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Volumn 5, Issue 10, 1998, Pages

Scratching the (cell) surface: Cytokine engineering for improved ligand/receptor trafficking dynamics

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EID: 0032193334     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-5521(98)90110-7     Document Type: Review
Times cited : (35)

References (58)
  • 1
    • 0012483730 scopus 로고
    • Media for cultivation of animal cells: An overview
    • Mizrahi, A. & Lazar, A. (1988). Media for cultivation of animal cells: an overview. Cytotechnology 1, 199-214.
    • (1988) Cytotechnology , vol.1 , pp. 199-214
    • Mizrahi, A.1    Lazar, A.2
  • 2
    • 84952939917 scopus 로고
    • Media for cell culture
    • G. Stephanopoulos, ed., VCH Publishers, New York
    • Wolfe, R.W. (1993). Media for cell culture. In Biotechnology, Vol. 3. (G. Stephanopoulos, ed.), pp. 141-156, VCH Publishers, New York.
    • (1993) Biotechnology , vol.3 , pp. 141-156
    • Wolfe, R.W.1
  • 3
    • 0007494238 scopus 로고    scopus 로고
    • Cellular determinants affecting the rate of cytokine depletion in cultures of human hematopoietic cells
    • Zandstra, P.W., Petzer, A.L., Eaves, C.J. & Piret, J.M. (1997). Cellular determinants affecting the rate of cytokine depletion in cultures of human hematopoietic cells. Biotech. Bioeng. 12, 909-914.
    • (1997) Biotech. Bioeng. , vol.12 , pp. 909-914
    • Zandstra, P.W.1    Petzer, A.L.2    Eaves, C.J.3    Piret, J.M.4
  • 4
    • 0030753482 scopus 로고    scopus 로고
    • Polypeptide growth factors: Targeted delivery systems
    • Nimmi, M.E. (1997). Polypeptide growth factors: targeted delivery systems. Biomaterials 18, 1201-1225.
    • (1997) Biomaterials , vol.18 , pp. 1201-1225
    • Nimmi, M.E.1
  • 5
    • 0028912032 scopus 로고
    • Increases in CD4 T lymphocytes with intermittent courses of interleukin-2 in patients with human immunodeficiency virus infection: A preliminary study
    • Kovacs, J.A., et al., & Lane, H.C. (1995). Increases in CD4 T lymphocytes with intermittent courses of interleukin-2 in patients with human immunodeficiency virus infection: a preliminary study. N. Engl. J. Med. 332, 567-575.
    • (1995) N. Engl. J. Med. , vol.332 , pp. 567-575
    • Kovacs, J.A.1    Lane, H.C.2
  • 6
    • 0029811148 scopus 로고    scopus 로고
    • Rational interleukin 2 therapy for HIV positive individuals: Daily low doses enhance immune function without toxicity
    • Jacobson, E.L., Pilaro, F. & Smith, K.A. (1996). Rational interleukin 2 therapy for HIV positive individuals: daily low doses enhance immune function without toxicity. Proc. Natl Acad. Sci. USA 93, 10405-10410.
    • (1996) Proc. Natl Acad. Sci. USA , vol.93 , pp. 10405-10410
    • Jacobson, E.L.1    Pilaro, F.2    Smith, K.A.3
  • 7
    • 13144295030 scopus 로고    scopus 로고
    • Engineered mutants of HGF/SF with reduced binding to heparan sulphate proteoglycans, decreased clearance and enhanced activity in vivo
    • Hartmann, G., et al., & Gherardi, E. (1997). Engineered mutants of HGF/SF with reduced binding to heparan sulphate proteoglycans, decreased clearance and enhanced activity in vivo. Curr. Biol. 8, 125-134.
    • (1997) Curr. Biol. , vol.8 , pp. 125-134
    • Hartmann, G.1    Gherardi, E.2
  • 8
    • 0027253357 scopus 로고
    • The conjugation of proteins with polyethylene glycol and other polymers: Altering properties of proteins to enhance their therapeutic potential
    • Katre, N.V. (1993). The conjugation of proteins with polyethylene glycol and other polymers: altering properties of proteins to enhance their therapeutic potential. Adv. Drug Delivery Rev. 10, 91-114.
