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Volumn 23, Issue 6, 2010, Pages 583-591

Nervous system tumors associated with familial tumor syndromes

Author keywords

Cowden syndrome; familial tumor syndrome; glioma; Li Fraumeni syndrome; medulloblastoma; neurofibromatosis; tuberous sclerosis; Turcot syndrome

Indexed keywords

MAMMALIAN TARGET OF RAPAMYCIN;

EID: 78649635096     PISSN: 13507540     EISSN: None     Source Type: Journal    
DOI: 10.1097/WCO.0b013e3283405b5f     Document Type: Review
Times cited : (23)

References (55)
  • 1
    • 0030957310 scopus 로고    scopus 로고
    • The diagnostic evaluation and multidisciplinary management of neurofibromatosis 1 and neurofibromatosis 2
    • Gutmann DH, Aylsworth A, Carey JC, et al. The diagnostic evaluation and multidisciplinary management of neurofibromatosis 1 and neurofibromatosis 2. JAMA 1997; 278:51-57.
    • (1997) JAMA , vol.278 , pp. 51-57
    • Gutmann, D.H.1    Aylsworth, A.2    Carey, J.C.3
  • 2
    • 0026746684 scopus 로고
    • A clinical study of type 2 neuro-fibromatosis
    • Evans DG, Huson SM, Donnai D, et al. A clinical study of type 2 neuro-fibromatosis. Q J Med 1992; 84:603-618.
    • (1992) Q J Med , vol.84 , pp. 603-618
    • Evans, D.G.1    Huson, S.M.2    Donnai, D.3
  • 3
    • 0023885121 scopus 로고
    • Neurofibromatosis. NIH consensus development conference statement
    • Stumpf DA, Alksne JF, Annegers JF. Neurofibromatosis. NIH consensus development conference statement. Arch Neurol 1988; 45:575-578.
    • (1988) Arch Neurol , vol.45 , pp. 575-578
    • Stumpf, D.A.1    Alksne, J.F.2    Annegers, J.F.3
  • 4
    • 0032989136 scopus 로고    scopus 로고
    • Tuberous Sclerosis Consensus Conference: Recommendations for diagnostic evaluation. National Tuberous Sclerosis Association
    • Roach ES, DiMario FJ, Kandt RS, Northrup H. Tuberous Sclerosis Consensus Conference: recommendations for diagnostic evaluation. National Tuberous Sclerosis Association. J Child Neurol 1999; 14:401-407.
    • (1999) J Child Neurol , vol.14 , pp. 401-407
    • Roach, E.S.1    Dimario, F.J.2    Kandt, R.S.3    Northrup, H.4
  • 5
    • 0023715595 scopus 로고
    • A cancer family syndrome in twenty-four kindreds
    • Li FP, Fraumeni JF Jr, Mulvihill JJ, et al. A cancer family syndrome in twenty-four kindreds. Cancer Res 1988; 48:5358-5362.
    • (1988) Cancer Res , vol.48 , pp. 5358-5362
    • Li, F.P.1    Fraumeni Jr., J.F.2    Mulvihill, J.J.3
  • 6
    • 0030798827 scopus 로고    scopus 로고
    • Brain tumor-polyposis syndrome: Two genetic diseases?
    • Paraf F, Jothy S, Van Meir EG. Brain tumor-polyposis syndrome: two genetic diseases? J Clin Oncol 1997; 15:2744-2758.
    • (1997) J Clin Oncol , vol.15 , pp. 2744-2758
    • Paraf, F.1    Jothy, S.2    Van Meir, E.G.3
  • 8
    • 0037622972 scopus 로고    scopus 로고
    • Nevoid basal cell carcinoma syndrome: Relation with desmoplastic medulloblastoma in infancy. A population-based study and review of the literature
    • Amlashi SF, Riffaud L, Brassier G, Morandi X. Nevoid basal cell carcinoma syndrome: relation with desmoplastic medulloblastoma in infancy. A population-based study and review of the literature. Cancer 2003; 98:618-624.
    • (2003) Cancer , vol.98 , pp. 618-624
    • Amlashi, S.F.1    Riffaud, L.2    Brassier, G.3    Morandi, X.4
  • 9
    • 0027231001 scopus 로고
    • Complications of the naevoid basal cell carcinoma syndrome: Results of a population based study
    • Evans DG, Ladusans EJ, Rimmer S, et al. Complications of the naevoid basal cell carcinoma syndrome: results of a population based study. J Med Genet 1993; 30:460-464.
