Production of heparanase constructs suitable for nuclear magnetic resonance and drug discovery studies

Biopolymers

Volumn 95, Issue 2, 2011, Pages 151-160

  Mosulén, Silvia ^a   Ortí, Leticia ^a   Bas, Esperanza ^a   Carbajo, Rodrigo J ^a   Pineda Lucena, Antonio ^a  

^a CENTRO DE INVESTIGACIÓN PRÍNCIPE FELIPE   (Spain)

Author keywords

drug discovery; expression; heparan sulphate; heparanase; NMR; purification; SPR

Indexed keywords

DRUG DISCOVERY; EXPRESSION; HEPARAN SULPHATE; HEPARANASE; NMR; SPR;

AMINO ACIDS; BINDING ENERGY; BINDING SITES; BIOCHEMISTRY; ENZYMES; PURIFICATION; RESONANCE;

NUCLEAR MAGNETIC RESONANCE;

GLUTAMIC ACID; HEPARAN SULFATE; HEPARANASE; NITROGEN 15;

ARTICLE; BINDING SITE; DRUG DEVELOPMENT; ENZYME BINDING; ENZYME SYNTHESIS; NUCLEAR MAGNETIC RESONANCE; PROTEIN EXPRESSION; PROTEIN PURIFICATION;

BASE SEQUENCE; DNA PRIMERS; DRUG DISCOVERY; GLUCURONIDASE; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; NITROGEN ISOTOPES; PROTEIN CONFORMATION; PROTEIN ENGINEERING; RECOMBINANT PROTEINS; SURFACE PLASMON RESONANCE;

EID: 78649639040     PISSN: 00063525     EISSN: 10970282     Source Type: Journal    
DOI: 10.1002/bip.21549     Document Type: Article

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