메뉴 건너뛰기




Volumn 5, Issue 11, 2010, Pages 1045-1052

Expanding the use of fluorogenic enzyme reporter substrates to imaging metabolic flux changes: The activity measurement of 5α-steroid reductase in intact mammalian cells

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN; ANDROSTANEDIOL; ANDROSTANOLONE; ENZYME INHIBITOR; STEROID 5ALPHA REDUCTASE; TESTOSTERONE;

EID: 78649661578     PISSN: 15548929     EISSN: 15548937     Source Type: Journal    
DOI: 10.1021/cb100196n     Document Type: Article
Times cited : (5)

References (29)
  • 2
    • 13444249851 scopus 로고    scopus 로고
    • Global strategies to integrate the proteome and metabolome
    • Saghatelian, A. and Cravatt, B. F. (2005) Global strategies to integrate the proteome and metabolome Curr. Opin. Chem. Biol. 9, 62-68
    • (2005) Curr. Opin. Chem. Biol. , vol.9 , pp. 62-68
    • Saghatelian, A.1    Cravatt, B.F.2
  • 4
    • 33846936829 scopus 로고    scopus 로고
    • Supramolecular analytical chemistry
    • Anslyn, E. V. (2007) Supramolecular analytical chemistry J. Org. Chem. 72, 687-699
    • (2007) J. Org. Chem. , vol.72 , pp. 687-699
    • Anslyn, E.V.1
  • 7
    • 16844374835 scopus 로고    scopus 로고
    • Design of optical switches as metabolic indicators: New fluorogenic probes for monoamine oxidases (MAO A and B)
    • Chen, G., Yee, D. J., Gubernator, N. G., and Sames, D. (2005) Design of optical switches as metabolic indicators: new fluorogenic probes for monoamine oxidases (MAO A and B) J. Am. Chem. Soc. 127, 4544-4545
    • (2005) J. Am. Chem. Soc. , vol.127 , pp. 4544-4545
    • Chen, G.1    Yee, D.J.2    Gubernator, N.G.3    Sames, D.4
  • 8
    • 38349097411 scopus 로고    scopus 로고
    • A luminescent sensor for tyrosine phosphorylation
    • Tremblay, M. S., Lee, M., and Sames, D. (2008) A luminescent sensor for tyrosine phosphorylation Org. Lett. 10, 5-8
    • (2008) Org. Lett. , vol.10 , pp. 5-8
    • Tremblay, M.S.1    Lee, M.2    Sames, D.3
  • 9
    • 36448935316 scopus 로고    scopus 로고
    • Harnessing functional plasticity of enzymes: A fluorogenic probe for imaging 17β-HSD10 dehydrogenase, an enzyme involved in Alzheimers and Parkinsons diseases
    • Froemming, M. K. and Sames, D. (2007) Harnessing functional plasticity of enzymes: A fluorogenic probe for imaging 17β-HSD10 dehydrogenase, an enzyme involved in Alzheimers and Parkinsons diseases J. Am. Chem. Soc. 129, 14518-14522
    • (2007) J. Am. Chem. Soc. , vol.129 , pp. 14518-14522
    • Froemming, M.K.1    Sames, D.2
  • 11
    • 0037665156 scopus 로고    scopus 로고
    • Chemical probes of signal-transducing proteins
    • Lawrence, D. S. (2003) Chemical probes of signal-transducing proteins Acc. Chem. Res. 36, 401-409
    • (2003) Acc. Chem. Res. , vol.36 , pp. 401-409
    • Lawrence, D.S.1
  • 12
    • 38149036581 scopus 로고    scopus 로고
    • Peptide-based fluorescent sensors of protein kinase activity: Design and applications
    • Sharma, V., Wang, Q., and Lawrence, D. S. (2008) Peptide-based fluorescent sensors of protein kinase activity: design and applications Biochim. Biophys. Acta 1784, 94-99
    • (2008) Biochim. Biophys. Acta , vol.1784 , pp. 94-99
    • Sharma, V.1    Wang, Q.2    Lawrence, D.S.3
  • 13
    • 0032416718 scopus 로고    scopus 로고
    • Aldol sensors for the rapid generation of tunable fluorescence by antibody catalysis
    • List, B., Barbas, C. F., III, and Lerner, R. A. (1998) Aldol sensors for the rapid generation of tunable fluorescence by antibody catalysis Proc. Natl. Acad. Sci. U.S.A. 95, 15351-15355
    • (1998) Proc. Natl. Acad. Sci. U.S.A. , vol.95 , pp. 15351-15355
    • List, B.1    Barbas Iii, C.F.2    Lerner, R.A.3
  • 14
    • 35949000072 scopus 로고    scopus 로고
    • Activity-based fluorescent reporters for monoamine oxidases in living cells
    • Albers, A. E., Rawls, K. A., and Chang, C. J. (2007) Activity-based fluorescent reporters for monoamine oxidases in living cells Chem. Commun. 44, 4647-4649
    • (2007) Chem. Commun. , vol.44 , pp. 4647-4649
    • Albers, A.E.1    Rawls, K.A.2    Chang, C.J.3
  • 16
    • 0018188390 scopus 로고
    • Enzyme immunoassays with special reference to ELISA techniques