    • (1993) Adv. Drug Delivery Rev. , vol.10 , pp. 91-114
    • Katre, N.V.1
  • 9
    • 0001354575 scopus 로고
    • Glomerular filtration
    • B.M. Brenner & F.C. Rector, eds, W.B. Saunders Co., Philadelphia
    • Brenner, B.M., Ichikawa, I. & Deen, W.M. (1981). Glomerular filtration. In The Kidney, Vol. 1. (B.M. Brenner & F.C. Rector, eds), pp. 289-327, W.B. Saunders Co., Philadelphia.
    • (1981) The Kidney , vol.1 , pp. 289-327
    • Brenner, B.M.1    Ichikawa, I.2    Deen, W.M.3
  • 10
    • 0027333415 scopus 로고
    • Signal-dependent membrane protein trafficking in the endocytic pathway
    • Trowbridge, I.S., Collawn, J.F. & Hopkins, C.R. (1993). Signal-dependent membrane protein trafficking in the endocytic pathway. Annu. Rev. Cell Biol. 9, 129-161.
    • (1993) Annu. Rev. Cell Biol. , vol.9 , pp. 129-161
    • Trowbridge, I.S.1    Collawn, J.F.2    Hopkins, C.R.3
  • 11
    • 0029752791 scopus 로고    scopus 로고
    • Endocytosis and molecular sorting
    • Mellman, I. (1996). Endocytosis and molecular sorting. Annu. Rev. Cell Dev. Biol. 12, 575-625.
    • (1996) Annu. Rev. Cell Dev. Biol. , vol.12 , pp. 575-625
    • Mellman, I.1
  • 12
    • 0025160570 scopus 로고
    • Quantitative analysis of the endocytic system involved in hormone-induced receptor internalization
    • Lund, K.A., Opresko, L.K., Starbuck, C., Walsh, B.J. & Wiley, H.S. (1990). Quantitative analysis of the endocytic system involved in hormone-induced receptor internalization. J. Biol. Chem. 265, 15713-15723.
    • (1990) J. Biol. Chem. , vol.265 , pp. 15713-15723
    • Lund, K.A.1    Opresko, L.K.2    Starbuck, C.3    Walsh, B.J.4    Wiley, H.S.5
  • 13
    • 0028104202 scopus 로고
    • Regulation of signal transduction and signal diversity by receptor oligimerization
    • Lemmon, M.A. & Schlessinger, J. (1994). Regulation of signal transduction and signal diversity by receptor oligimerization. Trends Biochem. Sci. 19, 459-463.
    • (1994) Trends Biochem. Sci. , vol.19 , pp. 459-463
    • Lemmon, M.A.1    Schlessinger, J.2
  • 14
    • 0028170817 scopus 로고
    • Receptor protein-tyrosine kinases and their signal transduction pathways
    • Van der Geer, P., Hunter, T. & Lindberg, R.A. (1994). Receptor protein-tyrosine kinases and their signal transduction pathways. Annu. Rev. Cell Biol. 10, 251-337.
    • (1994) Annu. Rev. Cell Biol. , vol.10 , pp. 251-337
    • Van Der Geer, P.1    Hunter, T.2    Lindberg, R.A.3
  • 15
    • 0027157416 scopus 로고
    • The functional importance of hydrophobicity of the tyrosine at position 13 of human epidermal growth factor in receptor binding
    • Tadaki, D.K. & Niyogi, S.K. (1993). The functional importance of hydrophobicity of the tyrosine at position 13 of human epidermal growth factor in receptor binding. J. Biol. Chem. 268, 10114-10119.
    • (1993) J. Biol. Chem. , vol.268 , pp. 10114-10119
    • Tadaki, D.K.1    Niyogi, S.K.2
  • 17
    • 0028969961 scopus 로고
    • Intracellular trafficking of epidermal growth factor family ligands is directly influenced by the pH sensitivity of the receptor/ligand interaction
    • French, A.R., Tadaki, D.K., Niyogi, S.K. & Lauffenburger, D.A. (1995). Intracellular trafficking of epidermal growth factor family ligands is directly influenced by the pH sensitivity of the receptor/ligand interaction. J. Biol. Chem. 270, 4334-4340.
    • (1995) J. Biol. Chem. , vol.270 , pp. 4334-4340
    • French, A.R.1    Tadaki, D.K.2    Niyogi, S.K.3    Lauffenburger, D.A.4
  • 19
    • 0023677140 scopus 로고
    • Anomalous binding of epidermal growth factor to A431 cells is due to the effect of high receptor densities and a saturable endocytic system
    • Wiley, H.S. (1988). Anomalous binding of epidermal growth factor to A431 cells is due to the effect of high receptor densities and a saturable endocytic system. J. Cell Biol. 107, 801-810.
