-
1
-
-
0036359548
-
Hypoxia-a key regulatory factor in tumour growth
-
Harris AL,. 2002. Hypoxia-a key regulatory factor in tumour growth. Nat Rev Cancer 2: 38-47.
-
(2002)
Nat Rev Cancer
, vol.2
, pp. 38-47
-
-
Harris, A.L.1
-
2
-
-
0042411985
-
Tumour hypoxia, chemotherapeutic resistance and hypoxia-related therapies
-
Shannon AM, Bouchier-Hayes DJ, Condron CM, et al. 2003. Tumour hypoxia, chemotherapeutic resistance and hypoxia-related therapies. Cancer Treat Rev 29: 297-307.
-
(2003)
Cancer Treat Rev
, vol.29
, pp. 297-307
-
-
Shannon, A.M.1
Bouchier-Hayes, D.J.2
Condron, C.M.3
-
3
-
-
40949142209
-
The role of hypoxia-inducible factors in tumorigenesis
-
Rankin EB, Giaccia AJ,. 2008. The role of hypoxia-inducible factors in tumorigenesis. Cell Death Differ 15: 678-685.
-
(2008)
Cell Death Differ
, vol.15
, pp. 678-685
-
-
Rankin, E.B.1
Giaccia, A.J.2
-
4
-
-
0029051439
-
Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension
-
Wang GL, Jiang BH, Rue EA, et al. 1995. Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. Proc Natl Acad Sci USA 92: 5510-5514.
-
(1995)
Proc Natl Acad Sci USA
, vol.92
, pp. 5510-5514
-
-
Wang, G.L.1
Jiang, B.H.2
Rue, E.A.3
-
5
-
-
0034663894
-
Mechanism of regulation of the hypoxia-inducible factor-1 alpha by the von Hippel-Lindau tumor suppressor protein
-
Tanimoto K, Makino Y, Pereira T, et al. 2000. Mechanism of regulation of the hypoxia-inducible factor-1 alpha by the von Hippel-Lindau tumor suppressor protein. EMBO J 19: 4298-4309.
-
(2000)
EMBO J
, vol.19
, pp. 4298-4309
-
-
Tanimoto, K.1
Makino, Y.2
Pereira, T.3
-
6
-
-
0033776536
-
Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein
-
Ohh M, Park CW, Ivan M, et al. 2000. Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein. Nat Cell Biol 2: 423-427.
-
(2000)
Nat Cell Biol
, vol.2
, pp. 423-427
-
-
Ohh, M.1
Park, C.W.2
Ivan, M.3
-
7
-
-
33745138232
-
Regulation of angiogenesis by hypoxia-inducible factor 1
-
Hirota K, Semenza GL,. 2006. Regulation of angiogenesis by hypoxia-inducible factor 1. Crit Rev Oncol Hematol 59: 15-26.
-
(2006)
Crit Rev Oncol Hematol
, vol.59
, pp. 15-26
-
-
Hirota, K.1
Semenza, G.L.2
-
8
-
-
0034614637
-
The hallmarks of cancer
-
Hanahan D, Weinberg RA,. 2000. The hallmarks of cancer. Cell 100: 57-70.
-
(2000)
Cell
, vol.100
, pp. 57-70
-
-
Hanahan, D.1
Weinberg, R.A.2
-
9
-
-
0034255036
-
Expression of the gene encoding the proapoptotic Nip3 protein is induced by hypoxia
-
Bruick RK,. 2000. Expression of the gene encoding the proapoptotic Nip3 protein is induced by hypoxia. Proc Natl Acad Sci USA 97: 9082-9087.
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 9082-9087
-
-
Bruick, R.K.1
-
10
-
-
0035884701
-
HIF-1-dependent regulation of hypoxic induction of the cell death factors BNIP3 and NIX in human tumors
-
Sowter HM, Ratcliffe PJ, Watson P, et al. 2001. HIF-1-dependent regulation of hypoxic induction of the cell death factors BNIP3 and NIX in human tumors. Cancer Res 61: 6669-6673.
