Insulin resistance is associated with advanced liver fibrosis and high body mass index in HIV/HCV-coinfected patients

Journal of Acquired Immune Deficiency Syndromes

Volumn 50, Issue 1, 2009, Pages 109-110

  Ryan, Pablo ^a   Berenguer, Juan ^a   Michelaud, Dariela ^a   Miralles, Pilar ^a   Bellon J M ^a   Alvarez, Emilio ^a   Catalán, Pilar ^a   Sánchez Conde, Matilde ^a   Resino, Salvador ^b  

^a HOSPITAL GENERAL UNIVERSITARIO GREGORIO MARAÑÓN   (Spain)

^b INSTITUTO DE SALUD CARLOS III   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

INSULIN;

ADULT; ANTIVIRAL THERAPY; BLOOD CELL COUNT; BLOOD CLOTTING TEST; BLOOD SAMPLING; BODY MASS; CD4 LYMPHOCYTE COUNT; DISEASE ASSOCIATION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HEPATITIS C; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INSULIN RESISTANCE; LETTER; LIVER BIOPSY; LIVER FIBROSIS; MAJOR CLINICAL STUDY; MALE; MIXED INFECTION; PRIORITY JOURNAL; WESTERN BLOTTING; COHORT ANALYSIS; CROSS-SECTIONAL STUDY; LIVER CIRRHOSIS; MIDDLE AGED;

ADULT; BODY MASS INDEX; COHORT STUDIES; CROSS-SECTIONAL STUDIES; FEMALE; HEPATITIS C; HIV INFECTIONS; HUMANS; INSULIN RESISTANCE; LIVER CIRRHOSIS; MALE; MIDDLE AGED;

EID: 64249128814     PISSN: 15254135     EISSN: None     Source Type: Journal    
DOI: 10.1097/QAI.0b013e318186ede8     Document Type: Letter

References (9)

1. Fartoux L, Poujol-Robert A, Guechot J, et al. Insulin resistance is a cause of steatosis and fibrosis progression in chronic hepatitis C. Gut. 2005;54:1003-1008.
2. Romero-Gomez M, Del Mar Viloria M, Andrade RJ, et al. Insulin resistance impairs sustained response rate to peginterferon plus ribavirin in chronic hepatitis C patients. Gastroenterology. 2005;128:636-641.
3. Matthews DR, Hosker JP, Rudenski AS, et al. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 1985;28:412-419.
4. Jacobs WH, Goldberg SB. Statement on outpatient percutaneous liver biopsy. Dig Dis Sci. 1989;34:322-323.
5. The French METAVIR Cooperative Study Group. Intraobserver and interobserver variations in liver biopsy interpretation in patients with chronic hepatitis C. The French METAVIR Cooperative Study Group. Hepatology. 1994; 20:15-20.
6. Paradis V, Perlemuter G, Bonvoust F, et al. High glucose and hyperinsulinemia stimulate connective tissue growth factor expression: a potential mechanism involved in progression to fibrosis in nonalcoholic steatohepatitis. Hepatology. 2001; 34:738-744.
7. Merchante N, Macias J, Ramayo E, et al. Insulin resistance is not associated with liver fibrosis progression in HIV/hepatitis C virus-coinfected patients. J Viral Hepat. 2006; 13: 449-456.
8. Boden G. Role of fatty acids in the pathogenesis of insulin resistance and NIDDM. Diabetes. 1997;46:3-10.
9. Hourigan LF, Macdonald GA, Purdie D, et al. Fibrosis in chronic hepatitis C correlates significantly with body mass index and steatosis. Hepatology. 1999;29:1215-1219.