    • (1988) J. Cell Biol. , vol.107 , pp. 801-810
    • Wiley, H.S.1
  • 20
    • 0028335378 scopus 로고
    • Regulation of postendocytic trafficking of the epidermal growth factor receptor through endosomal retention
    • Herbst, J.J., Opresko, L.K., Walsh, B.J., Lauffenburger, D.A. & Wiley, H.S. (1994). Regulation of postendocytic trafficking of the epidermal growth factor receptor through endosomal retention. J. Biol. Chem. 269, 12865-12873.
    • (1994) J. Biol. Chem. , vol.269 , pp. 12865-12873
    • Herbst, J.J.1    Opresko, L.K.2    Walsh, B.J.3    Lauffenburger, D.A.4    Wiley, H.S.5
  • 21
    • 0028224965 scopus 로고
    • Postendocytic trafficking of epidermal growth factor-receptor complexes is mediated through saturable and specific endosomal interactions
    • French, A.R., Sudlow, G.P., Wiley, H.S. & Lauffenburger, D.A. (1994). Postendocytic trafficking of epidermal growth factor-receptor complexes is mediated through saturable and specific endosomal interactions. J. Biol. Chem. 269, 15749-15755.
    • (1994) J. Biol. Chem. , vol.269 , pp. 15749-15755
    • French, A.R.1    Sudlow, G.P.2    Wiley, H.S.3    Lauffenburger, D.A.4
  • 22
    • 0029762883 scopus 로고    scopus 로고
    • Enhanced degradation of EGF receptors by a sorting nexin, SNX1
    • Kurten, R.C., Cadena, D.L. & Gill, G.N. (1996). Enhanced degradation of EGF receptors by a sorting nexin, SNX1. Science 272, 1008-1010.
    • (1996) Science , vol.272 , pp. 1008-1010
    • Kurten, R.C.1    Cadena, D.L.2    Gill, G.N.3
  • 23
    • 14844349947 scopus 로고
    • Epidermal growth factor and transforming growth factor-α: Differential intracellular routing and processing of ligand-receptor complexes
    • Ebner, R. & Derynck, R. (1991). Epidermal growth factor and transforming growth factor-α: differential intracellular routing and processing of ligand-receptor complexes. Cell Regulation 2, 599-612.
    • (1991) Cell Regulation , vol.2 , pp. 599-612
    • Ebner, R.1    Derynck, R.2
  • 24
    • 0029976245 scopus 로고    scopus 로고
    • Receptor-mediated effects on ligand availability influence relative mitogenic potencies of epidermal growth factor and transforming growth factor a
    • Reddy, C.C., Wells, A. & Lauffenburger, D.A. (1996). Receptor-mediated effects on ligand availability influence relative mitogenic potencies of epidermal growth factor and transforming growth factor a. J. Cell. Phys. 166, 512-522.
    • (1996) J. Cell. Phys. , vol.166 , pp. 512-522
    • Reddy, C.C.1    Wells, A.2    Lauffenburger, D.A.3
  • 26
    • 0027203952 scopus 로고
    • Ligand-induced internalization of the epidermal growth factor receptor is mediated by multiple endocytic codes analogous to the tyrosine motif found in constitutively internalized receptors
    • Chang, C., et al., & Gill, G.N. (1993). Ligand-induced internalization of the epidermal growth factor receptor is mediated by multiple endocytic codes analogous to the tyrosine motif found in constitutively internalized receptors. J. Biol. Chem. 268, 19312-19320.
    • (1993) J. Biol. Chem. , vol.268 , pp. 19312-19320
    • Chang, C.1    Gill, G.N.2
  • 27
    • 0032526729 scopus 로고    scopus 로고
    • Differential endocytic routing of homo- and heterodimeric ErbB tyrosine kinases confers signaling superiority to receptor heterodimers
    • Lenferink, A.E.G., et al., & Yarden, Y. (1998). Differential endocytic routing of homo- and heterodimeric ErbB tyrosine kinases confers signaling superiority to receptor heterodimers. EMBO J. 17, 3385-3397.
    • (1998) EMBO J. , vol.17 , pp. 3385-3397
    • Lenferink, A.E.G.1    Yarden, Y.2
  • 29
    • 0030968648 scopus 로고    scopus 로고
    • Structural aspects of the epidermal growth factor receptor required for transmodulation of erbB-2/neu
    • Worthylake, R. & Wiley, S.H. (1997). Structural aspects of the epidermal growth factor receptor required for transmodulation of erbB-2/neu. J. Biol. Chem. 272, 8594-8601.
