Two independent histidines, one in human prolactin and one in its receptor, are critical for pH-dependent receptor recognition and activation

Journal of Biological Chemistry

Volumn 285, Issue 49, 2010, Pages 38524-38533

  Kulkarni, Mandar V ^a   Tettamanzi, M Cristina ^a   Murphy, James W ^a   Keeler, Camille ^a   Myszka, David G ^b   Chayen, Naomi E ^c   Lolis, Elias J ^a   Hodsdon, Michael E ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^c IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CRYSTALLOGRAPHIC STRUCTURE; CYTOKINES; GROWTH FACTOR; HIGH-RESOLUTION STRUCTURES; INTERMOLECULAR INTERFACES; MOLECULAR ORIGINS; PH DEPENDENCE; PH-DEPENDENT; PROTONATION CONSTANTS; RECEPTOR BINDING; RECEPTOR BINDING INTERFACE; SITE-SPECIFIC; SOLUTION ACIDITY; THERMODYNAMIC MODELING;

ACIDITY; AMINO ACIDS; BINDING ENERGY; PROTONATION;

COMPLEXATION;

ALANINE; HISTIDINE; JANUS KINASE 2; PROLACTIN; PROLACTIN RECEPTOR; STAT5 PROTEIN;

ARTICLE; BINDING AFFINITY; BINDING KINETICS; COMPLEX FORMATION; CONTROLLED STUDY; CRYSTAL STRUCTURE; HUMAN; HUMAN CELL; PH; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN STRUCTURE; PROTON TRANSPORT; RECEPTOR BINDING; SURFACE PLASMON RESONANCE; X RAY CRYSTALLOGRAPHY;

CELL LINE, TUMOR; HISTIDINE; HUMANS; HYDROGEN-ION CONCENTRATION; KINETICS; MODELS, MOLECULAR; PROLACTIN; PROTEIN BINDING; PROTEIN STRUCTURE, QUATERNARY; RECEPTORS, PROLACTIN; THERMODYNAMICS;

EID: 78649658935     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.172072     Document Type: Article

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