    • (1993) J Med Genet , vol.30 , pp. 460-464
    • Evans, D.G.1    Ladusans, E.J.2    Rimmer, S.3
  • 10
    • 0031002840 scopus 로고    scopus 로고
    • Clinical manifestations in 105 persons with nevoid basal cell carcinoma syndrome
    • Kimonis VE, Goldstein AM, Pastakia B, et al. Clinical manifestations in 105 persons with nevoid basal cell carcinoma syndrome. Am J Med Genet 1997; 69:299-308.
    • (1997) Am J Med Genet , vol.69 , pp. 299-308
    • Kimonis, V.E.1    Goldstein, A.M.2    Pastakia, B.3
  • 11
    • 0028271569 scopus 로고
    • Nevoid basal cell carcinoma syndrome: Review of 118 affected individuals
    • Shanley S, Ratcliffe J, Hockey A, et al. Nevoid basal cell carcinoma syndrome: review of 118 affected individuals. Am J Med Genet 1994; 50:282-290.
    • (1994) Am J Med Genet , vol.50 , pp. 282-290
    • Shanley, S.1    Ratcliffe, J.2    Hockey, A.3
  • 12
    • 33746594132 scopus 로고    scopus 로고
    • Predisposition to atypical teratoid/rhabdoid tumor due to an inherited INI1 mutation
    • Janson K, Nedzi LA, David O, et al. Predisposition to atypical teratoid/rhabdoid tumor due to an inherited INI1 mutation. Pediatr Blood Cancer 2006; 47:279-284.
    • (2006) Pediatr Blood Cancer , vol.47 , pp. 279-284
    • Janson, K.1    Nedzi, L.A.2    David, O.3
  • 13
    • 78649631289 scopus 로고    scopus 로고
    • Merlin, a 'magic' linker between extracellular cues and intracellular signaling pathways that regulate cell motility, proliferation, and survival
    • Stamenkovic I, Yu Q. Merlin, a 'magic' linker between extracellular cues and intracellular signaling pathways that regulate cell motility, proliferation, and survival. Curr Protein Pept Sci 2010; 11:471-484.
    • (2010) Curr Protein Pept Sci , vol.11 , pp. 471-484
    • Stamenkovic, I.1    Yu, Q.2
  • 15
    • 0013908208 scopus 로고
    • Multiple primary intracranial tumors in von Recklinghausen's neurofibromatosis
    • Rodriguez HA, Berthrong M. Multiple primary intracranial tumors in von Recklinghausen's neurofibromatosis. Arch Neurol 1966; 14:467-475.
    • (1966) Arch Neurol , vol.14 , pp. 467-475
    • Rodriguez, H.A.1    Berthrong, M.2
  • 16
    • 0032213545 scopus 로고    scopus 로고
    • Hamartin, the product of the tuberous sclerosis 1 (TSC1) gene, interacts with tuberin and appears to be localized to cytoplasmic vesicles
    • Plank TL, Yeung RS, Henske EP. Hamartin, the product of the tuberous sclerosis 1 (TSC1) gene, interacts with tuberin and appears to be localized to cytoplasmic vesicles. Cancer Res 1998; 58:4766-4770.
    • (1998) Cancer Res , vol.58 , pp. 4766-4770
    • Plank, T.L.1    Yeung, R.S.2    Henske, E.P.3
  • 17
    • 0032903806 scopus 로고    scopus 로고
    • Mutational spectrum of the TSC1 gene in a cohort of 225 tuberous sclerosis complex patients: No evidence for genotype-phenotype correlation
    • Van SM, Verhoef S, Tempelaars A, et al. Mutational spectrum of the TSC1 gene in a cohort of 225 tuberous sclerosis complex patients: no evidence for genotype-phenotype correlation. J Med Genet 1999; 36:285-289.
    • (1999) J Med Genet , vol.36 , pp. 285-289
    • Van Sm Verhoef, S.1    Tempelaars, A.2
  • 18
    • 0025633582 scopus 로고
    • Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms
    • Malkin D, Li FP, Strong LC, et al. Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms. Science 1990; 250:1233-1238.
