; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS C-AKT; STRUCTURE-ACTIVITY RELATIONSHIP;

EUKARYOTA; MUS; RODENTIA;

EID: 78649681562     PISSN: 15548929     EISSN: 15548937     Source Type: Journal    
DOI: 10.1021/cb1002152     Document Type: Article

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