-
(2001)
Cancer Res
, vol.61
, pp. 6669-6673
-
-
Sowter, H.M.1
Ratcliffe, P.J.2
Watson, P.3
-
11
-
-
3042665524
-
Hypoxia inhibits tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by blocking Bax translocation
-
Kim M, Park SY, Pai HS, et al. 2004. Hypoxia inhibits tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by blocking Bax translocation. Cancer Res 64: 4078-4081.
-
(2004)
Cancer Res
, vol.64
, pp. 4078-4081
-
-
Kim, M.1
Park, S.Y.2
Pai, H.S.3
-
12
-
-
0035378480
-
Up-regulation of apoptosis inhibitory protein IAP-2 by hypoxia. Hif-1-independent mechanisms
-
Dong Z, Venkatachalam MA, Wang J, et al. 2001. Up-regulation of apoptosis inhibitory protein IAP-2 by hypoxia. Hif-1-independent mechanisms. J Biol Chem 276: 18702-18709.
-
(2001)
J Biol Chem
, vol.276
, pp. 18702-18709
-
-
Dong, Z.1
Venkatachalam, M.A.2
Wang, J.3
-
13
-
-
65649146814
-
BCL-xL is a target gene regulated by hypoxia-inducible factor-1{alpha}
-
Chen N, Chen X, Huang R, et al. 2009. BCL-xL is a target gene regulated by hypoxia-inducible factor-1{alpha}. J Biol Chem 284: 10004-10012.
-
(2009)
J Biol Chem
, vol.284
, pp. 10004-10012
-
-
Chen, N.1
Chen, X.2
Huang, R.3
-
14
-
-
0036278899
-
Overexpression of hypoxia-inducible factor 1alpha is associated with an unfavorable prognosis in lymph node-positive breast cancer
-
Schindl M, Schoppmann SF, Samonigg H, et al. 2002. Overexpression of hypoxia-inducible factor 1alpha is associated with an unfavorable prognosis in lymph node-positive breast cancer. Clin Cancer Res 8: 1831-1837.
-
(2002)
Clin Cancer Res
, vol.8
, pp. 1831-1837
-
-
Schindl, M.1
Schoppmann, S.F.2
Samonigg, H.3
-
15
-
-
33747176556
-
The relation between hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha expression with anemia and outcome in surgically treated head and neck cancer
-
Winter SC, Shah KA, Han C, et al. 2006. The relation between hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha expression with anemia and outcome in surgically treated head and neck cancer. Cancer 107: 757-766.
-
(2006)
Cancer
, vol.107
, pp. 757-766
-
-
Winter, S.C.1
Shah, K.A.2
Han, C.3
-
16
-
-
34547838192
-
Expression of hypoxia-inducible factor 1alpha, hypoxia-inducible factor 2alpha, and von Hippel-Lindau protein in epithelial ovarian neoplasms and allelic loss of von Hippel-Lindau gene: Nuclear expression of hypoxia-inducible factor 1alpha is an independent prognostic factor in ovarian carcinoma
-
Osada R, Horiuchi A, Kikuchi N, et al. 2007. Expression of hypoxia-inducible factor 1alpha, hypoxia-inducible factor 2alpha, and von Hippel-Lindau protein in epithelial ovarian neoplasms and allelic loss of von Hippel-Lindau gene: nuclear expression of hypoxia-inducible factor 1alpha is an independent prognostic factor in ovarian carcinoma. Hum Pathol 38: 1310-1320.
-
(2007)
Hum Pathol
, vol.38
, pp. 1310-1320
-
-
Osada, R.1
Horiuchi, A.2
Kikuchi, N.3
-
17
-
-
0034282518
-
Overexpression of hypoxia-inducible factor 1alpha is a marker for an unfavorable prognosis in early-stage invasive cervical cancer
-
Birner P, Schindl M, Obermair A, et al. 2000. Overexpression of hypoxia-inducible factor 1alpha is a marker for an unfavorable prognosis in early-stage invasive cervical cancer. Cancer Res 60: 4693-4696.
