Hypoxia induces HIF-1α and VEGF expression in chondrosarcoma cells and chondrocytes

Journal of Orthopaedic Research

Volumn 22, Issue 6, 2004, Pages 1175-1181

  Lin, Chuzhao ^a   McGough, Richard ^a   Aswad, Bassam ^a   Block, Joel A ^b   Terek, Richard ^a,c  

^a RHODE ISLAND HOSPITAL   (United States)

^b RUSH UNIVERSITY MEDICAL CENTER   (United States)

^c BROWN UNIVERSITY   (United States)

Author keywords

Angiogenesis; Cartilage metabolism; Chondrosarcoma; Hypoxia

Indexed keywords

ANGIOGENESIS INHIBITOR; HYPOXIA INDUCIBLE FACTOR 1ALPHA; MESSENGER RNA; SMALL INTERFERING RNA; VASCULOTROPIN;

ANGIOGENESIS; ARTICLE; CANCER CELL CULTURE; CARTILAGE CELL; CELL HYPOXIA; CHONDROSARCOMA; CONTROLLED STUDY; DRUG TARGETING; GENE EXPRESSION REGULATION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA EXTRACTION; WESTERN BLOTTING;

ANOXIA; BONE NEOPLASMS; CELLS, CULTURED; CHONDROCYTES; CHONDROSARCOMA; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; NEOVASCULARIZATION, PATHOLOGIC; RNA, SMALL INTERFERING; TRANSCRIPTION FACTORS; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 4844228509     PISSN: 07360266     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.orthres.2004.03.002     Document Type: Article

References (34)