    • (1990) Science , vol.250 , pp. 1233-1238
    • Malkin, D.1    Li, F.P.2    Strong, L.C.3
  • 19
    • 0030806921 scopus 로고    scopus 로고
    • Germ-line mutations of TP53 in Li-Fraumeni families: An extended study of 39 families
    • Varley JM, McGown G, Thorncroft M, et al. Germ-line mutations of TP53 in Li-Fraumeni families: an extended study of 39 families. Cancer Res 1997; 57:3245-3252.
    • (1997) Cancer Res , vol.57 , pp. 3245-3252
    • Varley, J.M.1    McGown, G.2    Thorncroft, M.3
  • 20
    • 43049128529 scopus 로고    scopus 로고
    • Tenets of PTEN tumor suppression
    • Salmena L, Carracedo A, Pandolfi PP. Tenets of PTEN tumor suppression. Cell 2008; 133:403-414.
    • (2008) Cell , vol.133 , pp. 403-414
    • Salmena, L.1    Carracedo, A.2    Pandolfi, P.P.3
  • 21
    • 0032905101 scopus 로고    scopus 로고
    • Novel PTEN mutations in patients with Cowden disease: Absence of clear genotype-phenotype correlations
    • Nelen MR, Kremer H, Konings IB, et al. Novel PTEN mutations in patients with Cowden disease: absence of clear genotype-phenotype correlations. Eur J Hum Genet 1999; 7:267-273.
    • (1999) Eur J Hum Genet , vol.7 , pp. 267-273
    • Nelen, M.R.1    Kremer, H.2    Konings, I.B.3
  • 22
    • 0033738748 scopus 로고    scopus 로고
    • Will the real Cowden syndrome please stand up: Revised diagnostic criteria
    • Eng C. Will the real Cowden syndrome please stand up: revised diagnostic criteria. J Med Genet 2000; 37:828-830.
    • (2000) J Med Genet , vol.37 , pp. 828-830
    • Eng, C.1
  • 23
    • 0036206130 scopus 로고    scopus 로고
    • Protean PTEN: Form and function
    • Waite KA, Eng C. Protean PTEN: form and function. Am J Hum Genet 2002; 70:829-844.
    • (2002) Am J Hum Genet , vol.70 , pp. 829-844
    • Waite, K.A.1    Eng, C.2
  • 24
    • 67649506174 scopus 로고    scopus 로고
    • Genetic prognostic and predictive markers in colorectal cancer
    • Walther A, Johnstone E, Swanton C, et al. Genetic prognostic and predictive markers in colorectal cancer. Nat Rev Cancer 2009; 9:489-499.
    • (2009) Nat Rev Cancer , vol.9 , pp. 489-499
    • Walther, A.1    Johnstone, E.2    Swanton, C.3
  • 25
    • 33746650621 scopus 로고    scopus 로고
    • Hedgehog signalling in skin development and cancer
    • Athar M, Tang X, Lee JL, et al. Hedgehog signalling in skin development and cancer. Exp Dermatol 2006; 15:667-677.
    • (2006) Exp Dermatol , vol.15 , pp. 667-677
    • Athar, M.1    Tang, X.2    Lee, J.L.3
  • 26
    • 0026043909 scopus 로고
    • The incidence of Gorlin syndrome in 173 consecutive casesofmedulloblastoma
    • Evans DG, Farndon PA, Burnell LD, et al. The incidence of Gorlin syndrome in 173 consecutive casesofmedulloblastoma.Br J Cancer 1991; 64:959-961.
    • (1991) Br J Cancer , vol.64 , pp. 959-961
    • Evans, D.G.1    Farndon, P.A.2    Burnell, L.D.3
  • 27
    • 1042290351 scopus 로고    scopus 로고
    • The SWI/SNF complex: Chromatin and cancer
    • Roberts CW, Orkin SH. The SWI/SNF complex: chromatin and cancer. Nat Rev Cancer 2004; 4:133-142.
    • (2004) Nat Rev Cancer , vol.4 , pp. 133-142
    • Roberts, C.W.1    Orkin, S.H.2
  • 28
    • 33646104935 scopus 로고    scopus 로고
    • Molecular genetics of atypical teratoid/rhabdoid tumor
    • Biegel JA. Molecular genetics of atypical teratoid/rhabdoid tumor. Neurosurg Focus 2006; 20:E11.
    • (2006) Neurosurg Focus , vol.20
    • Biegel, J.A.1
  • 29
    • 0042126838 scopus 로고    scopus 로고
    • Atypical teratoid/rhabdoid tumors and choroid plexus tumors: When genetics 'surprise' pathology
    • Gessi M, Giangaspero F, Pietsch T. Atypical teratoid/rhabdoid tumors and choroid plexus tumors: when genetics 'surprise' pathology. Brain Pathol 2003; 13:409-414.