-
(2000)
Cancer Res
, vol.60
, pp. 4693-4696
-
-
Birner, P.1
Schindl, M.2
Obermair, A.3
-
18
-
-
0032575688
-
The Bcl-2 protein family: Arbiters of cell survival
-
Adams JM, Cory S,. 1998. The Bcl-2 protein family: arbiters of cell survival. Science 281: 1322-1326.
-
(1998)
Science
, vol.281
, pp. 1322-1326
-
-
Adams, J.M.1
Cory, S.2
-
19
-
-
9044225527
-
BCL-2 family proteins: Regulators of cell death involved in the pathogenesis of cancer and resistance to therapy
-
DOI 10.1002/(SICI)1097-4644(19960101)60:1<23::AID-JCB5>3.0.CO;2-5
-
Reed JC, Miyashita T, Takayama S, et al. 1996. BCL-2 family proteins: regulators of cell death involved in the pathogenesis of cancer and resistance to therapy. J Cell Biochem 60: 23-32. (Pubitemid 26047917)
-
(1996)
Journal of Cellular Biochemistry
, vol.60
, Issue.1
, pp. 23-32
-
-
Reed, J.C.1
Miyashita, T.2
Takayama, S.3
Wang, H.-G.4
Sato, T.5
Krajewski, S.6
Aimesempe, C.7
Bodrug, S.8
Kitada, S.9
Hanada, M.10
-
20
-
-
49249095295
-
EGFR, p16, HPV Titer, Bcl-xL and p53, sex, and smoking as indicators of response to therapy and survival in oropharyngeal cancer
-
Kumar B, Cordell KG, Lee JS, et al. 2008. EGFR, p16, HPV Titer, Bcl-xL and p53, sex, and smoking as indicators of response to therapy and survival in oropharyngeal cancer. J Clin Oncol 26: 3128-3137.
-
(2008)
J Clin Oncol
, vol.26
, pp. 3128-3137
-
-
Kumar, B.1
Cordell, K.G.2
Lee, J.S.3
-
21
-
-
0035824823
-
Nuclear translocation of PDCD5 (TFAR19): An early signal for apoptosis?
-
Chen Y, Sun R, Han W, et al. 2001. Nuclear translocation of PDCD5 (TFAR19): an early signal for apoptosis? FEBS Lett 509: 191-196.
-
(2001)
FEBS Lett
, vol.509
, pp. 191-196
-
-
Chen, Y.1
Sun, R.2
Han, W.3
-
22
-
-
1542293250
-
Chondrosarcoma
-
Fletcher C.D.M., Unni K.K., Mertens F., editors. Lyon: IARC Press; p
-
Bertoni F, Bacchini P, Hogendoorn PCW,. 2002. Chondrosarcoma. In:, Fletcher CDM, Unni KK, Mertens F, editors. World Health Organisation classification of tumours. Pathology and genetics of tumours of soft tissue and bone. Lyon: IARC Press; p 247-251.
-
(2002)
World Health Organisation Classification of Tumours. Pathology and Genetics of Tumours of Soft Tissue and Bone
, pp. 247-251
-
-
Bertoni, F.1
Bacchini, P.2
Hogendoorn, P.C.W.3
-
23
-
-
0017695360
-
Prognostic factors in chondrosarcoma of bone: A clinicopathologic analysis with emphasis on histologic grading
-
Evans HL, Ayala AG, Romsdahl MM,. 1977. Prognostic factors in chondrosarcoma of bone: a clinicopathologic analysis with emphasis on histologic grading. Cancer 40: 818-831.
-
(1977)
Cancer
, vol.40
, pp. 818-831
-
-
Evans, H.L.1
Ayala, A.G.2
Romsdahl, M.M.3
-
24
-
-
0033233243
-
Regulation of mammalian O2 homeostasis by hypoxia-inducible factor 1
-
Semenza GL,. 1999. Regulation of mammalian O2 homeostasis by hypoxia-inducible factor 1. Annu Rev Cell Dev Biol 15: 551-578.
