Crystal structure of a prolactin receptor antagonist bound to the extracellular domain of the prolactin receptor

Journal of Biological Chemistry

Volumn 283, Issue 27, 2008, Pages 19085-19094

  Svensson, L Anders ^a   Bondensgaard, Kent ^a   Nørskov Lauritsen, Leif ^a   Christensen, Leif ^a   Becker, Peter ^a   Andersen, Mette D ^a   Maltesen, Morten J ^a,b   Rand, Kasper D ^a,c   Breinholt, Jens ^a  

^a NOVO NORDISK A S   (Denmark)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

^c UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING ENERGY; BINDING SITES; CRYSTALLOGRAPHY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROGEN; MASS SPECTROMETERS; MASS SPECTROMETRY; NUCLEAR MAGNETIC RESONANCE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PORT TERMINALS; SPECTROMETERS; SPECTROMETRY; SPECTRUM ANALYSIS; X RAY CRYSTALLOGRAPHY;

BINDING INTERFACES; COGNATE RECEPTORS; ENGLAND; EXTRACELLULAR DOMAINS; HELIX BUNDLES; HYDROGEN EXCHANGES; MASS SPECTROMETRY DATUMS; MUTAGENESIS STUDIES; NMR SPECTROSCOPIES; PROLACTIN RECEPTORS; RECEPTOR INTERACTIONS; SCALE REARRANGEMENTS; SOLUTION STATES; STRUCTURAL DATUMS; X-RAY CRYSTALLOGRAPHIES;

CRYSTAL STRUCTURE;

PROLACTIN RECEPTOR; PROLACTIN RECEPTOR ANTAGONIST; RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG; PEPTIDE; PROLACTIN;

AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CRYSTAL STRUCTURE; DRUG BINDING SITE; DRUG RECEPTOR BINDING; MASS SPECTROMETRY; MOLECULAR STABILITY; NITROGEN NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTON NUCLEAR MAGNETIC RESONANCE; X RAY CRYSTALLOGRAPHY; AMINO ACID SUBSTITUTION; BINDING SITE; CHEMISTRY; DRUG ANTAGONISM; GENETICS; HUMAN; METABOLISM; MUTAGENESIS; NUCLEAR MAGNETIC RESONANCE; PROTEIN QUATERNARY STRUCTURE; PROTEIN SECONDARY STRUCTURE; PROTEIN TERTIARY STRUCTURE;

AMINO ACID SUBSTITUTION; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; HUMANS; MUTAGENESIS; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PEPTIDES; PROLACTIN; PROTEIN STRUCTURE, QUATERNARY; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, PROLACTIN;

EID: 49649102937     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M801202200     Document Type: Article

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