Harnessing functional plasticity of enzymes: A fluorogenic probe for imaging 17β-HSD10 dehydrogenase, an enzyme involved in Alzheimer's and Parkinson's diseases

Journal of the American Chemical Society

Volumn 129, Issue 46, 2007, Pages 14518-14522

  Froemming, Mary K ^a   Sames, Dalibor ^a  

^a Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALZHEIMER'S DISEASES; METABOLIC ACTIVITIES; PARKINSON'S DISEASES; PROTEIN EXPRESSION;

BIOMARKERS; DISEASES; IMAGE ANALYSIS; METABOLISM; PEPTIDES; PLASTICITY;

ENZYMES;

17BETA HYDROXYSTEROID DEHYDROGENASE TYPE 10; AMYLOID BETA PROTEIN; FATTY ACID; ISOLEUCINE; STEROID; TESTOSTERONE 17BETA DEHYDROGENASE; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ARTICLE; CATABOLISM; CELL MEMBRANE PERMEABILITY; CONTROLLED STUDY; DOWN REGULATION; ENZYME SUBSTRATE; FATTY ACID OXIDATION; GLIA CELL; HUMAN; HUMAN CELL; NERVE CELL; NERVE CELL PLASTICITY; PARKINSON DISEASE; PROTEIN EXPRESSION; STRESS; UPREGULATION;

17-HYDROXYSTEROID DEHYDROGENASES; ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; CELL LINE; FLUORESCENT DYES; HUMANS; KIDNEY; KINETICS; MICROSCOPY, FLUORESCENCE; PARKINSON DISEASE; SPECTROMETRY, FLUORESCENCE; SUBSTRATE SPECIFICITY;

EID: 36448935316     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja072601x     Document Type: Article

References (21)

1. (a) Lawrence, D. S. Acc. Chem. Res. 2003, 36, 401-9.
2. (b) Baruch, A.; Jeffery, D. A.; Bogyo, M. Trends Cell Biol. 2004, 14, 29-35.
3. (c) Zhang, J.; Campbell, R. E.; Ting, A. Y.; Tsien, R. Y. Nat. Rev. Mol. Cell Biol. 2002, 3, 906-18.
4. (a) Chen, G.; Yee, D. J.; Gubernator, N. G.; Sames, D. J. Am. Chem. Soc. 2005, 127, 4544-5.
5. (b) Froemming, M. K.; Sames, D. Angew. Chem., Int. Ed. 2006, 45, 637-42.
6. (c) Yee, D. J.; Balsanek, V.; Bauman, D. R.; Penning, T. M.; Sames, D. Proc. Natl. Acad. Sci. U.S.A. 2006, 103, 13304-9.
7. (d) Halim, M.; Tremblay, M. S.; Jockusch, S.; Turro, N. J.; Sames, D. J. Am. Chem. Soc. 2007, 129, 7704-5.
8. Yang, S.-Y.; He, X.-Y.; Schulz, H. FEBS J. 2005, 272, 4874-83.
9. Ofman, R.; Ruiter, J. P.; Feenstra, M.; Duran, M.; Poll-The, B. T.; Zschocke, J.; Ensenauer, R.; Lehnert, W.; Sass, J. O.; Sperl, W.; Wanders, R. J. Am. J. Hum. Genet. 2003, 72, 1300-7.
10. (a) Yan, S. D.; Shi, Y.; Zhu, A.; Fu, J.; Zhu, H.; Zhu, Y.; Gibson, L.; Stern, E.; Collison, K.; Al-Mohanna, F.; Ogawa, S.; Roher, A.; Clarke, S. G.; Stern, D. M. J. Biol. Chem. 1999, 274, 2145-56.
11. (b) He, X.-Y.; Merz, G.; Mehta, P.; Schulz, H.; Yang, S. Y. J. Biol. Chem. 1999, 274, 15014-9.
12. (c) Shafqat, N.; Marschall, H. U.; Filling, C.; Nordling, E.; Wu, X. Q.; Björk, L.; Thyberg, J.; Mårtensson, E.; Salim, S.; Jörnvall, H.; Oppermann, U. Biochem. J. 2003, 376, 49-60.
13. Tieu, K.; Perier, C.; Vila, M.; Caspersen, C.; Zhang, H. P.; Teismann, P.; Jackson-Lewis, V.; Stern, D. M.; Yan, S. D.; Przedborski, S. Ann. Neurol. 2004, 56, 51-60.
14. Yan, S. D.; Zhu, Y.; Stern, E. D.; Hwang, Y. C.; Hori, O.; Ogawa, S.; Frosch, M. P.; Connolly, E. S., Jr.; McTaggert, R.; Pinsky, D. J.; Clarke, S.; Stern, D. M.; Ramasamy, R. J. Biol. Chem. 2000, 275, 27100-9.
15. Lustbader, J. W.; et al. Science 2004, 304, 448-52.
16. Yee, D. J.; Balsanek, V.; Sames, D. J. Am. Chem. Soc. 2004, 126, 2282-3 and references therein.
17. List, B.; Barbas, C. F., III; Lerner, R. A. Proc. Natl. Acad. Sci. U.S.A. 1998, 95, 15351-15355.
18. Bunker, C. E.; Bowen, T. L.; Sun, Y.-P. Photochem. Photobiol. 1993, 58, 499-505.
19. (a) Stryer, L. J. Mol. Biol. 1965, 13, 482-495.
20. (b) Cory, R. P.; Becker, R. R.; Rosenbluth, R.; Isenberg, I. J. Am. Chem. Soc. 1968, 90, 1643-1647.
21. Powell, A. J.; Read, J. A.; Banfield, M. J.; Gunn-Moore, F.; Yan, S. D.; Lustbader, J.; Stern, A. R.; Stern, D. M.; Brady, R. L. J. Mol. Biol. 2000, 303, 311-27.