    • (2003) Brain Pathol , vol.13 , pp. 409-414
    • Gessi, M.1    Giangaspero, F.2    Pietsch, T.3
  • 30
    • 2042432488 scopus 로고    scopus 로고
    • Constitutional mutations of the hSNF5/INI1 gene predispose to a variety of cancers
    • Sevenet N, Sheridan E, Amram D, et al. Constitutional mutations of the hSNF5/INI1 gene predispose to a variety of cancers. Am J Hum Genet 1999; 65:1342-1348.
    • (1999) Am J Hum Genet , vol.65 , pp. 1342-1348
    • Sevenet, N.1    Sheridan, E.2    Amram, D.3
  • 31
    • 0032484354 scopus 로고    scopus 로고
    • 'Turcot's syndrome': Phenotype of brain tumors, survival and mode of inheritance
    • Van Meir EG. 'Turcot's syndrome': phenotype of brain tumors, survival and mode of inheritance. Int J Cancer 1998; 75:162-164.
    • (1998) Int J Cancer , vol.75 , pp. 162-164
    • Van Meir, E.G.1
  • 32
    • 0025864035 scopus 로고
    • Phenotypes of the tuberous sclerosis complex with a revision of diagnostic criteria
    • Gomez MR. Phenotypes of the tuberous sclerosis complex with a revision of diagnostic criteria. Ann N Y Acad Sci 1991; 615:1-7.
    • (1991) Ann N y Acad Sci , vol.615 , pp. 1-7
    • Gomez, M.R.1
  • 33
    • 0025905689 scopus 로고
    • Subependymal giant cell astrocytoma: A clinical, pathological, and flow cytometric study
    • Shepherd CW, Scheithauer BW, Gomez MR, et al. Subependymal giant cell astrocytoma: a clinical, pathological, and flow cytometric study. Neurosurgery 1991; 28:864-868.
    • (1991) Neurosurgery , vol.28 , pp. 864-868
    • Shepherd, C.W.1    Scheithauer, B.W.2    Gomez, M.R.3
  • 34
    • 8844231735 scopus 로고    scopus 로고
    • Diagnosis of tuberous sclerosis complex
    • Roach ES, Sparagana SP. Diagnosis of tuberous sclerosis complex. J Child Neurol 2004; 19:643-649.
    • (2004) J Child Neurol , vol.19 , pp. 643-649
    • Roach, E.S.1    Sparagana, S.P.2
  • 35
    • 0034023746 scopus 로고    scopus 로고
    • National Institutes of Health consensus conference: Tuberous sclerosis complex
    • Hyman MH, Whittemore VH. National Institutes of Health consensus conference: tuberous sclerosis complex. Arch Neurol 2000; 57:662-665.
    • (2000) Arch Neurol , vol.57 , pp. 662-665
    • Hyman, M.H.1    Whittemore, V.H.2
  • 36
    • 0034761908 scopus 로고    scopus 로고
    • Prognostic factors and secondary malignancies in childhood medulloblastoma
    • Stavrou T, Bromley CM, Nicholson HS, et al. Prognostic factors and secondary malignancies in childhood medulloblastoma. J Pediatr Hematol Oncol 2001; 23:431-436.
    • (2001) J Pediatr Hematol Oncol , vol.23 , pp. 431-436
    • Stavrou, T.1    Bromley, C.M.2    Nicholson, H.S.3
  • 38
    • 0037473082 scopus 로고    scopus 로고
    • AXIN1 mutations but not deletions in cerebellar medulloblastomas
    • Baeza N, Masuoka J, Kleihues P, Ohgaki H. AXIN1 mutations but not deletions in cerebellar medulloblastomas. Oncogene 2003; 22:632-636.
    • (2003) Oncogene , vol.22 , pp. 632-636
    • Baeza, N.1    Masuoka, J.2    Kleihues, P.3    Ohgaki, H.4
  • 39
    • 0035477364 scopus 로고    scopus 로고
    • Deletions of AXIN1, a component of the WNT/wingless pathway, in sporadic medulloblastomas
    • Dahmen RP, Koch A, Denkhaus D, et al. Deletions of AXIN1, a component of the WNT/wingless pathway, in sporadic medulloblastomas. Cancer Res 2001; 61:7039-7043.
