Identification of novel small molecule activators of nuclear factor-κb with neuroprotective action via high-throughput screening

Journal of Neuroscience Research

Volumn 89, Issue 1, 2011, Pages 58-72

  Manuvakhova, Marina S ^a   Johnson, Guyla G ^a   White, Misti C ^a   Ananthan, Subramaniam ^a   Sosa, Melinda ^a   Maddox, Clinton ^a   McKellip, Sara ^a   Rasmussen, Lynn ^a   Wennerberg, Krister ^a   Hobrath, Judith V ^a   White, E Lucile ^a   Maddry, Joseph A ^a   Grimaldi, Maurizio ^a  

^a SOUTHERN RESEARCH INSTITUTE   (United States)

Author keywords

Astrocytes; High throughput screening; Neurons; Neuroprotection; NF B; P65; Small molecules; Translocation

Indexed keywords

CYTOKINE; GLUTAMIC ACID; I KAPPA B KINASE BETA; SCAFFOLD PROTEIN; SYNAPTOTAGMIN I;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; CELL ACTIVATION; CELL ASSAY; CLUSTER ANALYSIS; FEMALE; FOLLOW UP; GENE EXPRESSION; GENE TRANSLOCATION; HIGH THROUGHPUT SCREENING; MOLECULAR DOCKING; NERVE CELL NECROSIS; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; RAT; UPREGULATION;

ANIMALS; CELL LINE, TUMOR; CELLS, CULTURED; HUMANS; NEURONS; NEUROPROTECTIVE AGENTS; NF-KAPPA B; RATS; RATS, WISTAR; SIGNAL TRANSDUCTION; TRANSFECTION;

EID: 78649519864     PISSN: 03604012     EISSN: 10974547     Source Type: Journal    
DOI: 10.1002/jnr.22526     Document Type: Article

References (39)

