메뉴 건너뛰기




Volumn 9, Issue 1, 2005, Pages 62-68

Global strategies to integrate the proteome and metabolome

Author keywords

[No Author keywords available]

Indexed keywords

CONIFERYL ALCOHOL; COUMARIN; ETHANOLAMINE; KAEMPFEROL; PROTEOME; TAURINE;

EID: 13444249851     PISSN: 13675931     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cbpa.2004.12.004     Document Type: Review
Times cited : (84)

References (27)
  • 1
    • 0036007687 scopus 로고    scopus 로고
    • Metabolomics-the link between genotypes and phenotypes
    • O. Fiehn Metabolomics-the link between genotypes and phenotypes Plant Mol Biol 48 2002 155 171
    • (2002) Plant Mol Biol , vol.48 , pp. 155-171
    • Fiehn, O.1
  • 3
    • 0142138236 scopus 로고    scopus 로고
    • Metabonomics: NMR spectroscopy and pattern recognition analysis of body fluids and tissues for characterisation of xenobiotic toxicity and disease diagnosis
    • J.L. Griffin Metabonomics: NMR spectroscopy and pattern recognition analysis of body fluids and tissues for characterisation of xenobiotic toxicity and disease diagnosis Curr Opin Chem Biol 7 2003 648 654
    • (2003) Curr Opin Chem Biol , vol.7 , pp. 648-654
    • Griffin, J.L.1
  • 7
    • 0036468251 scopus 로고    scopus 로고
    • Metabolic changes detected by in vivo magnetic resonance studies of HEPA-1 wild-type tumors and tumors deficient in hypoxia-inducible factor-1beta (HIF-1beta): Evidence of an anabolic role for the HIF-1 pathway
    • J.R. Griffiths, P.M. McSheehy, S.P. Robinson, H. Troy, Y.L. Chung, R.D. Leek, K.J. Williams, I.J. Stratford, A.L. Harris, and M. Stubbs Metabolic changes detected by in vivo magnetic resonance studies of HEPA-1 wild-type tumors and tumors deficient in hypoxia-inducible factor-1beta (HIF-1beta): evidence of an anabolic role for the HIF-1 pathway Cancer Res 62 2002 688 695
    • (2002) Cancer Res , vol.62 , pp. 688-695
    • Griffiths, J.R.1    McSheehy, P.M.2    Robinson, S.P.3    Troy, H.4    Chung, Y.L.5    Leek, R.D.6    Williams, K.J.7    Stratford, I.J.8    Harris, A.L.9    Stubbs, M.10
  • 9
    • 0038699591 scopus 로고    scopus 로고
    • High-throughput classification of yeast mutants for functional genomics using metabolic footprinting
    • J. Allen, H.M. Davey, D. Broadhurst, J.K. Heald, J.J. Rowland, S.G. Oliver, and D.B. Kell High-throughput classification of yeast mutants for functional genomics using metabolic footprinting Nat Biotechnol 21 2003 692 696 This paper describes the use of direct-inject MS methods to rapidly profile global metabolic changes that accompany the deletion of specific enzymes in yeast. The authors show that enzymes can be classified into functional sub-groups on the basis of their shared metabolomic profiles, even though the metabolites under investigation remain unknown.
    • (2003) Nat Biotechnol , vol.21 , pp. 692-696
    • Allen, J.1    Davey, H.M.2    Broadhurst, D.3    Heald, J.K.4    Rowland, J.J.5    Oliver, S.G.6    Kell, D.B.7
  • 11
    • 3042823722 scopus 로고    scopus 로고
    • Metabolic profiles of cancer cells
    • J.L. Griffin, and J.P. Shockcor Metabolic profiles of cancer cells Nat Rev Cancer 4 2004 551 561 An excellent review highlighting both current metabolomic technologies and their biological applications, especially as relates to the comparative metabolite profiling of health and disease.
    • (2004) Nat Rev Cancer , vol.4 , pp. 551-561
    • Griffin, J.L.1    Shockcor, J.P.2
  • 12
    • 0002301232 scopus 로고    scopus 로고
    • Metabonomic applications in toxicity screening and disease diagnosis
    • J.P. Shockcor, and E. Holmes Metabonomic applications in toxicity screening and disease diagnosis Curr Top Med Chem 2 2002 35 51
    • (2002) Curr Top Med Chem , vol.2 , pp. 35-51
    • Shockcor, J.P.1    Holmes, E.2
  • 13
    • 0036810893 scopus 로고    scopus 로고
    • Toward the implementation of metabolomic assessments of human health and nutrition
    • S.M. Watkins, and J.B. German Toward the implementation of metabolomic assessments of human health and nutrition Curr Opin Biotechnol 13 2002 512 516
    • (2002) Curr Opin Biotechnol , vol.13 , pp. 512-516
    • Watkins, S.M.1    German, J.B.2
  • 16
    • 0034944377 scopus 로고    scopus 로고
    • Visualization of biochemical networks in living cells
    • I. Remy, and S.W. Michnick Visualization of biochemical networks in living cells Proc Natl Acad Sci USA 98 2001 7678 7683
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 7678-7683
    • Remy, I.1    Michnick, S.W.2
  • 17
    • 0033604499 scopus 로고    scopus 로고
    • Active site-directed protein regulation
    • B. Kobe, and B.E. Kemp Active site-directed protein regulation Nature 402 1999 373 376
    • (1999) Nature , vol.402 , pp. 373-376
    • Kobe, B.1    Kemp, B.E.2
  • 18
    • 13444301492 scopus 로고    scopus 로고