    • (1997) J. Biol. Chem. , vol.272 , pp. 8594-8601
    • Worthylake, R.1    Wiley, S.H.2
  • 30
    • 0026833077 scopus 로고
    • Mathematical model for the effects of epidermal growth factor receptor trafficking dynamics on fibroblast proliferation responses
    • Starbuck, C. & Lauffenburger, D.A. (1992). Mathematical model for the effects of epidermal growth factor receptor trafficking dynamics on fibroblast proliferation responses. Biotech. Progr. 8, 132-143.
    • (1992) Biotech. Progr. , vol.8 , pp. 132-143
    • Starbuck, C.1    Lauffenburger, D.A.2
  • 31
    • 0030570842 scopus 로고    scopus 로고
    • Intracellular receptor/ligand sorting based on endosomal retention components
    • French, A.R. & Lauffenburger, D.A. (1996). Intracellular receptor/ligand sorting based on endosomal retention components. Biotech. Bioeng. 51, 281-297.
    • (1996) Biotech. Bioeng. , vol.51 , pp. 281-297
    • French, A.R.1    Lauffenburger, D.A.2
  • 32
    • 0032556454 scopus 로고    scopus 로고
    • Analysis of receptor internalization as a mechanism for modulating signal transduction
    • in press
    • Haugh, J.M. & Lauffenburger, D.A. (1998). Analysis of receptor internalization as a mechanism for modulating signal transduction. J. Theor. Biol., in press.
    • (1998) J. Theor. Biol.
    • Haugh, J.M.1    Lauffenburger, D.A.2
  • 33
    • 0028084891 scopus 로고
    • Cell movement elicited by epidermal growth factor receptor requires kinase and autophosphorylation but is separable from mitogenesis
    • Chen, P., Gupta, K. & Wells, A. (1994). Cell movement elicited by epidermal growth factor receptor requires kinase and autophosphorylation but is separable from mitogenesis. J. Cell Biol. 124, 547-555.
    • (1994) J. Cell Biol. , vol.124 , pp. 547-555
    • Chen, P.1    Gupta, K.2    Wells, A.3
  • 34
    • 0028089832 scopus 로고
    • Epidermal growth factor receptor-mediated cell motility: Phospholipase C activity is required, but mitogen-activated protein kinase activity is not sufficient for induced cell movement
    • Chen, P., Xie, H., Sekar, M.C, Gupta, K. & Wells, A. (1994). Epidermal growth factor receptor-mediated cell motility: phospholipase C activity is required, but mitogen-activated protein kinase activity is not sufficient for induced cell movement. J. Cell Biol. 127, 847-857.
    • (1994) J. Cell Biol. , vol.127 , pp. 847-857
    • Chen, P.1    Xie, H.2    Sekar, M.C.3    Gupta, K.4    Wells, A.5
  • 36
    • 0026763387 scopus 로고
    • Unraveling the structure of IL-2
    • Bazan, J.F. (1992). Unraveling the structure of IL-2. Science 257, 410-412.
    • (1992) Science , vol.257 , pp. 410-412
    • Bazan, J.F.1
  • 37
    • 0018174365 scopus 로고
    • T-cell growth factor: Parameters of production and a quantitative microassay for activity
    • Gillis, S., Ferm, M.M., Ou, W. & Smith, K.A. (1978). T-cell growth factor: parameters of production and a quantitative microassay for activity. J. Immunol. 121, 2027-2032.
    • (1978) J. Immunol. , vol.121 , pp. 2027-2032
    • Gillis, S.1    Ferm, M.M.2    Ou, W.3    Smith, K.A.4
  • 38
    • 0023907493 scopus 로고
    • Interleukin-2: Inception, impact and implications
    • Smith, K.A. (1988). Interleukin-2: inception, impact and implications. Science 240, 1169-1176.
    • (1988) Science , vol.240 , pp. 1169-1176
    • Smith, K.A.1
  • 39
    • 0019448114 scopus 로고
    • Interleukin-2 augments natural killer cell activity
    • Henny, C.S., Kuribayashi, K., Kern, D.R. & Gillis, S. (1981). Interleukin-2 augments natural killer cell activity. Nature 291, 335-338.
    • (1981) Nature , vol.291 , pp. 335-338
    • Henny, C.S.1    Kuribayashi, K.2    Kern, D.R.3    Gillis, S.4
  • 40
    • 0026441413 scopus 로고
    • Clinical applications of cytokines for immunostimulation and immunosuppression
    • Lee, B. & Ciardelli, T.L. (1992). Clinical applications of cytokines for immunostimulation and immunosuppression. Prog. Drug Res. 39, 167-197.