1. Albensi BC, Mattson MP. 2000. Evidence for the involvement of TNF and NF-kappaB in hippocampal synaptic plasticity. Synapse 35: 151-159.
2. Antczak M, Kung HJ. 1990. Transformation of chicken embryo fibroblasts by direct DNA transfection of single oncogenes: comparative analyses of src, erbB, myc, and ras. J Virol 64: 1451-1458.
3. Auld DS, Southall NT, Jadhav A, Johnson RL, Diller DJ, Simeonov A, Austin CP, Inglese J. 2008. Characterization of chemical libraries for luciferase inhibitory activity. J Med Chem 51: 2372-2386.
4. Berkowitz B, Huang DB, Chen-Park FE, Sigler PB, Ghosh G. 2002. The x-ray crystal structure of the NF-kappa B p50.p65 heterodimer bound to the interferon beta-kappa B site. J Biol Chem 277: 24694-24700.
5. Bhakar AL, Tannis LL, Zeindler C, Russo MP, Jobin C, Park DS, MacPherson S, Barker PA. 2002. Constitutive nuclear factor-kappa B activity is required for central neuron survival. J Neurosci 22: 8466-8475.
6. Biedler JL, Roffler-Tarlov S, Schachner M, Freedman LS. 1978. Multiple neurotransmitter synthesis by human neuroblastoma cell lines and clones. Cancer Res 38: 3751-3757.
7. Chen FE, Huang DB, Chen YQ, Ghosh G. 1998. Crystal structure of p50/p65 heterodimer of transcription factor NF-kappaB bound to DNA. Nature 391: 410-413.
8. Cheng B, Christakos S, Mattson MP. 1994. Tumor necrosis factors protect neurons against metabolic-excitotoxic insults and promote maintenance of calcium homeostasis. Neuron 12: 139-153.
9. Cogswell PC, Kashatus DF, Keifer JA, Guttridge DC, Reuther JY, Bristow C, Roy S, Nicholson DW, Baldwin ASJr. 2003. NF-kappa B and I kappa B alpha are found in the mitochondria. Evidence for regulation of mitochondrial gene expression by NF-kappa B. J Biol Chem 278: 2963-2968.
10. Favit A, Grimaldi M, Nelson TJ, Alkon DL. 1998. Alzheimer's-specific effects of soluble beta-amyloid on protein kinase C-alpha and -gamma degradation in human fibroblasts. Proc Natl Acad Sci U S A 95: 5562-5567.
11. Gilmore TD. 1990. NF-kappa B, KBF1, dorsal, and related matters. Cell 62: 841-843.
12. Gilmore TD. 2006. Introduction to NF-kappaB: players, pathways, perspectives. Oncogene 25: 6680-6684.
13. Grimaldi M, Pozzoli G, Navarra P, Preziosi P, Schettini G. 1994. Vasoactive intestinal peptide and forskolin stimulate interleukin 6 production by rat cortical astrocytes in culture via a cyclic AMP-dependent, prostaglandin-independent mechanism. J Neurochem 63: 344-350.
14. Grimaldi M, Favit A, Alkon DL. 1999. cAMP-induced cytoskeleton rearrangement increases calcium transients through the enhancement of capacitative calcium entry. J Biol Chem 274: 33557-33564.
15. Guerrini L, Blasi F, Denis-Donini S. 1995. Synaptic activation of NF-kappa B by glutamate in cerebellar granule neurons in vitro. Proc Natl Acad Sci U S A 92: 9077-9081.
16. Guo Q, Robinson N, Mattson MP. 1998. Secreted beta-amyloid precursor protein counteracts the proapoptotic action of mutant presenilin-1 by activation of NF-kappaB and stabilization of calcium homeostasis. J Biol Chem 273: 12341-12351.
17. Hart DJ, Speight RE, Sutherland JD, Blackburn JM. 2001. Analysis of the NF-kappaB p50 dimer interface by diversity screening. J Mol Biol 310: 563-575.
18. Hoffmann A, Natoli G, Ghosh G. 2006. Transcriptional regulation via the NF-kappaB signaling module. Oncogene 25: 6706-6716.
19. Holloway JN, Murthy S, El-Ashry D. 2004. A cytoplasmic substrate of mitogen-activated protein kinase is responsible for estrogen receptor-alpha down-regulation in breast cancer cells: the role of nuclear factor-kappaB. Mol Endocrinol 18: 1396-1410.
20. Huberman M, Berg PE, Curcio MJ, DiPietro J, Henderson AS, Anderson WF. 1984. Fate and structure of DNA microinjected into mouse TK-L cells. Exp Cell Res 153: 347-362.
21. Huxford T, Malek S, Ghosh G. 1999. Structure and mechanism in NF-kappa B/I kappa B signaling. Cold Spring Harbor Symp Quant Biol 64: 533-540.
22. Kaltschmidt B, Uherek M, Wellmann H, Volk B, Kaltschmidt C. 1999. Inhibition of NF-kappaB potentiates amyloid beta-mediated neuronal apoptosis. Proc Natl Acad Sci U S A 96: 9409-9414.
23. Kaltschmidt B, Widera D, Kaltschmidt C. 2005. Signaling via NF-kappaB in the nervous system. Biochim Biophys Acta 1745: 287-299.
24. Kaltschmidt C, Kaltschmidt B, Baeuerle PA. 1995. Stimulation of ionotropic glutamate receptors activates transcription factor NF-kappa B in primary neurons. Proc Natl Acad Sci U S A 92: 9618-9622.
25. Karin M, Ben-Neriah Y. 2000. Phosphorylation meets ubiquitination: the control of NF-κB activity. Annu Rev Immunol 18: 621-663.
26. Leahy P, Carmichael GG, Rossomando EF. 1997. Transcription from plasmid expression vectors is increased up to 14-fold when plasmids are transfected as concatemers. Nucleic Acids Res 25: 449-450.
27. Liu CA, Wang MJ, Chi CW, Wu CW, Chen JY. 2004. Overexpression of rho effector rhotekin confers increased survival in gastric adenocarcinoma. J Biomed Sci 11: 661-670.
28. Lopes FM, Schroder R, da Frota MLJr, Zanotto-Filho A, Muller CB, Pires AS, Meurer RT, Colpo GD, Gelain DP, Kapczinski F, Moreira JC, Fernandes Mda C, Klamt F. 2010. Comparison between proliferative and neuron-like SH-SY5Y cells as an in vitro model for Parkinson disease studies. Brain Res 1337: 85-94.
29. Lu Q, Qiu X, Hu N, Wen H, Su Y, Richardson BC. 2006. Epigenetics, disease, and therapeutic interventions. Ageing Res Rev 5: 449-467.
30. Marchetti L, Klein M, Schlett K, Pfizenmaier K, Eisel UL. 2004. Tumor necrosis factor (TNF)-mediated neuroprotection against glutamate-induced excitotoxicity is enhanced by N-methyl-D-aspartate receptor activation. Essential role of a TNF receptor 2-mediated phosphatidylinositol 3-kinase-dependent NF-kappa B pathway. J Biol Chem 279: 32869-32881.
31. Mattson MP, Meffert MK. 2006. Roles for NF-kappaB in nerve cell survival, plasticity, and disease. Cell Death Differ 13: 852-860.
32. Meberg PJ, Kinney WR, Valcourt EG, Routtenberg A. 1996. Gene expression of the transcription factor NF-kappa B in hippocampus: regulation by synaptic activity. Brain Res Mol Brain Res 38: 179-190.
33. Pascale A, Alkon DL, Grimaldi M. 2004. Translocation of protein kinase C-betaII in astrocytes requires organized actin cytoskeleton and is not accompanied by synchronous RACK1 relocation. Glia 46: 169-182.
34. Pizzi M, Sarnico I, Boroni F, Benarese M, Steimberg N, Mazzoleni G, Dietz GP, Bahr M, Liou HC, Spano PF. 2005. NF-kappaB factor c-Rel mediates neuroprotection elicited by mGlu5 receptor agonists against amyloid beta-peptide toxicity. Cell Death Differ 12: 761-772.
35. Schmid JA, Birbach A, Hofer-Warbinek R, Pengg M, Burner U, Furtmuller PG, Binder BR, de Martin R. 2000. Dynamics of NF kappa B and Ikappa Balpha studied with green fluorescent protein (GFP) fusion proteins. Investigation of GFP-p65 binding to DNa by fluorescence resonance energy transfer. J Biol Chem 275: 17035-17042.
36. Sengchanthalangsy LL, Datta S, Huang DB, Anderson E, Braswell EH, Ghosh G. 1999. Characterization of the dimer interface of transcription factor NFkappaB p50 homodimer. J Mol Biol 289: 1029-1040.
37. Wooten MW. 1999. Function for NF-κB in neuronal survival: regulation by atypical protein kinase C. J Neurosci Res 58: 607-611.
38. Zhang JH, Chung TD, Oldenburg KR. 1999. A simple statistical parameter for use in evaluation and validation of high throughput screening assays. J Biomol Screen 4: 67-73.
39. Zhang W, Potrovita I, Tarabin V, Herrmann O, Beer V, Weih F, Schneider A, Schwaninger M. 2005. Neuronal activation of NF-kappaB contributes to cell death in cerebral ischemia. J Cereb Blood Flow Metab 25: 30-40.