1. Aebersold D.M. Burri P. Beer K.T. Laissue J. Djonov V. Greiner R.H. et al. Expression of hypoxia-inducible factor-1alpha: a novel predictive and prognostic parameter in the radiotherapy of oropharyngeal cancer Cancer Res. 1 2001 2911-2916
2. Arbiser J.L. Petros J. Klafter R. Govindajaran B. McLaughlin E.R. Brown L.F. et al. Reactive oxygen generated by Nox1 triggers the angiogenic switch Proc Natl. Acad. Sci. USA 99 2002 715-720
3. Ayala G. Liu C. Nicosia R. Horowitz S. Lackman R. Microvasculature and VEGF expression in cartilaginous tumors Hum. Pathol. 31 2000 341-346
4. Comerford K.M. Wallace T.J. Karhausen J. Louis N.A. Montalto M.C. Colgan S.P. Hypoxia-inducible factor-1-dependent regulation of the multidrug resistance (MDR1) gene Cancer Res. 62 2002 3387-3394
5. Enomoto H. Inoki I. Komiya K. Shiomi T. Ikeda E. Obeta K. et al. Vascular endothelial growth factor isoforms and their receptors are expressed in human osteoarthritic cartilage Am. J. Pathol. 162 2003 171-181
6. Ferrara N. Davis-Smyth T. The biology of vascular endothelial growth factor Endocr. Rev. 18 1997 4-25
7. Grimshaw M.J. Mason R.M. Bovine articular chondrocyte function in vitro depends upon oxygen tension Osteoarthr. Cartil. 8 2000 386-392
8. Grimshaw M.J. Mason R.M. Modulation of bovine articular chondrocyte gene expression in vitro by oxygen tension Osteoarthr. Cart. 9 2001 357-364
9. Hanahan D. Weinberg R.A. The hallmarks of cancer Cell 100 2000 57-70
10. Haselgrove J.C. Shapiro I.M. Silverton S.F. Computer modeling of the oxygen supply and demand of cells of the avian growth cartilage Am. J. Physiol. 265 1993 C497-C506
11. Hayami T. Shukunami C. Mitsui K. Endo N. Tokunaga K. Kondo J. et al. Specific loss of chondromodulin-I gene expression in chondrosarcoma and the suppression of tumor angiogenesis and growth by its recombinant protein in vivo FEBS Lett. 458 1999 436-440
12. Hiraki Y. Mitsui K. Endo N. Takahashi K. Hayami T. Inoue H. et al. Molecular cloning of human chondromodulin-I, a cartilage-derived growth modulating factor, and its expression in Chinese hamster ovary cells Eur. J. Biochem. 260 1999 869-878
13. Hiraki Y. Shukunami C. Chondromodulin-I as a novel cartilage-specific growth-modulating factor Pediatr. Nephrol. 14 2000 602-605
14. Kaelin W.G. Jr. The von Hippel-Lindau gene, kidney cancer, and oxygen sensing J. Am Soc. Nephrol. 14 2003 2703-2711
15. Krishnamachary B. Berg-Dixon S. Kelly B. Agani F. Feldser D. Ferreira G. et al. Regulation of colon carcinoma cell invasion by hypoxia-inducible factor 1 Cancer Res. 63 2003 1138-1143
16. Lin C. Mak S. Meitner P.A. Wolf J.M. Bluman E.M. Block J.A. et al. Cancer/testis antigen CSAGE is concurrently expressed with MAGE in chondrosarcoma Gene 285 2002 269-278
17. Livak K.J. Schmittgen T.D. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method Methods 25 2001 402-408
18. Maxwell P.H. Pugh C.W. Ratcliffe P.J. Activation of the HIF pathway in cancer Curr. Opin. Genet. Dev. 11 2001 293-299
19. McGough R. Ayala G. Terek R. Microvascularity of cartilage tumors Clin. Orth. Rel. Res. 2002
20. Morioka H. Weissbach L. Vogel T. Nielsen G.P. Faircloth G.T. Shao L. et al. Antiangiogenesis treatment combined with chemotherapy produces chondrosarcoma necrosis Clin. Cancer Res. 9 2003 1211-1217
21. Moses M.A. Wiederschain D. Wu I. Fernandez C.A. Ghazizadeh V. Lane W.S. et al. Troponin I is present in human cartilage and inhibits angiogenesis Proc. Natl. Acad. Sci. USA 96 1999 2645-2650
22. Pfander D. Kortje D. Zimmermann R. Weseloh G. Kirsch T. Gesslein M. et al. Vascular endothelial growth factor in articular cartilage of healthy and osteoarthritic human knee joints Ann. Rheum. Dis. 60 2001 1070-1073
23. Rapisarda A. Uranchimeg B. Scudiero D.A. Selby M. Sausville E.A. Shoemaker R.H. et al. Identification of small molecule inhibitors of hypoxia-inducible factor 1 transcriptional activation pathway Cancer Res. 62 2002 4316-4324
24. Schipani E. Ryan H.E. Didrickson S. Kobayashi T. Knight M. Johnson R.S. Hypoxia in cartilage: HIF-1alpha is essential for chondrocyte growth arrest and survival Genes Dev. 15 2001 2865-2876
25. Semenza G.L. HIF-1: using two hands to flip the angiogenic switch Cancer Metastasis Rev. 19 2000 59-65
26. Shapiro I.M. Mansfield K.D. Evans S.M. Lord E.M. Koch C.J. Chondrocytes in the endochondral growth cartilage are not hypoxic Am. J. Physiol. 272 1997 C1134-C1143
27. Shi Y. Mammalian RNAi for the masses Trends Genet. 19 2003 9-12
28. Shukunami C. Hiraki Y. Role of cartilage-derived anti-angiogenic factor, chondromodulin-I, during endochondral bone formation Osteoarthr. Cart. 9 Suppl A 2001 S91-S101
29. Silver I.A. Measurement of pH and ionic composition of pericellular sites Philos. Trans. R. Soc. Lond. Ser. B 271 1975 261-272
30. Steinbrech D.S. Mehrara B.J. Saadeh P.B. Greenwald J.A. Spector J.A. Gittes G.K. et al. VEGF expression in an osteoblast-like cell line is regulated by a hypoxia response mechanism Am. J. Physiol. Cell Physiol. 278 2000 C853-C860
31. Terek R, Aswad B, Lin C. HIF-1aplha is expressed in chondrosarcoma. In: 48th Annual Meeting of the Orthopaedic Research Society; 2002
32. Weidner N. Semple J.P. Welch W.R. Folkman J. Tumor angiogenesis and metastasis-correlation in invasive breast carcinoma N Engl. J. Med. 324 1991 1-8
33. Wiesener M.S. Turley H. Allen W.E. Willam C. Eckardt K.U. Talks K.L. et al. Induction of endothelial PAS domain protein-1 by hypoxia: characterization and comparison with hypoxia-inducible factor-1alpha Blood 92 1998 2260-2268
34. Wyman J.J. Hornstein A.M. Meitner P.A. Mak S. Verdier P. Block J.A. et al. Multidrug resistance-1 and p-glycoprotein in human chondrosarcoma cell lines: expression correlates with decreased intracellular doxorubicin and in vitro chemoresistance J. Orthop. Res. 17 1999 935-940