-
(1999)
Annu Rev Cell Dev Biol
, vol.15
, pp. 551-578
-
-
Semenza, G.L.1
-
25
-
-
77954582482
-
Recombinant human PDCD5 sensitizes chondrosarcomas to cisplatin chemotherapy in vitro and in vivo
-
Chen C, Zhou H, Xu L, et al. 2010. Recombinant human PDCD5 sensitizes chondrosarcomas to cisplatin chemotherapy in vitro and in vivo. Apoptosis 15: 805-813.
-
(2010)
Apoptosis
, vol.15
, pp. 805-813
-
-
Chen, C.1
Zhou, H.2
Xu, L.3
-
26
-
-
0033571682
-
Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases
-
Zhong H, De Marzo AM, Laughner E, et al. 1999. Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases. Cancer Res 59: 5830-5835.
-
(1999)
Cancer Res
, vol.59
, pp. 5830-5835
-
-
Zhong, H.1
De Marzo, A.M.2
Laughner, E.3
-
27
-
-
41149125007
-
Expression of hypoxia-inducible factor-1alpha and its relationship to tumour angiogenesis and cell proliferation in cartilage tumours
-
Kubo T, Sugita T, Shimose S, et al. 2008. Expression of hypoxia-inducible factor-1alpha and its relationship to tumour angiogenesis and cell proliferation in cartilage tumours. J Bone Joint Surg Br 90: 364-370.
-
(2008)
J Bone Joint Surg Br
, vol.90
, pp. 364-370
-
-
Kubo, T.1
Sugita, T.2
Shimose, S.3
-
31
-
-
4844228509
-
Hypoxia induces HIF-1alpha and VEGF expression in chondrosarcoma cells and chondrocytes
-
Lin C, McGough R, Aswad B, et al. 2004. Hypoxia induces HIF-1alpha and VEGF expression in chondrosarcoma cells and chondrocytes. J Orthop Res 22: 1175-1181.
-
(2004)
J Orthop Res
, vol.22
, pp. 1175-1181
-
-
Lin, C.1
McGough, R.2
Aswad, B.3
-
32
-
-
33846652552
-
Hypoxia-inducible factor-1alpha is a key regulator of metastasis in a transgenic model of cancer initiation and progression
-
Liao D, Corle C, Seagroves TN, et al. 2007. Hypoxia-inducible factor-1alpha is a key regulator of metastasis in a transgenic model of cancer initiation and progression. Cancer Res 67: 563-572.
-
(2007)
Cancer Res
, vol.67
, pp. 563-572
-
-
Liao, D.1
Corle, C.2
Seagroves, T.N.3
-
33
-
-
3843107242
-
Expression of hypoxia-inducible factor (HIF)-1alpha is associated with vascular endothelial growth factor expression and tumour angiogenesis in human oesophageal squamous cell carcinoma
-
Kimura S, Kitadai Y, Tanaka S, et al. 2004. Expression of hypoxia-inducible factor (HIF)-1alpha is associated with vascular endothelial growth factor expression and tumour angiogenesis in human oesophageal squamous cell carcinoma. Eur J Cancer 40: 1904-1912.
-
(2004)
Eur J Cancer
, vol.40
, pp. 1904-1912
-
-
Kimura, S.1
Kitadai, Y.2
Tanaka, S.3
-
35
-
-
28344457690
-
Recent advances in the basic science of chondrosarcoma
-
Terek RM,. 2006. Recent advances in the basic science of chondrosarcoma. Orthop Clin North Am 37: 9-14.
-
(2006)
Orthop Clin North Am
, vol.37
, pp. 9-14
-
-
Terek, R.M.1
-
36
-
-
33644551073
-
Gene expression programs in response to hypoxia: Cell type specificity and prognostic significance in human cancers
-
Chi JT, Wang Z, Nuyten DS, et al. 2006. Gene expression programs in response to hypoxia: cell type specificity and prognostic significance in human cancers. PLoS Med 3: e47.