    • Voller, A., Bartlett, A., and Bidwell, D. E. (1978) Enzyme immunoassays with special reference to ELISA techniques J. Clin. Pathol. 31, 507-520
    • (1978) J. Clin. Pathol. , vol.31 , pp. 507-520
    • Voller, A.1    Bartlett, A.2    Bidwell, D.E.3
  • 18
    • 0028173882 scopus 로고
    • Steroid 5α-reductase: Two genes/two enzymes
    • Russell, D. W. and Wilson, J. D. (1994) Steroid 5α-reductase: two genes/two enzymes Annu. Rev. Biochem. 63, 25-61
    • (1994) Annu. Rev. Biochem. , vol.63 , pp. 25-61
    • Russell, D.W.1    Wilson, J.D.2
  • 19
    • 0035236795 scopus 로고    scopus 로고
    • Formation and effects of neuroactive steroids in the central and peripheral nervous system
    • Melcangi, R. C., Magnaghi, V., Galbiati, M., and Martini, L. (2001) Formation and effects of neuroactive steroids in the central and peripheral nervous system Int. Rev. Neurobiol. 46, 145-176
    • (2001) Int. Rev. Neurobiol. , vol.46 , pp. 145-176
    • Melcangi, R.C.1    Magnaghi, V.2    Galbiati, M.3    Martini, L.4
  • 20
    • 17644362707 scopus 로고    scopus 로고
    • Differential alterations in 5α-reductase type 1 and type 2 levels during development and progression of prostrate cancer
    • Thomas, L. N., Lazier, C. B., Gupta, R., Norman, R. W., Troyer, D. A., OBrien, S. P., and Rittmaster, R. S. (2005) Differential alterations in 5α-reductase type 1 and type 2 levels during development and progression of prostrate cancer Prostate 63, 231-239
    • (2005) Prostate , vol.63 , pp. 231-239
    • Thomas, L.N.1    Lazier, C.B.2    Gupta, R.3    Norman, R.W.4    Troyer, D.A.5    Obrien, S.P.6    Rittmaster, R.S.7
  • 24
    • 33846945701 scopus 로고    scopus 로고
    • Carbonyl reductases: The complex relationships of mammalian carbonyl- and quinone-reducing enzymes and their role in physiology
    • Oppermann, U. (2007) Carbonyl reductases: the complex relationships of mammalian carbonyl- and quinone-reducing enzymes and their role in physiology Annu. Rev. Pharmacol. Toxicol. 47, 293-322
    • (2007) Annu. Rev. Pharmacol. Toxicol. , vol.47 , pp. 293-322
    • Oppermann, U.1
  • 25
    • 33748588711 scopus 로고    scopus 로고
    • Fluorogenic metabolic probes for direct activity readout of redox enzymes: Selective measurement of human AKR1C2 in living cells
    • Yee, D. J., Balsanek, V., Bauman, D. R., Penning, T. M., and Sames, D. (2006) Fluorogenic metabolic probes for direct activity readout of redox enzymes: selective measurement of human AKR1C2 in living cells Proc. Natl. Acad. Sci. U.S.A. 103, 13304-13309
    • (2006) Proc. Natl. Acad. Sci. U.S.A. , vol.103 , pp. 13304-13309
    • Yee, D.J.1    Balsanek, V.2    Bauman, D.R.3    Penning, T.M.4    Sames, D.5
  • 26
    • 54849441238 scopus 로고    scopus 로고
    • Imaging induction of cytoprotective enzymes in intact human cells: Coumberone, a metabolic reporter for human AKR1C enzymes reveals activation by panaxytriol, an active component of red ginseng
    • Halim, M., Yee, D. J., and Sames, D. (2008) Imaging induction of cytoprotective enzymes in intact human cells: coumberone, a metabolic reporter for human AKR1C enzymes reveals activation by panaxytriol, an active component of red ginseng J. Am. Chem. Soc. 130, 14123-14128
    • (2008) J. Am. Chem. Soc. , vol.130 , pp. 14123-14128
    • Halim, M.1    Yee, D.J.2    Sames, D.3
  • 27
    • 0032726293 scopus 로고    scopus 로고
    • Real-time measurements of dark substrate catalysis
    • Xie, D., Suvorov, L., Erickson, J. W., and Gulnik, S. (1999) Real-time measurements of dark substrate catalysis Protein Sci. 8, 2460-2464
    • (1999) Protein Sci. , vol.8 , pp. 2460-2464
    • Xie, D.1    Suvorov, L.2    Erickson, J.W.3    Gulnik, S.4
  • 28
    • 34250294875 scopus 로고
    • Towards a method of determining the solubility of testosterone derivatives
    • Fedorova, E. A., Shashkina, L. F., and Fedorov, V. K. (1976) Towards a method of determining the solubility of testosterone derivatives Pharm. Chem. J. 10, 412-415
    • (1976) Pharm. Chem. J. , vol.10 , pp. 412-415
    • Fedorova, E.A.1    Shashkina, L.F.2    Fedorov, V.K.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.