    • (1992) Prog. Drug Res. , vol.39 , pp. 167-197
    • Lee, B.1    Ciardelli, T.L.2
  • 41
    • 0021680251 scopus 로고
    • Detection and functional studies of -60-65 (Tac antigen) on activated human B cells
    • Jung, L.K.L., Hara, R. & Fu, S.M. (1984). Detection and functional studies of -60-65 (Tac antigen) on activated human B cells. J. Exp. Med. 160, 1597-1602.
    • (1984) J. Exp. Med. , vol.160 , pp. 1597-1602
    • Jung, L.K.L.1    Hara, R.2    Fu, S.M.3
  • 43
    • 0028021879 scopus 로고
    • Interleukin-2 and the interleukin-2 receptor complex
    • Gaulton, G.N. & Williamson, P. (1994). Interleukin-2 and the interleukin-2 receptor complex. Chem. Immunol. 59, 91-114.
    • (1994) Chem. Immunol. , vol.59 , pp. 91-114
    • Gaulton, G.N.1    Williamson, P.2
  • 44
    • 0024836051 scopus 로고
    • A restricted cytoplasmic region of IL-2 receptor β chain is essential for growth signal transduction but not for ligand binding and internalization
    • Hatekeyama, M., Mori, H., Doi, T. & Taniguchi, T. (1989). A restricted cytoplasmic region of IL-2 receptor β chain is essential for growth signal transduction but not for ligand binding and internalization. Cell 59, 837-845.
    • (1989) Cell , vol.59 , pp. 837-845
    • Hatekeyama, M.1    Mori, H.2    Doi, T.3    Taniguchi, T.4
  • 45
    • 0026092535 scopus 로고
    • Modulation of interleukin 2 internalization and interleukin 2-dependent cell growth by antireceptor antibodies
    • Duprez, V., Ferrer, M., Cornet, V., Olive, D. & Dautry-Varsat, A. (1991). Modulation of interleukin 2 internalization and interleukin 2-dependent cell growth by antireceptor antibodies. J. Biol. Chem. 266, 1497-1501.
    • (1991) J. Biol. Chem. , vol.266 , pp. 1497-1501
    • Duprez, V.1    Ferrer, M.2    Cornet, V.3    Olive, D.4    Dautry-Varsat, A.5
  • 46
    • 0027238222 scopus 로고
    • Reconstitution of functional interleukin 2 receptor complexes on fibroblastoid cells: Involvement of the cytoplasmic domain of the γ chain in two distinct signaling pathways
    • Asao, H., Takeshita, T., Ishii, N., Kumaki, S., Nakamura, M. & Sugamura, K. (1993). Reconstitution of functional interleukin 2 receptor complexes on fibroblastoid cells: involvement of the cytoplasmic domain of the γ chain in two distinct signaling pathways. Proc. Natl Acad. Sci. USA 90, 4127-4131.
    • (1993) Proc. Natl Acad. Sci. USA , vol.90 , pp. 4127-4131
    • Asao, H.1    Takeshita, T.2    Ishii, N.3    Kumaki, S.4    Nakamura, M.5    Sugamura, K.6
  • 47
    • 0029081380 scopus 로고
    • Identification of a variable region within the cytoplasmic tail of the IL-2 receptor β chain that is required for growth signal transduction
    • Liu, K.D., Lai, S.Y., Goldsmith, M.A. & Greene, W.C. (1995). Identification of a variable region within the cytoplasmic tail of the IL-2 receptor β chain that is required for growth signal transduction. J. Biol. Chem. 270, 22176-22181.
    • (1995) J. Biol. Chem. , vol.270 , pp. 22176-22181
    • Liu, K.D.1    Lai, S.Y.2    Goldsmith, M.A.3    Greene, W.C.4
  • 48
    • 0029054455 scopus 로고
    • Three distinct IL-2 signaling pathways mediated by bcl-2, c-myc, and lck cooperate in hematopoietic cell proliferation
    • Miyazaki, T., et al., & Taniguchi, T. (1995). Three distinct IL-2 signaling pathways mediated by bcl-2, c-myc, and lck cooperate in hematopoietic cell proliferation. Cell 81, 223-231.
