Adiponectin changes in HCV-Genotype 4: Relation to liver histology and response to treatment

Journal of Viral Hepatitis

Volumn 16, Issue 10, 2009, Pages 689-696

  Derbala, M ^a   Rizk, N ^b   Al Kaabi, S ^a   Amer, A ^c   Shebl, F ^d   Al Marri, A ^c   Aigha, I ^c   Alyaesi, D ^c   Mohamed, H ^c   Aman, H ^c   Basem, N ^c  

^a THEODOR BILHARZ RESEARCH INSTITUTE   (Egypt)

^b QATAR UNIVERSITY   (Qatar)

^c HAMAD MEDICAL CORPORATION   (Qatar)

^d UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

Author keywords

Adiponectin; HCV genotype 4; Pegylated IFN

Indexed keywords

ADIPONECTIN; INSULIN; PEGINTERFERON ALPHA2A; RIBAVIRIN; VIRUS RNA;

ADULT; AGED; ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; GENOTYPE; HEPATITIS C; HEPATITIS C VIRUS; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; LIVER CIRRHOSIS; LIVER FIBROSIS; MAJOR CLINICAL STUDY; MALE; MOLECULAR WEIGHT; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; SENSITIVITY AND SPECIFICITY; TREATMENT RESPONSE; VIRUS LOAD;

ADIPONECTIN; ADULT; AGED; ANTIVIRAL AGENTS; GENOTYPE; HEPACIVIRUS; HEPATITIS C, CHRONIC; HUMANS; INSULIN; INSULIN RESISTANCE; LIVER; LIVER CIRRHOSIS; MIDDLE AGED; PREDICTIVE VALUE OF TESTS; SENSITIVITY AND SPECIFICITY; SEX FACTORS; TREATMENT OUTCOME; VIRAL LOAD; YOUNG ADULT;

EID: 70349242028     PISSN: 13520504     EISSN: 13652893     Source Type: Journal    
DOI: 10.1111/j.1365-2893.2009.01096.x     Document Type: Article

References (27)

1. Juge-Aubry CE, Henrichot E, Meier CA. Adipose tissue: a regulator of inflammation. Best Pract Res Clin Endocrinol Metab 2005 19 : 547 566.
2. Koerner A, Kratzsch J, Kiess W. Adipocytokines: leptin - the classical, resistin - the controversical, adiponectin - the promising, and more to come. Best Pract Res Clin Endocrinol Metab 2005 19 : 525 546.
3. Xu A, Wang Y, Keshaw H et al. The fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver diseases in mice. J Clin Invest 2003 112 : 91 100.
4. Kamada Y, Tamura S, Kiso S et al. Enhanced carbon tetrachloride-induced liver fibrosis in mice lacking adiponectin. Gastroenterology 2003 125 (6 1796 1807.
5. Neumeier M, Hellerbrand C, Gäbele E et al. Adiponectin and its receptors in rodent models of fatty liver disease and liver cirrhosis. World J Gastroenterol 2006 12 (34 5490 5494.
6. Negro F. Insulin resistance and HCV: will new knowledge modify clinical management?. J Hepatol 2006 45 (4 514 519.
7. Gil-Campos M, Canete R, Gil A. Adiponectin, the missing link in insulin resistance and obesity. Clin Nutr 2004 23 (5 963 974.
8. Kaser S, Moschen A, Cayon A et al. Adiponectin and its receptors in non-alcoholic steatohepatitis. Gut 2005 54 (1 117 121. (Pubitemid 40007229)
9. Tschritter O, Fritsche A, Thamer C et al. Plasma adiponectin concentrations predict insulin sensitivity of both glucose and lipid metabolism. Diabetes 2003 52 : 239 243.
10. Tacke F, Wüstefeld T, Horn R et al. High adiponectin in chronic liver disease and cholestasis suggests biliary route of adiponectin excretion in vivo. J Hepatol 2005 42 (5 666 673.
11. Moucari R, Asselah T, Cazals-Hatem D et al. Insulin resistance in chronic hepatitis C: association with genotypes 1 and 4, serum HCV RNA level, and liver fibrosis. Gastroenterology 2008 134 (2 416 423.
12. Lindsay RS, Funahashi T, Hanson RL et al. Adiponectin and development of type 2 diabetes in the Pima Indian population. Lancet 2002 360 (9326 57 58.
13. Weyer C, Funahashi T, Tanaka S et al. Hypoadiponectinemia in obesity and type 2 diabetes: close correlation with insulin resistance and hyperinsulinemia. J Clin Endocrinol Metab 2001 86 : 1930 1935.
14. Furusyo N, Sawayama Y, Maeda S et al. High molecular weight form of adiponectin levels of Japanese patients with chronic hepatitis C virus infection. Hepatology Research 2007 37 : 1052 1061.
15. Zografos T, Liaskos C, Rigopoulou E et al. Adiponectin: a new independent predictor of liver steatosis and response to IFN-α treatment in chronic hepatitis C. Am J Gastroenterol 2008 103 : 605 614.
16. Friedewald W, Levy R, Fredrickson D. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 1972 18 (6 499 502.
17. Yokoyama H, Hirose H, Ohgo H, Saito I. Inverse association between serum adiponectin level and transaminase activities in Japanese male workers. J Hepatol 2004 41 (1 19 24.
18. Lu J, Su T, Liu Y, Hsu H, Chen C, Yang W. Lower plasma adiponectin is correlated to higher alanine aminotransferase independent of metabolic factors and hepatitis B virus carrier status. Int Med J 2007 37 : 365 371.
19. Tietge U, Boker K, Manns M, Bahr M. Elevated circulating adiponectin levels in liver cirrhosis are associated with reduced liver function and altered hepatic hemodynamics. Am J Physiol Endocrinol Metab 2004 287 : E82 E89.
20. Masaki T, Chiba S, Tatsukawa H et al. Adiponectin protects LPS-induced liver injury through modulation of TNF-a in KK-Ay obese mice. Hepatology 2004 40 : 177 184.
21. Sohara N, Takagi H, Kakizaki I, Sato K, Mori M. Elevated plasma adiponectin concentrations in patients with liver cirrhosis correlate with plasma insulin levels. Liver Int 2005 25 (1 28.
22. Pajvani U, Hawkins M, Combs T et al. Complex distribution, not absolute amount of adiponectin, correlates with thiazolidinedione-mediated improvement in insulin sensitivity. J Biol Chem 2004 279 : 12152 12162.
23. Hsu C, Liu C, Liu C et al. High hepatitis C viral load is associated with insulin resistance in patients with chronic hepatitis C. Liver Int 2008 28 (2 271 277.
24. Zografos T, Liaskos C, Rigopoulou E et al. Adiponectin: a new independent predictor of liver steatosis and response to IFN-α treatment in chronic hepatitis C. Am J Gastroenterol 2007 102 : 1 10.
25. Mbow M, Sarisky R. What is disrupting IFNalpha's antiviral activity? Trends Biotechnol 2004 22 : 395 399.
26. Tsochatzis E, Papatheodoridis GV, Archimandritis AJ. The evolving role of leptin and adiponectin in chronic liver diseases. Am J Gastroenterol 2006 101 (11 2629 2640.
27. Hui C, Zhang H, Lee N et al. Serum adiponectin is increased in advancing liver fibrosis and declines with reduction in fibrosis in chronic hepatitis B. J Hepatol 2007 47 (2 191 202. Epub 2007 Apr 12.