Imaging induction of cytoprotective enzymes in intact human cells: Coumberone, a metabolic reporter for human AKR1C enzymes reveals activation by panaxytriol, an active component of red ginseng

Journal of the American Chemical Society

Volumn 130, Issue 43, 2008, Pages 14123-14128

  Halim, Marlin ^a   Yee, Dominic J ^a   Sames, Dalibor ^a  

^a Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL CULTURE; CATALYSTS; CELL CULTURE; CELLS; CHEMICAL ACTIVATION; ENZYMES; FLUORESCENCE MICROSCOPY; MICROSCOPIC EXAMINATION; PROTEINS; TRANSCRIPTION; TRANSCRIPTION FACTORS;

ACTIVE COMPONENTS; ALDO-KETO REDUCTASES; ANTICANCER PROPERTIES; ANTIOXIDANT RESPONSE ELEMENTS; CANCER.; CELL LINES; CELLULAR MECHANISMS; CELLULAR STRESSES; DYNAMIC RANGES; FLUORESCENCE MICROSCOPY IMAGING; FLUORIMETRIC ASSAYS; FLUOROGENIC PROBES; HEPG2 CELLS; HIGH SENSITIVITIES; HUMAN CELLS; HUMAN LIVERS; HUMAN NEUROBLASTOMA; IMAGING; INTACT CELLS; ISOFORM; METABOLIC CAPABILITIES; NATURAL PRODUCTS; NEURODEGENERATION; NEURODEGENERATIVE DISEASES; NEUROTROPHIC; OPTICAL METHODS; PANAXYTRIOL; PROTECTIVE EFFECTS; RED GINSENGS; SELECTIVE INHIBITORS; UPREGULATION;

CYTOLOGY;

AKR1C ENZYME; CELL MARKER; COUMBERONE; FLUORESCENT DYE; GINSENG EXTRACT; INDOMETACIN; NATURAL PRODUCT; NEUROTROPHIC FACTOR; OXIDOREDUCTASE; PANAXYTRIOL; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PROTEIN KINASE C; PROTEIN KINASE C INHIBITOR; SCABRONINE G METHYLESTER; SPIROTENUIPESINE A; SPIROTENUIPESINE B; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ANTIOXIDANT RESPONSIVE ELEMENT; ARTICLE; CARCINOGENESIS; CELL LINE; CELL METABOLISM; CELL PROTECTION; CELL STRAIN COS1; CELL STRAIN HEPG2; CELL STRAIN IMR32; CELL STRESS; CONTROLLED STUDY; DEGENERATIVE DISEASE; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME INDUCTION; ENZYME MECHANISM; ENZYME REGULATION; ENZYME SUBSTRATE; FLUORESCENCE MICROSCOPY; FLUOROMETRY; GINSENG; HUMAN; HUMAN CELL; MOLECULAR IMAGING; MOLECULAR PROBE; NEOPLASM; NEUROBLASTOMA CELL; NEUROPROTECTION; NONHUMAN; UPREGULATION;

3-HYDROXYSTEROID DEHYDROGENASES; ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CERCOPITHECUS AETHIOPS; COS CELLS; CYTOPROTECTION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; ENEDIYNES; ENZYME ACTIVATION; ENZYME INDUCTION; FATTY ALCOHOLS; FLUORESCENT DYES; HETEROCYCLIC COMPOUNDS WITH 4 OR MORE RINGS; HUMANS; HYDROXYPROSTAGLANDIN DEHYDROGENASES; HYDROXYSTEROID DEHYDROGENASES; INDOMETHACIN; MICROSCOPY, FLUORESCENCE; MODELS, BIOLOGICAL; MOLECULAR STRUCTURE; NERVE DEGENERATION; NEUROPROTECTIVE AGENTS; PANAX; SENSITIVITY AND SPECIFICITY; UP-REGULATION; URSODEOXYCHOLIC ACID;

EID: 54849441238     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja801245y     Document Type: Article

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