    • (1995) Cell , vol.81 , pp. 223-231
    • Miyazaki, T.1    Taniguchi, T.2
  • 51
    • 0022591978 scopus 로고
    • High-affinity receptor-mediated internalization and degradation of interleukin-2 in human T cells
    • Fujii, M., Sugamura, K., Sano, K., Nakai, M., Sugita, K. & Hinuma, Y. (1986). High-affinity receptor-mediated internalization and degradation of interleukin-2 in human T cells. J. Exp. Med. 163, 550-562.
    • (1986) J. Exp. Med. , vol.163 , pp. 550-562
    • Fujii, M.1    Sugamura, K.2    Sano, K.3    Nakai, M.4    Sugita, K.5    Hinuma, Y.6
  • 52
    • 0023499734 scopus 로고
    • Analysis of dynamics and functions of high-affinity interleukin-2 receptors
    • Gullberg, M. (1987), Analysis of dynamics and functions of high-affinity interleukin-2 receptors. Mol. Immunol. 24, 1365-1371.
    • (1987) Mol. Immunol. , vol.24 , pp. 1365-1371
    • Gullberg, M.1
  • 53
    • 0023217606 scopus 로고
    • Internalization of interleukin-2 is mediated by the β chain of the high affinity interleukin-2 receptor
    • Robb, R.J. & Greene, W.C. (1987). Internalization of interleukin-2 is mediated by the β chain of the high affinity interleukin-2 receptor. J. Exp. Med. 165, 1201-1206.
    • (1987) J. Exp. Med. , vol.165 , pp. 1201-1206
    • Robb, R.J.1    Greene, W.C.2
  • 54
    • 0028341239 scopus 로고
    • Trafficking of interleukin 2 and transferrin in endosomal fractions of T lymphocytes
    • Duprez, V., Smoljanovic, M., Lieb, M. & Dautry-Varsat, A. (1994). Trafficking of interleukin 2 and transferrin in endosomal fractions of T lymphocytes. J. Cell Sci. 107, 1289-1295.
    • (1994) J. Cell Sci. , vol.107 , pp. 1289-1295
    • Duprez, V.1    Smoljanovic, M.2    Lieb, M.3    Dautry-Varsat, A.4
  • 55
    • 0028913166 scopus 로고
    • Endocytosis of interleukin 2 receptors in human T lymphocytes: Distinct intracellular localization and fate of the receptor α, β, and γ chains
    • Hemar, A., Subtil, A., Lieb, M., Morelon, E., Hellio, R. & Dautry-Varsat, A. (1995). Endocytosis of interleukin 2 receptors in human T lymphocytes: distinct intracellular localization and fate of the receptor α, β, and γ chains. J. Cell Biol. 129, 55-64.
    • (1995) J. Cell Biol. , vol.129 , pp. 55-64
    • Hemar, A.1    Subtil, A.2    Lieb, M.3    Morelon, E.4    Hellio, R.5    Dautry-Varsat, A.6
  • 56
    • 0028339220 scopus 로고
    • Mutagenic analysis of a receptor contact site on interleukin-2: Preparation of an IL-2 analog with increased potency
    • Berndt, W.G., Chang, D.Z., Smith, K.A. & Ciardelli, T.L. (1994). Mutagenic analysis of a receptor contact site on interleukin-2: preparation of an IL-2 analog with increased potency. Biochemistry 33, 6571-6577.
    • (1994) Biochemistry , vol.33 , pp. 6571-6577
    • Berndt, W.G.1    Chang, D.Z.2    Smith, K.A.3    Ciardelli, T.L.4
  • 57
    • 0028817666 scopus 로고
    • Structural analogs of interleukin-2: A point mutation that facilitates biological response
    • Chang, D.Z., Tasayco, M.L. & Ciardelli, T.L. (1995). Structural analogs of interleukin-2: a point mutation that facilitates biological response. Mol. Pharm. 47, 206-211.
    • (1995) Mol. Pharm. , vol.47 , pp. 206-211
    • Chang, D.Z.1    Tasayco, M.L.2    Ciardelli, T.L.3
  • 58
    • 0029886354 scopus 로고    scopus 로고
    • A point mutation in interleukin-2 that alters ligand internalization
    • Chang, D.Z., Wu, Z. & Ciardelli, T.L. (1996). A point mutation in interleukin-2 that alters ligand internalization. J. Biol. Chem. 271, 13349-13355.
    • (1996) J. Biol. Chem. , vol.271 , pp. 13349-13355
    • Chang, D.Z.1    Wu, Z.2    Ciardelli, T.L.3


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