    • Molecular phenotyping of the pal1 and pal2 mutants of Arabidopsis thaliana reveals far-reaching consequences on phenylpropanoid, amino acid, and carbohydrate metabolism
    • A. Rohde, K. Morreel, J. Ralph, G. Goeminne, V. Hostyn, R. De Rycke, S. Kushnir, J. Van Doorsselaere, J.P. Joseleau, and M. Vuylsteke Molecular phenotyping of the pal1 and pal2 mutants of Arabidopsis thaliana reveals far-reaching consequences on phenylpropanoid, amino acid, and carbohydrate metabolism Plant Cell 16 2004 2749 2771 This paper describes the use of targeted metabolite profiling to identify both the primary and secondary metabolic changes that result from inactivation of specific phenylalanine ammmonia lyase (PAL) enzymes in plants. The authors illustrate the ability of metabolomic approaches to distinguish the specific functions of different PAL enzymes and to identify novel phenolic metabolites regulated by PAL enzymes in vivo.
    • (2004) Plant Cell , vol.16 , pp. 2749-2771
    • Rohde, A.1    Morreel, K.2    Ralph, J.3    Goeminne, G.4    Hostyn, V.5    De Rycke, R.6    Kushnir, S.7    Van Doorsselaere, J.8    Joseleau, J.P.9    Vuylsteke, M.10
  • 19
    • 85047690932 scopus 로고    scopus 로고
    • ENU mutagenesis identifies mice with mitochondrial branched-chain aminotransferase deficiency resembling human maple syrup urine disease
    • J.Y. Wu, H.J. Kao, S.C. Li, R. Stevens, S. Hillman, D. Millington, and Y.T. Chen ENU mutagenesis identifies mice with mitochondrial branched-chain aminotransferase deficiency resembling human maple syrup urine disease J Clin Invest 113 2004 434 440 This paper describes the use of targeted metabolite profiling to characterize defects in amino acid metabolism in ENU-mutagenized mice. A mutant mouse strain was identified that possessed elevated plasma levels of branched-chain amino acids, a metabolic defect that was determined to result from mutation of the mitochondrial branched chain aminotransferase enzyme.
    • (2004) J Clin Invest , vol.113 , pp. 434-440
    • Wu, J.Y.1    Kao, H.J.2    Li, S.C.3    Stevens, R.4    Hillman, S.5    Millington, D.6    Chen, Y.T.7
  • 20
    • 0027523237 scopus 로고
    • Identification of the mitochondrial branched chain aminotransferase as a branched chain alpha-keto acid transport protein
    • S.M. Hutson, and T.R. Hall Identification of the mitochondrial branched chain aminotransferase as a branched chain alpha-keto acid transport protein J Biol Chem 268 1993 3084 3091
    • (1993) J Biol Chem , vol.268 , pp. 3084-3091
    • Hutson, S.M.1    Hall, T.R.2
  • 21
    • 8544253237 scopus 로고    scopus 로고
    • Assignment of endogenous substrates to enzymes by global metabolite profiling
    • A. Saghatelian, S.A. Trauger, E.J. Want, E.G. Hawkins, G. Siuzdak, and B.F. Cravatt Assignment of endogenous substrates to enzymes by global metabolite profiling Biochemistry 43 2004 14332 14339 This paper describes the development of an untargeted LC-MS profiling method to globally characterize the metabolic consequences of enzyme inactivation in vivo. This discovery metabolite profiling (DMP) method was used to comparatively characterize brain metabolomes of wild type mice and mice lacking the fatty acid amide hydrolase (FAAH) enzyme. Numerous endogenous substrates of FAAH were identified, including a structurally novel class of nervous system-enriched natural products (the N-acyl taurines).
    • (2004) Biochemistry , vol.43 , pp. 14332-14339
    • Saghatelian, A.1    Trauger, S.A.2    Want, E.J.3    Hawkins, E.G.4    Siuzdak, G.5    Cravatt, B.F.6
  • 24
    • 0038545287 scopus 로고    scopus 로고
    • Increased seizure susceptibility and proconvulsant activity of anandamide in mice lacking fatty acid amide hydrolase
    • A.B. Clement, E.G. Hawkins, A.H. Lichtman, and B.F. Cravatt Increased seizure susceptibility and proconvulsant activity of anandamide in mice lacking fatty acid amide hydrolase J Neurosci 23 2003 3916 3923
    • (2003) J Neurosci , vol.23 , pp. 3916-3923
    • Clement, A.B.1    Hawkins, E.G.2    Lichtman, A.H.3    Cravatt, B.F.4
  • 26
    • 1842579937 scopus 로고    scopus 로고
    • A role for ligand-gated ion channels in rod photoreceptor development
    • T.L. Young, and C.L. Cepko A role for ligand-gated ion channels in rod photoreceptor development Neuron 41 2004 867 879
    • (2004) Neuron , vol.41 , pp. 867-879
    • Young, T.L.1    Cepko, C.L.2
  • 27
    • 1042287130 scopus 로고    scopus 로고
    • The development and application of methods for activity-based protein profiling
    • N. Jessani, and B.F. Cravatt The development and application of methods for activity-based protein profiling Curr Opin Chem Biol 8 2004 54 59
    • (2004) Curr Opin Chem Biol , vol.8 , pp. 54-59
    • Jessani, N.1    Cravatt, B.F.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.