-
(2006)
PLoS Med
, vol.3
, pp. 47
-
-
Chi, J.T.1
Wang, Z.2
Nuyten, D.S.3
-
37
-
-
26944465042
-
Array-based comparative gene expression analysis of tumor cells with increased apoptosis resistance after hypoxic selection
-
Weinmann M, Belka C, Guner D, et al. 2005. Array-based comparative gene expression analysis of tumor cells with increased apoptosis resistance after hypoxic selection. Oncogene 24: 5914-5922.
-
(2005)
Oncogene
, vol.24
, pp. 5914-5922
-
-
Weinmann, M.1
Belka, C.2
Guner, D.3
-
38
-
-
21344438419
-
Up-regulation of gene expression by hypoxia is mediated predominantly by hypoxia-inducible factor 1 (HIF-1)
-
Greijer AE, van der Groep P, Kemming D, et al. 2005. Up-regulation of gene expression by hypoxia is mediated predominantly by hypoxia-inducible factor 1 (HIF-1). J Pathol 206: 291-304.
-
(2005)
J Pathol
, vol.206
, pp. 291-304
-
-
Greijer, A.E.1
Van Der Groep, P.2
Kemming, D.3
-
39
-
-
1542305379
-
Hypoxia selection of death-resistant cells. A role for Bcl-X(L)
-
Dong Z, Wang J,. 2004. Hypoxia selection of death-resistant cells. A role for Bcl-X(L). J Biol Chem 279: 9215-9221.
-
(2004)
J Biol Chem
, vol.279
, pp. 9215-9221
-
-
Dong, Z.1
Wang, J.2
-
40
-
-
0036083168
-
Hypoxia inhibition of apoptosis induced by tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)
-
Park SY, Billiar TR, Seol DW,. 2002. Hypoxia inhibition of apoptosis induced by tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). Biochem Biophys Res Commun 291: 150-153.
-
(2002)
Biochem Biophys Res Commun
, vol.291
, pp. 150-153
-
-
Park, S.Y.1
Billiar, T.R.2
Seol, D.W.3
-
41
-
-
0031013458
-
Bcl-2 lies downstream of parathyroid hormone-related peptide in a signaling pathway that regulates chondrocyte maturation during skeletal development
-
Amling M, Neff L, Tanaka S, et al. 1997. Bcl-2 lies downstream of parathyroid hormone-related peptide in a signaling pathway that regulates chondrocyte maturation during skeletal development. J Cell Biol 136: 205-213.
-
(1997)
J Cell Biol
, vol.136
, pp. 205-213
-
-
Amling, M.1
Neff, L.2
Tanaka, S.3
-
42
-
-
0034537352
-
Up-regulation of PTHrP and Bcl-2 expression characterizes the progression of osteochondroma towards peripheral chondrosarcoma and is a late event in central chondrosarcoma
-
Bovee JV, van den Broek LJ, Cleton-Jansen AM, et al. 2000. Up-regulation of PTHrP and Bcl-2 expression characterizes the progression of osteochondroma towards peripheral chondrosarcoma and is a late event in central chondrosarcoma. Lab Invest 80: 1925-1934.
-
(2000)
Lab Invest
, vol.80
, pp. 1925-1934
-
-
Bovee, J.V.1
Van Den Broek, L.J.2
Cleton-Jansen, A.M.3
-
43
-
-
18744397844
-
The use of Bcl-2 and PTHLH immunohistochemistry in the diagnosis of peripheral chondrosarcoma in a clinicopathological setting
-
Hameetman L, Kok P, Eilers PH, et al. 2005. The use of Bcl-2 and PTHLH immunohistochemistry in the diagnosis of peripheral chondrosarcoma in a clinicopathological setting. Virchows Arch 446 (4): 430-437.
-
(2005)
Virchows Arch
, vol.446
, Issue.4
, pp. 430-437
-
-
Hameetman, L.1
Kok, P.2
Eilers, P.H.3
|