Enhanced responsiveness to T-cell help causes loss of B-lymphocyte tolerance to a β-cell neo-self-antigen in type 1 diabetes prone NOD mice

European Journal of Immunology

Volumn 40, Issue 12, 2010, Pages 3413-3425

  Cox, Selwyn Lewis ^a,b   Stolp, Jessica ^a,b   Hallahan, Nicole L ^a,b   Counotte, Jacqueline ^a,b   Zhang, Wenyu ^a,b   Serreze, David V ^c   Basten, Antony ^a,b   Silveira, Pablo A ^a,b  

^a GARVAN INSTITUTE OF MEDICAL RESEARCH   (Australia)

^b UNIVERSITY OF NEW SOUTH WALES   (Australia)

^c JACKSON LABORATORY   (United States)

Author keywords

Anergy; B lymphocytes; Self tolerance; Transgenic mice; Type 1 diabetes

Indexed keywords

AUTOANTIGEN; INSULIN; LYSOZYME;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN PRESENTING CELL; ARTICLE; B LYMPHOCYTE; CLONAL ANERGY; CONTROLLED STUDY; DISEASE PREDISPOSITION; GENE; GENE LOCUS; GENE MAPPING; IDD5 GENE; IDD9 GENE; IMMUNE RESPONSE; IMMUNOLOGICAL TOLERANCE; IN VIVO STUDY; INSULIN DEPENDENT DIABETES MELLITUS; MOUSE; NONHUMAN; NONOBESE DIABETIC MOUSE; PANCREAS ISLET BETA CELL; PATHOGENESIS; PRIORITY JOURNAL; PROMOTER REGION; T LYMPHOCYTE;

ADOPTIVE TRANSFER; ANIMALS; AUTOANTIGENS; B-LYMPHOCYTES; CYTOKINES; DIABETES MELLITUS, TYPE 1; GENETIC PREDISPOSITION TO DISEASE; IMMUNOGLOBULINS; INSULIN; INSULIN-SECRETING CELLS; MICE; MICE, INBRED C57BL; MICE, INBRED NOD; MICE, TRANSGENIC; MURAMIDASE; PROMOTER REGIONS, GENETIC; SELF TOLERANCE; T-LYMPHOCYTES, HELPER-INDUCER; TRANSGENES; TRANSPLANTATION CHIMERA;

EID: 78649603355     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.201040817     Document Type: Article

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