    • (2001) Cancer Res , vol.61 , pp. 7039-7043
    • Dahmen, R.P.1    Koch, A.2    Denkhaus, D.3
  • 40
    • 22544487213 scopus 로고    scopus 로고
    • Association between benign and malignant peripheral nerve sheath tumors in NF1
    • Tucker T, Wolkenstein P, Revuz J, et al. Association between benign and malignant peripheral nerve sheath tumors in NF1. Neurology 2005; 65:205-211.
    • (2005) Neurology , vol.65 , pp. 205-211
    • Tucker, T.1    Wolkenstein, P.2    Revuz, J.3
  • 41
    • 0015834647 scopus 로고
    • Peripheral nerve tumors with rhabdomyosarcomatous differentiation (malignant 'Triton' tumors)
    • Woodruff JM, Chernik NL, Smith MC, et al. Peripheral nerve tumors with rhabdomyosarcomatous differentiation (malignant 'Triton' tumors). Cancer 1973; 32:426-439.
    • (1973) Cancer , vol.32 , pp. 426-439
    • Woodruff, J.M.1    Chernik, N.L.2    Smith, M.C.3
  • 42
    • 0029077524 scopus 로고
    • Neuropathology and molecular genetics of neurofibromatosis 2 and related tumors
    • Louis DN, Ramesh V, Gusella JF. Neuropathology and molecular genetics of neurofibromatosis 2 and related tumors. Brain Pathol 1995; 5:163-172.
    • (1995) Brain Pathol , vol.5 , pp. 163-172
    • Louis, D.N.1    Ramesh, V.2    Gusella, J.F.3
  • 43
    • 0030883541 scopus 로고    scopus 로고
    • Proliferation potential and histological features in neurofibromatosis 2-associated and sporadic meningiomas
    • Antinheimo J, Haapasalo H, Haltia M, et al. Proliferation potential and histological features in neurofibromatosis 2-associated and sporadic meningiomas. J Neurosurg 1997; 87:610-614.
    • (1997) J Neurosurg , vol.87 , pp. 610-614
    • Antinheimo, J.1    Haapasalo, H.2    Haltia, M.3
  • 44
    • 0034810446 scopus 로고    scopus 로고
    • Aggressive phenotypic and genotypic features in pediatric and NF2-associated meningiomas: A clinicopathologic study of 53 cases
    • Perry A, Giannini C, Raghavan R, et al. Aggressive phenotypic and genotypic features in pediatric and NF2-associated meningiomas: a clinicopathologic study of 53 cases. J Neuropathol Exp Neurol 2001; 60:994-1003.
    • (2001) J Neuropathol Exp Neurol , vol.60 , pp. 994-1003
    • Perry, A.1    Giannini, C.2    Raghavan, R.3
  • 45
    • 70350560341 scopus 로고    scopus 로고
    • Hearing improvement after bevacizumab for neurofibromatosis type 2
    • Diao JS, Xia WS, Guo SZ. Hearing improvement after bevacizumab for neurofibromatosis type 2. N Engl J Med 2009; 361:1810-1811.
    • (2009) N Engl J Med , vol.361 , pp. 1810-1811
    • Diao, J.S.1    Xia, W.S.2    Guo, S.Z.3
  • 46
    • 48449101742 scopus 로고    scopus 로고
    • Medulloblastoma can be initiated by deletion of Patched in lineage-restricted progenitors or stem cells
    • Yang ZJ, Ellis T, Markant SL, et al. Medulloblastoma can be initiated by deletion of Patched in lineage-restricted progenitors or stem cells. Cancer Cell 2008; 14:135-145.
    • (2008) Cancer Cell , vol.14 , pp. 135-145
    • Yang, Z.J.1    Ellis, T.2    Markant, S.L.3
  • 47
    • 72949103044 scopus 로고    scopus 로고
    • Small-molecule modulators of the Sonic Hedgehog signaling pathway
    • Stanton BZ, Peng LF. Small-molecule modulators of the Sonic Hedgehog signaling pathway. Mol Biosyst 2010; 6:44-54.
    • (2010) Mol Biosyst , vol.6 , pp. 44-54
    • Stanton, B.Z.1    Peng, L.F.2
  • 48
    • 70349244812 scopus 로고    scopus 로고
    • Treatment of medulloblastoma with hedgehog pathway inhibitor GDC-0449
    • Rudin CM, Hann CL, Laterra J, et al. Treatment of medulloblastoma with hedgehog pathway inhibitor GDC-0449. N Engl J Med 2009; 361:1173-1178.
