Essential structural features of TNF-α lectin-like domain derived peptides for activation of amiloride-sensitive sodium current in A549 cells

Journal of Medicinal Chemistry

Volumn 53, Issue 22, 2010, Pages 8021-8029

  Hazemi, Parastoo ^a   Tzotzos, Susan J ^b   Fischer, Bernhard ^b   Andavan, Gowri Shankar Bagavananthem ^a   Fischer, Hendrik ^b   Pietschmann, Helmut ^b   Lucas, Rudolf ^c   Lemmens Gruber, Rosa ^a  

^a UNIVERSITY OF VIENNA   (Austria)

^b APEPTICO Forschung und Entwicklung GmbH   (Austria)

^c MEDICAL COLLEGE OF GEORGIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMILORIDE; CYCLO (4 AMINOBUTANOIC ACID GLYCYLGLUTAMINYLARGINYLGLUTAMYLTHREONYLPROLYLGLUTAMYLGLYCYLALANYLGLUTAMYLALANYLLYSYLPROLYLTRYPTOPHANYLTYROSYLASPARTIC ACID); CYCLO (4 AMINOBUTANOIC ACID GLYCYLGLUTAMINYLARGINYLGLUTAMYLTHREONYLPROLYLGLUTAMYLGLYCYLALANYLGLUTAMYLALANYLLYSYLPROLYLTRYPTOPHANYLTYROSYLGLYCINE); CYCLO (5 AMINOPENTANOIC ACID GLYCYLGLUTAMINYLARGINYLGLUTAMYLTHREONYLPROLYLGLUTAMYLGLYCYLALANYLGLUTAMYLALANYLLYSYLPROLYLTRYPTOPHANYLTYROSYLGLYCINE); CYCLO (6 AMINOHEXANOIC ACID GLYCYLGLUTAMINYLARGINYLGLUTAMYLTHREONYLPROLYLGLUTAMYLGLYCYLALANYLGLUTAMYLERRORLYSYLPROLYLTRYPTOPHANYLTYROSYLGLYCINE); CYCLO (7 AMINOHEPTANOIC ACID GLYCYLGLUTAMINYLARGINYLGLUTAMYLTHREONYLPROLYLGLUTAMYLGLYCYLALANYLGLUTAMYLALANYLLYSYLPROLYLTRYPTOPHANYLTYROSINE); CYCLO (BETA ALANINE GLYCYLGLUTAMINYLARGINYLGLUTAMYLTHREONYLPROLYLGLUTAMYLALANYLLYSYLPROLYLLYSYLPROLYLTRYPTOPHANYLTYROSYLGLUTAMIC ACID); CYCLO (CYSTEINYLGLUTAMINYLARGINYLGLUTAMYLTHREONYLPROLYLGLUTAMYLGLYCYLALANYLGLUTAMYLLYSYLGLYCYLGLYCYLCYSTEINE); CYCLO (CYSTEINYLGLYCYLGLUTAMINYLARGINYLGLUTAMYLALANYLPROLYLALANYLGLYCYLALANYLALANYLALANYLALANYLLYSYLPROLYLTRYPTOPHANYLTYROSYLCYSTEINE); CYCLO (CYSTEINYLGLYCYLGLUTAMINYLARGINYLGLUTAMYLTHREONYLPROLYLGLUTAMYLGLYCYLALANYLGLUTAMYLALANYLLYSYLPROLYLTRYPTOPHANYLTYROSYLCYSTEINE); CYCLO (LYSYLGLYCYLGLUTAMINYLARGINYLGLUTAMYLTHREONYLPROLYLGLUTAMYLGLYCYLALANYLLYSYLPROLYLTRYPTOPHANYLTYROSYLGLYCINE); CYCLO (LYSYLSERYLPROLYLGLYCYLGLUTAMINYLARGINYLGLUTAMYLTHREONYLPROLYLGLUTAMYLGLYCYLALANYLGLUTAMYLALANYLLYSYLPROLYLTRYPTOPHANYLTYROSYLGLUTAMIC ACID); CYCLO (ORNITHINE GLYCYLGLUTAMINYLARGINYLGLUTAMYLTHREONYLPROLYLGLUTAMYLGLYCYLALANYLGLUTAMYLALANYLLYSYLPROLYLTRYPTOPHANYLTYROSYLGLYCINE); DISULFIDE; EPITHELIAL SODIUM CHANNEL; LECTIN; PEPTIDE DERIVATIVE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; DISULFIDE BOND; DRUG STRUCTURE; HUMAN; HUMAN CELL; PROTEIN DOMAIN; PROTEIN STRUCTURE; SODIUM CURRENT; SODIUM TRANSPORT; STRUCTURE ACTIVITY RELATION;

AMILORIDE; CATIONS, MONOVALENT; CELL LINE, TUMOR; EPITHELIAL SODIUM CHANNEL; HUMANS; LECTINS; MODELS, MOLECULAR; PATCH-CLAMP TECHNIQUES; PEPTIDES, CYCLIC; PEPTIDOMIMETICS; POTASSIUM; PROTEIN STRUCTURE, TERTIARY; SODIUM; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR NECROSIS FACTOR-ALPHA;

EID: 78649529048     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm100767p     Document Type: Article

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