Serum levels of adipokines in HIV/HCV co-infected patients and their association with insulin resistance and liver disease severity

Journal of Infection

Volumn 61, Issue 6, 2010, Pages 499-501

  Fernández de Castro, Isabel ^a   Berenguer, Juan ^b   Micheloud, Dariela ^a   Guzmán Fulgencio, María ^b   Cosín, Jaime ^a   Álvarez, Emilio ^b   López, Juan Carlos ^b   Miralles, Pilar ^b   García Álvarez, Mónica ^b   Resino, Salvador ^a  

^a INSTITUTO DE SALUD CARLOS III   (Spain)

^b HOSPITAL GENERAL UNIVERSITARIO GREGORIO MARAÑÓN   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ADIPOCYTOKINE; ANTIRETROVIRUS AGENT; INSULIN;

ADULT; CROSS-SECTIONAL STUDY; DISEASE ASSOCIATION; DISEASE SEVERITY; FATTY LIVER; FEMALE; HEPATITIS C; HEPATITIS C VIRUS; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HUMAN TISSUE; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; LETTER; LIVER BIOPSY; LIVER DISEASE; LIVER FIBROSIS; LIVER INJURY; MAJOR CLINICAL STUDY; MALE; MIXED INFECTION; OUTCOMES RESEARCH; PROTEIN ANALYSIS; PROTEIN BLOOD LEVEL; PROTEIN FUNCTION; SPAIN; VIRUS LOAD;

ADIPOKINES; ADULT; FEMALE; HEPATITIS C; HIV INFECTIONS; HUMANS; INSULIN RESISTANCE; LIVER CIRRHOSIS; MALE; SERUM; SEVERITY OF ILLNESS INDEX;

EID: 78649636615     PISSN: 01634453     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jinf.2010.06.006     Document Type: Letter

References (12)

1. Calza L., Manfredi R., Pocaterra D., Chiodo F. Risk of premature atherosclerosis and ischemic heart disease associated with HIV infection and antiretroviral therapy. J Infect 2008 Jul, 57(1):16-32.
2. Duong M., Petit J.M., Piroth L., Grappin M., Buisson M., Chavanet P., et al. Association between insulin resistance and hepatitis C virus chronic infection in HIV-hepatitis C virus-coinfected patients undergoing antiretroviral therapy. J Acquir Immune Defic Syndr 2001 Jul 1, 27(3):245-250.
3. Grigorescu M., Radu C., Crisan D., Grigorescu M.D., Serban A., Neculoiu D., et al. Metabolic syndrome, insulin resistance and adiponectin level in patients with chronic hepatitis C. J Gastrointestin Liver Dis 2008 Jun, 17(2):147-154.
4. Marra F., Bertolani C. Adipokines in liver diseases. Hepatology 2009 Sep, 50(3):957-969.
5. Ryan P., Berenguer J., Michelaud D., Miralles P., Bellon J.M., Alvarez E., et al. Insulin resistance is associated with advanced liver fibrosis and high body mass index in HIV/HCV-coinfected patients. J Acquir Immune Defic Syndr 2009 Jan 1, 50(1):109-110.
6. Martin S.S., Qasim A., Reilly M.P. Leptin resistance: a possible interface of inflammation and metabolism in obesity-related cardiovascular disease. J Am Coll Cardiol 2008 Oct 7, 52(15):1201-1210.
7. Derbala M., Rizk N., Al-Kaabi S., Amer A., Shebl F., Al Marri A., et al. Adiponectin changes in HCV-Genotype 4: relation to liver histology and response to treatment. J Viral Hepat 2009 Oct, 16(10):689-696.
8. Liu C.J., Chen P.J., Jeng Y.M., Huang W.L., Yang W.S., Lai M.Y., et al. Serum adiponectin correlates with viral characteristics but not histologic features in patients with chronic hepatitis C. J Hepatol 2005 Aug, 43(2):235-242.
9. Tilg H., Moschen A.R. Adipocytokines: mediators linking adipose tissue, inflammation and immunity. Nat Rev Immunol 2006 Oct, 6(10):772-783.
10. Bertolani C., Marra F. The role of adipokines in liver fibrosis. Pathophysiology 2008 Aug, 15(2):91-101.
11. Bertolani C., Sancho-Bru P., Failli P., Bataller R., Aleffi S., DeFranco R., et al. Resistin as an intrahepatic cytokine: overexpression during chronic injury and induction of proinflammatory actions in hepatic stellate cells. Am J Pathol 2006 Dec, 169(6):2042-2053.
12. Wang J., Leclercq I., Brymora J.M., Xu N., Ramezani-Moghadam M., London R.M., et al. Kupffer cells mediate leptin-induced liver fibrosis. Gastroenterology 2009 Aug, 137(2):713-723.