    • (2009) N Engl J Med , vol.361 , pp. 1173-1178
    • Rudin, C.M.1    Hann, C.L.2    Laterra, J.3
  • 49
    • 70350496540 scopus 로고    scopus 로고
    • Smoothened mutation confers resistance to a Hedgehog pathway inhibitor in medulloblastoma
    • Yauch RL, Dijkgraaf GJ, Alicke B, et al. Smoothened mutation confers resistance to a Hedgehog pathway inhibitor in medulloblastoma. Science 2009; 326:572-574.
    • (2009) Science , vol.326 , pp. 572-574
    • Yauch, R.L.1    Dijkgraaf, G.J.2    Alicke, B.3
  • 50
    • 45849110311 scopus 로고    scopus 로고
    • Response of a neuronal model of tuberous sclerosis to mammalian target of rapamycin (mTOR) inhibitors: Effects on mTORC1 and Akt signaling lead to improved survival and function
    • Meikle L, Pollizzi K, Egnor A, et al. Response of a neuronal model of tuberous sclerosis to mammalian target of rapamycin (mTOR) inhibitors: effects on mTORC1 and Akt signaling lead to improved survival and function. J Neurosci 2008; 28:5422-5432.
    • (2008) J Neurosci , vol.28 , pp. 5422-5432
    • Meikle, L.1    Pollizzi, K.2    Egnor, A.3
  • 51
    • 33644827461 scopus 로고    scopus 로고
    • Rapamycin causes regression of astrocytomas in tuberous sclerosis complex
    • Franz DN, Leonard J, Tudor C, et al. Rapamycin causes regression of astrocytomas in tuberous sclerosis complex. Ann Neurol 2006;59:490-498.
    • (2006) Ann Neurol , vol.59 , pp. 490-498
    • Franz, D.N.1    Leonard, J.2    Tudor, C.3
  • 52
    • 78649634601 scopus 로고    scopus 로고
    • Everolimus for subependymal giant-cell astrocytomas (SEGAs) in tuberous sclerosis (TS) [abstract]
    • Franz DN, Krueger DA, Care MM, et al. Everolimus for subependymal giant-cell astrocytomas (SEGAs) in tuberous sclerosis (TS) [abstract]. J Clin Oncol 2010; 28 (Suppl):2004.
    • (2010) J Clin Oncol , vol.28 , Issue.SUPPL. , pp. 2004
    • Franz, D.N.1    Krueger, D.A.2    Care, M.M.3
  • 53
    • 0038615946 scopus 로고    scopus 로고
    • Analysis of the phosphatidylinositol 3'-kinase signaling pathway in glioblastoma patients in vivo
    • Choe G, Horvath S, Cloughesy TF, et al. Analysis of the phosphatidylinositol 3'-kinase signaling pathway in glioblastoma patients in vivo. Cancer Res 2003; 63:2742-2746.
    • (2003) Cancer Res , vol.63 , pp. 2742-2746
    • Choe, G.1    Horvath, S.2    Cloughesy, T.F.3
  • 54
    • 67649411967 scopus 로고    scopus 로고
    • Antagonism of the mammalian target of rapamycin selectively mediates metabolic effects of epidermal growth factor receptor inhibition and protects human malignant glioma cells from hypoxia-induced cell death
    • Ronellenfitsch MW, Brucker DP, Burger MC, et al. Antagonism of the mammalian target of rapamycin selectively mediates metabolic effects of epidermal growth factor receptor inhibition and protects human malignant glioma cells from hypoxia-induced cell death. Brain 2009; 132:1509-1522.
    • (2009) Brain , vol.132 , pp. 1509-1522
    • Ronellenfitsch, M.W.1    Brucker, D.P.2    Burger, M.C.3
  • 55
    • 38849208347 scopus 로고    scopus 로고
    • Antitumor activity of rapamycin in a Phase i trial for patients with recurrent PTEN-deficient glioblastoma
    • Cloughesy TF, Yoshimoto K, Nghiemphu P, et al. Antitumor activity of rapamycin in a Phase I trial for patients with recurrent PTEN-deficient glioblastoma. PLoS Med 2008; 5:e8.
    • (2008) PLoS Med , vol.5
    • Cloughesy, T.F.1    Yoshimoto, K.2    Nghiemphu, P.3


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